Umapathy N Siddaramappa &ndash; Scholarly Output

2018

CB1R-mediated activation of caspase-3 causes epigenetic and neurobehavioral abnormalities in postnatal ethanol-exposed mice

Subbanna, S., Nagre, N. N., Shivakumar, M., Joshi, V., Psychoyos, D., Kutlar, A., Umapathy, N. S. & Basavarajappa, B. S., Feb 20 2018, In : Frontiers in Molecular Neuroscience. 11, 45.

Research output: Contribution to journal › Article

Epigenomics

Caspase 3

Ethanol

Methyl-CpG-Binding Protein 2

Fetal Alcohol Spectrum Disorders

2017

1 Citation (Scopus)

Impaired pulmonary endothelial barrier function in sickle cell mice

Siddaramappa, U. N., Gonzales, J. N., Makala, L. H., Xu, H., Biddinger, P. W. & Pace, B. S., Jan 1 2017, In : Haematologica. 102, 1, p. e26-e29

Research output: Contribution to journal › Letter

2015

26 Citations (Scopus)

Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R Exon1 Histone H4K8 acetylation and up-regulating CB1R function causing neurobehavioral abnormalities in adult mice

Subbanna, S., Nagre, N. N., Umapathy, N. S., Pace, B. S. & Basavarajappa, B. S., Mar 1 2015, In : International Journal of Neuropsychopharmacology. 18, 5, p. 1-15 15 p.

Research output: Contribution to journal › Article

Acetylation

Histones

Ethanol

Cytoskeleton

Memory Disorders

2014

46 Citations (Scopus)

Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice

Subbanna, S., Nagre, N. N., Shivakumar, M., Siddaramappa, U. N., Psychoyos, D. & Basavarajappa, B. S., Jan 31 2014, In : Neuroscience. 258, p. 422-432 11 p.

Research output: Contribution to journal › Article

Acetylation

Histones

Ethanol

Methyl-CpG-Binding Protein 2

Lysine

10 Citations (Scopus)

Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction

Czikora, I., Sridhar, S., Gorshkov, B. A., Alieva, I. B., Kasa, A., Gonzales, J. N., Potapenko, O., Siddaramappa, U. N., Pillich, H., Rick, F. G., Block, N. L., Verin, A. D., Chakraborty, T., Matthay, M. A., Schally, A. V. & Lucas, R., Jan 1 2014, In : Frontiers in Physiology. 5 JUL, 00259.

Research output: Contribution to journal › Article

Bacterial Toxins

Growth Hormone-Releasing Hormone

Cyclic AMP-Dependent Protein Kinases

Lung

Endothelial Cells

2013

19 Citations (Scopus)

Adenosine A1 Receptors Promote Vasa Vasorum Endothelial Cell Barrier Integrity via G_i and Akt-Dependent Actin Cytoskeleton Remodeling

Siddaramappa Umapathy, N., Kaczmarek, E., Fatteh, N., Burns, N., Lucas, R., Stenmark, K. R., Verin, A. D. & Gerasimovskaya, E. V., Apr 16 2013, In : PloS one. 8, 4, e59733.

Research output: Contribution to journal › Article

Vasa Vasorum

Adenosine A1 Receptors

Endothelial cells

adenosine

microfilaments

Correction: Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via G_i and akt-dependent actin cytoskeleton remodeling (PLoS ONE, 8, 4 (e59733) DOI: 10.1371/journal.pone.0059733)

Umapathy, N. S., Kaczmarek, E., Fatteh, N., Burns, N., Lucas, R., Stenmark, K. R., Verin, A. D. & Gerasimovskaya, E. V., May 1 2013, In : PloS one. 8, 5

Research output: Contribution to journal › Comment/debate

Vasa Vasorum

Adenosine A1 Receptors

adenosine

microfilaments

Actin Cytoskeleton

55 Citations (Scopus)

G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain

Subbanna, S., Shivakumar, M., Siddaramappa, U. N., Saito, M., Mohan, P. S., Kumar, A., Nixon, R. A., Verin, A. D., Psychoyos, D. & Basavarajappa, B. S., Jun 1 2013, In : Neurobiology of Disease. 54, p. 475-485 11 p.

Research output: Contribution to journal › Article

Histones

Methylation

Ethanol

Brain

Lysine

18 Citations (Scopus)

Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs

Lucas, R., Czikora, I., Sridhar, S., Zemskov, E. A., Gorshkov, B. A., Siddaramappa, U. N., Oseghale, A., Lawson, J., Verin, A. D., Rick, F. G., Block, N. L., Pillich, H., Romero Lucas, M. J., Leustik, M., Schally, A. V. & Chakraborty, T., Jul 1 2013, In : Toxins. 5, 7, p. 1244-1260 17 p.

Research output: Contribution to journal › Review article

Anti-Bacterial Agents

Lung

Edema

Sodium

Epithelial Sodium Channels

2012

34 Citations (Scopus)

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema

Lucas, R., Sridhar, S., Rick, F. G., Gorshkov, B. A., Siddaramappa, U. N., Yang, G., Oseghale, A., Verin, A. D., Chakraborty, T., Matthay, M. A., Zemskov, E. A., White, R., Block, N. L. & Schally, A. V., Feb 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 6, p. 2084-2089 6 p.

Research output: Contribution to journal › Article

Growth Hormone-Releasing Hormone

Pulmonary Edema

Permeability

Edema

Lung

12 Citations (Scopus)

Molecular characterization of myosin phosphatase in endothelium

Kim, K. M., Csortos, C., Czikora, I., Fulton, D., Umapathy, N. S., Olah, G. & Verin, A. D., Apr 1 2012, In : Journal of Cellular Physiology. 227, 4, p. 1701-1708 8 p.

Research output: Contribution to journal › Article

Myosin-Light-Chain Phosphatase

Myosins

Endothelium

Endothelial cells

Phosphoric Monoester Hydrolases

33 Citations (Scopus)

Protein kinase C-α and arginase I mediate pneumolysin-induced pulmonary endothelial hyperpermeability

Lucas, R., Yang, G., Gorshkov, B. A., Zemskov, E. A., Sridhar, S., Siddaramappa, U. N., Jezierska-Drutel, A., Alieva, I. B., Leustik, M., Hossain, H., Fischer, B., Catravas, J. D., Verin, A. D., Pittet, J. F., Caldwell, R. B., Mitchell, T. J., Cederbaum, S. D., Fulton, D. J., Matthay, M. A., Caldwell, R. W. & 2 others, Romero Lucas, M. J. & Chakraborty, T., Oct 1 2012, In : American journal of respiratory cell and molecular biology. 47, 4, p. 445-453 9 p.

Research output: Contribution to journal › Article

Arginase

Protein Kinase C

Lung

Endothelial cells

Endothelial Cells

10 Citations (Scopus)

β-Nicotinamide adenine dinucleotide attenuates lipopolysaccharide- induced inflammatory effects in a murine model of acute lung injury

Siddaramappa, U. N., Gonzales, J. N., Fulzele, S. T., Kim, K. M., Lucas, R. & Verin, A. D., Jun 1 2012, In : Experimental Lung Research. 38, 5, p. 223-232 10 p.

Research output: Contribution to journal › Article

Acute Lung Injury

NAD

Lipopolysaccharides

Bronchoalveolar Lavage Fluid

Lung

2011

83 Citations (Scopus)

Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway

Shatanawi, A., Romero, M. J., Iddings, J. A., Chandra, S., Umapathy, N. S., Verin, A. D., Caldwell, R. B. & Caldwell, R. W., May 1 2011, In : American Journal of Physiology - Cell Physiology. 300, 5, p. C1181-C1192

Research output: Contribution to journal › Article

Arginase

rho-Associated Kinases

p38 Mitogen-Activated Protein Kinases

Angiotensin II

Blood Vessels

12 Citations (Scopus)

P2Y receptors as regulators of lung endothelial barrier integrity

Zemskov, E. A., Lucas, R., Verin, A. D. & Siddaramappa, U. N., Jan 1 2011, In : Journal of Cardiovascular Disease Research. 2, 1, p. 14-22 9 p.

Research output: Contribution to journal › Article

Blood Vessels

Permeability

Lung

Endothelial Cells

Protective Agents

2010

Extracellular purines in endothelial cell barrier regulation

Siddaramappa, U. N., Zemskov, E. A., Jezierska, A., Kolosova, I. A., Lucas, R., Catravas, J. D. & Verin, A. D., Dec 1 2010, Extracellular ATP and Adenosine as Regulators of Endothelial Cell Function: Implications for Health and Disease. Springer Netherlands, p. 39-55 17 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Purines

Acute Lung Injury

Endothelial cells

Adult Respiratory Distress Syndrome

Permeability

30 Citations (Scopus)

Extracellular β-nicotinamide adenine dinucleotide (β-NAD) promotes the endothelial cell barrier integrity via PKA- and EPAC1/Rac1-dependent actin cytoskeleton rearrangement

Siddaramappa, U. N., Zemskov, E. A., Gonzales, J. N., Gorshkov, B. A., Sridhar, S., Chakraborty, T., Lucas, R. & Verin, A. D., Apr 1 2010, In : Journal of Cellular Physiology. 223, 1, p. 215-223 9 p.

Research output: Contribution to journal › Article

Endothelial cells

Actin Cytoskeleton

NAD

Actins

Endothelial Cells

29 Citations (Scopus)

Molecular mechanisms involved in adenosine-induced endothelial cell barrier enhancement

Siddaramappa, U. N., Fan, Z. H., Zemskov, E. A., Alieva, I. B., Black, S. M. & Verin, A. D., May 1 2010, In : Vascular Pharmacology. 52, 5-6, p. 199-206 8 p.

Research output: Contribution to journal › Article

Adenosine

Endothelial Cells

Electric Impedance

Pulmonary Artery

Small Interfering RNA

22 Citations (Scopus)

Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter

Miyauchi, S., Gopal, E., Babu, E., Srinivas, S. R., Kubo, Y., Siddaramappa, U. N., Thakkar, S. V., Ganapathy, V. & Prasad, P. D., Jun 1 2010, In : Biochimica et Biophysica Acta - Biomembranes. 1798, 6, p. 1164-1171 8 p.

Research output: Contribution to journal › Article

Pyrrolidonecarboxylic Acid

Sodium

Amino Acid Transport Systems

Chemical activation

Oocytes

23 Citations (Scopus)

The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - A crucial role for protein kinase C-α inhibition

Xiong, C., Yang, G., Kumar, S., Aggarwal, S., Leustik, M., Snead, C., Hamacher, J., Fischer, B., Siddaramappa, U. N., Hossain, H., Wendel, A., Catravas, J. D., Verin, A. D., Fulton, D. J., Black, S. M., Chakraborty, T. & Lucas, R., May 1 2010, In : Vascular Pharmacology. 52, 5-6, p. 207-213 7 p.

Research output: Contribution to journal › Article

Lectins

Protein Kinase C

Myosin Light Chains

Endothelial Cells

Lung

2009

16 Citations (Scopus)

Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity

Kumar, S., Sun, X., Wiseman, D. A., Tian, J., Umapathy, N. S., Verin, A. D. & Black, S. M., Mar 1 2009, In : DNA and cell biology. 28, 3, p. 119-129 11 p.

Research output: Contribution to journal › Article

Nitric Oxide Synthase Type III

Hydrogen Peroxide

Transcription Factor AP-1

Hydroxyl Radical

Zinc

33 Citations (Scopus)

The carboxyl-terminal domain of Atypical protein kinase Cζ binds to ceramide and regulates junction formation in Epithelial cells

Wang, G., Krishnamurthy, K., Siddaramappa, U. N., Verin, A. D. & Bieberich, E., May 22 2009, In : Journal of Biological Chemistry. 284, 21, p. 14469-14475 7 p.

Research output: Contribution to journal › Article

Ceramides

Epithelial Cells

Protein Kinases

Madin Darby Canine Kidney Cells

Electric Impedance

2008

16 Citations (Scopus)

Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells

Umapathy, N. S., Dun, Y., Martin, P. M., Duplantier, J. N., Roon, P., Prasad, P., Smith, S. B. & Ganapathy, V., Nov 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 5151-5160 10 p.

Research output: Contribution to journal › Article

Retinal Ganglion Cells

Glutamine

Ganglia

Neuroglia

In Situ Hybridization

55 Citations (Scopus)

Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy

Karunakaran, S., Siddaramappa, U. N., Thangaraju, M., Hatanaka, T., Itagaki, S., Munn, D. H., Prasad, P. D. & Ganapathy, V., Sep 15 2008, In : Biochemical Journal. 414, 3, p. 343-355 13 p.

Research output: Contribution to journal › Article

Chemotherapy

Tryptophan

Cells

Derivatives

Drug Therapy

2007

49 Citations (Scopus)

Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney

Gopal, E., Siddaramappa, U. N., Martin, P. M., Ananth, S., Gnana-Prakasam, J. P., Becker, H., Wagner, C. A., Ganapathy, V. & Prasad, P. D., Nov 1 2007, In : Biochimica et Biophysica Acta - Biomembranes. 1768, 11, p. 2690-2697 8 p.

Research output: Contribution to journal › Article

Cloning

Niacin

Organism Cloning

Lactic Acid

Monocarboxylic Acid Transporters

43 Citations (Scopus)

Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types

Umapathy, N. S., Gnana-Prakasam, J. P., Martin, P. M., Mysona, B., Dun, Y., Smith, S. B., Ganapathy, V. & Prasad, P. D., Nov 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 11, p. 5299-5305 7 p.

Research output: Contribution to journal › Article

Proton-Coupled Folate Transporter

Retina

Organism Cloning

Folic Acid

Xenopus laevis

35 Citations (Scopus)

Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB^0,+

Srinivas, S. R., Prasad, P. D., Siddaramappa, U. N., Ganapathy, V. & Shekhawat, P. S., Nov 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 293, 5

Research output: Contribution to journal › Article

Amino Acid Transport Systems

Carnitine

Prodrugs

Butyrates

Inflammation

2006

43 Citations (Scopus)

Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3)

Hu, H., Endres, C. J., Chang, C., Umapathy, N. S., Lee, E. W., Fei, Y. J., Itagaki, S., Swaan, P. W., Ganapathy, V. & Unadkat, J. D., May 1 2006, In : Molecular Pharmacology. 69, 5, p. 1542-1553 12 p.

Research output: Contribution to journal › Article

Nucleoside Transport Proteins

Structure-Activity Relationship

gemcitabine

Quantitative Structure-Activity Relationship

Membrane Potentials

19 Citations (Scopus)

Functional Characteristics of NaS2, a Placenta-specific Na⁺-coupled Transporter for Sulfate and Oxyanions of the Micronutrients Selenium and Chromium

Miyauchi, S., Srinivas, S. R., Fei, Y. J., Gopal, E., Umapathy, N. S., Wang, H., Conway, S. J., Ganapathy, V. & Prasad, P. D., Jun 1 2006, In : Placenta. 27, 6-7, p. 550-559 10 p.

Research output: Contribution to journal › Article

Micronutrients

Chromium

Selenium

Placenta

Sulfates

2005

40 Citations (Scopus)

Expression and function of glutamine transporters SN1 (SNAT3) and SN2 (SNAT5) in retinal Müller cells

Umapathy, N. S., Li, W., Mysona, B. A., Smith, S. B. & Ganapathy, V., Nov 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 11, p. 3980-3987 8 p.

Research output: Contribution to journal › Article

Glutamine

Protein Isoforms

system N protein 1

Messenger RNA

Substrate Specificity

2004

31 Citations (Scopus)

Induction of cystine-glutamate transporter X_c ^- by human immunodeficiency virus type 1 transactivator protein Tat in retinal pigment epithelium

Bridges, C. C., Hu, H., Miyauchi, S., Siddaramappa, U. N., Ganapathy, M. E., Ignatowicz, L., Maddox, D. M., Smith, S. B. & Ganapathy, V., Sep 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 9, p. 2906-2914 9 p.

Research output: Contribution to journal › Article

tat Gene Products

Amino Acid Transport System X-AG

Trans-Activators

Cystine

Retinal Pigment Epithelium

45 Citations (Scopus)

Transport of amino acid esters and the amino-acid-based prodrug valganciclovir by the amino acid transporter ATB ^0,+

Siddaramappa, U. N., Ganapathy, V. & Ganapathy, M. E., Jul 1 2004, In : Pharmaceutical Research. 21, 7, p. 1303-1310 8 p.

Research output: Contribution to journal › Article

Amino Acid Transport Systems

Prodrugs

Esters

Amino Acids

Induced currents

2001

28 Citations (Scopus)

Novel scintillation proximity assay for measuring membrane-associated steps of peptidoglycan biosynthesis in Escherichia coli

Chandrakala, B., Elias, B. C., Mehra, U., Umapathy, N. S., Dwarakanath, P., Balganesh, T. S. & DeSousa, S. M., Mar 12 2001, In : Antimicrobial Agents and Chemotherapy. 45, 3, p. 768-775 8 p.

Research output: Contribution to journal › Article

Peptidoglycan

Escherichia coli

Membranes

Uridine Diphosphate Sugars

Enzymes