Weiqin Chen

Associate Professor

  • 1154 Citations
  • 18 h-Index
20032020

Research output per year

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Research Output

  • 1154 Citations
  • 18 h-Index
  • 35 Article
  • 2 Comment/debate
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Article
2020
Open Access
2019

Enhancer of zeste homolog 2 (EZH2) regulates adipocyte lipid metabolism independent of adipogenic differentiation: Role of apolipoprotein e

Yiew, N. K. H., Greenway, C., Zarzour, A., Ahmadieh, S., Goo, B., Kim, D., Benson, T. W., Ogbi, M., Tang, Y. L., Chen, W., Stepp, D., Patel, V., Hilton, R., Lu, X. Y., Hui, D. Y., Kim, H. W. & Weintraub, N. L., May 24 2019, In : Journal of Biological Chemistry. 294, 21, p. 8577-8591 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Leptin restores endothelial function via endothelial PPARγ-nox1-mediated mechanisms in a mouse model of congenital generalized lipodystrophy

Bruder-Nascimento, T., Faulkner, J. L., Haigh, S., Kennard, S., Antonova, G., Patel, V. S., Fulton, D. J. R., Chen, W. & De Chantemèle, E. J. B., Dec 1 2019, In : Hypertension. 74, 6, p. 1399-1408 10 p.

Research output: Contribution to journalArticle

Novel metabolic disorders in skeletal muscle of Lipodystrophic Bscl2/Seipin deficient mice

Xu, W., Zhou, H., Xuan, H., Saha, P., Wang, G. & Chen, W., Feb 15 2019, In : Molecular and Cellular Endocrinology. 482, p. 1-10 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

Obesity-associated family with sequence similarity 13, member A (FAM13A) is dispensable for adipose development and insulin sensitivity

Tang, J., Zhou, H., Sahay, K., Xu, W., Yang, J., Zhang, W. & Chen, W., Jun 1 2019, In : International Journal of Obesity. 43, 6, p. 1269-1280 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

S100a4-Cre–mediated deletion of Ptch1 causes hypogonadotropic hypogonadism: Role of pituitary hematopoietic cells in endocrine regulation

Ren, Y. A., Monkkonen, T., Lewis, M. T., Bernard, D. J., Christian, H. C., Jorgez, C. J., Moore, J. A., Landua, J. D., Chin, H. M., Chen, W., Singh, S., Kim, I. S., Zhang, X. H. F., Xia, Y., Phillips, K. J., MacKay, H., Waterland, R. A., Cecilia Ljungberg, M., Saha, P. K., Hartig, S. M. & 2 others, Coll, T. F. & Richards, J. A. S., Jul 25 2019, In : JCI Insight. 4, 14, :e126325.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy

Zhou, H., Lei, X., Yan, Y., Lydic, T., Li, J., Weintraub, N. L., Su, H. & Chen, W., Jul 25 2019, In : JCI Insight. 4, 14, e129781.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

Deletion of the Duffy antigen receptor for chemokines (DARC) promotes insulin resistance and adipose tissue inflammation during high fat feeding

Benson, T. W., Weintraub, D. S., Crowe, M., Yiew, N. K. H., Popoola, O., Pillai, A., Joseph, J., Archer, K., Greenway, C., Chatterjee, T. K., Mintz, J., Stepp, D. W., Stansfield, B. K., Chen, W., Brittain, J., Bogdanov, V. Y., Gao, Y., Wilson, J. G., Tang, Y. L., Kim, H. W. & 1 others, Weintraub, N. L., Sep 15 2018, In : Molecular and Cellular Endocrinology. 473, p. 79-88 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
12 Scopus citations

Seipin deficiency leads to increased endoplasmic reticulum stress and apoptosis in mammary gland alveolar epithelial cells during lactation

El Zowalaty, A. E., Li, R., Chen, W. & Ye, X., Apr 1 2018, In : Biology of reproduction. 98, 4, p. 570-578 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity

Yiew, N. K. H., Chatterjee, T. K., Tang, Y. L., Pellenberg, R., Stansfield, B. K., Bagi, Z., Fulton, D. J., Stepp, D. W., Chen, W., Patel, V., Kamath, V. M., Litwin, S. E., Hui, D. Y., Rudich, S. M., Kim, H. W. & Weintraub, N. L., Apr 14 2017, In : Journal of Biological Chemistry. 292, 15, p. 6312-6324 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016
12 Scopus citations

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase

Pagac, M., Cooper, D. E., Qi, Y., Lukmantara, I. E., Mak, H. Y., Wu, Z., Tian, Y., Liu, Z., Lei, M., Du, X., Ferguson, C., Kotevski, D., Sadowski, P., Chen, W., Boroda, S., Harris, T. E., Liu, G., Parton, R. G., Huang, X., Coleman, R. A. & 1 others, Yang, H., Nov 1 2016, In : Cell Reports. 17, 6, p. 1546-1559 14 p.

Research output: Contribution to journalArticle

62 Scopus citations
2015

Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals

Zhou, H., Lei, X., Benson, T., Mintz, J., Xu, X., Harris, R. B., Weintraub, N. L., Wang, X. & Chen, W., Oct 1 2015, In : Journal of Lipid Research. 56, 10, p. 1912-1925 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Obesity associated Lyplal1 gene is regulated in diet induced obesity but not required for adipocyte differentiation

Lei, X., Callaway, M., Zhou, H., Yang, Y. & Chen, W., Aug 5 2015, In : Molecular and Cellular Endocrinology. 411, p. 207-213 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Obesity is associated with more activated neutrophils in African American male youth

Xu, X., Su, S., Wang, X., Barnes, V., De Miguel, C., Ownby, D., Pollock, J., Snieder, H. & Chen, W., Jan 10 2015, In : International Journal of Obesity. 39, 1, p. 26-32 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Segregated responses of mammary gland development and vaginal opening to prepubertal genistein exposure in Bscl2-/- female mice with lipodystrophy

Li, R., El Zowalaty, A. E., Chen, W., Dudley, E. A. & Ye, X., Jul 1 2015, In : Reproductive Toxicology. 54, p. 76-83 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Seipin deficiency increases chromocenter fragmentation and disrupts acrosome formation leading to male infertility

El Zowalaty, A. E., Baumann, C., Li, R., Chen, W., De La Fuente, R. & Ye, X., Jul 1 2015, In : Cell Death and Disease. 6, 7, e1817.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/seipin-deficient mice

Chen, W., Zhou, H., Saha, P., Li, L. & Chan, L., Nov 1 2014, In : Endocrinology. 155, 11, p. 4215-4225 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2013

Altered lipid metabolism in residual white adipose tissues of Bscl2 deficient mice

Chen, W., Zhou, H., Liu, S., Fhaner, C. J., Gross, B. C., Lydic, T. A. & Reid, G. E., Dec 16 2013, In : PloS one. 8, 12, e82526.

Research output: Contribution to journalArticle

13 Scopus citations

Inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in mice

Chen, W., Chang, B., Wu, X., Li, L., Sleeman, M. & Chan, L., Apr 1 2013, In : American Journal of Physiology - Endocrinology and Metabolism. 304, 7, p. E770-E779

Research output: Contribution to journalArticle

40 Scopus citations
2012

Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation

Chen, W., Chang, B., Saha, P., Hartig, S. M., Li, L., Reddy, V. T., Yang, Y., Yechoor, V., Mancini, M. A. & Chan, L., Mar 2012, In : Molecular and Cellular Biology. 32, 6, p. 1099-1111 13 p.

Research output: Contribution to journalArticle

96 Scopus citations
2011

A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis

Cheng, N. H., Zhang, W., Chen, W. Q., Jin, J., Cui, X., Butte, N. F., Chan, L. & Hirschi, K. D., Jul 1 2011, In : FEBS Journal. 278, 14, p. 2525-2539 15 p.

Research output: Contribution to journalArticle

37 Scopus citations

The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice

Yang, Y., Chang, B. H. J., Yechoor, V., Chen, W., Li, L., Tsai, M. J. & Chan, L., Oct 1 2011, In : Diabetologia. 54, 10, p. 2595-2605 11 p.

Research output: Contribution to journalArticle

32 Scopus citations
2010

Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP)

Li, M. V., Chen, W., Harmancey, R. N., Nuotio-Antar, A. M., Imamura, M., Saha, P., Taegtmeyer, H. & Chan, L., May 7 2010, In : Biochemical and Biophysical Research Communications. 395, 3, p. 395-400 6 p.

Research output: Contribution to journalArticle

72 Scopus citations

Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling

Liou, G. Y., Zhang, H., Miller, E. M., Seibold, S. A., Chen, W. & Gallo, K. A., May 1 2010, In : Biochemical Journal. 427, 3, p. 435-443 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease

Chen, W., Chang, B., Li, L. & Chan, L., Sep 1 2010, In : Hepatology. 52, 3, p. 1134-1142 9 p.

Research output: Contribution to journalArticle

147 Scopus citations

Remodeling of retinal fatty acids in an animal model of diabetes: A decrease in long-chain polyunsaturated fatty acids is associated with a decrease in fatty acid elongases Elovl2 and Elovl4

Tikhonenko, M., Lydic, T. A., Wang, Y., Chen, W., Opreanu, M., Sochacki, A., McSorley, K. M., Renis, R. L., Kern, T., Jump, D. B., Reid, G. E. & Busik, J. V., Jan 1 2010, In : Diabetes. 59, 1, p. 219-227 9 p.

Research output: Contribution to journalArticle

75 Scopus citations
2009

The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation

Chen, W., Yechoor, V. K., Chang, B. H. J., Li, M. V., March, K. L. & Chan, L., Oct 2009, In : Endocrinology. 150, 10, p. 4552-4561 10 p.

Research output: Contribution to journalArticle

94 Scopus citations
2008

Glucose-mediated transactivation of carbohydrate response element-binding protein requires cooperative actions from Mondo conserved regions and essential trans-acting factor 14-3-3

Li, M. V., Chen, W., Poungvarin, N., Imamura, M. & Chan, L., Jul 1 2008, In : Molecular Endocrinology. 22, 7, p. 1658-1672 15 p.

Research output: Contribution to journalArticle

35 Scopus citations
2007

Aquaporin 7 is a β-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, β-cell mass, and insulin production and secretion

Matsumura, K., Chang, B. H. J., Fujimiya, M., Chen, W., Kulkarni, R. N., Eguchi, Y., Kimura, H., Kojima, H. & Chan, L., Sep 1 2007, In : Molecular and Cellular Biology. 27, 17, p. 6026-6037 12 p.

Research output: Contribution to journalArticle

58 Scopus citations

Inhibition of cytokine signaling in human retinal endothelial cells through modification of caveolae/lipid rafts by docosahexaenoic acid

Chen, W., Jump, D. B., Esselman, W. J. & Busik, J. V., Jan 2007, In : Investigative Ophthalmology and Visual Science. 48, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

66 Scopus citations
2005

Anti-inflammatory effect of docosahexaenoic acid on cytokine-induced adhesion molecule expression in human retinal vascular endothelial cells

Chen, W., Esselman, W. J., Jump, D. B. & Busik, J. V., Nov 2005, In : Investigative Ophthalmology and Visual Science. 46, 11, p. 4342-4347 6 p.

Research output: Contribution to journalArticle

108 Scopus citations
2004

Evidence for U-tail stabilization of gRNA/mRNA interactions in kinetoplastid RNA editing.

Koslowsky, D. J., Reifur, L., Yu, L. E. & Chen, W., May 2004, In : RNA biology. 1, 1, p. 27-33 7 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations
2003

Dyslipidemia, but Not Hyperglycemia, Induces Inflammatory Adhesion Molecules in Human Retinal Vascular Endothelial Cells

Chen, W., Jump, D. B., Grant, M. B., Esselman, W. J. & Busik, J. V., Nov 1 2003, In : Investigative Ophthalmology and Visual Science. 44, 11, p. 5016-5022 7 p.

Research output: Contribution to journalArticle

54 Scopus citations