Weiqin Chen

Associate Professor

  • 1065 Citations
  • 17 h-Index
20032019
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Research Output 2003 2019

  • 1065 Citations
  • 17 h-Index
  • 31 Article
  • 2 Comment/debate
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Article
2019

Enhancer of zeste homolog 2 (EZH2) regulates adipocyte lipid metabolism independent of adipogenic differentiation: Role of apolipoprotein e

Yiew, N. K. H., Greenway, C., Zarzour, A., Ahmadieh, S., Goo, B., Kim, D., Benson, T. W., Ogbi, M., Tang, Y. L., Chen, W., Stepp, D., Patel, V., Hilton, R., Lu, X. Y., Hui, D. Y., Kim, H. W. & Weintraub, N. L., Jan 1 2019, In : Journal of Biological Chemistry. 294, 21, p. 8577-8591 15 p.

Research output: Contribution to journalArticle

Apolipoproteins
Lipid Metabolism
Adipocytes
Lipids
Lipoproteins
1 Citation (Scopus)

Novel metabolic disorders in skeletal muscle of Lipodystrophic Bscl2/Seipin deficient mice

Xu, W., Zhou, H., Xuan, H., Saha, P., Wang, G. & Chen, W., Feb 15 2019, In : Molecular and Cellular Endocrinology. 482, p. 1-10 10 p.

Research output: Contribution to journalArticle

Congenital Generalized Lipodystrophy
Muscle
Skeletal Muscle
Glycogen
Lipodystrophy

Obesity-associated family with sequence similarity 13, member A (FAM13A) is dispensable for adipose development and insulin sensitivity

Tang, J., Zhou, H., Sahay, K., Xu, W., Yang, J., Zhang, W. & Chen, W., Jun 1 2019, In : International Journal of Obesity. 43, 6, p. 1269-1280 12 p.

Research output: Contribution to journalArticle

Adipogenesis
Insulin Resistance
Obesity
Adipocytes
PPAR gamma
2018
5 Citations (Scopus)

Deletion of the Duffy antigen receptor for chemokines (DARC) promotes insulin resistance and adipose tissue inflammation during high fat feeding

Benson, T. W., Weintraub, D. S., Crowe, M., Yiew, N. K. H., Popoola, O., Pillai, A., Joseph, J., Archer, K., Greenway, C., Chatterjee, T. K., Mintz, J., Stepp, D. W., Stansfield, B. K., Chen, W., Brittain, J., Bogdanov, V. Y., Gao, Y., Wilson, J. G., Tang, Y. L., Kim, H. W. & 1 others, Weintraub, N. L., Sep 15 2018, In : Molecular and Cellular Endocrinology. 473, p. 79-88 10 p.

Research output: Contribution to journalArticle

Antigen Receptors
Chemokines
Insulin Resistance
Adipose Tissue
Fats
7 Citations (Scopus)
Cardiac Myocytes
Cullin Proteins
Heart Failure
Ubiquitins
cdc Genes
4 Citations (Scopus)

Seipin deficiency leads to increased endoplasmic reticulum stress and apoptosis in mammary gland alveolar epithelial cells during lactation

El Zowalaty, A. E., Li, R., Chen, W. & Ye, X., Apr 1 2018, In : Biology of reproduction. 98, 4, p. 570-578 9 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Endoplasmic Reticulum Stress
Human Mammary Glands
Lactation
Apoptosis
2017
5 Citations (Scopus)

A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity

Yiew, N. K. H., Chatterjee, T. K., Tang, Y. L., Pellenberg, R., Stansfield, B. K., Bagi, Z., Fulton, D. J., Stepp, D. W., Chen, W., Patel, V., Kamath, V. M., Litwin, S. E., Hui, D. Y., Rudich, S. M., Kim, H. W. & Weintraub, N. L., Apr 14 2017, In : Journal of Biological Chemistry. 292, 15, p. 6312-6324 13 p.

Research output: Contribution to journalArticle

Adenomatous Polyposis Coli
Nutrition
Adipocytes
Obesity
Diet
2016
10 Citations (Scopus)

Berardinelli-Seip congenital lipodystrophy 2/seipin is not required for brown adipogenesis but regulates brown adipose tissue development and function

Zhou, H., Black, S. M., Benson, T. W., Weintraub, N. L. & Chen, W., Jan 1 2016, In : Molecular and Cellular Biology. 36, 15, p. 2027-2038 12 p.

Research output: Contribution to journalArticle

Congenital Generalized Lipodystrophy
Adipogenesis
Brown Adipose Tissue
Brown Adipocytes
Adenylate Kinase
48 Citations (Scopus)

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

Pagac, M., Cooper, D. E., Qi, Y., Lukmantara, I. E., Mak, H. Y., Wu, Z., Tian, Y., Liu, Z., Lei, M., Du, X., Ferguson, C., Kotevski, D., Sadowski, P., Chen, W., Boroda, S., Harris, T. E., Liu, G., Parton, R. G., Huang, X., Coleman, R. A. & 1 others, Yang, H., Nov 1 2016, In : Cell Reports. 17, 6, p. 1546-1559 14 p.

Research output: Contribution to journalArticle

Acyltransferases
Adipocytes
Lipids
Adipogenesis
Congenital Generalized Lipodystrophy
2015
14 Citations (Scopus)

Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals

Zhou, H., Lei, X., Benson, T., Mintz, J., Xu, X., Harris, R. B., Weintraub, N. L., Wang, X. & Chen, W., Oct 1 2015, In : Journal of Lipid Research. 56, 10, p. 1912-1925 14 p.

Research output: Contribution to journalArticle

Congenital Generalized Lipodystrophy
Lipolysis
Energy balance
Adipocytes
Adipose Tissue
6 Citations (Scopus)

Obesity associated Lyplal1 gene is regulated in diet induced obesity but not required for adipocyte differentiation

Lei, X., Callaway, M., Zhou, H., Yang, Y. & Chen, W., Aug 5 2015, In : Molecular and Cellular Endocrinology. 411, p. 207-213 7 p.

Research output: Contribution to journalArticle

Nutrition
Adipocytes
Obesity
Genes
Diet
21 Citations (Scopus)

Obesity is associated with more activated neutrophils in African American male youth

Xu, X., Su, S., Wang, X., Barnes, V. A., De Miguel, C., Ownby, D. R., Pollock, J., Snieder, H. & Chen, W., Jan 10 2015, In : International Journal of Obesity. 39, 1, p. 26-32 7 p.

Research output: Contribution to journalArticle

African Americans
Neutrophils
Obesity
Neutrophil Activation
Leukocytes
6 Citations (Scopus)

Segregated responses of mammary gland development and vaginal opening to prepubertal genistein exposure in Bscl2-/- female mice with lipodystrophy

Li, R., El Zowalaty, A. E., Chen, W., Dudley, E. A. & Ye, X., Jul 1 2015, In : Reproductive Toxicology. 54, p. 76-83 8 p.

Research output: Contribution to journalArticle

Congenital Generalized Lipodystrophy
Lipodystrophy
Genistein
Human Mammary Glands
Estrogen Receptors
11 Citations (Scopus)

Seipin deficiency increases chromocenter fragmentation and disrupts acrosome formation leading to male infertility

El Zowalaty, A. E., Baumann, C., Li, R., Chen, W., De La Fuente, R. & Ye, X., Jul 1 2015, In : Cell Death and Disease. 6, 7, e1817.

Research output: Contribution to journalArticle

Acrosome
Spermatids
Male Infertility
Spermatocytes
Chromatin
2014
20 Citations (Scopus)

Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/seipin-deficient mice

Chen, W., Zhou, H., Saha, P., Li, L. & Chan, L., Nov 1 2014, In : Endocrinology. 155, 11, p. 4215-4225 11 p.

Research output: Contribution to journalArticle

Insulin Resistance
Fasting
Liver
Congenital Generalized Lipodystrophy
Insulin
2013
13 Citations (Scopus)

Altered lipid metabolism in residual white adipose tissues of Bscl2 deficient mice

Chen, W., Zhou, H., Liu, S., Fhaner, C. J., Gross, B. C., Lydic, T. A. & Reid, G. E., Dec 16 2013, In : PloS one. 8, 12, e82526.

Research output: Contribution to journalArticle

White Adipose Tissue
white adipose tissue
Lipid Metabolism
lipid metabolism
Fatty Acids
37 Citations (Scopus)

Inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in mice

Chen, W., Chang, B., Wu, X., Li, L., Sleeman, M. & Chan, L., Apr 1 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 304, 7, p. E770-E779

Research output: Contribution to journalArticle

Down-Regulation
Lipids
White Adipose Tissue
Brown Adipose Tissue
Genes
2012
88 Citations (Scopus)

Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation

Chen, W., Chang, B., Saha, P., Hartig, S. M., Li, L., Reddy, V. T., Yang, Y., Yechoor, V., Mancini, M. A. & Chan, L., Mar 1 2012, In : Molecular and Cellular Biology. 32, 6, p. 1099-1111 13 p.

Research output: Contribution to journalArticle

Congenital Generalized Lipodystrophy
Lipolysis
Adipocytes
Cyclic AMP-Dependent Protein Kinases
White Adipose Tissue
2011
35 Citations (Scopus)

A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis

Cheng, N. H., Zhang, W., Chen, W. Q., Jin, J., Cui, X., Butte, N. F., Chan, L. & Hirschi, K. D., Jul 1 2011, In : FEBS Journal. 278, 14, p. 2525-2539 15 p.

Research output: Contribution to journalArticle

Glutaredoxins
Embryonic Development
Cell Cycle
Yeast
Cells
31 Citations (Scopus)

The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice

Yang, Y., Chang, B. H. J., Yechoor, V., Chen, W., Li, L., Tsai, M. J. & Chan, L., Oct 1 2011, In : Diabetologia. 54, 10, p. 2595-2605 11 p.

Research output: Contribution to journalArticle

Zinc Fingers
Islets of Langerhans
Proteins
Transcription Factors
Gene Targeting
2010
66 Citations (Scopus)

Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP)

Li, M. V., Chen, W., Harmancey, R. N., Nuotio-Antar, A. M., Imamura, M., Saha, P., Taegtmeyer, H. & Chan, L., May 7 2010, In : Biochemical and Biophysical Research Communications. 395, 3, p. 395-400 6 p.

Research output: Contribution to journalArticle

Glucose-6-Phosphate
Carrier Proteins
Chemical activation
Carbohydrates
Glucose
6 Citations (Scopus)

Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling

Liou, G. Y., Zhang, H., Miller, E. M., Seibold, S. A., Chen, W. & Gallo, K. A., May 1 2010, In : Biochemical Journal. 427, 3, p. 435-443 9 p.

Research output: Contribution to journalArticle

Proteolysis
JNK Mitogen-Activated Protein Kinases
mitogen-activated protein kinase kinase kinase 11
Peptide Hydrolases
Phosphotransferases
136 Citations (Scopus)

Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease

Chen, W., Chang, B., Li, L. & Chan, L., Sep 1 2010, In : Hepatology. 52, 3, p. 1134-1142 9 p.

Research output: Contribution to journalArticle

Phospholipases
Fatty Liver
Liver Diseases
Liver
Messenger RNA
73 Citations (Scopus)

Remodeling of retinal fatty acids in an animal model of diabetes: A decrease in long-chain polyunsaturated fatty acids is associated with a decrease in fatty acid elongases Elovl2 and Elovl4

Tikhonenko, M., Lydic, T. A., Wang, Y., Chen, W., Opreanu, M., Sochacki, A., McSorley, K. M., Renis, R. L., Kern, T., Jump, D. B., Reid, G. E. & Busik, J. V., Jan 1 2010, In : Diabetes. 59, 1, p. 219-227 9 p.

Research output: Contribution to journalArticle

Unsaturated Fatty Acids
Fatty Acids
Animal Models
Retina
Diabetes Complications
2009
89 Citations (Scopus)

The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation

Chen, W., Yechoor, V. K., Chang, B. H. J., Li, M. V., March, K. L. & Chan, L., Oct 1 2009, In : Endocrinology. 150, 10, p. 4552-4561 10 p.

Research output: Contribution to journalArticle

Congenital Generalized Lipodystrophy
Lipodystrophy
Adipogenesis
pioglitazone
Adipocytes
2008
34 Citations (Scopus)

Glucose-mediated transactivation of carbohydrate response element-binding protein requires cooperative actions from Mondo conserved regions and essential trans-acting factor 14-3-3

Li, M. V., Chen, W., Poungvarin, N., Imamura, M. & Chan, L., Jul 1 2008, In : Molecular Endocrinology. 22, 7, p. 1658-1672 15 p.

Research output: Contribution to journalArticle

Trans-Activators
Response Elements
Transcriptional Activation
Carrier Proteins
Carbohydrates
2007
57 Citations (Scopus)

Aquaporin 7 is a β-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, β-cell mass, and insulin production and secretion

Matsumura, K., Chang, B. H. J., Fujimiya, M., Chen, W., Kulkarni, R. N., Eguchi, Y., Kimura, H., Kojima, H. & Chan, L., Sep 1 2007, In : Molecular and Cellular Biology. 27, 17, p. 6026-6037 12 p.

Research output: Contribution to journalArticle

Glycerol Kinase
Aquaporins
Glycerol
Insulin
Proteins
64 Citations (Scopus)

Inhibition of cytokine signaling in human retinal endothelial cells through modification of caveolae/lipid rafts by docosahexaenoic acid

Chen, W., Jump, D. B., Esselman, W. J. & Busik, J. V., Jan 1 2007, In : Investigative Ophthalmology and Visual Science. 48, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

Caveolae
Docosahexaenoic Acids
Endothelial Cells
Cytokines
Lipids
2005
105 Citations (Scopus)

Anti-inflammatory effect of docosahexaenoic acid on cytokine-induced adhesion molecule expression in human retinal vascular endothelial cells

Chen, W., Esselman, W. J., Jump, D. B. & Busik, J. V., Nov 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 11, p. 4342-4347 6 p.

Research output: Contribution to journalArticle

Retinal Vessels
Docosahexaenoic Acids
Anti-Inflammatory Agents
Cell Adhesion Molecules
Endothelial Cells
2004
19 Citations (Scopus)

Evidence for U-tail stabilization of gRNA/mRNA interactions in kinetoplastid RNA editing.

Koslowsky, D. J., Reifur, L., Yu, L. E. & Chen, W., Jan 1 2004, In : RNA biology. 1, 1, p. 28-34 7 p.

Research output: Contribution to journalArticle

Guide RNA
RNA Editing
Messenger RNA
Trypanosomiasis
Thermodynamics
2003
54 Citations (Scopus)

Dyslipidemia, but Not Hyperglycemia, Induces Inflammatory Adhesion Molecules in Human Retinal Vascular Endothelial Cells

Chen, W., Jump, D. B., Grant, M. B., Esselman, W. J. & Busik, J. V., Nov 1 2003, In : Investigative Ophthalmology and Visual Science. 44, 11, p. 5016-5022 7 p.

Research output: Contribution to journalArticle

Retinal Vessels
Dyslipidemias
Hyperglycemia
Endothelial Cells
Unsaturated Fatty Acids