Umapathy N Siddaramappa

2018

CB1R-mediated activation of caspase-3 causes epigenetic and neurobehavioral abnormalities in postnatal ethanol-exposed mice

Subbanna, S., Nagre, N. N., Shivakumar, M., Joshi, V., Psychoyos, D., Kutlar, A., Umapathy, N. S. & Basavarajappa, B. S., Feb 20 2018, In : Frontiers in Molecular Neuroscience. 11, 45.

Research output: Contribution to journal › Article

9 Scopus citations

2017

Impaired pulmonary endothelial barrier function in sickle cell mice

Umapathy, N. S., Gonzales, J., Makala, L. H., Xu, H., Biddinger, P. & Pace, B. S., Jan 1 2017, In : Haematologica. 102, 1, p. e26-e29

Research output: Contribution to journal › Letter

1 Scopus citations

2015

Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R Exon1 Histone H4K8 acetylation and up-regulating CB1R function causing neurobehavioral abnormalities in adult mice

Subbanna, S., Nagre, N. N., Umapathy, N. S., Pace, B. S. & Basavarajappa, B. S., Mar 1 2015, In : International Journal of Neuropsychopharmacology. 18, 5, p. 1-15 15 p.

Research output: Contribution to journal › Article

29 Scopus citations

2014

Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice

Subbanna, S., Nagre, N. N., Shivakumar, M., Umapathy, N. S., Psychoyos, D. & Basavarajappa, B. S., Jan 31 2014, In : Neuroscience. 258, p. 422-432 11 p.

Research output: Contribution to journal › Article

50 Scopus citations

Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction

Czikora, I., Sridhar, S., Gorshkov, B. A., Alieva, I. B., Kasa, A., Gonzales, J. N., Potapenko, O., Siddaramappa, U. N., Pillich, H., Rick, F. G., Block, N. L., Verin, A. D., Chakraborty, T., Matthay, M. A., Schally, A. V. & Lucas, R., Jan 1 2014, In : Frontiers in Physiology. 5 JUL, 00259.

Research output: Contribution to journal › Article

11 Scopus citations

2013

Adenosine A1 Receptors Promote Vasa Vasorum Endothelial Cell Barrier Integrity via G_i and Akt-Dependent Actin Cytoskeleton Remodeling

Siddaramappa Umapathy, N., Kaczmarek, E., Fatteh, N., Burns, N., Lucas, R., Stenmark, K. R., Verin, A. D. & Gerasimovskaya, E. V., Apr 16 2013, In : PloS one. 8, 4, e59733.

Research output: Contribution to journal › Article

21 Scopus citations

Correction: Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via G_i and akt-dependent actin cytoskeleton remodeling (PLoS ONE, 8, 4 (e59733) DOI: 10.1371/journal.pone.0059733)

Umapathy, N. S., Kaczmarek, E., Fatteh, N., Burns, N., Lucas, R., Stenmark, K. R., Verin, A. D. & Gerasimovskaya, E. V., May 1 2013, In : PloS one. 8, 5

Research output: Contribution to journal › Comment/debate

G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain

Subbanna, S., Shivakumar, M., Umapathy, N. S., Saito, M., Mohan, P. S., Kumar, A., Nixon, R. A., Verin, A. D., Psychoyos, D. & Basavarajappa, B. S., Jun 1 2013, In : Neurobiology of Disease. 54, p. 475-485 11 p.

Research output: Contribution to journal › Article

59 Scopus citations

Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs

Lucas, R., Czikora, I., Sridhar, S., Zemskov, E. A., Gorshkov, B. A., Siddaramappa, U. N., Oseghale, A., Lawson, J., Verin, A. D., Rick, F. G., Block, N. L., Pillich, H., Romero Lucas, M. J., Leustik, M., Schally, A. V. & Chakraborty, T., Jul 1 2013, In : Toxins. 5, 7, p. 1244-1260 17 p.

Research output: Contribution to journal › Review article

18 Scopus citations

2012

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema

Lucas, R., Sridhar, S., Rick, F. G., Gorshkov, B. A., Siddaramappa, U. N., Yang, G., Oseghale, A., Verin, A. D., Chakraborty, T., Matthay, M. A., Zemskov, E. A., White, R., Block, N. L. & Schally, A. V., Feb 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 6, p. 2084-2089 6 p.

Research output: Contribution to journal › Article

36 Scopus citations

Molecular characterization of myosin phosphatase in endothelium

Kim, K. M., Csortos, C., Czikora, I., Fulton, D., Umapathy, N. S., Olah, G. & Verin, A. D., Apr 1 2012, In : Journal of Cellular Physiology. 227, 4, p. 1701-1708 8 p.

Research output: Contribution to journal › Article

13 Scopus citations

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability

Lucas, R., Yang, G., Gorshkov, B. A., Zemskov, E. A., Sridhar, S., Siddaramappa, U. N., Jezierska-Drutel, A., Alieva, I. B., Leustik, M., Hossain, H., Fischer, B., Catravas, J. D., Verin, A. D., Pittet, J. F., Caldwell, R. B., Mitchell, T. J., Cederbaum, S. D., Fulton, D. J., Matthay, M. A., Caldwell, R. W. & 2 others, Romero Lucas, M. J. & Chakraborty, T., Oct 1 2012, In : American journal of respiratory cell and molecular biology. 47, 4, p. 445-453 9 p.

Research output: Contribution to journal › Article

34 Scopus citations

β-Nicotinamide adenine dinucleotide attenuates lipopolysaccharide- induced inflammatory effects in a murine model of acute lung injury

Siddaramappa, U. N., Gonzales, J. N., Fulzele, S. T., Kim, K. M., Lucas, R. & Verin, A. D., Jun 1 2012, In : Experimental Lung Research. 38, 5, p. 223-232 10 p.

Research output: Contribution to journal › Article

10 Scopus citations

2011

Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway

Shatanawi, A., Romero, M. J., Iddings, J. A., Chandra, S., Umapathy, N. S., Verin, A. D., Caldwell, R. B. & Caldwell, R. W., May 1 2011, In : American Journal of Physiology - Cell Physiology. 300, 5, p. C1181-C1192

Research output: Contribution to journal › Article

89 Scopus citations

P2Y receptors as regulators of lung endothelial barrier integrity

Zemskov, E., Lucas, R., Verin, A. D. & Umapathy, N. S., Jan 1 2011, In : Journal of Cardiovascular Disease Research. 2, 1, p. 14-22 9 p.

Research output: Contribution to journal › Article

20 Scopus citations

2010

Extracellular purines in endothelial cell barrier regulation

Siddaramappa, U. N., Zemskov, E. A., Jezierska, A., Kolosova, I. A., Lucas, R., Catravas, J. D. & Verin, A. D., Dec 1 2010, Extracellular ATP and Adenosine as Regulators of Endothelial Cell Function: Implications for Health and Disease. Springer Netherlands, p. 39-55 17 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Extracellular β-nicotinamide adenine dinucleotide (β-NAD) promotes the endothelial cell barrier integrity via PKA- and EPAC1/Rac1-dependent actin cytoskeleton rearrangement

Siddaramappa, U. N., Zemskov, E. A., Gonzales, J. N., Gorshkov, B. A., Sridhar, S., Chakraborty, T., Lucas, R. & Verin, A. D., Apr 1 2010, In : Journal of Cellular Physiology. 223, 1, p. 215-223 9 p.

Research output: Contribution to journal › Article

32 Scopus citations

Molecular mechanisms involved in adenosine-induced endothelial cell barrier enhancement

Siddaramappa, U. N., Fan, Z. H., Zemskov, E. A., Alieva, I. B., Black, S. M. & Verin, A. D., May 1 2010, In : Vascular Pharmacology. 52, 5-6, p. 199-206 8 p.

Research output: Contribution to journal › Article

29 Scopus citations

Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter

Miyauchi, S., Gopal, E., Babu, E., Srinivas, S. R., Kubo, Y., Umapathy, N. S., Thakkar, S. V., Ganapathy, V. & Prasad, P. D., Jun 1 2010, In : Biochimica et Biophysica Acta - Biomembranes. 1798, 6, p. 1164-1171 8 p.

Research output: Contribution to journal › Article

23 Scopus citations

The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - A crucial role for protein kinase C-α inhibition

Xiong, C., Yang, G., Kumar, S., Aggarwal, S., Leustik, M., Snead, C., Hamacher, J., Fischer, B., Siddaramappa, U. N., Hossain, H., Wendel, A., Catravas, J. D., Verin, A. D., Fulton, D. J., Black, S. M., Chakraborty, T. & Lucas, R., May 1 2010, In : Vascular Pharmacology. 52, 5-6, p. 207-213 7 p.

Research output: Contribution to journal › Article

23 Scopus citations

2009

Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity

Kumar, S., Sun, X., Wiseman, D. A., Tian, J., Umapathy, N. S., Verin, A. D. & Black, S. M., Mar 1 2009, In : DNA and cell biology. 28, 3, p. 119-129 11 p.

Research output: Contribution to journal › Article

17 Scopus citations

The carboxyl-terminal domain of Atypical protein kinase Cζ binds to ceramide and regulates junction formation in Epithelial cells

Wang, G., Krishnamurthy, K., Umapathy, N. S., Verin, A. D. & Bieberich, E., May 22 2009, In : Journal of Biological Chemistry. 284, 21, p. 14469-14475 7 p.

Research output: Contribution to journal › Article

35 Scopus citations

2008

Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells

Umapathy, N. S., Dun, Y., Martin, P. M., Duplantier, J. N., Roon, P., Prasad, P., Smith, S. B. & Ganapathy, V., Nov 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 5151-5160 10 p.

Research output: Contribution to journal › Article

16 Scopus citations

Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy

Karunakaran, S., Siddaramappa, U. N., Thangaraju, M., Hatanaka, T., Itagaki, S., Munn, D. H., Prasad, P. D. & Ganapathy, V., Sep 15 2008, In : Biochemical Journal. 414, 3, p. 343-355 13 p.

Research output: Contribution to journal › Article

62 Scopus citations

2007

Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney

Gopal, E., Umapathy, N. S., Martin, P. M., Ananth, S., Gnana-Prakasam, J. P., Becker, H., Wagner, C. A., Ganapathy, V. & Prasad, P. D., Nov 1 2007, In : Biochimica et Biophysica Acta - Biomembranes. 1768, 11, p. 2690-2697 8 p.

Research output: Contribution to journal › Article

54 Scopus citations

Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types

Umapathy, N. S., Gnana-Prakasam, J. P., Martin, P. M., Mysona, B., Dun, Y., Smith, S. B., Ganapathy, V. & Prasad, P. D., Nov 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 11, p. 5299-5305 7 p.

Research output: Contribution to journal › Article

45 Scopus citations

Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB^0,+

Srinivas, S. R., Prasad, P. D., Umapathy, N. S., Ganapathy, V. & Shekhawat, P. S., Nov 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 293, 5, p. G1046-G1053

Research output: Contribution to journal › Article

42 Scopus citations

2006

Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3)

Hu, H., Endres, C. J., Chang, C., Umapathy, N. S., Lee, E. W., Fei, Y. J., Itagaki, S., Swaan, P. W., Ganapathy, V. & Unadkat, J. D., May 1 2006, In : Molecular pharmacology. 69, 5, p. 1542-1553 12 p.

Research output: Contribution to journal › Article

43 Scopus citations

Functional Characteristics of NaS2, a Placenta-specific Na⁺-coupled Transporter for Sulfate and Oxyanions of the Micronutrients Selenium and Chromium

Miyauchi, S., Srinivas, S. R., Fei, Y. J., Gopal, E., Umapathy, N. S., Wang, H., Conway, S. J., Ganapathy, V. & Prasad, P. D., Jun 1 2006, In : Placenta. 27, 6-7, p. 550-559 10 p.

Research output: Contribution to journal › Article

20 Scopus citations

2005

Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells

Umapathy, N. S., Li, W., Mysona, B. A., Smith, S. B. & Ganapathy, V., Nov 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 11, p. 3980-3987 8 p.

Research output: Contribution to journal › Article

41 Scopus citations

2004

Induction of cystine-glutamate transporter X_c ^- by human immunodeficiency virus type 1 transactivator protein Tat in retinal pigment epithelium

Bridges, C. C., Hu, H., Miyauchi, S., Siddaramappa, U. N., Ganapathy, M. E., Ignatowicz, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 2906-2914 9 p.

Research output: Contribution to journal › Article

32 Scopus citations

Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB ^0,+

Umapathy, N. S., Ganapathy, V. & Ganapathy, M. E., Jul 1 2004, In : Pharmaceutical Research. 21, 7, p. 1303-1310 8 p.

Research output: Contribution to journal › Article

49 Scopus citations

2001

Novel scintillation proximity assay for measuring membrane-associated steps of peptidoglycan biosynthesis in Escherichia coli

Chandrakala, B., Elias, B. C., Mehra, U., Umapathy, N. S., Dwarakanath, P., Balganesh, T. S. & DeSousa, S. M., Mar 12 2001, In : Antimicrobial agents and chemotherapy. 45, 3, p. 768-775 8 p.

Research output: Contribution to journal › Article

30 Scopus citations