• 4215 Citations
  • 28 h-Index
20022019
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Research Output 2002 2019

Review article
22 Citations (Scopus)

Effects of angiotensinogen and angiotensin II type I receptor genes on blood pressure and left ventricular mass trajectories in multiethnic youth

Wang, X., Zhu, H., Dong, Y., Treiber, F. A. & Snieder, H., Jun 1 2006, In : Twin Research and Human Genetics. 9, 3, p. 393-402 10 p.

Research output: Contribution to journalReview article

Angiotensin I
Angiotensinogen
Angiotensin Receptors
Haplotypes
Blood Pressure
60 Citations (Scopus)

Ethnic differences in resting heart rate variability: A systematic review and meta-analysis

Hill, L. K., Hu, D. D., Koenig, J., Sollers, J. J., Kapuku, G., Wang, X., Snieder, H. & Thayer, J. F., Jan 1 2015, In : Psychosomatic Medicine. 77, 1, p. 16-25 10 p.

Research output: Contribution to journalReview article

Meta-Analysis
Heart Rate
African Americans
Cardiovascular Diseases
Research
22 Citations (Scopus)

The Georgia Cardiovascular Twin Study: Influence of genetic predisposition and chronic stress on risk for cardiovascular disease and type 2 diabetes

Ge, D., Dong, Y., Wang, X., Treiber, F. A. & Snieder, H., Dec 1 2006, In : Twin Research and Human Genetics. 9, 6, p. 965-970 6 p.

Research output: Contribution to journalReview article

Twin Studies
Genetic Predisposition to Disease
Type 2 Diabetes Mellitus
Cardiovascular Diseases
Longitudinal Studies
8 Citations (Scopus)

Update on G-protein polymorphisms in hypertension

Zhu, H., Wang, X., Lu, Y., Poola, J., Momin, Z., Harshfield, G. A., Snieder, H. & Dong, Y., Apr 1 2006, In : Current Hypertension Reports. 8, 1, p. 23-29 7 p.

Research output: Contribution to journalReview article

GTP-Binding Proteins
Hypertension
Genes
Pertussis Toxin
Protein Subunits
Letter
5 Citations (Scopus)

Ethnic differences in heart rate variability: Does ultralow-frequency heart rate variability really measure autonomic tone?

Thayer, J. F., Wang, X. & Snieder, H., Sep 1 2006, In : American Heart Journal. 152, 3

Research output: Contribution to journalLetter

Autonomic Nervous System
Ethnic Groups
African Americans
Research Design
Heart Rate
11 Citations (Scopus)

Waist-to-height ratio and BMI predict different cardiovascular risk factors in Chinese children [6]

Yan, W., Wang, X., Yao, H., Dai, J., Zheng, Y., Yang, X., Yibulayin, X. & Cui, J., Dec 1 2006, In : Diabetes Care. 29, 12, p. 2760-2761 2 p.

Research output: Contribution to journalLetter

Body Size
China
Body Mass Index
Cardiovascular Diseases
Waist-Height Ratio
Editorial

Assessing genetic risk of hypertension at an early age: future research directions

Wang, X. & Snieder, H., Nov 2 2017, In : Expert Review of Cardiovascular Therapy. 15, 11, p. 809-812 4 p.

Research output: Contribution to journalEditorial

Blood Pressure
Hypertension
Direction compound
Conference contribution
3 Citations (Scopus)

5. Role of gene-stress interactions in gene-finding studies

Snieder, H., Wang, X., Lagou, V., Penninx, B. W. J. H., Riese, H. & Hartman, C. A., Nov 19 2008, Genetic Effects on Environmental Vulnerability to Disease. p. 71-82 12 p. (Novartis Foundation Symposium; vol. 293).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Genes
Genome-Wide Association Study
Single Nucleotide Polymorphism
Endophenotypes
Gene-Environment Interaction
Comment/debate
Lipids
Genes
hydroquinone
21 Citations (Scopus)

Genome-wide association studies and beyond: What's next in blood pressure genetics?

Wang, X. & Snieder, H., Dec 1 2010, In : Hypertension. 56, 6, p. 1035-1037 3 p.

Research output: Contribution to journalComment/debate

Ambulatory Blood Pressure Monitoring
Genetic Loci
Genome-Wide Association Study
Genetic Association Studies
Genetic Predisposition to Disease
Chapter
1 Citation (Scopus)

Familial aggregation of blood pressure

Wang, X. & Snieder, H., Jan 1 2013, Pediatric Hypertension: Third Edition. Humana Press Inc., p. 195-209 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Twin Studies
Blood Pressure
Hypotension
Cross-Sectional Studies
Hypertension

Heritability and familial aggregation of blood pressure

Wang, X. & Snieder, H., Jan 1 2018, Pediatric Hypertension. Springer International Publishing, p. 159-176 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Blood Pressure
Twin Studies
Hypotension
Epidemiologic Studies
Cross-Sectional Studies
4 Citations (Scopus)

Role of Gene-Stress Interactions in Gene-Finding Studies

Snieder, H., Wang, X., Lagou, V., Penninx, B. W. J. H., Riese, H. & Hartman, C. A., Aug 12 2008, Genetic Effects on Environmental Vulnerability to Disease. wiley, p. 71-82 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Genes
Genome-Wide Association Study
Single Nucleotide Polymorphism
Endophenotypes
Gene-Environment Interaction
Article
4 Citations (Scopus)

[The effect of oral alpha-lipoic acid in overweight/obese individuals on brachial-ankle pulse wave velocity and supine blood pressure: a randomized, crossover, double-blind, placebo-controlled trial].

Huang, Y. D., Li, N., Zhang, W. G., Hu, X. J., Wang, Q., Wang, C. C., Xu, R. W., Yan, K., Hou, X. Y., Naerkeze, Wang, X. & Yan, W. L., Mar 2011, In : Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi. 32, 3, p. 290-296 7 p.

Research output: Contribution to journalArticle

Thioctic Acid
Pulse Wave Analysis
Ankle
Arm
Placebos
41 Citations (Scopus)

A 15-year longitudinal study on ambulatory blood pressure tracking from childhood to early adulthood

Li, Z., Snieder, H., Harshfield, G. A., Treiber, F. A. & Wang, X., Aug 12 2009, In : Hypertension Research. 32, 5, p. 404-410 7 p.

Research output: Contribution to journalArticle

Longitudinal Studies
Blood Pressure
Reading
Ambulatory Blood Pressure Monitoring
African Americans
3 Citations (Scopus)

A 2-step penalized regression method for family-based next-generation sequencing association studies

Ding, X., Su, S., Nandakumar, K., Wang, X. & Fardo, D. W., Jun 17 2014, In : BMC Proceedings. 8, S25.

Research output: Contribution to journalArticle

Pedigree
58 Citations (Scopus)

Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity

Kyriakou, T., Collins, L. J., Spencer-Jones, N. J., Malcolm, C., Wang, X., Snieder, H., Swaminathan, R., Burling, K. A., Hart, D. J., Spector, T. D. & O'Dell, S. D., Aug 1 2008, In : Journal of Human Genetics. 53, 8, p. 718-727 10 p.

Research output: Contribution to journalArticle

Adiponectin
Haplotypes
Single Nucleotide Polymorphism
Serum
Population
50 Citations (Scopus)

Adverse childhood experiences and blood pressure trajectories from childhood to young adulthood: the Georgia stress and Heart study

Su, S., Wang, X., Pollock, J. S., Treiber, F. A., Xu, X., Snieder, H., McCall, W. V., Stefanek, M. & Harshfield, G. A., May 12 2015, In : Circulation. 131, 19, p. 1674-81 8 p.

Research output: Contribution to journalArticle

Blood Pressure
Social Class
Health Behavior
Street Drugs
Risk-Taking
41 Citations (Scopus)

Adverse childhood experiences are associated with detrimental hemodynamics and elevated circulating endothelin-1 in adolescents and young adults

Su, S., Wang, X., Kapuku, K. G., Treiber, F. A., Pollock, D. M., Harshfield, G. A., McCall, W. V. & Pollock, J. S., Jan 1 2014, In : Hypertension. 64, 1, p. 201-207 7 p.

Research output: Contribution to journalArticle

Endothelin-1
Psychological Stress
Vascular Resistance
Young Adult
Hemodynamics
47 Citations (Scopus)

A genome-wide methylation study of severe vitamin d deficiency in African American adolescents

Zhu, H., Wang, X., Shi, H., Su, S., Harshfield, G. A., Gutin, B., Snieder, H. & Dong, Y., Jan 1 2013, In : Journal of Pediatrics. 162, 5

Research output: Contribution to journalArticle

Avitaminosis
African Americans
Methylation
Vitamin D Deficiency
Genome
43 Citations (Scopus)

A Genome-Wide Methylation Study on Essential Hypertension in Young African American Males

Wang, X., Falkner, B., Zhu, H., Shi, H., Su, S., Xu, X., Sharma, A. K., Dong, Y., Treiber, F., Gutin, B., Harshfield, G. & Snieder, H., Jan 17 2013, In : PloS one. 8, 1, e53938.

Research output: Contribution to journalArticle

Methylation
African Americans
methylation
hypertension
DNA Methylation
96 Citations (Scopus)

A genome-wide methylation study on obesity: Differential variability and differential methylation

Xu, X., Su, S., Barnes, V. A., De Miguel, C., Pollock, J., Ownby, D., Shi, H., Zhu, H., Snieder, H. & Wang, X., May 2013, In : Epigenetics. 8, 5, p. 522-533 12 p.

Research output: Contribution to journalArticle

Methylation
Obesity
Genome
Neoplasms
Genes
84 Citations (Scopus)

A longitudinal study in youth of heart rate variability at rest and in response to stress

Li, Z., Snieder, H., Su, S., Ding, X., Thayer, J. F., Treiber, F. A. & Wang, X., Sep 1 2009, In : International Journal of Psychophysiology. 73, 3, p. 212-217 6 p.

Research output: Contribution to journalArticle

Longitudinal Studies
Heart Rate
African Americans
Sex Characteristics
Young Adult
38 Citations (Scopus)

A longitudinal study of blood pressure variability in African-American and European American youth

Li, Z., Snieder, H., Su, S., Harshfield, G. A., Treiber, F. A. & Wang, X., Apr 1 2010, In : Journal of hypertension. 28, 4, p. 715-722 8 p.

Research output: Contribution to journalArticle

African Americans
Longitudinal Studies
Blood Pressure
Hypertension
Adiposity
55 Citations (Scopus)

A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension

EchoGen consortium, CHARGE-HF consortium, International Consortium for Blood Pressure GWAS (ICBP), CARDIoGRAM consortium, CKDGen Consortium & KidneyGen Consortium, Mar 18 2015, In : PLoS Genetics. 11, 3, e1005035.

Research output: Contribution to journalArticle

hypertension
meta-analysis
Transcriptome
gene expression
blood pressure
14 Citations (Scopus)

A Method to Detect Differentially Methylated Loci With Next-Generation Sequencing

Xu, H., Podolsky, R. H., Ryu, D., Wang, X., Su, S., Shi, H. & George, V., May 1 2013, In : Genetic Epidemiology. 37, 4, p. 377-382 6 p.

Research output: Contribution to journalArticle

Methylation
Alleles
DNA Methylation
B-Cell Chronic Lymphocytic Leukemia
Epigenomics
2 Citations (Scopus)

An epigenome-wide study of obesity in African American youth and young adults: novel findings, replication in neutrophils, and relationship with gene expression

Wang, X., Pan, Y., Zhu, H., Hao, G., Huang, Y., Barnes, V., Shi, H., Snieder, H., Pankow, J., North, K., Grove, M., Guan, W., Demerath, E., Dong, Y. & Su, S., Jan 1 2018, In : Clinical epigenetics. 10, 1 p.

Research output: Contribution to journalArticle

African Americans
Young Adult
Neutrophils
Obesity
Gene Expression
17 Citations (Scopus)

Angiotensin II type I receptor gene and myocardial infarction: Tagging SNPs and haplotype based association study. The Beijing atherosclerosis study

Su, S., Chen, J., Zhao, J., Huang, J., Wang, X., Chen, R. & Gu, D., Oct 1 2004, In : Pharmacogenetics. 14, 10, p. 673-681 9 p.

Research output: Contribution to journalArticle

Angiotensin I
Angiotensin Receptors
Haplotypes
Single Nucleotide Polymorphism
Atherosclerosis

Association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese

Wang, X., Fan, Z. J., Huang, J. F., Su, S., Zhao, J. G. & Gu, D. F., Jul 1 2005, In : Acta Genetica Sinica. 32, 7, p. 675-681 7 p.

Research output: Contribution to journalArticle

Multigene Family
Coronary Disease
Alleles
Haplotypes
Population
Adolescent Behavior
Pediatric Obesity
Muscles
12 Citations (Scopus)

Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals

Zhou, H., Lei, X., Benson, T., Mintz, J., Xu, X., Harris, R. B., Weintraub, N. L., Wang, X. & Chen, W., Oct 1 2015, In : Journal of Lipid Research. 56, 10, p. 1912-1925 14 p.

Research output: Contribution to journalArticle

Congenital Generalized Lipodystrophy
Lipolysis
Energy balance
Adipocytes
Adipose Tissue
20 Citations (Scopus)

Beyond genome-wide association studies: New strategies for identifying genetic determinants of hypertension

Wang, X., Prins, B. P., Sõber, S., Laan, M. & Snieder, H., Dec 1 2011, In : Current Hypertension Reports. 13, 6, p. 442-451 10 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Hypertension
Blood Pressure
Genes
Histone Code
24 Citations (Scopus)

Blood pressure trajectories from childhood to young adulthood associated with cardiovascular risk

Hao, G., Wang, X., Treiber, F. A., Harshfield, G., Kapuku, G. & Su, S., Mar 1 2017, In : Hypertension. 69, 3, p. 435-442 8 p.

Research output: Contribution to journalArticle

Blood Pressure
Carotid Intima-Media Thickness
6 Citations (Scopus)
Body Mass Index
Cardiovascular Diseases
Population
28 Citations (Scopus)

Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease

CHARGE Consortium Hemostatic Factor Working Group, ICBP Consortium & CHARGE Consortium Subclinical Working Group, Jun 1 2017, In : Journal of the American Heart Association. 6, 6, e004918.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Coronary Disease
Odds Ratio
Mendelian Randomization Analysis
Genome-Wide Association Study
14 Citations (Scopus)

Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins

Jamshidi, Y., Snieder, H., Wang, X., Spector, T. D., Carter, N. D. & O'Dell, S. D., Feb 1 2006, In : Diabetologia. 49, 2, p. 306-310 5 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Insulin Resistance
Body Weight
Lipids
Gene Frequency
6 Citations (Scopus)

Common STAT3 variants are not associated with obesity or insulin resistance in female twins

Jamshidi, Y., Kyriakou, T., Gooljar, S. B., Collins, L. J., Lane, C. A., Snieder, H., Wang, X., Spector, T. D. & O'Dell, S. D., Jul 1 2007, In : Obesity. 15, 7, p. 1634-1639 6 p.

Research output: Contribution to journalArticle

Insulin Resistance
Obesity
Single Nucleotide Polymorphism
Homeostasis
Animal Models
2 Citations (Scopus)

Determinants of pulse wave velocity trajectories from youth to young adulthood: the Georgia Stress and Heart Study

Liang, X., Su, S., Hao, G., Snieder, H., Treiber, F., Kapuku, G. & Wang, X., Mar 1 2019, In : Journal of hypertension. 37, 3, p. 563-571 9 p.

Research output: Contribution to journalArticle

Pulse Wave Analysis
African Americans
Marital Status
Cannabis
Arterial Pressure
57 Citations (Scopus)

Dietary sodium, adiposity, and inflammation in healthy adolescents

Zhu, H., Pollock, N. K., Kotak, I., Gutin, B., Wang, X., Bhagatwala, J., Parikh, S., Harshfield, G. A. & Dong, Y., Jan 1 2014, In : Pediatrics. 133, 3, p. e635-e642

Research output: Contribution to journalArticle

Dietary Sodium
Adiposity
Sodium
Abdominal Subcutaneous Fat
Inflammation
3 Citations (Scopus)

Differential methylation tests of regulatory regions

Ryu, D., Xu, H., George, V., Su, S., Wang, X., Shi, H. & Podolsky, R. H., Jun 1 2016, In : Statistical Applications in Genetics and Molecular Biology. 15, 3, p. 237-251 15 p.

Research output: Contribution to journalArticle

Methylation
Nucleic Acid Regulatory Sequences
Gift Giving
Statistical tests
B-Cell Chronic Lymphocytic Leukemia

Discovery and Validation of a Novel Neutrophil Activation Marker Associated with Obesity

Pan, Y., Choi, J-H., Shi, H., Zhang, L., Su, S. & Wang, X., Dec 1 2019, In : Scientific Reports. 9, 1, 3433.

Research output: Contribution to journalArticle

Neutrophil Activation
Obesity
Alkaline Phosphatase
Cardiovascular Diseases
Kidney
84 Citations (Scopus)

DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring

Küpers, L. K., Xu, X., Jankipersadsing, S. A., Vaez, A., La Bastide-van Gemert, S., Scholtens, S., Nolte, I. M., Richmond, R. C., Relton, C. L., Felix, J. F., Duijts, L., Van Meurs, J. B., Tiemeier, H., Jaddoe, V. W., Wang, X., Corpeleijn, E. & Snieder, H., Aug 2015, In : International Journal of Epidemiology. 44, 4, p. 1224-1237 14 p.

Research output: Contribution to journalArticle

DNA Methylation
Smoking
Mothers
Pregnancy
Methylation
22 Citations (Scopus)

DNA methylation of the LY86 gene is associated with obesity, insulin resistance, and inflammation

Su, S., Zhu, H., Xu, X., Wang, X., Wang, X., Dong, Y., Kapuku, K. G., Treiber, F., Gutin, B., Harshfield, G. A. & Snieder, H., Jun 2014, In : Twin Research and Human Genetics. 17, 3, p. 183-191 9 p.

Research output: Contribution to journalArticle

Methylation
Insulin Resistance
Obesity
Lymphocytes
Inflammation
11 Citations (Scopus)

Effect of oral ALA supplementation on oxidative stress and insulin sensitivity among overweight/obese adults: A double-blinded, randomized, controlled, cross-over intervention trial

Yan, W., Li, N., Hu, X., Huang, Y., Zhang, W., Wang, Q., Wang, F., Wang, C., Zhai, X., Xu, R., Yan, K., Ding, X. & Wang, X., Jul 31 2013, In : International Journal of Cardiology. 167, 2, p. 602-603 2 p.

Research output: Contribution to journalArticle

alpha-Linolenic Acid
Double-Blind Method
Cross-Over Studies
Oral Administration
Insulin Resistance
15 Citations (Scopus)

Effects of Dopamine Receptor Type 1 and Gs Protein α Subunit Gene Polymorphisms on Blood Pressure at Rest and in Response to Stress

Lu, Y., Zhu, H., Wang, X., Snieder, H., Huang, Y., Harshfield, G. A., Treiber, F. A. & Dong, Y., Aug 1 2006, In : American Journal of Hypertension. 19, 8, p. 832-836 5 p.

Research output: Contribution to journalArticle

Dopamine Receptors
Protein Subunits
Blood Pressure
Genes
Alleles
12 Citations (Scopus)

Effects of oral α-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial

Li, N., Yan, W., Hu, X., Huang, Y., Wang, F., Zhang, W., Wang, Q., Wang, X. & Sun, K., May 1 2017, In : Clinical Endocrinology. 86, 5, p. 680-687 8 p.

Research output: Contribution to journalArticle

Thioctic Acid
Placebos
Body Weight
Waist Circumference
Body Weight Changes
27 Citations (Scopus)

Endothelin-1 gene and progression of blood pressure and left ventricular mass: Longitudinal findings in youth

Dong, Y., Wang, X., Zhu, H., Treiber, F. A. & Snieder, H., Dec 1 2004, In : Hypertension. 44, 6, p. 884-890 7 p.

Research output: Contribution to journalArticle

Endothelin-1
Alleles
Haplotypes
Blood Pressure
Left Ventricular Hypertrophy
1 Citation (Scopus)

Epigenome-Wide Association Study of Dietary Fiber Intake in African American Adolescents

Chen, L., Dong, Y., Wang, X., Hao, G., Huang, Y., Gutin, B. & Zhu, H., Jun 1 2018, In : Molecular Nutrition and Food Research. 62, 12, 1800155.

Research output: Contribution to journalArticle

Adiposity
Dietary Fiber
DNA Methylation
African Americans
dietary fiber
101 Citations (Scopus)

Ethnic and gender differences in ambulatory blood pressure trajectories: Results from a 15-year longitudinal study in youth and young adults

Wang, X., Poole, J. C., Treiber, F. A., Harshfield, G. A., Hanevold, C. D. & Snieder, H., Dec 1 2006, In : Circulation. 114, 25, p. 2780-2787 8 p.

Research output: Contribution to journalArticle

Longitudinal Studies
Young Adult
Blood Pressure
African Americans
Cross-Sectional Studies
74 Citations (Scopus)

Ethnic differences and heritability of heart rate variability in African- and European American youth

Wang, X., Thayer, J. F., Treiber, F. & Snieder, H., Oct 15 2005, In : American Journal of Cardiology. 96, 8, p. 1166-1172 7 p.

Research output: Contribution to journalArticle

African Americans
Heart Rate
Supine Position