• 1461 Citations
  • 19 h-Index
1981 …2018

Research output per year

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Research Output

  • 1461 Citations
  • 19 h-Index
  • 46 Article
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Article
2018

A Synbiotic with Tumor Necrosis Factor- α Inhibitory Activity Ameliorates Experimental Jejunoileal Mucosal Injury

Takahashi, R., Noguchi, T., Mizoguchi, Y., Shimoyama, T., Nakazawa, T. & Ikuta, T., Jan 1 2018, In : BioMed Research International. 2018, 9184093.

Research output: Contribution to journalArticle

Serum of sickle cell disease patients contains fetal hemoglobin silencing factors secreted from leukocytes

Ikuta, T., Sellak, H., Liu, S. Y. & Odo, N., Jun 22 2018, In : Journal of Blood Medicine. 9, p. 95-104 10 p.

Research output: Contribution to journalArticle

2016

Nitric oxide-cGMP signaling stimulates erythropoiesis through multiple lineage-specific transcription factors: Clinical implications and a novel target for erythropoiesis

Ikuta, T., Sellak, H., Odo, N., Adekile, A. D. & Gaensler, K. M. L., Jan 4 2016, In : PloS one. 11, 1, e0144561.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Glycosylation inhibitors efficiently inhibit P-selectin-mediated cell adhesion to endothelial cells

Ghoshal, P., Rajendran, M., Odo, N. & Ikuta, T., Jun 19 2014, In : PloS one. 9, 6, e99363.

Research output: Contribution to journalArticle

10 Scopus citations

Molecular mechanisms underlying synergistic adhesion of sickle red blood cells by hypoxia and low nitric oxide bioavailability

Gutsaeva, D. R., Montero-Huerta, P., Parkerson, J. B., Yerigenahally, S. D., Ikuta, T. & Head, C. A., Mar 20 2014, In : Blood. 123, 12, p. 1917-1926 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2011

Inhibition of cell adhesion by anti-P-selectin aptamer: A new potential therapeutic agent for sickle cell disease

Gutsaeva, D. R., Parkerson, J. B., Yerigenahally, S. D., Kurz, J. C., Schaub, R. G., Ikuta, T. & Head, C. A., Jan 13 2011, In : Blood. 117, 2, p. 727-735 9 p.

Research output: Contribution to journalArticle

77 Scopus citations

Nitric oxide reduces sickle hemoglobin polymerization: Potential role of nitric oxide-induced charge alteration in depolymerization

Ikuta, T., Thatte, H. S., Tang, J. X., Mukerji, I., Knee, K., Bridges, K. R., Wang, S., Montero-Huerta, P., Joshi, R. M. & Head, C. A., Jun 1 2011, In : Archives of Biochemistry and Biophysics. 510, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

The proinflammatory cytokine GM-CSF downregulates fetal hemoglobin expression by attenuating the cAMP-dependent pathway in sickle cell disease

Ikuta, T., Adekile, A. D., Gutsaeva, D. R., Parkerson, J. B., Yerigenahally, S. D., Clair, B., Kutlar, A., Odo, N. & Head, C. A., Dec 15 2011, In : Blood Cells, Molecules, and Diseases. 47, 4, p. 235-242 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2010

Beneficial effects of nitric oxide breathing in adult patients with sickle cell crisis

Head, C. A., Swerdlow, P., McDade, W. A., Joshi, R. M., Ikuta, T., Cooper, M. L. & Eckman, J. R., Oct 2010, In : American Journal of Hematology. 85, 10, p. 800-802 3 p.

Research output: Contribution to journalArticle

45 Scopus citations

Regulation of the human HBA genes by KLF4 in erythroid cell lines

Marini, M. G., Porcu, L., Asunis, I., Loi, M. G., Ristaldi, M. S., Porcu, S., Ikuta, T., Cao, A. & Moi, P., Jun 1 2010, In : British Journal of Haematology. 149, 5, p. 748-758 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2008

Immunoblotting conditions for human hemoglobin chains

Suzuki, Y., Takeda, Y. & Ikuta, T., Jul 15 2008, In : Analytical Biochemistry. 378, 2, p. 218-220 3 p.

Research output: Contribution to journalArticle

17 Scopus citations
2007

Expression of the γ-globin gene is sustained by the cAMP-dependent pathway in β-thalassaemia

Bailey, L., Kuroyanagi, Y., Franco-Penteado, C. F., Conran, N., Costa, F. F., Ausenda, S., Cappellini, M. D. & Ikuta, T., Aug 1 2007, In : British Journal of Haematology. 138, 3, p. 382-395 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Leukocyte numbers correlate with plasma levels of granulocyte-macrophage colony-stimulating factor in sickle cell disease

Conran, N., Saad, S. T. O., Costa, F. F. & Ikuta, T., Apr 1 2007, In : Annals of Hematology. 86, 4, p. 255-261 7 p.

Research output: Contribution to journalArticle

29 Scopus citations
2006

cAMP differentially regulates γ-globin gene expression in erythroleukemic cells and primary erythroblasts through c-Myb expression

Kuroyanagi, Y., Kaneko, Y., Muta, K., Park, B. S., Moi, P., Ausenda, S., Cappellini, M. D. & Ikuta, T., Jun 9 2006, In : Biochemical and Biophysical Research Communications. 344, 3, p. 1038-1047 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
2004

Negative regulation of γ-globin gene expression by cyclic AMP-dependent pathway in erythroid cells

Inoue, A., Kuroyanagi, Y., Terui, K., Moi, P. & Ikuta, T., Mar 1 2004, In : Experimental Hematology. 32, 3, p. 244-253 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2001
113 Scopus citations

Mutation analysis in Rett syndrome

Milunsky, J. M., Lebo, R. V., Ikuta, T., Maher, T. A., Haverty, C. E. & Milunsky, A., Jan 1 2001, In : Genetic Testing. 5, 4, p. 321-325 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Rett syndrome from quintuple and triple deletions within the MECP2 deletion hotspot region

Lebo, R. V., Ikuta, T., Milunsky, J. M. & Milunsky, A., Jul 14 2001, In : Clinical Genetics. 59, 6, p. 406-417 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
1998

Alterations in protein-DNA interactions in the γ-globin gene promoter in response to butyrate therapy

Ikuta, T., Kan, Y. W., Swerdlow, P. S., Faller, D. V. & Perrine, S. P., Oct 15 1998, In : Blood. 92, 8, p. 2924-2933 10 p.

Research output: Contribution to journalArticle

57 Scopus citations

Cellular and molecular effects of a pulse butyrate regimen and new inducers of globin gene expression and hematopoiesis

Ikuta, T., Atweh, G., Boosalis, V., White, G. L., Fonseca, S. D. A., Boosalis, M., Faller, D. V. & Perrine, S. P., Jan 1 1998, In : Annals of the New York Academy of Sciences. 850, p. 87-99 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
1997

Abrogation of IL-3 requirements and stimulation of hematopoietic cell proliferation in vitro and in vivo by carboxylic acids

Boosalis, M. S., Ikuta, T., Pace, B. S., Fonseca, S. D., White, G. L., Faller, D. V. & Perrine, S. P., Dec 1997, In : Blood Cells, Molecules and Diseases. 23, 3, p. 434-442 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
1996

Globin gene switching: In vivo protein-DNA interactions of the human β-globin locus in erythroid cells expressing the fetal or the adult globin gene program

Ikuta, T., Papayannopoulou, T., Stamatoyannopoulos, G. & Kan, Y. W., Jan 1 1996, In : Journal of Biological Chemistry. 271, 24, p. 14082-14091 10 p.

Research output: Contribution to journalArticle

29 Scopus citations
1993

A Short-Term Trial of Butyrate to Stimulate Fetal-Globin-Gene Expression in the β-Globin Disorders

Perrine, S. P., Ginder, G. D., Faller, D. V., Dover, G. H., Ikuta, T., Witkowska, H. E., Cai, S. P., Vichinsky, E. P. & Olivieri, N. F., Jan 14 1993, In : New England Journal of Medicine. 328, 2, p. 81-86 6 p.

Research output: Contribution to journalArticle

388 Scopus citations

Inter-ethnic polymorphism of the β-globin gene locus control region (LCR) in sickle-cell anemia patients

Périchon, B., Ragusa, A., Lapouméroulie, C., Romand, A., Moi, P., Ikuta, T., Labie, D., Elion, J. & Krishnamoorthy, R., Jun 1 1993, In : Human Genetics. 91, 5, p. 464-468 5 p.

Research output: Contribution to journalArticle

38 Scopus citations
1991

In vivo protein-DNA interactions at the β-globin gene locus

Ikuta, T. & Yuet Wai Kan, W. K., Jan 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 22, p. 10188-10192 5 p.

Research output: Contribution to journalArticle

68 Scopus citations
1988

Direct determination of usual (Caucasian-type) and atypical (oriental-type) alleles of the class I human alcohol dehydrogenase-2 locus

Ikuta, T., Shibuya, A. & Yoshida, A., Jan 1 1988, In : Biochemical Genetics. 26, 7-8, p. 519-525 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Direct determination of usual (Caucasian-type) and atypical (Oriental-type) alleles of the class I human alcohol dehydrogenase-2 locus

Ikuta, T., Shibuya, A. & Yoshida, A., Aug 1988, In : Biochemical Genetics. 26, 7, p. 519-525 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Molecular genetics of alcohol-metabolizing enzymes

Yoshida, A., Hsu, L. C., Ikuta, T., Kikuchi, I., Shibuya, A. & Mohandas, T. K., Jan 1 1988, In : Biochemical Society Transactions. 16, 3, p. 230-232 3 p.

Research output: Contribution to journalArticle

4 Scopus citations
1986

Human glucose-6-phosphate dehydrogenase: Primary structure and cDNA cloning

Takizawa, T., Huang, I. Y., Ikuta, T. & Yoshida, A., Jan 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 12, p. 4157-4161 5 p.

Research output: Contribution to journalArticle

83 Scopus citations

Human lymphocytes synthesize C-reactive protein

Ikuta, T., Okubo, H., Ishibashi, H., Okumura, Y. & Hayashida, K., Sep 1 1986, In : Inflammation. 10, 3, p. 223-232 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

mRNA for the three human alcohol dehydrogenase subunits: Size heterogeneity and developmental changes

Ikuta, T. & Yoshida, A., Nov 14 1986, In : Biochemical and Biophysical Research Communications. 140, 3, p. 1020-1027 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
60 Scopus citations
1985

Influence of acute-phase proteins on the activity of natural killer cells

Okumura, Y., Kudo, J., Ikuta, T., Kurokawa, S., Ishibashi, H. & Okubo, H., Jun 1 1985, In : Inflammation. 9, 2, p. 211-219 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Molecular cloning of a full-length cDNA for human alcohol dehydrogenase

Ikuta, T., Fujiyoshi, T., Kurachi, K. & Yoshida, A., Jan 1 1985, In : Proceedings of the National Academy of Sciences of the United States of America. 82, 9, p. 2703-2707 5 p.

Research output: Contribution to journalArticle

46 Scopus citations

Transformation of Lennert's lymphoma into malignant lymphoma of pleomorphic type

Ikuta, T., Niho, Y., Okubo, H., Tsuneyoshi, M. & Kikuchi, M., Apr 24 1985, In : Acta Haematologica Japonica. 48, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

1984

Selective IgA deficiency: Analysis of Ig production in vitro

Inoue, T., Okubo, H., Kudo, J., Ikuta, T., Hachimine, K., Shibata, R., Yoshinari, O., Fukada, K. & Yanase, T., May 1 1984, In : Journal of Clinical Immunology. 4, 3, p. 235-241 7 p.

Research output: Contribution to journalArticle

17 Scopus citations
1983

Abnormalities of B cell, helper T and suppressor T cell functions in a patient with common variable hypogammaglobulinemia

Inoue, T., Okubo, H., Okeda, T., Ikuta, T., Hirata, Y., Hayashida, K. & Hamaguchi, K., Jan 1983, In : Japanese Journal of Clinical Immunology. 6, 6, p. 505-511 7 p.

Research output: Contribution to journalArticle

Abnormalities of IgA specific B cell and suppressor T cell functions in a patient with selective IgA deficiency and systemic lupus erythematosus

Inoue, T., Ikuta, T., Kudo, J., Hachimine, K., Kusaba, T., Shibata, K. & Okubo, H., Jan 1983, In : Japanese Journal of Clinical Immunology. 6, 2, p. 96-101 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Purification of C-reactive protein

Ikuta, T., Okubo, H., Yukimura, H. & Ishibashi, H., Jan 1 1983, In : Biochemistry International. 6, 2, p. 275-282 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
1982

Acute phase proteins-dynamics in inflammatory or tumor-bearing animals

Okubo, H., Shibata, K., Ishibashi, H., Kudo, J., Ikuta, T. & Tsuda-Kawamura, K., Nov 22 1982, In : Fukuoka Acta Medica. 73, 3, p. 146-154 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Alpha1-antitrypsin synthesis by human lymphocytes

Ikuta, T., Okubo, H., Kudo, J., Ishibashi, H. & Inoue, T., Feb 26 1982, In : Biochemical and Biophysical Research Communications. 104, 4, p. 1509-1516 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effect of α2-macroglobulin on the lymphocyte response

Miyanaga, O., Okubo, H., Kudo, J., Ikuta, T. & Hirata, Y., Dec 4 1982, In : Immunology. 47, 2, p. 351-356 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Immunoregulatory function of human acute phase reactive (APR) proteins

Kudo, J., Okubo, H. & Ikuta, T., Jan 1 1982, In : Biomedical Research. 3, 4, p. 422-428 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interaction of acute phase reactive (APR) proteins with lectins: Its relationship to lymphocyte transformation

Kudo, J., Okubo, H. & Ikuta, T., Jan 1 1982, In : Biomedical Research. 3, 4, p. 417-421 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

On the study of α 2-macroglobulin. II. Effect on the lymphocyte response

Miyanaga, O., Kudo, J., Okubo, H., Ikuta, T. & Ishibashi, H., Dec 1 1982, In : Fukuoka Acta Medica. 73, 11, p. 647-656 10 p.

Research output: Contribution to journalArticle

1981

Purification and immunological determination of α2-macroglobulin in serum from injured rats

Okubo, H., Miyanaga, O., Nagano, M., Ishibashi, H., Kudo, J., Ikuta, T. & Shibata, K., Apr 28 1981, In : BBA - Protein Structure. 668, 2, p. 257-267 11 p.

Research output: Contribution to journalArticle

59 Scopus citations