• 1433 Citations
  • 19 h-Index
1981 …2018
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Research Output 1981 2018

  • 1433 Citations
  • 19 h-Index
  • 46 Article
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Article
2018

A Synbiotic with Tumor Necrosis Factor- α Inhibitory Activity Ameliorates Experimental Jejunoileal Mucosal Injury

Takahashi, R., Noguchi, T., Mizoguchi, Y., Shimoyama, T., Nakazawa, T. & Ikuta, T., Jan 1 2018, In : BioMed Research International. 2018, 9184093.

Research output: Contribution to journalArticle

Synbiotics
Tablets
Tumor Necrosis Factor-alpha
Inflammatory Bowel Diseases
Wounds and Injuries

Serum of sickle cell disease patients contains fetal hemoglobin silencing factors secreted from leukocytes

Ikuta, T., Sellak, H., Liu, S. Y. & Odo, N., Jun 22 2018, In : Journal of Blood Medicine. 9, p. 95-104 10 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Sickle Cell Anemia
Hydroxyurea
Leukocytes
Serum
2016
5 Citations (Scopus)

Nitric oxide-cGMP signaling stimulates erythropoiesis through multiple lineage-specific transcription factors: Clinical implications and a novel target for erythropoiesis

Ikuta, T., Sellak, H., Odo, N., Adekile, A. D. & Gaensler, K. M. L., Jan 4 2016, In : PloS one. 11, 1, e0144561.

Research output: Contribution to journalArticle

erythropoiesis
Erythropoiesis
nitric oxide
Nitric Oxide
Transcription Factors
2014
9 Citations (Scopus)

Glycosylation inhibitors efficiently inhibit P-selectin-mediated cell adhesion to endothelial cells

Ghoshal, P., Rajendran, M., Odo, N. & Ikuta, T., Jun 19 2014, In : PloS one. 9, 6, e99363.

Research output: Contribution to journalArticle

Glycosylation
P-Selectin
Cell adhesion
Endothelial cells
glycosylation
18 Citations (Scopus)

Molecular mechanisms underlying synergistic adhesion of sickle red blood cells by hypoxia and low nitric oxide bioavailability

Gutsaeva, D. R., Montero-Huerta, P., Parkerson, J. B., Yerigenahally, S. D., Ikuta, T. & Head, C. A., Mar 20 2014, In : Blood. 123, 12, p. 1917-1926 10 p.

Research output: Contribution to journalArticle

Cell Hypoxia
Cell adhesion
Biological Availability
Cell Adhesion
Nitric Oxide
2011
73 Citations (Scopus)

Inhibition of cell adhesion by anti-P-selectin aptamer: A new potential therapeutic agent for sickle cell disease

Gutsaeva, D. R., Parkerson, J. B., Yerigenahally, S. D., Kurz, J. C., Schaub, R. G., Ikuta, T. & Head, C. A., Jan 13 2011, In : Blood. 117, 2, p. 727-735 9 p.

Research output: Contribution to journalArticle

P-Selectin
Cell adhesion
Sickle Cell Anemia
Cell Adhesion
Endothelial cells
13 Citations (Scopus)

Nitric oxide reduces sickle hemoglobin polymerization: Potential role of nitric oxide-induced charge alteration in depolymerization

Ikuta, T., Thatte, H. S., Tang, J. X., Mukerji, I., Knee, K., Bridges, K. R., Wang, S., Montero-Huerta, P., Joshi, R. M. & Head, C. A., Jun 1 2011, In : Archives of Biochemistry and Biophysics. 510, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

Sickle Hemoglobin
Depolymerization
Polymerization
Nitric Oxide
Oxygen
8 Citations (Scopus)

The proinflammatory cytokine GM-CSF downregulates fetal hemoglobin expression by attenuating the cAMP-dependent pathway in sickle cell disease

Ikuta, T., Adekile, A. D., Gutsaeva, D. R., Parkerson, J. B., Yerigenahally, S. D., Clair, B., Kutlar, A., Odo, N. & Head, C. A., Dec 15 2011, In : Blood Cells, Molecules, and Diseases. 47, 4, p. 235-242 8 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Sickle Cell Anemia
Granulocyte-Macrophage Colony-Stimulating Factor
Down-Regulation
Cytokines
2010
44 Citations (Scopus)

Beneficial effects of nitric oxide breathing in adult patients with sickle cell crisis

Head, C. A., Swerdlow, P., McDade, W. A., Joshi, R. M., Ikuta, T., Cooper, M. L. & Eckman, J. R., Oct 2010, In : American Journal of Hematology. 85, 10, p. 800-802 3 p.

Research output: Contribution to journalArticle

Nitric Oxide
Respiration
Pain
Placebos
Sickle Cell Anemia
11 Citations (Scopus)

Regulation of the human HBA genes by KLF4 in erythroid cell lines

Marini, M. G., Porcu, L., Asunis, I., Loi, M. G., Ristaldi, M. S., Porcu, S., Ikuta, T., Cao, A. & Moi, P., Jun 1 2010, In : British Journal of Haematology. 149, 5, p. 748-758 11 p.

Research output: Contribution to journalArticle

Erythroid Cells
Globins
Cell Line
Genes
Gene Expression
2008
16 Citations (Scopus)

Immunoblotting conditions for human hemoglobin chains

Suzuki, Y., Takeda, Y. & Ikuta, T., Jul 15 2008, In : Analytical Biochemistry. 378, 2, p. 218-220 3 p.

Research output: Contribution to journalArticle

Globins
Immunoblotting
Hemoglobins
Collodion
Glutaral
2007
19 Citations (Scopus)

Expression of the γ-globin gene is sustained by the cAMP-dependent pathway in β-thalassaemia

Bailey, L., Kuroyanagi, Y., Franco-Penteado, C. F., Conran, N., Costa, F. F., Ausenda, S., Cappellini, M. D. & Ikuta, T., Aug 1 2007, In : British Journal of Haematology. 138, 3, p. 382-395 14 p.

Research output: Contribution to journalArticle

Thalassemia
Globins
Cyclic AMP
Erythroblasts
Gene Expression
27 Citations (Scopus)

Leukocyte numbers correlate with plasma levels of granulocyte-macrophage colony-stimulating factor in sickle cell disease

Conran, N., Saad, S. T. O., Costa, F. F. & Ikuta, T., Apr 1 2007, In : Annals of Hematology. 86, 4, p. 255-261 7 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Granulocyte-Macrophage Colony-Stimulating Factor
Leukocyte Count
Hydroxyurea
Leukocytosis
2006
26 Citations (Scopus)

cAMP differentially regulates γ-globin gene expression in erythroleukemic cells and primary erythroblasts through c-Myb expression

Kuroyanagi, Y., Kaneko, Y., Muta, K., Park, B. S., Moi, P., Ausenda, S., Cappellini, M. D. & Ikuta, T., Jun 9 2006, In : Biochemical and Biophysical Research Communications. 344, 3, p. 1038-1047 10 p.

Research output: Contribution to journalArticle

Erythroblasts
Globins
K562 Cells
Gene expression
Gene Expression
2004
25 Citations (Scopus)

Negative regulation of γ-globin gene expression by cyclic AMP-dependent pathway in erythroid cells

Inoue, A., Kuroyanagi, Y., Terui, K., Moi, P. & Ikuta, T., Mar 1 2004, In : Experimental Hematology. 32, 3, p. 244-253 10 p.

Research output: Contribution to journalArticle

Erythroid Cells
Globins
Gene Expression Regulation
Cyclic AMP
Cyclic GMP
2001
110 Citations (Scopus)
Cyclic GMP-Dependent Protein Kinases
Globins
Gene Expression
Fetal Hemoglobin
Erythroid Cells
14 Citations (Scopus)

Mutation analysis in Rett syndrome

Milunsky, J. M., Lebo, R. V., Ikuta, T., Maher, T. A., Haverty, C. E. & Milunsky, A., Jan 1 2001, In : Genetic Testing. 5, 4, p. 321-325 5 p.

Research output: Contribution to journalArticle

Rett Syndrome
Mutation
Microcephaly
Phenotype
Genes
12 Citations (Scopus)

Rett syndrome from quintuple and triple deletions within the MECP2 deletion hotspot region

Lebo, R. V., Ikuta, T., Milunsky, J. M. & Milunsky, A., Jul 14 2001, In : Clinical Genetics. 59, 6, p. 406-417 12 p.

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Rett Syndrome
Genetic Recombination
Guanosine
Genes
1998
56 Citations (Scopus)

Alterations in protein-DNA interactions in the γ-globin gene promoter in response to butyrate therapy

Ikuta, T., Kan, Y. W., Swerdlow, P. S., Faller, D. V. & Perrine, S. P., Oct 15 1998, In : Blood. 92, 8, p. 2924-2933 10 p.

Research output: Contribution to journalArticle

Globins
Butyrates
Genes
DNA
Proteins
29 Citations (Scopus)

Cellular and molecular effects of a pulse butyrate regimen and new inducers of globin gene expression and hematopoiesis

Ikuta, T., Atweh, G., Boosalis, V., White, G. L., Fonseca, S. D. A., Boosalis, M., Faller, D. V. & Perrine, S. P., Jan 1 1998, In : Annals of the New York Academy of Sciences. 850, p. 87-99 13 p.

Research output: Contribution to journalArticle

Globins
Butyrates
Hematopoiesis
Gene expression
Gene Expression
1997
13 Citations (Scopus)

Abrogation of IL-3 requirements and stimulation of hematopoietic cell proliferation in vitro and in vivo by carboxylic acids

Boosalis, M. S., Ikuta, T., Pace, B. S., Fonseca, S. D., White, G. L., Faller, D. V. & Perrine, S. P., Jan 1 1997, In : Blood Cells, Molecules and Diseases. 23, 3, p. 434-442 9 p.

Research output: Contribution to journalArticle

Globins
Interleukin-3
Carboxylic Acids
Cell Proliferation
Volatile Fatty Acids
1996
29 Citations (Scopus)

Globin gene switching: In vivo protein-DNA interactions of the human β-globin locus in erythroid cells expressing the fetal or the adult globin gene program

Ikuta, T., Papayannopoulou, T., Stamatoyannopoulos, G. & Kan, Y. W., Jan 1 1996, In : Journal of Biological Chemistry. 271, 24, p. 14082-14091 10 p.

Research output: Contribution to journalArticle

Erythroid Cells
Globins
Genes
Cells
DNA
1993
382 Citations (Scopus)

A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the β-Globin Disorders

Perrine, S. P., Ginder, G. D., Faller, D. V., Dover, G. H., Ikuta, T., Witkowska, H. E., Cai, S. P., Vichinsky, E. P. & Olivieri, N. F., Jan 14 1993, In : New England Journal of Medicine. 328, 2, p. 81-86 6 p.

Research output: Contribution to journalArticle

Globins
Butyrates
Gene Expression
Thalassemia
Sickle Cell Anemia
38 Citations (Scopus)

Inter-ethnic polymorphism of the β-globin gene locus control region (LCR) in sickle-cell anemia patients

Périchon, B., Ragusa, A., Lapouméroulie, C., Romand, A., Moi, P., Ikuta, T., Labie, D., Elion, J. & Krishnamoorthy, R., Jun 1 1993, In : Human Genetics. 91, 5, p. 464-468 5 p.

Research output: Contribution to journalArticle

Locus Control Region
Globins
Linkage Disequilibrium
Sickle Cell Anemia
Microsatellite Repeats
1991
67 Citations (Scopus)

In vivo protein-DNA interactions at the β-globin gene locus

Ikuta, T. & Yuet Wai Kan, W. K., Jan 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 22, p. 10188-10192 5 p.

Research output: Contribution to journalArticle

Globins
K562 Cells
DNA
HeLa Cells
Genes
1988
1 Citation (Scopus)

Direct determination of usual (Caucasian-type) and atypical (oriental-type) alleles of the class I human alcohol dehydrogenase-2 locus

Ikuta, T., Shibuya, A. & Yoshida, A., Jan 1 1988, In : Biochemical Genetics. 26, 7-8, p. 519-525 7 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
alcohol dehydrogenase
alcohol
allele
Alleles
12 Citations (Scopus)

Direct determination of usual (Caucasian-type) and atypical (Oriental-type) alleles of the class I human alcohol dehydrogenase-2 locus

Ikuta, T., Shibuya, A. & Yoshida, A., Aug 1988, In : Biochemical Genetics. 26, 7, p. 519-525 7 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
alcohol dehydrogenase
alcohol
allele
Alleles
4 Citations (Scopus)

Molecular genetics of alcohol-metabolizing enzymes

Yoshida, A., Hsu, L. C., Ikuta, T., Kikuchi, I., Shibuya, A. & Mohandas, T. K., Jan 1 1988, In : Biochemical Society Transactions. 16, 3, p. 230-232 3 p.

Research output: Contribution to journalArticle

Alcohols
Enzymes
Genetics
1986
82 Citations (Scopus)

Human glucose-6-phosphate dehydrogenase: Primary structure and cDNA cloning

Takizawa, T., Huang, I. Y., Ikuta, T. & Yoshida, A., Jan 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 12, p. 4157-4161 5 p.

Research output: Contribution to journalArticle

Glucosephosphate Dehydrogenase
Organism Cloning
Complementary DNA
Gene Library
Enzymes
24 Citations (Scopus)

Human lymphocytes synthesize C-reactive protein

Ikuta, T., Okubo, H., Ishibashi, H., Okumura, Y. & Hayashida, K., Sep 1 1986, In : Inflammation. 10, 3, p. 223-232 10 p.

Research output: Contribution to journalArticle

C-Reactive Protein
Lymphocytes
Monocytes
Glutamine
Radioactivity
19 Citations (Scopus)

mRNA for the three human alcohol dehydrogenase subunits: Size heterogeneity and developmental changes

Ikuta, T. & Yoshida, A., Nov 14 1986, In : Biochemical and Biophysical Research Communications. 140, 3, p. 1020-1027 8 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Messenger RNA
Complementary DNA
Polyadenylation
Liver
60 Citations (Scopus)
Alcohol Dehydrogenase
Molecular Structure
Complementary DNA
Clone Cells
Amino Acid Sequence
1985
16 Citations (Scopus)

Influence of acute-phase proteins on the activity of natural killer cells

Okumura, Y., Kudo, J., Ikuta, T., Kurokawa, S., Ishibashi, H. & Okubo, H., Jun 1 1985, In : Inflammation. 9, 2, p. 211-219 9 p.

Research output: Contribution to journalArticle

Acute-Phase Proteins
Natural Killer Cells
K562 Cells
Glycoproteins
Acids
46 Citations (Scopus)

Molecular cloning of a full-length cDNA for human alcohol dehydrogenase

Ikuta, T., Fujiyoshi, T., Kurachi, K. & Yoshida, A., Jan 1 1985, In : Proceedings of the National Academy of Sciences of the United States of America. 82, 9, p. 2703-2707 5 p.

Research output: Contribution to journalArticle

Alcohol Dehydrogenase
Molecular Cloning
Complementary DNA
Amino Acid Sequence
Initiator Codon

Transformation of Lennert's lymphoma into malignant lymphoma of pleomorphic type

Ikuta, T., Niho, Y., Okubo, H., Tsuneyoshi, M. & Kikuchi, M., Apr 24 1985, In : Acta Haematologica Japonica. 48, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

Hodgkin Disease
Lymphoma
Lymph Nodes
Biopsy
1984
17 Citations (Scopus)

Selective IgA deficiency: Analysis of Ig production in vitro

Inoue, T., Okubo, H., Kudo, J., Ikuta, T., Hachimine, K., Shibata, R., Yoshinari, O., Fukada, K. & Yanase, T., May 1 1984, In : Journal of Clinical Immunology. 4, 3, p. 235-241 7 p.

Research output: Contribution to journalArticle

IgA Deficiency
Immunoglobulins
B-Lymphocytes
Lymphocytes
Immunoglobulin A
1983

Abnormalities of B cell, helper T and suppressor T cell functions in a patient with common variable hypogammaglobulinemia

Inoue, T., Okubo, H., Okeda, T., Ikuta, T., Hirata, Y., Hayashida, K. & Hamaguchi, K., Jan 1983, In : Japanese Journal of Clinical Immunology. 6, 6, p. 505-511 7 p.

Research output: Contribution to journalArticle

Common Variable Immunodeficiency
B-Lymphocytes
T-Lymphocytes
Immunoglobulins
Idiopathic Thrombocytopenic Purpura
1 Citation (Scopus)

Abnormalities of IgA specific B cell and suppressor T cell functions in a patient with selective IgA deficiency and systemic lupus erythematosus

Inoue, T., Ikuta, T., Kudo, J., Hachimine, K., Kusaba, T., Shibata, K. & Okubo, H., Jan 1983, In : Japanese Journal of Clinical Immunology. 6, 2, p. 96-101 6 p.

Research output: Contribution to journalArticle

IgA Deficiency
Systemic Lupus Erythematosus
Immunoglobulin A
B-Lymphocytes
T-Lymphocytes
2 Citations (Scopus)

Purification of C-reactive protein

Ikuta, T., Okubo, H., Yukimura, H. & Ishibashi, H., Jan 1 1983, In : Biochemistry International. 6, 2, p. 275-282 8 p.

Research output: Contribution to journalArticle

C-Reactive Protein
Purification
Lecithins
Pleural Effusion
Buffers
1982
1 Citation (Scopus)

Acute phase proteins-dynamics in inflammatory or tumor-bearing animals

Okubo, H., Shibata, K., Ishibashi, H., Kudo, J., Ikuta, T. & Tsuda-Kawamura, K., Nov 22 1982, In : Fukuoka Acta Medica. 73, 3, p. 146-154 9 p.

Research output: Contribution to journalArticle

Experimental Neoplasms
Inbred Strains Rats
alpha-Macroglobulins
Orosomucoid
alpha 1-Antitrypsin
12 Citations (Scopus)

Alpha1-antitrypsin synthesis by human lymphocytes

Ikuta, T., Okubo, H., Kudo, J., Ishibashi, H. & Inoue, T., Feb 26 1982, In : Biochemical and Biophysical Research Communications. 104, 4, p. 1509-1516 8 p.

Research output: Contribution to journalArticle

Lymphocytes
Concanavalin A
Monocytes
Conditioned Culture Medium
Cell culture
18 Citations (Scopus)

Effect of α2-macroglobulin on the lymphocyte response

Miyanaga, O., Okubo, H., Kudo, J., Ikuta, T. & Hirata, Y., Dec 4 1982, In : Immunology. 47, 2, p. 351-356 6 p.

Research output: Contribution to journalArticle

Macroglobulins
Lectins
Lymphocytes
Proteins
Esterases
6 Citations (Scopus)

Immunoregulatory function of human acute phase reactive (APR) proteins

Kudo, J., Okubo, H. & Ikuta, T., Jan 1 1982, In : Biomedical Research. 3, 4, p. 422-428 7 p.

Research output: Contribution to journalArticle

Proteins
9 Citations (Scopus)

Interaction of acute phase reactive (APR) proteins with lectins: Its relationship to lymphocyte transformation

Kudo, J., Okubo, H. & Ikuta, T., Jan 1 1982, In : Biomedical Research. 3, 4, p. 417-421 5 p.

Research output: Contribution to journalArticle

Lymphocytes
Acute-Phase Proteins
Phytohemagglutinins
Lymphocyte Activation
Concanavalin A

On the study of α 2-macroglobulin. II. Effect on the lymphocyte response

Miyanaga, O., Kudo, J., Okubo, H., Ikuta, T. & Ishibashi, H., Dec 1 1982, In : Fukuoka Acta Medica. 73, 11, p. 647-656 10 p.

Research output: Contribution to journalArticle

alpha-Macroglobulins
Lymphocyte Activation
Lectins
Lymphocytes
1981
59 Citations (Scopus)

Purification and immunological determination of α2-macroglobulin in serum from injured rats

Okubo, H., Miyanaga, O., Nagano, M., Ishibashi, H., Kudo, J., Ikuta, T. & Shibata, K., Apr 28 1981, In : BBA - Protein Structure. 668, 2, p. 257-267 11 p.

Research output: Contribution to journalArticle

Macroglobulins
Purification
Rats
Serum
Turpentine