• 6113 Citations
  • 42 h-Index
1986 …2020

Research output per year

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Research Output

2001

Molecular Characterization and Developmental Expression of NORPEG, a Novel Gene Induced by Retinoic Acid

Kutty, R. K., Kutty, G., Samuel, W., Duncan, T., Bridges, C. C., El-Sherbeeny, A., Nagineni, C. N., Smith, S. B. & Wiggert, B., Jan 26 2001, In : Journal of Biological Chemistry. 276, 4, p. 2831-2840 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Regulation of taurine transporter expression by NO in cultured human retinal pigment epithelial cells

Bridges, C. C., Ola, M. S., Prasad, P. D., El-Sherbeny, A., Ganapathy, V. & Smith, S. B., Jan 1 2001, In : American Journal of Physiology - Cell Physiology. 281, 6 50-6, p. C1825-C1836

Research output: Contribution to journalArticle

45 Scopus citations

Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells

Bridges, C. C., Kekuda, R., Wang, H., Prasad, P. D., Mehta, P., Huang, W., Smith, S. B. & Ganapathy, V., Jan 30 2001, In : Investigative Ophthalmology and Visual Science. 42, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

100 Scopus citations
2002

Analysis of sigma receptor (σR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabetic mice

Shamsul Ola, M., Martin, P. M., Maddox, D., El-Sherbeny, A., Huang, W., Roon, P., Agarwal, N., Ganapathy, V. & Smith, S. B., Nov 15 2002, In : Molecular Brain Research. 107, 2, p. 97-107 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Ciliary neurotrophic factor induces glial fibrillary acidic protein in retinal Müller cells through the JAK/STAT signal transduction pathway

Wang, Y., Smith, S. B., Ogilvie, J. M., McCool, D. J. & Sarthy, V., Oct 23 2002, In : Current Eye Research. 24, 4, p. 305-312 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Diabetic retinopathy and the NMDA receptor

Smith, S. B., Jul 2 2002, In : Drug News and Perspectives. 15, 4, p. 226-232 7 p.

Research output: Contribution to journalReview article

18 Scopus citations

Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice

Naggar, H., Shamsul Ola, M., Martin, P. M., Huang, W., Bridges, C. C., Ganapathy, V. & Smith, S. B., Feb 11 2002, In : Investigative Ophthalmology and Visual Science. 43, 2, p. 556-563 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain

Inoue, K., Zhuang, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Oct 18 2002, In : Journal of Biological Chemistry. 277, 42, p. 39469-39476 8 p.

Research output: Contribution to journalArticle

78 Scopus citations

Transcellular transfer of folate across the retinal pigment epithelium

Bridges, C. C., El-Sherbeny, A., Ola, M. S., Ganapathy, V. & Smith, S. B., Jan 1 2002, In : Current Eye Research. 24, 2, p. 129-138 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Transport of D-serine via the amino acid transporter ATB0,+ expressed in the colon

Hatanaka, T., Huang, W., Nakanishi, T., Bridges, C. C., Ganapathy, V., Smith, S. B., Prasad, P. D., Ganapathy, V. & Ganapathy, M. E., Jan 1 2002, In : Biochemical and Biophysical Research Communications. 291, 2, p. 291-295 5 p.

Research output: Contribution to journalArticle

67 Scopus citations
2003

Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action

Inoue, K., Zhuang, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Aug 15 2003, In : Biochemical Journal. 374, 1, p. 21-26 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Identification of a novel Na+- And Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat

Hu, H., Miyauchi, S., Bridges, C. C., Smith, S. B. & Ganapathy, V., Oct 1 2003, In : Biochemical Journal. 375, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

21 Scopus citations
42 Scopus citations
14 Scopus citations
2004

Death of retinal neurons in streptozotocin-induced diabetic mice

Martin, P. M., Roon, P., Van Ells, T. K., Ganapathy, V. & Smith, S. B., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 3330-3336 7 p.

Research output: Contribution to journalArticle

324 Scopus citations

Expression of slc5a8 in kidney and its role in Na+-coupled transport of lactate

Gopal, E., Fei, Y. J., Sugawara, M., Miyauchi, S., Zhuang, L., Martin, P., Smith, S. B., Prasad, P. D. & Ganapathy, V., Oct 22 2004, In : Journal of Biological Chemistry. 279, 43, p. 44522-44532 11 p.

Research output: Contribution to journalArticle

108 Scopus citations

Induction of cystine-glutamate transporter Xc - by human immunodeficiency virus type 1 transactivator protein Tat in retinal pigment epithelium

Bridges, C. C., Hu, H., Miyauchi, S., Siddaramappa, U. N., Ganapathy, M. E., Ignatowicz, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 2906-2914 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Osmoregulation of Taurine Transporter Function and Expression in Retinal Pigment Epithelial, Ganglion, and Müller Cells

El-Sherbeny, A., Naggar, H., Miyauchi, S., Ola, M. S., Maddox, D. M., Martin, P. M., Ganapathy, V. & Smith, S. B., Feb 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 2, p. 694-701 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

SLC19: The folate/thiamine transporter family

Ganapathy, V., Smith, S. B. & Prasad, P. D., Feb 1 2004, In : Pflugers Archiv European Journal of Physiology. 447, 5, p. 641-646 6 p.

Research output: Contribution to journalReview article

119 Scopus citations

The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate

Martin, P. M., Ola, M. S., Agarwal, N., Ganapathy, V. & Smith, S. B., Apr 7 2004, In : Molecular Brain Research. 123, 1-2, p. 66-75 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

Transport of Amino Acid-Based Prodrugs by the Na+- and Cl --Coupled Amino Acid Transporter ATB0,+ and Expression of the Transporter in Tissues Amenable for Drug Delivery

Hatanaka, T., Haramura, M., Fei, Y. J., Miyauchi, S., Bridges, C. C., Ganapathy, P. S., Smith, S. B., Ganapathy, V. & Ganapathy, M. E., Mar 1 2004, In : Journal of Pharmacology and Experimental Therapeutics. 308, 3, p. 1138-1147 10 p.

Research output: Contribution to journalArticle

102 Scopus citations
25 Scopus citations
2005
41 Scopus citations

Regulation of reduced-folate transporter-1 in retinal pigment epithelial cells by folate

Naggar, H., Van Ells, T. K., Ganapathy, V. & Smith, S. B., Jan 1 2005, In : Current Eye Research. 30, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2006

c/ebpδ null mouse as a model for the double knock-out of slc5a8 and slc5a12 in kidney

Thangaraju, M., Ananth, S., Martin, P. M., Roon, P., Smith, S. B., Sterneck, E., Prasad, P. D. & Ganapathy, V., Sep 15 2006, In : Journal of Biological Chemistry. 281, 37, p. 26769-26773 5 p.

Research output: Contribution to journalArticle

55 Scopus citations

Expression, subcellular localization, and regulation of sigma receptor in retinal Müller cells

Jiang, G., Mysona, B., Dun, Y., Gnana-Prakasam, J. P., Pabla, N., Li, W., Dong, Z., Ganapathy, V. & Smith, S. B., Dec 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 12, p. 5576-5582 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Expression and polarized localization of the hemochromatosis gene product HFE in retinal pigment epithelium

Martin, P. M., Gnana-Prakasam, J. P., Roon, P., Smith, R. G., Smith, S. B. & Ganapathy, V., Oct 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 10, p. 4238-4244 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Expression of the cystine-glutamate exchanger (xc-) in retinal ganglion cells and regulation by nitric oxide and oxidative stress

Dun, Y., Mysona, B., Van Ells, T., Amarnath, L., Shamsul Ola, M., Ganapathy, V. & Smith, S. B., May 1 2006, In : Cell and Tissue Research. 324, 2, p. 189-202 14 p.

Research output: Contribution to journalArticle

78 Scopus citations

Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain

Martin, P. M., Gopal, E., Ananth, S., Zhuang, L., Itagaki, S., Prasad, B. M., Smith, S. B., Prasad, P. D. & Ganapathy, V., Jul 1 2006, In : Journal of Neurochemistry. 98, 1, p. 279-288 10 p.

Research output: Contribution to journalArticle

89 Scopus citations

Immunofluorescence analysis of the expression of Norpeg (Rai14) in retinal Müller and ganglion cells

Kutty, R. K., Samuel, W., Chen, S., Vijayasarathy, C., Dun, Y., Mysona, B., Wiggert, B. & Smith, S. B., Sep 1 2006, In : Neuroscience Letters. 404, 3, p. 294-298 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Regulation of taurine transporter activity in cultured rat retinal ganglion cells and rat retinal Müller cells

Eissa, L. A., Smith, S. B. & El-Sherbeny, A. A., Jan 1 2006, In : Saudi Pharmaceutical Journal. 14, 1, p. 16-26 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta

Sugita, S., Futagami, Y., Smith, S. B., Naggar, H. & Mochizuki, M., Dec 1 2006, In : Experimental eye research. 83, 6, p. 1459-1471 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases

Thangaraju, M., Gopal, E., Martin, P. M., Ananth, S., Smith, S. B., Prasad, P. D., Sterneck, E. & Ganapathy, V., Dec 15 2006, In : Cancer Research. 66, 24, p. 11560-11564 5 p.

Research output: Contribution to journalArticle

95 Scopus citations
2007
45 Scopus citations

Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity

Jiang, M., Wei, Q., Pabla, N., Dong, G., Wang, C. Y., Yang, T., Smith, S. B. & Dong, Z., May 1 2007, In : Biochemical Pharmacology. 73, 9, p. 1499-1510 12 p.

Research output: Contribution to journalArticle

124 Scopus citations

Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines

Gopal, E., Miyauchi, S., Martin, P. M., Ananth, S., Srinivas, S. R., Smith, S. B., Prasad, P. D. & Ganapathy, V., Jan 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 292, 1, p. G402-G408

Research output: Contribution to journalArticle

36 Scopus citations

Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina

Martin, P. M., Dun, Y., Mysona, B., Ananth, S., Roon, P., Smith, S. B. & Ganapathy, V., Jul 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 7, p. 3356-3363 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Functional and molecular analysis of d-serine transport in retinal Müller cells

Dun, Y., Mysona, B., Itagaki, S., Martin-Studdard, A., Ganapathy, V. & Smith, S. B., Jan 1 2007, In : Experimental eye research. 84, 1, p. 191-199 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
68 Scopus citations

Progesterone inhibits folic acid transport in human trophoblasts

Keating, E., Gonçalves, P., Lemos, C., Costa, F., Campos, I., Smith, S. B., Bridges, C. C. & Martel, F., Apr 1 2007, In : Journal of Membrane Biology. 216, 2-3, p. 143-152 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract

Gopal, E., Miyauchi, S., Martin, P. M., Ananth, S., Roon, P., Smith, S. B. & Ganapathy, V., Mar 1 2007, In : Pharmaceutical Research. 24, 3, p. 575-584 10 p.

Research output: Contribution to journalArticle

72 Scopus citations
2008

A role for macroautophagy in protection against 4-hydroxytamoxifen-induced cell death and the development of antiestrogen resistance

Samaddar, J. S., Gaddy, V. T., Duplantier, J., Thandavan, S. P., Shah, M., Smith, M. J., Browning, D., Rawson, J., Smith, S. B., Barrett, J. T. & Schoenlein, P. V., Oct 22 2008, In : Molecular cancer therapeutics. 7, 9, p. 2977-2987 11 p.

Research output: Contribution to journalArticle

127 Scopus citations

Effects of targeted Bcl-2 expression in mitochondria or endoplasmic reticulum on renal tubular cell apoptosis

Bhatt, K., Feng, L., Pabla, N., Liu, K., Smith, S. & Dong, Z., Mar 1 2008, In : American Journal of Physiology - Renal Physiology. 294, 3, p. F499-F507

Research output: Contribution to journalArticle

37 Scopus citations

Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells

Umapathy, N. S., Dun, Y., Martin, P. M., Duplantier, J. N., Roon, P., Prasad, P., Smith, S. B. & Ganapathy, V., Nov 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 5151-5160 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe

Gnana-Prakasam, J. P., Martin, P. M., Mysona, B. A., Roon, P., Smith, S. B. & Ganapathy, V., Apr 1 2008, In : Biochemical Journal. 411, 1, p. 79-88 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine

Smith, S. B., Duplantier, J., Dun, Y., Mysona, B., Roon, P., Martin, P. M. & Ganapathy, V., Sep 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 9, p. 4154-4161 8 p.

Research output: Contribution to journalArticle

82 Scopus citations

Serine racemase expression and D-serine content are developmentally regulated in neuronal ganglion cells of the retina

Dun, Y., Duplantier, J., Roon, P., Martin, P. M., Ganapathy, V. & Smith, S. B., Feb 1 2008, In : Journal of Neurochemistry. 104, 4, p. 970-978 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
2009

Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: Role of cystine/glutamate exchanger

Gnana-Prakasam, J. P., Thangaraju, M., Liu, K., Ha, Y., Martin, P. M., Smith, S. B. & Ganapathy, V., Dec 1 2009, In : Biochemical Journal. 424, 2, p. 243-252 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Effects of hyperglycemia and oxidative stress on the glutamate transporters GLAST and system xc in mouse retinal Müller glial cells

Mysona, B., Dun, Y., Duplantier, J., Ganapathy, V. & Smith, S. B., Mar 2009, In : Cell and Tissue Research. 335, 3, p. 477-488 12 p.

Research output: Contribution to journalArticle

50 Scopus citations

Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-β-synthase mutant mouse

Ganapathy, P. S., Moister, B., Roon, P., Mysona, B. A., Duplantier, J., Dun, Y., Moister, T. K. V. E., Farley, M. J., Prasad, P. D., Liu, K. & Smith, S. B., Dec 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 9, p. 4460-4470 11 p.

Research output: Contribution to journalArticle

41 Scopus citations