• 5720 Citations
  • 41 h-Index
1986 …2019
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Research Output 1986 2019

2006
46 Citations (Scopus)

Expression, subcellular localization, and regulation of sigma receptor in retinal Müller cells

Jiang, G., Mysona, B. A., Dun, Y., Gnana-Prakasam, J. P., Pabla, N., Li, W., Dong, Z., Ganapathy, V. & Smith, S. B., Dec 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 12, p. 5576-5582 7 p.

Research output: Contribution to journalArticle

sigma Receptors
Pentazocine
Ligands
Reactive Oxygen Species
Nitric Oxide
30 Citations (Scopus)

Expression and polarized localization of the hemochromatosis gene product HFE in retinal pigment epithelium

Martin, P. M., Gnana-Prakasam, J. P., Roon, P., Smith, R. G., Smith, S. B. & Ganapathy, V., Oct 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 10, p. 4238-4244 7 p.

Research output: Contribution to journalArticle

Hemochromatosis
Retinal Pigment Epithelium
Retina
Genes
Transferrin Receptors
77 Citations (Scopus)

Expression of the cystine-glutamate exchanger (xc-) in retinal ganglion cells and regulation by nitric oxide and oxidative stress

Dun, Y., Mysona, B. A., Van Ells, T., Amarnath, L., Shamsul Ola, M., Ganapathy, V. & Smith, S. B., May 1 2006, In : Cell and Tissue Research. 324, 2, p. 189-202 14 p.

Research output: Contribution to journalArticle

Oxidative stress
Cystine
Retinal Ganglion Cells
Glutamic Acid
Nitric Oxide
83 Citations (Scopus)

Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain

Martin, P. M., Gopal, E., Ananth, S., Zhuang, L., Itagaki, S., Prasad, B. M., Smith, S. B., Prasad, P. D. & Ganapathy, V., Jul 1 2006, In : Journal of Neurochemistry. 98, 1, p. 279-288 10 p.

Research output: Contribution to journalArticle

Ketone Bodies
Neurons
Lactic Acid
Brain
Hydroxybutyrates
3 Citations (Scopus)

Immunofluorescence analysis of the expression of Norpeg (Rai14) in retinal Müller and ganglion cells

Kutty, R. K., Samuel, W., Chen, S., Vijayasarathy, C., Dun, Y., Mysona, B. A., Wiggert, B. & Smith, S. B., Sep 1 2006, In : Neuroscience Letters. 404, 3, p. 294-298 5 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Fluorescent Antibody Technique
Retina
Ganglia
Ankyrin Repeat
2 Citations (Scopus)

Regulation of taurine transporter activity in cultured rat retinal ganglion cells and rat retinal Müller cells

Eissa, L. A., Smith, S. B. & El-Sherbeny, A. A., Jan 1 2006, In : Saudi Pharmaceutical Journal. 14, 1, p. 16-26 11 p.

Research output: Contribution to journalArticle

Retinal Ganglion Cells
Taurine
Nitric Oxide Donors
Diabetic Retinopathy
Glutamic Acid
52 Citations (Scopus)

Retinal and ciliary body pigment epithelium suppress activation of T lymphocytes via transforming growth factor beta

Sugita, S., Futagami, Y., Smith, S. B., Naggar, H. & Mochizuki, M., Dec 1 2006, In : Experimental Eye Research. 83, 6, p. 1459-1471 13 p.

Research output: Contribution to journalArticle

Ciliary Body
Transforming Growth Factor beta
Epithelium
T-Lymphocytes
Retinal Pigment Epithelium
88 Citations (Scopus)

SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases

Thangaraju, M., Gopal, E., Martin, P. M., Ananth, S., Smith, S. B., Prasad, P. D., Sterneck, E. & Ganapathy, V., Dec 15 2006, In : Cancer Research. 66, 24, p. 11560-11564 5 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Pyruvic Acid
Apoptosis
Lactic Acid
Neoplasms
2005
40 Citations (Scopus)
Glutamine
Protein Isoforms
system N protein 1
Messenger RNA
Substrate Specificity
7 Citations (Scopus)

Regulation of reduced-folate transporter-1 in retinal pigment epithelial cells by folate

Naggar, H., Van Ells, T. K., Ganapathy, V. & Smith, S. B., Jan 1 2005, In : Current Eye Research. 30, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

Reduced Folate Carrier Protein
Retinal Pigments
Folic Acid
Epithelial Cells
Folic Acid Transporters
2004
312 Citations (Scopus)

Death of retinal neurons in streptozotocin-induced diabetic mice

Martin, P. M., Roon, P., Van Ells, T. K., Ganapathy, V. & Smith, S. B., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 3330-3336 7 p.

Research output: Contribution to journalArticle

Retinal Neurons
Streptozocin
Ganglia
Retina
Cell Death
104 Citations (Scopus)

Expression of slc5a8 in kidney and its role in Na+-coupled transport of lactate

Gopal, E., Fei, Y. J., Sugawara, M., Miyauchi, S., Zhuang, L., Martin, P. M., Smith, S. B., Prasad, P. D. & Ganapathy, V., Oct 22 2004, In : Journal of Biological Chemistry. 279, 43, p. 44522-44532 11 p.

Research output: Contribution to journalArticle

Lactic Acid
Kidney
Volatile Fatty Acids
Fatty Acids
Propionates
31 Citations (Scopus)

Induction of cystine-glutamate transporter Xc - by human immunodeficiency virus type 1 transactivator protein Tat in retinal pigment epithelium

Bridges, C. C., Hu, H., Miyauchi, S., Siddaramappa, U. N., Ganapathy, M. E., Ignatowicz, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 2906-2914 9 p.

Research output: Contribution to journalArticle

tat Gene Products
Amino Acid Transport System X-AG
Trans-Activators
Cystine
Retinal Pigment Epithelium
55 Citations (Scopus)

Osmoregulation of Taurine Transporter Function and Expression in Retinal Pigment Epithelial, Ganglion, and Müller Cells

El-Sherbeny, A., Naggar, H., Miyauchi, S., Ola, M. S., Maddox, D. M., Martin, P. M., Ganapathy, V. & Smith, S. B., Feb 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 2, p. 694-701 8 p.

Research output: Contribution to journalArticle

Osmoregulation
Retinal Pigments
Ganglia
Taurine
Mannitol
117 Citations (Scopus)

SLC19: The folate/thiamine transporter family

Ganapathy, V., Smith, S. B. & Prasad, P. D., Feb 1 2004, In : Pflugers Archiv European Journal of Physiology. 447, 5, p. 641-646 6 p.

Research output: Contribution to journalReview article

Folic Acid Transporters
Thiamine
Folic Acid
Genes
Substrates
62 Citations (Scopus)

The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate

Martin, P. M., Ola, M. S., Agarwal, N., Ganapathy, V. & Smith, S. B., Apr 7 2004, In : Molecular Brain Research. 123, 1-2, p. 66-75 10 p.

Research output: Contribution to journalArticle

sigma Receptors
Pentazocine
Retinal Ganglion Cells
Homocysteine
Glutamic Acid
95 Citations (Scopus)

Transport of Amino Acid-Based Prodrugs by the Na+- and Cl --Coupled Amino Acid Transporter ATB0,+ and Expression of the Transporter in Tissues Amenable for Drug Delivery

Hatanaka, T., Haramura, M., Fei, Y. J., Miyauchi, S., Bridges, C. C., Ganapathy, P. S., Smith, S. B., Ganapathy, V. & Ganapathy, M. E., Mar 1 2004, In : Journal of Pharmacology and Experimental Therapeutics. 308, 3, p. 1138-1147 10 p.

Research output: Contribution to journalArticle

valacyclovir
Amino Acid Transport Systems
Prodrugs
Aspartic Acid
Amino Acids
25 Citations (Scopus)
Sodium
Canavan Disease
Dicarboxylic Acid Transporters
Optic Nerve Diseases
Messenger RNA
2003
46 Citations (Scopus)

Human sodium-coupled citrate transporter, the orthologue of Drosophila Indy, as a novel target for lithium action

Inoue, K., Zhuang, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Aug 15 2003, In : Biochemical Journal. 374, 1, p. 21-26 6 p.

Research output: Contribution to journalArticle

Lithium
Drosophila
Citric Acid
Liver
Genes
19 Citations (Scopus)

Identification of a novel Na+- And Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat

Hu, H., Miyauchi, S., Bridges, C. C., Smith, S. B. & Ganapathy, V., Oct 1 2003, In : Biochemical Journal. 375, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

Retinal Pigments
Opioid Peptides
Retinal Pigment Epithelium
HIV-1
Cells
42 Citations (Scopus)
Reduced Folate Carrier Protein
Limb Buds
Yolk Sac
Rhombencephalon
Neural Tube
14 Citations (Scopus)
Reduced Folate Carrier Protein
Retinal Pigments
Homocysteine
Epithelial Cells
Folic Acid
2002
38 Citations (Scopus)

Analysis of sigma receptor (σR1) expression in retinal ganglion cells cultured under hyperglycemic conditions and in diabetic mice

Shamsul Ola, M., Martin, P. M., Maddox, D., El-Sherbeny, A., Huang, W., Roon, P., Agarwal, N., Ganapathy, V. & Smith, S. B., Nov 15 2002, In : Molecular Brain Research. 107, 2, p. 97-107 11 p.

Research output: Contribution to journalArticle

sigma Receptors
Retinal Ganglion Cells
Retina
Streptozocin
N-Methyl-D-Aspartate Receptors
35 Citations (Scopus)

Ciliary neurotrophic factor induces glial fibrillary acidic protein in retinal Müller cells through the JAK/STAT signal transduction pathway

Wang, Y., Smith, S. B., Ogilvie, J. M., McCool, D. J. & Sarthy, V., Oct 23 2002, In : Current Eye Research. 24, 4, p. 305-312 8 p.

Research output: Contribution to journalArticle

Ciliary Neurotrophic Factor
Glial Fibrillary Acidic Protein
Signal Transduction
Immunohistochemistry
Intravitreal Injections
16 Citations (Scopus)

Diabetic retinopathy and the NMDA receptor

Smith, S. B., Jul 2 2002, In : Drug News and Perspectives. 15, 4, p. 226-232 7 p.

Research output: Contribution to journalReview article

Diabetic Retinopathy
N-Methyl-D-Aspartate Receptors
Retina
Glutamate Receptors
N-Methylaspartate
28 Citations (Scopus)

Downregulation of reduced-folate transporter by glucose in cultured RPE cells and in RPE of diabetic mice

Naggar, H., Shamsul Ola, M., Martin, P. M., Huang, W., Bridges, C. C., Ganapathy, V. & Smith, S. B., Feb 11 2002, In : Investigative Ophthalmology and Visual Science. 43, 2, p. 556-563 8 p.

Research output: Contribution to journalArticle

Folic Acid Transporters
Reduced Folate Carrier Protein
Retinal Pigments
Down-Regulation
Epithelial Cells
75 Citations (Scopus)

Structure, function, and expression pattern of a novel sodium-coupled citrate transporter (NaCT) cloned from mammalian brain

Inoue, K., Zhuang, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Oct 18 2002, In : Journal of Biological Chemistry. 277, 42, p. 39469-39476 8 p.

Research output: Contribution to journalArticle

Citric Acid
Brain
Sodium
Liver
Rats
27 Citations (Scopus)

Transcellular transfer of folate across the retinal pigment epithelium

Bridges, C. C., El-Sherbeny, A., Ola, M. S., Ganapathy, V. & Smith, S. B., Jan 1 2002, In : Current Eye Research. 24, 2, p. 129-138 10 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Folic Acid
Membranes
Reduced Folate Carrier Protein
Photoreceptor Cells
64 Citations (Scopus)

Transport of D-serine via the amino acid transporter ATB0,+ expressed in the colon

Hatanaka, T., Huang, W., Nakanishi, T., Bridges, C. C., Ganapathy, V., Smith, S. B., Prasad, P. D., Ganapathy, V. & Ganapathy, M. E., Jan 1 2002, In : Biochemical and Biophysical Research Communications. 291, 2, p. 291-295 5 p.

Research output: Contribution to journalArticle

Amino Acid Transport Systems
Serine
Colon
Enantiomers
Intestines
2001
17 Citations (Scopus)

A comparison of caveolae and caveolin-1 to folate receptor α in retina and retinal pigment epithelium

Bridges, C. C., El-Sherbeny, A., Roon, P., Shamsul Ola, M., Kekuda, R., Ganapathy, V., Cameron, R. S., Cameron, P. L. & Smith, S. B., Jan 1 2001, In : Histochemical Journal. 33, 3, p. 149-158 10 p.

Research output: Contribution to journalArticle

Caveolin 1
Caveolae
Retinal Pigment Epithelium
Folic Acid
Retina
118 Citations (Scopus)

Apoptotic cell death in the mouse retinal ganglion cell layer is induced in vivo by the excitatory amino acid homocysteine

Martin, P. M., El-sherbeny, A., Roon, P., Schoenlein, P. V., Ganapathy, V. & Smith, S. B., Jan 1 2001, In : Experimental Eye Research. 73, 1, p. 45-57 13 p.

Research output: Contribution to journalArticle

Excitatory Amino Acids
Retinal Ganglion Cells
Homocysteine
Cell Death
Ganglia
64 Citations (Scopus)

Expression pattern of sigma receptor 1 mRNA and protein in mammalian retina

Shamsul Ola, M., Martin, P. M., El-Sherbeny, A., Roon, P., Agarwal, N., Sarthy, V. P., Casellas, P., Ganapathy, V. & Smith, S. B., Nov 1 2001, In : Molecular Brain Research. 95, 1-2, p. 86-95 10 p.

Research output: Contribution to journalArticle

Retina
Messenger RNA
Proteins
Ganglia
Retinal Pigments
69 Citations (Scopus)

Expression pattern of the type 1 sigma receptor in the brain and identity of critical anionic amino acid residues in the ligand-binding domain of the receptor

Seth, P., Ganapathy, M. E., Conway, S. J., Bridges, C. D., Smith, S. B., Casellas, P. & Ganapathy, V., Jul 25 2001, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1540, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

Ligands
Amino Acids
Brain
Exons
Ethyldimethylaminopropyl Carbodiimide
29 Citations (Scopus)

Molecular Characterization and Developmental Expression of NORPEG, a Novel Gene Induced by Retinoic Acid

Kutty, R. K., Kutty, G., Samuel, W., Duncan, T., Bridges, C. C., El-Sherbeeny, A., Nagineni, C. N., Smith, S. B. & Wiggert, B., Jan 26 2001, In : Journal of Biological Chemistry. 276, 4, p. 2831-2840 10 p.

Research output: Contribution to journalArticle

Tretinoin
Genes
Proteins
Testis
Cytoplasm
45 Citations (Scopus)

Regulation of taurine transporter expression by NO in cultured human retinal pigment epithelial cells

Bridges, C. C., Ola, M. S., Prasad, P. D., El-Sherbeny, A., Ganapathy, V. & Smith, S. B., Dec 1 2001, In : American Journal of Physiology - Cell Physiology. 281, 6 50-6

Research output: Contribution to journalArticle

Retinal Pigments
Taurine
Nitric Oxide
Epithelial Cells
Nitric Oxide Donors
93 Citations (Scopus)

Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells

Bridges, C. C., Kekuda, R., Wang, H., Prasad, P. D., Mehta, P., Huang, W., Smith, S. B. & Ganapathy, V., Jan 30 2001, In : Investigative Ophthalmology and Visual Science. 42, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Retinal Pigments
Cystine
Epithelial Cells
Light
2000
112 Citations (Scopus)

Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor α in mammalian retinal pigment epithelium

Chancy, C. D., Kekuda, R., Huang, W., Prasad, P. D., Kuhnel, J. M., Sirotnak, F. M., Roon, P., Ganapathy, V. & Smith, S. B., Jul 7 2000, In : Journal of Biological Chemistry. 275, 27, p. 20676-20684 9 p.

Research output: Contribution to journalArticle

Reduced Folate Carrier Protein
Retinal Pigments
Retinal Pigment Epithelium
Folic Acid
Polarization
49 Citations (Scopus)

Expression of the extraneuronal monoamine transporter in RPE and neural retina

Rajan, P. D., Kekuda, R., Chancy, C. D., Huang, W., Ganapathy, V. & Smith, S. B., Jan 1 2000, In : Current Eye Research. 20, 3, p. 195-204 10 p.

Research output: Contribution to journalArticle

Retina
Cations
Histamine
Dopamine
Dopamine Plasma Membrane Transport Proteins
78 Citations (Scopus)

The rhodopsin cycle is preserved in IRBP 'knockout' mice despite abnormalities in retinal structure and function

Ripps, H., Peachey, N. S., Xu, X., Nozell, S. E., Smith, S. B. & Liou, G. I., Jan 1 2000, In : Visual Neuroscience. 17, 1, p. 97-105 9 p.

Research output: Contribution to journalArticle

Rhodopsin
Knockout Mice
Retinoids
Retina
Light
5 Citations (Scopus)

Ultrastructural and ERG findings in mice with adenomatous polyposis coli gene disruption

Marcus, D. M., Rustgi, A. K., Defoe, D., Kucherlapati, R., Edelmann, W., Hamasaki, D., Liou, G. I. & Smith, S. B., Dec 1 2000, In : Molecular Vision. 6, 23, p. 169-177 9 p.

Research output: Contribution to journalArticle

APC Genes
Adenomatous Polyposis Coli
Light
Mutation
Codon
1999
7 Citations (Scopus)

Evidence of decreased adhesion between the neural retina and retinal pigmented epithelium of the Mitf(vit) (vitiligo) mutant mouse

Bora, N., Defoe, D. & Smith, S. B., Jan 11 1999, In : Cell and Tissue Research. 295, 1, p. 65-75 11 p.

Research output: Contribution to journalArticle

Vitiligo
Retina
Epithelium
Photoreceptor Cells
Retinal Photoreceptor Cell Outer Segment
35 Citations (Scopus)

Expression of folate receptor α in the mammalian retinol pigmented epithelium and retina

Smith, S. B., Kekuda, R., Gu, X., Chancy, C., Conway, S. J. & Ganapathy, V., Apr 13 1999, In : Investigative Ophthalmology and Visual Science. 40, 5, p. 840-848 9 p.

Research output: Contribution to journalArticle

Vitamin A
Folic Acid
Retinal Pigments
Retina
Epithelium
20 Citations (Scopus)

Functional dissection of the promoter of the interphotoreceptor retinoid-binding protein gene: The cone-rod-homeobox element is essential for photoreceptor-specific expression in vivo

Fei, Y., Matragoon, S., Smith, S. B., Overbeek, P. A., Chen, S., Zack, D. J. & Liou, G. I., Jan 1 1999, In : Journal of Biochemistry. 125, 6, p. 1189-1199 11 p.

Research output: Contribution to journalArticle

Dissection
Vertebrate Photoreceptor Cells
Homeobox Genes
Cones
Genes
8 Citations (Scopus)

Levels of retinoic acid and retinaldehyde dehydrogenase expression in eyes of the Mitfvit mouse model of retinal degeneration

Duncan, T., Swint, C., Smith, S. B. & Wiggert, B. N., Jan 1 1999, In : Molecular Vision. 5, 9

Research output: Contribution to journalArticle

Retinaldehyde
Retinal Degeneration
Tretinoin
Oxidoreductases
Retina

Levels of retinoic acid and retinaldehyde dehydrogenase expression in eyes of the Mitf-vit mouse model of retinal degeneration.

Duncan, T., Swint, C., Smith, S. B. & Wiggert, B. N., Jun 28 1999, In : Molecular Vision. 5

Research output: Contribution to journalArticle

Retinaldehyde
Retinal Degeneration
Tretinoin
Oxidoreductases
Retina
174 Citations (Scopus)

Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations

Cayouette, M., Smith, S. B., Becerra, S. P. & Gravel, C., Jan 1 1999, In : Neurobiology of Disease. 6, 6, p. 523-532 10 p.

Research output: Contribution to journalArticle

Retinal Degeneration
Serine Proteinase Inhibitors
Retinitis Pigmentosa
Retinal Pigments
Retinoblastoma
25 Citations (Scopus)

Regulation of the reduced-folate transporter by nitric oxide in cultured human retinal pigment epithelial cells

Smith, S. B., Huang, W., Chancy, C. & Ganapathy, V., Apr 13 1999, In : Biochemical and Biophysical Research Communications. 257, 2, p. 279-283 5 p.

Research output: Contribution to journalArticle

Folic Acid Transporters
Retinal Pigments
Nitric Oxide
Epithelial Cells
Sulfhydryl Compounds
19 Citations (Scopus)

Stable and efficient gene transfer into the mutant retinal pigment epithelial cells of the Mitf(vit) mouse using a lentiviral vector

Galileo, D. S., Hunter, K. & Smith, S. B., Jan 1 1999, In : Current Eye Research. 18, 2, p. 135-142 8 p.

Research output: Contribution to journalArticle

Retinal Pigments
Epithelial Cells
Vitiligo
Microphthalmos
Photoreceptor Cells
1998
22 Citations (Scopus)
Microphthalmia-Associated Transcription Factor
Vitiligo
Monophenol Monooxygenase
Choroid
Proteins
26 Citations (Scopus)

Transient overexpression of the microphthalmia gene in the eyes of microphthalmia vitiligo mutant mice

Bora, N., Conway, S. J., Liang, H. & Smith, S. B., Nov 1 1998, In : Developmental Dynamics. 213, 3, p. 283-292 10 p.

Research output: Contribution to journalArticle

Microphthalmos
Vitiligo
Retinal Pigment Epithelium
Pigmentation
Genes