• 5769 Citations
  • 42 h-Index
1986 …2019
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Research Output 1986 2019

26 Citations (Scopus)

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B. & Zhang, W., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1900.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Glaucoma
Intraocular Pressure
Inflammation
Wounds and Injuries
Microphthalmos
Vitiligo
Choroid
Monophenol Monooxygenase
Genes
17 Citations (Scopus)
Photoreceptor Cells
Vitiligo
Inbred C57BL Mouse
Retina
Guinea Pigs
7 Citations (Scopus)

Evidence of decreased adhesion between the neural retina and retinal pigmented epithelium of the Mitf(vit) (vitiligo) mutant mouse

Bora, N., Defoe, D. & Smith, S. B., Jan 11 1999, In : Cell and Tissue Research. 295, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

Vitiligo
Retina
Epithelium
Photoreceptor Cells
Retinal Photoreceptor Cell Outer Segment
3 Citations (Scopus)

Excess homocysteine upregulates the NRF2-antioxidant pathway in retinal Müller glial cells

Navneet, S., Cui, X., Zhao, J., Wang, J., Kaidery, N. A., Thomas, B., Bollinger, K. E., Yoon, Y. & Smith, S. B., Jan 1 2019, In : Experimental eye research. 178, p. 228-237 10 p.

Research output: Contribution to journalArticle

Homocysteine
Neuroglia
Up-Regulation
Antioxidants
Oxidative Stress
47 Citations (Scopus)

Expression, subcellular localization, and regulation of sigma receptor in retinal Müller cells

Jiang, G., Mysona, B., Dun, Y., Gnana-Prakasam, J. P., Pabla, N., Li, W., Dong, Z., Ganapathy, V. & Smith, S. B., Dec 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 12, p. 5576-5582 7 p.

Research output: Contribution to journalArticle

sigma Receptors
Pentazocine
Ligands
Reactive Oxygen Species
Nitric Oxide
112 Citations (Scopus)

Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor α in mammalian retinal pigment epithelium

Chancy, C. D., Kekuda, R., Huang, W., Prasad, P. D., Kuhnel, J. M., Sirotnak, F. M., Roon, P., Ganapathy, V. & Smith, S. B., Jul 7 2000, In : Journal of Biological Chemistry. 275, 27, p. 20676-20684 9 p.

Research output: Contribution to journalArticle

Reduced Folate Carrier Protein
Retinal Pigments
Retinal Pigment Epithelium
Folic Acid
Polarization
34 Citations (Scopus)

Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines

Gopal, E., Miyauchi, S., Martin, P. M., Ananth, S., Srinivas, S. R., Smith, S. B., Prasad, P. D. & Ganapathy, V., Jan 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 292, 1, p. G402-G408

Research output: Contribution to journalArticle

Citric Acid
Cell Line
Liver
Hepatocytes
rat Slc13a5 protein
40 Citations (Scopus)
Glutamine
Protein Isoforms
system N protein 1
Messenger RNA
Substrate Specificity
30 Citations (Scopus)

Expression and function of iron-regulatory proteins in retina

Gnana-Prakasam, J. P., Martin, P. M., Smith, S. B. & Ganapathy, V., May 1 2010, In : IUBMB Life. 62, 5, p. 363-370 8 p.

Research output: Contribution to journalReview article

Iron-Regulatory Proteins
Retina
Iron
Hemochromatosis
Iron Overload
16 Citations (Scopus)

Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells

Umapathy, N. S., Dun, Y., Martin, P. M., Duplantier, J. N., Roon, P., Prasad, P., Smith, S. B. & Ganapathy, V., Nov 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 5151-5160 10 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Glutamine
Ganglia
Neuroglia
In Situ Hybridization
27 Citations (Scopus)

Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium

Gnana-Prakasam, J. P., Ananth, S., Prasad, P. D., Zhang, M., Atherton, S. S., Martin, P. M., Smith, S. B. & Ganapathy, V., May 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 6, p. 3751-3758 8 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Succinic Acid
Vascular Endothelial Growth Factor A
Iron
Hemochromatosis
49 Citations (Scopus)

Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium

Martin, P. M., Ananth, S., Cresci, G., Roon, P., Smith, S. B. & Ganapathy, V., Feb 16 2009, In : Molecular Vision. 15, p. 362-372 11 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Retina
Messenger RNA
Niacin
Diabetic Retinopathy
30 Citations (Scopus)

Expression and polarized localization of the hemochromatosis gene product HFE in retinal pigment epithelium

Martin, P. M., Gnana-Prakasam, J. P., Roon, P., Smith, R. G., Smith, S. B. & Ganapathy, V., Oct 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 10, p. 4238-4244 7 p.

Research output: Contribution to journalArticle

Hemochromatosis
Retinal Pigment Epithelium
Retina
Genes
Transferrin Receptors
36 Citations (Scopus)

Expression of folate receptor α in the mammalian retinol pigmented epithelium and retina

Smith, S. B., Kekuda, R., Gu, X., Chancy, C., Conway, S. J. & Ganapathy, V., Apr 13 1999, In : Investigative Ophthalmology and Visual Science. 40, 5, p. 840-848 9 p.

Research output: Contribution to journalArticle

Vitamin A
Folic Acid
Retinal Pigments
Retina
Epithelium
105 Citations (Scopus)

Expression of slc5a8 in kidney and its role in Na+-coupled transport of lactate

Gopal, E., Fei, Y. J., Sugawara, M., Miyauchi, S., Zhuang, L., Martin, P. M., Smith, S. B., Prasad, P. D. & Ganapathy, V., Oct 22 2004, In : Journal of Biological Chemistry. 279, 43, p. 44522-44532 11 p.

Research output: Contribution to journalArticle

Lactic Acid
Kidney
Volatile Fatty Acids
Fatty Acids
Propionates
77 Citations (Scopus)

Expression of the cystine-glutamate exchanger (xc-) in retinal ganglion cells and regulation by nitric oxide and oxidative stress

Dun, Y., Mysona, B. A., Van Ells, T., Amarnath, L., Shamsul Ola, M., Ganapathy, V. & Smith, S. B., May 1 2006, In : Cell and Tissue Research. 324, 2, p. 189-202 14 p.

Research output: Contribution to journalArticle

Oxidative stress
Cystine
Retinal Ganglion Cells
Glutamic Acid
Nitric Oxide
49 Citations (Scopus)

Expression of the extraneuronal monoamine transporter in RPE and neural retina

Rajan, P. D., Kekuda, R., Chancy, C. D., Huang, W., Ganapathy, V. & Smith, S. B., Mar 2000, In : Current Eye Research. 20, 3, p. 195-204 10 p.

Research output: Contribution to journalArticle

Retina
Cations
Histamine
Dopamine
Dopamine Plasma Membrane Transport Proteins
19 Citations (Scopus)

Expression of the iron-regulatory protein haemojuvelin in retina and its regulation during cytomegalovirus infection

Gnana-Prakasam, J. P., Zhang, M., Martin, P. M., Atherton, S. S., Smith, S. B. & Ganapathy, V., May 1 2009, In : Biochemical Journal. 419, 3, p. 533-543 11 p.

Research output: Contribution to journalArticle

Iron-Regulatory Proteins
Retinal Pigments
Retinal Pigment Epithelium
Cytomegalovirus Infections
Retina
28 Citations (Scopus)

Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina

Martin, P. M., Dun, Y., Mysona, B. A., Ananth, S., Roon, P., Smith, S. B. & Ganapathy, V., Jul 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 7, p. 3356-3363 8 p.

Research output: Contribution to journalArticle

Retina
Sodium
Ganglia
Messenger RNA
Proteins
22 Citations (Scopus)
Microphthalmia-Associated Transcription Factor
Vitiligo
Monophenol Monooxygenase
Choroid
Proteins
65 Citations (Scopus)

Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina

Shamsul Ola, M., Martin, P. M., El-Sherbeny, A., Roon, P., Agarwal, N., Sarthy, V. P., Casellas, P., Ganapathy, V. & Smith, S. B., Nov 1 2001, In : Molecular Brain Research. 95, 1-2, p. 86-95 10 p.

Research output: Contribution to journalArticle

Retina
Messenger RNA
Proteins
Ganglia
Retinal Pigments
69 Citations (Scopus)

Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor

Seth, P., Ganapathy, M. E., Conway, S. J., Bridges, C. D., Smith, S. B., Casellas, P. & Ganapathy, V., Jul 25 2001, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1540, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

Ligands
Amino Acids
Brain
Exons
Ethyldimethylaminopropyl Carbodiimide

Folate Transport in Retina and Consequences on Retinal Structure and Function of Hyperhomocysteinemia

Smith, S. B., Ganapathy, P. S., Bozard, R. B. & Ganapathy, V., Apr 10 2014, Handbook of Nutrition, Diet and the Eye. Elsevier Inc., p. 349-359 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hyperhomocysteinemia
Folic Acid
Retina
Proton-Coupled Folate Transporter
Reduced Folate Carrier Protein
38 Citations (Scopus)

Functional and molecular analysis of d-serine transport in retinal Müller cells

Dun, Y., Mysona, B. A., Itagaki, S., Martin-Studdard, A., Ganapathy, V. & Smith, S. B., Jan 1 2007, In : Experimental eye research. 84, 1, p. 191-199 9 p.

Research output: Contribution to journalArticle

Serine
N-Methyl-D-Aspartate Receptors
Immunoblotting
Retina
Retinal Neurons
6 Citations (Scopus)

Functional characterization of folate transport proteins in staten's seruminstitut rabbit corneal epithelial cell line

Jwala, J., Boddu, S. H. S., Paturi, D. K., Shah, S., Smith, S. B., Pal, D. & Mitra, A. K., Jan 1 2011, In : Current Eye Research. 36, 5, p. 404-416 13 p.

Research output: Contribution to journalArticle

Folic Acid Transporters
Folic Acid
Epithelial Cells
Rabbits
Cell Line
20 Citations (Scopus)

Functional dissection of the promoter of the interphotoreceptor retinoid-binding protein gene: The cone-rod-homeobox element is essential for photoreceptor-specific expression in vivo

Fei, Y., Matragoon, S., Smith, S. B., Overbeek, P. A., Chen, S., Zack, D. J. & Liou, G. I., Jan 1 1999, In : Journal of Biochemistry. 125, 6, p. 1189-1199 11 p.

Research output: Contribution to journalArticle

Dissection
Vertebrate Photoreceptor Cells
Homeobox Genes
Cones
Genes
11 Citations (Scopus)

Functional Identification of a Novel Transport System for Endogenous and Synthetic Opioid Peptides in the Rabbit Conjunctival Epithelial Cell Line CJVE

Ananth, S., Karunakaran, S., Martin, P. M., Nagineni, C. N., Hooks, J. J., Smith, S. B., Prasad, P. D. & Ganapathy, V., May 1 2009, In : Pharmaceutical Research. 26, 5, p. 1226-1235 10 p.

Research output: Contribution to journalArticle

Opioid Peptides
Epithelial Cells
Leucine-2-Alanine Enkephalin
Rabbits
Cell Line
42 Citations (Scopus)

GADD34 induces cell death through inactivation of Akt following traumatic brain injury

Farook, J. M., Shields, J., Tawfik, A., Markand, S., Sen, T., Smith, S. B., Brann, D., Dhandapani, K. M. & Sen, N., Aug 2013, In : Cell Death and Disease. 4, 8, e754.

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 6
Cell Death
Activating Transcription Factor 4
Phosphorylation
Ubiquitin-Protein Ligases
10 Citations (Scopus)

Glial fibrillary acidic protein (GFAP) is synthesized in the early stages of the photoreceptor cell degeneration of the mivit/mivit (vitiligo) mouse.

Smith, S. B., Brodjian, S., Desai, S. & Sarthy, V., Jan 1 1997, In : Experimental eye research. 64, 4, p. 645-650 6 p.

Research output: Contribution to journalArticle

Mutant Strains Mice
Retinal Diseases
Photoreceptor Cells
Vitiligo
Glial Fibrillary Acidic Protein
221 Citations (Scopus)

GPFM 09A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon

Thangaraju, M., Cresci, G. A., Liu, K., Ananth, S., Gnanaprakasam, J. P., Browning, D. D., Mellinger, J. D., Smith, S. B., Digby, G. J., Lambert, N. A., Prasad, P. D. & Ganapathy, V., Apr 1 2009, In : Cancer Research. 69, 7, p. 2826-2832 7 p.

Research output: Contribution to journalArticle

Butyrates
G-Protein-Coupled Receptors
Fermentation
Colon
Colonic Neoplasms
46 Citations (Scopus)

GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.

Gambhir, D., Ananth, S., Veeranan-Karmegam, R., Elangovan, S., Hester, S., Jennings, E., Offermanns, S., Nussbaum, J. J., Smith, S. B., Thangaraju, M., Ganapathy, V. & Martin, P. M., Jan 1 2012, In : Investigative ophthalmology & visual science. 53, 4, p. 2208-2217 10 p.

Research output: Contribution to journalArticle

Retinal Pigments
Retinal Pigment Epithelium
Diabetic Retinopathy
Anti-Inflammatory Agents
Epithelial Cells
56 Citations (Scopus)

Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe

Gnana-Prakasam, J. P., Martin, P. M., Mysona, B. A., Roon, P., Smith, S. B. & Ganapathy, V., Apr 1 2008, In : Biochemical Journal. 411, 1, p. 79-88 10 p.

Research output: Contribution to journalArticle

Hepcidins
Toll-Like Receptor 4
Lipopolysaccharides
Retina
Homeostasis
30 Citations (Scopus)

Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells

Ganapathy, P. S., Perry, R. L., Tawfik, A. M., Smith, R. M., Perry, E., Roon, P., Renee Bozard, B., Ha, Y. & Smith, S. B., Jul 1 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5551-5558 8 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Retinal Ganglion Cells
Homocysteine
Mitochondria
Ganglia
46 Citations (Scopus)

Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action

Inoue, K., Zhuang, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Aug 15 2003, In : Biochemical Journal. 374, 1, p. 21-26 6 p.

Research output: Contribution to journalArticle

Lithium
Drosophila
Citric Acid
Liver
Genes
57 Citations (Scopus)
Acute Kidney Injury
Hyperglycemia
Apoptosis
Kidney
Glucose
9 Citations (Scopus)

Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress

Mohamed, R., Sharma, I., Ibrahim, A. S., Saleh, H. M., Elsherbiny, N. M., Fulzele, S. T., Elmasry, K., Smith, S. B., Al-Shabrawey, M. & Tawfik, A. M., Dec 1 2017, In : Scientific Reports. 7, 1, 09731.

Research output: Contribution to journalArticle

Hyperhomocysteinemia
Oxidative Stress
Endothelial Cells
Homocysteine
Blood-Retinal Barrier
10 Citations (Scopus)

Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration

Ibrahim, A. S., Mander, S., Hussein, K. A., Elsherbiny, N. M., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., Jan 1 2016, In : Oncotarget. 7, 8, p. 8532-8545 14 p.

Research output: Contribution to journalArticle

Hyperhomocysteinemia
Retinal Pigments
Macular Degeneration
Homocysteine
Choroidal Neovascularization
2 Citations (Scopus)

Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2

Navneet, S., Zhao, J., Wang, J., Mysona, B. A., Barwick, S., Ammal Kaidery, N., Saul, A. B., Kaddour-Djebbar, I., Bollag, W. B., Thomas, B., Bollinger, K. E. & Smith, S. B., Jun 1 2019, In : Redox Biology. 24, 101199.

Research output: Contribution to journalArticle

Open Access
Hyperhomocysteinemia
Retinal Ganglion Cells
Neuroglia
Antioxidants
Excitatory Amino Acids
8 Citations (Scopus)

Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth

Sonne, S. R., Bhalla, V. K., Barman, S. A., White, R. E., Zhu, S., Newman, T. M., Prasad, P. D., Smith, S. B., Offermanns, S. & Ganapathy, V., May 14 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 8, p. 1149-1158 10 p.

Research output: Contribution to journalArticle

Hyperhomocysteinemia
Premature Birth
Homocysteine
Pregnancy
Dinoprostone
19 Citations (Scopus)

Identification of a novel Na+- And Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat

Hu, H., Miyauchi, S., Bridges, C. C., Smith, S. B. & Ganapathy, V., Oct 1 2003, In : Biochemical Journal. 375, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

Retinal Pigments
Opioid Peptides
Retinal Pigment Epithelium
HIV-1
Cells
11 Citations (Scopus)

Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells

Chothe, P. P., Thakkar, S. V., Gnana-Prakasam, J. P., Ananth, S., Hinton, D. R., Kannan, R., Smith, S. B., Martin, P. M. & Ganapathy, V., Jan 1 2010, In : Investigative Ophthalmology and Visual Science. 51, 1, p. 413-420 8 p.

Research output: Contribution to journalArticle

Oligopeptides
Retinal Pigments
Epithelial Cells
Sodium
HIV-1
84 Citations (Scopus)

Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain

Martin, P. M., Gopal, E., Ananth, S., Zhuang, L., Itagaki, S., Prasad, B. M., Smith, S. B., Prasad, P. D. & Ganapathy, V., Jul 1 2006, In : Journal of Neurochemistry. 98, 1, p. 279-288 10 p.

Research output: Contribution to journalArticle

Ketone Bodies
Neurons
Lactic Acid
Brain
Hydroxybutyrates
3 Citations (Scopus)

Immunofluorescence analysis of the expression of Norpeg (Rai14) in retinal Müller and ganglion cells

Kutty, R. K., Samuel, W., Chen, S., Vijayasarathy, C., Dun, Y., Mysona, B. A., Wiggert, B. & Smith, S. B., Sep 1 2006, In : Neuroscience Letters. 404, 3, p. 294-298 5 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Fluorescent Antibody Technique
Retina
Ganglia
Ankyrin Repeat
23 Citations (Scopus)

Increase in retinyl palmitate concentration in eyes and livers and the concentration of interphotoreceptor retinoid-binding protein in eyes of vitiligo mutant mice

Smith, S. B., Duncan, T., Kutty, G., Kutty, R. K. & Wiggert, B., Jan 1 1994, In : Biochemical Journal. 300, 1, p. 63-68 6 p.

Research output: Contribution to journalArticle

Vitiligo
Retinoids
Liver
Retinal Pigments
Vitamin A
31 Citations (Scopus)

Induction of cystine-glutamate transporter Xc - by human immunodeficiency virus type 1 transactivator protein Tat in retinal pigment epithelium

Bridges, C. C., Hu, H., Miyauchi, S., Siddaramappa, U. N., Ganapathy, M. E., Ignatowicz, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 2906-2914 9 p.

Research output: Contribution to journalArticle

tat Gene Products
Amino Acid Transport System X-AG
Trans-Activators
Cystine
Retinal Pigment Epithelium
7 Citations (Scopus)

Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells

Mo, J., Zhang, M., Marshall, B., Smith, S. B., Covar, J. & Atherton, S., Aug 14 2014, In : Molecular Vision. 20, p. 1161-1173 13 p.

Research output: Contribution to journalArticle

Muromegalovirus
Retinal Pigments
Autophagy
Cytomegalovirus Infections
Epithelial Cells
5 Citations (Scopus)
sigma Receptors
Neurodegenerative diseases
Molecular imaging
Retinal Degeneration
Somatoform Disorders
Vitiligo
Retina
Photoreceptor Cells
In Vitro Techniques
Phagocytosis