• 5769 Citations
  • 42 h-Index
1986 …2019
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Research Output 1986 2019

2001
65 Citations (Scopus)

Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina

Shamsul Ola, M., Martin, P. M., El-Sherbeny, A., Roon, P., Agarwal, N., Sarthy, V. P., Casellas, P., Ganapathy, V. & Smith, S. B., Nov 1 2001, In : Molecular Brain Research. 95, 1-2, p. 86-95 10 p.

Research output: Contribution to journalArticle

Retina
Messenger RNA
Proteins
Ganglia
Retinal Pigments
69 Citations (Scopus)

Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor

Seth, P., Ganapathy, M. E., Conway, S. J., Bridges, C. D., Smith, S. B., Casellas, P. & Ganapathy, V., Jul 25 2001, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1540, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

Ligands
Amino Acids
Brain
Exons
Ethyldimethylaminopropyl Carbodiimide
29 Citations (Scopus)

Molecular Characterization and Developmental Expression of NORPEG, a Novel Gene Induced by Retinoic Acid

Kutty, R. K., Kutty, G., Samuel, W., Duncan, T., Bridges, C. C., El-Sherbeeny, A., Nagineni, C. N., Smith, S. B. & Wiggert, B., Jan 26 2001, In : Journal of Biological Chemistry. 276, 4, p. 2831-2840 10 p.

Research output: Contribution to journalArticle

Tretinoin
Genes
Proteins
Testis
Cytoplasm
45 Citations (Scopus)

Regulation of taurine transporter expression by NO in cultured human retinal pigment epithelial cells

Bridges, C. C., Ola, M. S., Prasad, P. D., El-Sherbeny, A., Ganapathy, V. & Smith, S. B., Dec 1 2001, In : American Journal of Physiology - Cell Physiology. 281, 6 50-6

Research output: Contribution to journalArticle

Retinal Pigments
Taurine
Nitric Oxide
Epithelial Cells
Nitric Oxide Donors
96 Citations (Scopus)

Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells

Bridges, C. C., Kekuda, R., Wang, H., Prasad, P. D., Mehta, P., Huang, W., Smith, S. B. & Ganapathy, V., Jan 30 2001, In : Investigative Ophthalmology and Visual Science. 42, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Retinal Pigments
Cystine
Epithelial Cells
Light
2002
38 Citations (Scopus)

Analysis of sigma receptor (σR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabetic mice

Shamsul Ola, M., Martin, P. M., Maddox, D., El-Sherbeny, A., Huang, W., Roon, P., Agarwal, N., Ganapathy, V. & Smith, S. B., Nov 15 2002, In : Molecular Brain Research. 107, 2, p. 97-107 11 p.

Research output: Contribution to journalArticle

sigma Receptors
Retinal Ganglion Cells
Retina
Streptozocin
N-Methyl-D-Aspartate Receptors
35 Citations (Scopus)

Ciliary neurotrophic factor induces glial fibrillary acidic protein in retinal Müller cells through the JAK/STAT signal transduction pathway

Wang, Y., Smith, S. B., Ogilvie, J. M., McCool, D. J. & Sarthy, V., Oct 23 2002, In : Current Eye Research. 24, 4, p. 305-312 8 p.

Research output: Contribution to journalArticle

Ciliary Neurotrophic Factor
Glial Fibrillary Acidic Protein
Signal Transduction
Immunohistochemistry
Intravitreal Injections
16 Citations (Scopus)

Diabetic retinopathy and the NMDA receptor

Smith, S. B., Jul 2 2002, In : Drug News and Perspectives. 15, 4, p. 226-232 7 p.

Research output: Contribution to journalReview article

Diabetic Retinopathy
N-Methyl-D-Aspartate Receptors
Retina
Glutamate Receptors
N-Methylaspartate
29 Citations (Scopus)

Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice

Naggar, H., Shamsul Ola, M., Martin, P. M., Huang, W., Bridges, C. C., Ganapathy, V. & Smith, S. B., Feb 11 2002, In : Investigative Ophthalmology and Visual Science. 43, 2, p. 556-563 8 p.

Research output: Contribution to journalArticle

Folic Acid Transporters
Reduced Folate Carrier Protein
Retinal Pigments
Down-Regulation
Epithelial Cells
76 Citations (Scopus)

Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain

Inoue, K., Zhuang, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Oct 18 2002, In : Journal of Biological Chemistry. 277, 42, p. 39469-39476 8 p.

Research output: Contribution to journalArticle

Citric Acid
Brain
Sodium
Liver
Rats
27 Citations (Scopus)

Transcellular transfer of folate across the retinal pigment epithelium

Bridges, C. C., El-Sherbeny, A., Ola, M. S., Ganapathy, V. & Smith, S. B., Jan 1 2002, In : Current Eye Research. 24, 2, p. 129-138 10 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Folic Acid
Membranes
Reduced Folate Carrier Protein
Photoreceptor Cells
65 Citations (Scopus)

Transport of D-serine via the amino acid transporter ATB0,+ expressed in the colon

Hatanaka, T., Huang, W., Nakanishi, T., Bridges, C. C., Ganapathy, V., Smith, S. B., Prasad, P. D., Ganapathy, V. & Ganapathy, M. E., Jan 1 2002, In : Biochemical and Biophysical Research Communications. 291, 2, p. 291-295 5 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Serine
Colon
Enantiomers
Intestines
2003
46 Citations (Scopus)

Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action

Inoue, K., Zhuang, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Aug 15 2003, In : Biochemical Journal. 374, 1, p. 21-26 6 p.

Research output: Contribution to journalArticle

Lithium
Drosophila
Citric Acid
Liver
Genes
19 Citations (Scopus)

Identification of a novel Na+- And Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat

Hu, H., Miyauchi, S., Bridges, C. C., Smith, S. B. & Ganapathy, V., Oct 1 2003, In : Biochemical Journal. 375, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

Retinal Pigments
Opioid Peptides
Retinal Pigment Epithelium
HIV-1
Cells
42 Citations (Scopus)
Reduced Folate Carrier Protein
Limb Buds
Yolk Sac
Rhombencephalon
Neural Tube
14 Citations (Scopus)
Reduced Folate Carrier Protein
Retinal Pigments
Homocysteine
Epithelial Cells
Folic Acid
2004
312 Citations (Scopus)

Death of retinal neurons in streptozotocin-induced diabetic mice

Martin, P. M., Roon, P., Van Ells, T. K., Ganapathy, V. & Smith, S. B., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 3330-3336 7 p.

Research output: Contribution to journalArticle

Retinal Neurons
Streptozocin
Ganglia
Retina
Cell Death
105 Citations (Scopus)

Expression of slc5a8 in kidney and its role in Na+-coupled transport of lactate

Gopal, E., Fei, Y. J., Sugawara, M., Miyauchi, S., Zhuang, L., Martin, P. M., Smith, S. B., Prasad, P. D. & Ganapathy, V., Oct 22 2004, In : Journal of Biological Chemistry. 279, 43, p. 44522-44532 11 p.

Research output: Contribution to journalArticle

Lactic Acid
Kidney
Volatile Fatty Acids
Fatty Acids
Propionates
31 Citations (Scopus)

Induction of cystine-glutamate transporter Xc - by human immunodeficiency virus type 1 transactivator protein Tat in retinal pigment epithelium

Bridges, C. C., Hu, H., Miyauchi, S., Siddaramappa, U. N., Ganapathy, M. E., Ignatowicz, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 2906-2914 9 p.

Research output: Contribution to journalArticle

tat Gene Products
Amino Acid Transport System X-AG
Trans-Activators
Cystine
Retinal Pigment Epithelium
55 Citations (Scopus)

Osmoregulation of Taurine Transporter Function and Expression in Retinal Pigment Epithelial, Ganglion, and Müller Cells

El-Sherbeny, A., Naggar, H., Miyauchi, S., Ola, M. S., Maddox, D. M., Martin, P. M., Ganapathy, V. & Smith, S. B., Feb 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 2, p. 694-701 8 p.

Research output: Contribution to journalArticle

Osmoregulation
Retinal Pigments
Ganglia
Taurine
Mannitol
117 Citations (Scopus)

SLC19: The folate/thiamine transporter family

Ganapathy, V., Smith, S. B. & Prasad, P. D., Feb 1 2004, In : Pflugers Archiv European Journal of Physiology. 447, 5, p. 641-646 6 p.

Research output: Contribution to journalReview article

Folic Acid Transporters
Thiamine
Folic Acid
Genes
Substrates
62 Citations (Scopus)

The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate

Martin, P. M., Ola, M. S., Agarwal, N., Ganapathy, V. & Smith, S. B., Apr 7 2004, In : Molecular Brain Research. 123, 1-2, p. 66-75 10 p.

Research output: Contribution to journalArticle

sigma Receptors
Pentazocine
Retinal Ganglion Cells
Homocysteine
Glutamic Acid
97 Citations (Scopus)

Transport of Amino Acid-Based Prodrugs by the Na+- and Cl --Coupled Amino Acid Transporter ATB0,+ and Expression of the Transporter in Tissues Amenable for Drug Delivery

Hatanaka, T., Haramura, M., Fei, Y. J., Miyauchi, S., Bridges, C. C., Ganapathy, P. S., Smith, S. B., Ganapathy, V. & Ganapathy, M. E., Mar 1 2004, In : Journal of Pharmacology and Experimental Therapeutics. 308, 3, p. 1138-1147 10 p.

Research output: Contribution to journalArticle

valacyclovir
Amino Acid Transport Systems
Prodrugs
Aspartic Acid
Amino Acids
25 Citations (Scopus)
Sodium
Canavan Disease
Dicarboxylic Acid Transporters
Optic Nerve Diseases
Messenger RNA
2005
40 Citations (Scopus)
Glutamine
Protein Isoforms
system N protein 1
Messenger RNA
Substrate Specificity
7 Citations (Scopus)

Regulation of reduced-folate transporter-1 in retinal pigment epithelial cells by folate

Naggar, H., Van Ells, T. K., Ganapathy, V. & Smith, S. B., Jan 1 2005, In : Current Eye Research. 30, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

Reduced Folate Carrier Protein
Retinal Pigments
Folic Acid
Epithelial Cells
Folic Acid Transporters
2006
54 Citations (Scopus)

c/ebpδ null mouse as a model for the double knock-out of slc5a8 and slc5a12 in kidney

Thangaraju, M., Ananth, S., Martin, P. M., Roon, P., Smith, S. B., Sterneck, E., Prasad, P. D. & Ganapathy, V., Sep 15 2006, In : Journal of Biological Chemistry. 281, 37, p. 26769-26773 5 p.

Research output: Contribution to journalArticle

Lactic Acid
Kidney
Uric Acid
Monocarboxylic Acid Transporters
Tissue
47 Citations (Scopus)

Expression, subcellular localization, and regulation of sigma receptor in retinal Müller cells

Jiang, G., Mysona, B., Dun, Y., Gnana-Prakasam, J. P., Pabla, N., Li, W., Dong, Z., Ganapathy, V. & Smith, S. B., Dec 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 12, p. 5576-5582 7 p.

Research output: Contribution to journalArticle

sigma Receptors
Pentazocine
Ligands
Reactive Oxygen Species
Nitric Oxide
30 Citations (Scopus)

Expression and polarized localization of the hemochromatosis gene product HFE in retinal pigment epithelium

Martin, P. M., Gnana-Prakasam, J. P., Roon, P., Smith, R. G., Smith, S. B. & Ganapathy, V., Oct 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 10, p. 4238-4244 7 p.

Research output: Contribution to journalArticle

Hemochromatosis
Retinal Pigment Epithelium
Retina
Genes
Transferrin Receptors
77 Citations (Scopus)

Expression of the cystine-glutamate exchanger (xc-) in retinal ganglion cells and regulation by nitric oxide and oxidative stress

Dun, Y., Mysona, B. A., Van Ells, T., Amarnath, L., Shamsul Ola, M., Ganapathy, V. & Smith, S. B., May 1 2006, In : Cell and Tissue Research. 324, 2, p. 189-202 14 p.

Research output: Contribution to journalArticle

Oxidative stress
Cystine
Retinal Ganglion Cells
Glutamic Acid
Nitric Oxide
84 Citations (Scopus)

Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain

Martin, P. M., Gopal, E., Ananth, S., Zhuang, L., Itagaki, S., Prasad, B. M., Smith, S. B., Prasad, P. D. & Ganapathy, V., Jul 1 2006, In : Journal of Neurochemistry. 98, 1, p. 279-288 10 p.

Research output: Contribution to journalArticle

Ketone Bodies
Neurons
Lactic Acid
Brain
Hydroxybutyrates
3 Citations (Scopus)

Immunofluorescence analysis of the expression of Norpeg (Rai14) in retinal Müller and ganglion cells

Kutty, R. K., Samuel, W., Chen, S., Vijayasarathy, C., Dun, Y., Mysona, B. A., Wiggert, B. & Smith, S. B., Sep 1 2006, In : Neuroscience Letters. 404, 3, p. 294-298 5 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Fluorescent Antibody Technique
Retina
Ganglia
Ankyrin Repeat
2 Citations (Scopus)

Regulation of taurine transporter activity in cultured rat retinal ganglion cells and rat retinal Müller cells

Eissa, L. A., Smith, S. B. & El-Sherbeny, A. A., Jan 1 2006, In : Saudi Pharmaceutical Journal. 14, 1, p. 16-26 11 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Taurine
Nitric Oxide Donors
Diabetic Retinopathy
Glutamic Acid
54 Citations (Scopus)

Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta

Sugita, S., Futagami, Y., Smith, S. B., Naggar, H. & Mochizuki, M., Dec 1 2006, In : Experimental Eye Research. 83, 6, p. 1459-1471 13 p.

Research output: Contribution to journalArticle

Ciliary Body
Transforming Growth Factor beta
Epithelium
T-Lymphocytes
Retinal Pigment Epithelium
88 Citations (Scopus)

SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases

Thangaraju, M., Gopal, E., Martin, P. M., Ananth, S., Smith, S. B., Prasad, P. D., Sterneck, E. & Ganapathy, V., Dec 15 2006, In : Cancer Research. 66, 24, p. 11560-11564 5 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Pyruvic Acid
Apoptosis
Lactic Acid
Neoplasms
2007
43 Citations (Scopus)
Proton-Coupled Folate Transporter
Retina
Organism Cloning
Folic Acid
Xenopus laevis
122 Citations (Scopus)

Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity

Livingston, M. J., Wei, Q., Pabla, N., Dong, G., Wang, C. Y., Yang, T., Smith, S. B. & Dong, Z., May 1 2007, In : Biochemical Pharmacology. 73, 9, p. 1499-1510 12 p.

Research output: Contribution to journalArticle

Scavenging
Hydroxyl Radical
Cisplatin
Chemical activation
Apoptosis
34 Citations (Scopus)

Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines

Gopal, E., Miyauchi, S., Martin, P. M., Ananth, S., Srinivas, S. R., Smith, S. B., Prasad, P. D. & Ganapathy, V., Jan 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 292, 1, p. G402-G408

Research output: Contribution to journalArticle

Citric Acid
Cell Line
Liver
Hepatocytes
rat Slc13a5 protein
28 Citations (Scopus)

Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina

Martin, P. M., Dun, Y., Mysona, B. A., Ananth, S., Roon, P., Smith, S. B. & Ganapathy, V., Jul 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 7, p. 3356-3363 8 p.

Research output: Contribution to journalArticle

Retina
Sodium
Ganglia
Messenger RNA
Proteins
38 Citations (Scopus)

Functional and molecular analysis of d-serine transport in retinal Müller cells

Dun, Y., Mysona, B. A., Itagaki, S., Martin-Studdard, A., Ganapathy, V. & Smith, S. B., Jan 1 2007, In : Experimental eye research. 84, 1, p. 191-199 9 p.

Research output: Contribution to journalArticle

Serine
N-Methyl-D-Aspartate Receptors
Immunoblotting
Retina
Retinal Neurons
67 Citations (Scopus)
Pentazocine
Retinal Ganglion Cells
Glutamic Acid
Homocysteine
Ligands
24 Citations (Scopus)

Progesterone inhibits folic acid transport in human trophoblasts

Keating, E., Gonçalves, P., Lemos, C., Costa, F., Campos, I., Smith, S. B., Bridges, C. C. & Martel, F., Apr 1 2007, In : Journal of Membrane Biology. 216, 2-3, p. 143-152 10 p.

Research output: Contribution to journalArticle

Trophoblasts
Folic Acid
Progesterone
Reduced Folate Carrier Protein
Estradiol
68 Citations (Scopus)

Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract

Gopal, E., Miyauchi, S., Martin, P. M., Ananth, S., Roon, P., Smith, S. B. & Ganapathy, V., Mar 1 2007, In : Pharmaceutical Research. 24, 3, p. 575-584 10 p.

Research output: Contribution to journalArticle

Niacin
Oocytes
Pharmaceutical Preparations
Epithelial Cells
Membranes
2008
117 Citations (Scopus)

A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance

Samaddar, J. S., Gaddy, V. T., Duplantier, J., Thandavan, S. P., Shah, M., Smith, M. J., Browning, D., Rawson, J., Smith, S. B., Barrett, J. T. & Schoenlein, P. V., Oct 22 2008, In : Molecular cancer therapeutics. 7, 9, p. 2977-2987 11 p.

Research output: Contribution to journalArticle

Estrogen Receptor Modulators
Autophagy
Cell Death
Breast Neoplasms
Caspases
35 Citations (Scopus)

Effects of targeted Bcl-2 expression in mitochondria or endoplasmic reticulum on renal tubular cell apoptosis

Bhatt, K., Feng, L., Pabla, N., Liu, K., Smith, S. & Dong, Z., Mar 1 2008, In : American Journal of Physiology - Renal Physiology. 294, 3, p. F499-F507

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Mitochondria
Apoptosis
Kidney
Cytochromes c
16 Citations (Scopus)

Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells

Umapathy, N. S., Dun, Y., Martin, P. M., Duplantier, J. N., Roon, P., Prasad, P., Smith, S. B. & Ganapathy, V., Nov 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 5151-5160 10 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Glutamine
Ganglia
Neuroglia
In Situ Hybridization
56 Citations (Scopus)

Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe

Gnana-Prakasam, J. P., Martin, P. M., Mysona, B. A., Roon, P., Smith, S. B. & Ganapathy, V., Apr 1 2008, In : Biochemical Journal. 411, 1, p. 79-88 10 p.

Research output: Contribution to journalArticle

Hepcidins
Toll-Like Receptor 4
Lipopolysaccharides
Retina
Homeostasis
81 Citations (Scopus)

In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine

Smith, S. B., Duplantier, J., Dun, Y., Mysona, B., Roon, P., Martin, P. M. & Ganapathy, V., Sep 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 9, p. 4154-4161 8 p.

Research output: Contribution to journalArticle

Pentazocine
Ligands
Retina
Ganglia
sigma-1 receptor
38 Citations (Scopus)

Serine racemase expression and D-serine content are developmentally regulated in neuronal ganglion cells of the retina

Dun, Y., Duplantier, J., Roon, P., Martin, P. M., Ganapathy, V. & Smith, S. B., Feb 1 2008, In : Journal of Neurochemistry. 104, 4, p. 970-978 9 p.

Research output: Contribution to journalArticle

Ganglia
Serine
Retina
Vertebrates
serine racemase
2009
34 Citations (Scopus)

Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: Role of cystine/glutamate exchanger

Gnana-Prakasam, J. P., Thangaraju, M., Liu, K., Ha, Y., Martin, P. M., Smith, S. B. & Ganapathy, V., Dec 1 2009, In : Biochemical Journal. 424, 2, p. 243-252 10 p.

Research output: Contribution to journalArticle

Iron-Regulatory Proteins
Retinal Pigments
Cystine
Retinal Pigment Epithelium
Glutamic Acid