• 4155 Citations
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20022019
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Research Output 2002 2019

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Article
2019
1 Citation (Scopus)

Determinants of pulse wave velocity trajectories from youth to young adulthood: the Georgia Stress and Heart Study

Liang, X., Su, S., Hao, G., Snieder, H., Treiber, F., Kapuku, K. G. & Wang, X., Mar 1 2019, In : Journal of hypertension. 37, 3, p. 563-571 9 p.

Research output: Contribution to journalArticle

Pulse Wave Analysis
African Americans
Marital Status
Cannabis
Arterial Pressure

Discovery and Validation of a Novel Neutrophil Activation Marker Associated with Obesity

Pan, Y., Choi, J-H., Shi, H., Zhang, L., Su, S. & Wang, X., Dec 1 2019, In : Scientific Reports. 9, 1, 3433.

Research output: Contribution to journalArticle

Neutrophil Activation
Obesity
Alkaline Phosphatase
Cardiovascular Diseases
Kidney
2 Citations (Scopus)

Leisure-time physical activity and DNA methylation age - A twin study

Sillanpää, E., Ollikainen, M., Kaprio, J., Wang, X., Leskinen, T., Kujala, U. M. & Törmäkangas, T., Jan 19 2019, In : Clinical epigenetics. 11, 1, 12.

Research output: Contribution to journalArticle

Twin Studies
Leisure Activities
DNA Methylation
Exercise
Epigenomics
2018
2 Citations (Scopus)

An epigenome-wide study of obesity in African American youth and young adults: novel findings, replication in neutrophils, and relationship with gene expression

Wang, X., Pan, Y., Zhu, H., Hao, G., Huang, Y., Barnes, V., Shi, H., Snieder, H., Pankow, J., North, K., Grove, M., Guan, W., Demerath, E., Dong, Y. & Su, S., Jan 1 2018, In : Clinical epigenetics. 10, 1 p.

Research output: Contribution to journalArticle

African Americans
Young Adult
Neutrophils
Obesity
Gene Expression
Adolescent Behavior
Pediatric Obesity
Muscles
6 Citations (Scopus)
Body Mass Index
Cardiovascular Diseases
Population

Epigenome-Wide Association Study of Dietary Fiber Intake in African American Adolescents

Chen, L., Dong, Y., Wang, X., Hao, G., Huang, Y., Gutin, B. & Zhu, H., Jun 1 2018, In : Molecular Nutrition and Food Research. 62, 12, 1800155.

Research output: Contribution to journalArticle

Adiposity
Dietary Fiber
DNA Methylation
African Americans
dietary fiber
3 Citations (Scopus)

Genetic and environmental effects on gene expression signatures of blood pressure: A transcriptome-wide twin study

Huang, Y., Ollikainen, M., Sipil, P., Mustelin, L., Wang, X., Su, S., Huan, T., Levy, D., Wilson, J., Snieder, H., Kaprio, J. & Wang, X., Jan 1 2018, In : Hypertension. 71, 3, p. 457-464 8 p.

Research output: Contribution to journalArticle

Twin Studies
Transcriptome
Blood Pressure
Genes
Poly(ADP-ribose) Polymerases
1 Citation (Scopus)
DNA Methylation
Methylation
Colorectal Neoplasms
Genome
Neoplasm Genes
2017
22 Citations (Scopus)

Blood pressure trajectories from childhood to young adulthood associated with cardiovascular risk

Hao, G., Wang, X., Treiber, F. A., Harshfield, G. A., Kapuku, K. G. & Su, S., Mar 1 2017, In : Hypertension. 69, 3, p. 435-442 8 p.

Research output: Contribution to journalArticle

Blood Pressure
Carotid Intima-Media Thickness
26 Citations (Scopus)

Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease

CHARGE Consortium Hemostatic Factor Working Group, ICBP Consortium & CHARGE Consortium Subclinical Working Group, Jun 1 2017, In : Journal of the American Heart Association. 6, 6, e004918.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Coronary Disease
Odds Ratio
Mendelian Randomization Analysis
Genome-Wide Association Study
12 Citations (Scopus)

Effects of oral α-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial

Li, N., Yan, W., Hu, X., Huang, Y., Wang, F., Zhang, W., Wang, Q., Wang, X. & Sun, K., May 1 2017, In : Clinical Endocrinology. 86, 5, p. 680-687 8 p.

Research output: Contribution to journalArticle

Thioctic Acid
Placebos
Body Weight
Waist Circumference
Body Weight Changes
19 Citations (Scopus)

Intracellular adenosine regulates epigenetic programming in endothelial cells to promote angiogenesis

Xu, Y., Wang, Y., Yan, S., Zhou, Y., Yang, Q., Pan, Y., Zeng, X., An, X., Liu, Z., Wang, L., Xu, J., Cao, Y., Fulton, D. J., Weintraub, N. L., Bagi, Z., Hoda, MD. N., Wang, X., Li, Q., Hong, M., Jiang, X. & 4 others, Boison, D., Weber, C., Wu, C. & Huo, Y., Sep 2017, In : EMBO Molecular Medicine. 9, 9, p. 1263-1278 16 p.

Research output: Contribution to journalArticle

Adenosine Kinase
Epigenomics
Adenosine
Endothelial Cells
Methylation
8 Citations (Scopus)

Racial/ethnic differences in the association of childhood adversities with depression and the role of resilience

Youssef, N. A., Belew, D., Hao, G., Wang, X., Treiber, F. A., Stefanek, M. E., Yassa, M., Boswell, E., McCall, W. V. & Su, S., Jan 15 2017, In : Journal of Affective Disorders. 208, p. 577-581 5 p.

Research output: Contribution to journalArticle

Depression
Wounds and Injuries
Young Adult
Therapeutic Human Experimentation
African Americans
2016
3 Citations (Scopus)

Differential methylation tests of regulatory regions

Ryu, D., Xu, H., George, V., Su, S., Wang, X., Shi, H. & Podolsky, R. H., Jun 1 2016, In : Statistical Applications in Genetics and Molecular Biology. 15, 3, p. 237-251 15 p.

Research output: Contribution to journalArticle

Methylation
Nucleic Acid Regulatory Sequences
Gift Giving
Statistical tests
B-Cell Chronic Lymphocytic Leukemia
167 Citations (Scopus)

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Pattaro, C., Teumer, A., Gorski, M., Chu, A. Y., Li, M., Mijatovic, V., Garnaas, M., Tin, A., Sorice, R., Li, Y., Taliun, D., Olden, M., Foster, M., Yang, Q., Chen, M. H., Pers, T. H., Johnson, A. D., Ko, Y. A., Fuchsberger, C., Tayo, B. & 678 others, Nalls, M., Feitosa, M. F., Isaacs, A., Dehghan, A., D'Adamo, P., Adeyemo, A., Dieffenbach, A. K., Zonderman, A. B., Nolte, I. M., Van Der Most, P. J., Wright, A. F., Shuldiner, A. R., Morrison, A. C., Hofman, A., Smith, A. V., Dreisbach, A. W., Franke, A., Uitterlinden, A. G., Metspalu, A., Tonjes, A., Lupo, A., Robino, A., Johansson, Å., Demirkan, A., Kollerits, B., Freedman, B. I., Ponte, B., Oostra, B. A., Paulweber, B., Krämer, B. K., Mitchell, B. D., Buckley, B. M., Peralta, C. A., Hayward, C., Helmer, C., Rotimi, C. N., Shaffer, C. M., Müller, C., Sala, C., Van Duijn, C. M., Saint-Pierre, A., Ackermann, D., Shriner, D., Ruggiero, D., Toniolo, D., Lu, Y., Cusi, D., Czamara, D., Ellinghaus, D., Siscovick, D. S., Ruderfer, D., Gieger, C., Grallert, H., Rochtchina, E., Atkinson, E. J., Holliday, E. G., Boerwinkle, E., Salvi, E., Bottinger, E. P., Murgia, F., Rivadeneira, F., Ernst, F., Kronenberg, F., Hu, F. B., Navis, G. J., Curhan, G. C., Ehret, G. B., Homuth, G., Coassin, S., Thun, G. A., Pistis, G., Gambaro, G., Malerba, G., Montgomery, G. W., Eiriksdottir, G., Jacobs, G., Li, G., Wichmann, H. E., Campbell, H., Schmidt, H., Wallaschofski, H., Völzke, H., Brenner, H., Kroemer, H. K., Kramer, H., Lin, H., Leach, I. M., Ford, I., Guessous, I., Rudan, I., Prokopenko, I., Borecki, I., Heid, I. M., Kolcic, I., Persico, I., Jukema, J. W., Wilson, J. F., Felix, J. F., Divers, J., Lambert, J. C., Stafford, J. M., Gaspoz, J. M., Smith, J. A., Faul, J. D., Wang, J. J., Ding, J., Hirschhorn, J. N., Attia, J., Whitfield, J. B., Chalmers, J., Viikari, J., Coresh, J., Denny, J. C., Karjalainen, J., Fernandes, J. K., Endlich, K., Butterbach, K., Keene, K. L., Lohman, K., Portas, L., Launer, L. J., Lyytikäinen, L. P., Yengo, L., Franke, L., Ferrucci, L., Rose, L. M., Kedenko, L., Rao, M., Struchalin, M., Kleber, M. E., Cavalieri, M., Haun, M., Cornelis, M. C., Ciullo, M., Pirastu, M., De Andrade, M., McEvoy, M. A., Woodward, M., Adam, M., Cocca, M., Nauck, M., Imboden, M., Waldenberger, M., Pruijm, M., Metzger, M., Stumvoll, M., Evans, M. K., Sale, M. M., Kähönen, M., Boban, M., Bochud, M., Rheinberger, M., Verweij, N., Bouatia-Naji, N., Martin, N. G., Hastie, N., Probst-Hensch, N., Soranzo, N., Devuyst, O., Raitakari, O., Gottesman, O., Franco, O. H., Polasek, O., Gasparini, P., Munroe, P. B., Ridker, P. M., Mitchell, P., Muntner, P., Meisinger, C., Smit, J. H., Abecasis, G. R., Adair, L. S., Alexander, M., Altshuler, D., Amin, N., Arking, D. E., Arora, P., Aulchenko, Y., Bakker, S. J. L., Bandinelli, S., Barroso, I., Beckmann, J. S., Beilby, J. P., Bergman, R. N., Bergmann, S., Bis, J. C., Boehnke, M., Bonnycastle, L. L., Bornstein, S. R., Bots, M. L., Bragg-Gresham, J. L., Brand, S. M., Brand, E., Braund, P. S., Brown, M. J., Burton, P. R., Casas, J. P., Caulfield, M. J., Chakravarti, A., Chambers, J. C., Chandak, G. R., Chang, Y. P. C., Charchar, F. J., Chaturvedi, N., Cho, Y. S., Clarke, R., Collins, F. S., Collins, R., Connell, J. M., Cooper, J. A., Cooper, M. N., Cooper, R. S., Corsi, A. M., Dörr, M., Dahgam, S., Danesh, J., Smith, G. D., Day, I. N. M., Deloukas, P., Denniff, M., Dominiczak, A. F., Dong, Y., Doumatey, A., Elliott, P., Elosua, R., Erdmann, J., Eyheramendy, S., Farrall, M., Fava, C., Forrester, T., Fowkes, F. G. R., Fox, E. R., Frayling, T. M., Galan, P., Ganesh, S. K., Garcia, M., Gaunt, T. R., Glazer, N. L., Go, M. J., Goel, A., Grässler, J., Grobbee, D. E., Groop, L., Guarrera, S., Guo, X., Hadley, D., Hamsten, A., Han, B. G., Hardy, R., Hartikainen, A. L., Heath, S., Heckbert, S. R., Hedblad, B., Hercberg, S., Hernandez, D., Hicks, A. A., Hilton, G., Hingorani, A. D., Hoffman Bolton, J. A., Hopewell, J. C., Howard, P., Humphries, S. E., Hunt, S. C., Hveem, K., Ikram, M. A., Islam, M., Iwai, N., Jarvelin, M. R., Jackson, A. U., Jafar, T. H., Janipalli, C. S., Johnson, T., Kathiresan, S., Khaw, K. T., Kim, H. L., Kinra, S., Kita, Y., Kivimaki, M., Kooner, J. S., Kumar, M. J. K., Kuh, D., Kulkarni, S. R., Kumari, M., Kuusisto, J., Kuznetsova, T., Laakso, M., Laan, M., Laitinen, J., Lakatta, E. G., Langefeld, C. D., Larson, M. G., Lathrop, M., Lawlor, D. A., Lawrence, R. W., Lee, J. Y., Lee, N. R., Levy, D., Li, Y., Longstreth, W. T., Luan, J., Lucas, G., Ludwig, B., Mangino, M., Mani, K. R., Marmot, M. G., Mattace-Raso, F. U. S., Matullo, G., McArdle, W. L., McKenzie, C. A., Meitinger, T., Melander, O., Meneton, P., Meschia, J. F., Miki, T., Milaneschi, Y., Mohlke, K. L., Mooser, V., Morken, M. A., Morris, R. W., Mosley, T. H., Najjar, S., Narisu, N., Newton-Cheh, C., Nguyen, K. D. H., Nilsson, P., Nyberg, F., O'Donnell, C. J., Ogihara, T., Ohkubo, T., Okamura, T., Ong, R. T. H., Ongen, H., Onland-Moret, N. C., O'Reilly, P. F., Org, E., Orru, M., Palmas, W., Palmen, J., Palmer, L. J., Palmer, N. D., Parker, A. N., Peden, J. F., Peltonen, L., Perola, M., Pihur, V., Platou, C. G. P., Plump, A., Prabhakaran, D., Psaty, B. M., Raffel, L. J., Rao, D. C., Rasheed, A., Ricceri, F., Rice, K. M., Rosengren, A., Rotter, J. I., Rudock, M. E., Sõber, S., Salako, T., Saleheen, D., Salomaa, V., Samani, N. J., Schwartz, S. M., Schwarz, P. E. H., Scott, L. J., Scott, J., Scuteri, A., Sehmi, J. S., Seielstad, M., Seshadri, S., Sharma, P., Shaw-Hawkins, S., Shi, G., Shrine, N. R. G., Sijbrands, E. J. G., Sim, X., Singleton, A., Sjögren, M., Smith, N. L., Artigas, M. S., Spector, T. D., Staessen, J. A., Stancakova, A., Steinle, N. I., Strachan, D. P., Stringham, H. M., Sun, Y. V., Swift, A. J., Tabara, Y., Tai, E. S., Talmud, P. J., Taylor, A., Terzic, J., Thelle, D. S., Tobin, M. D., Tomaszewski, M., Tripathy, V., Tuomilehto, J., Tzoulaki, I., Uda, M., Ueshima, H., Uiterwaal, C. S. P. M., Umemura, S., Van Der Harst, P., Van Der Schouw, Y. T., Van Gilst, W. H., Vartiainen, E., Vasan, R. S., Veldre, G., Verwoert, G. C., Viigimaa, M., Vinay, D. G., Vineis, P., Voight, B. F., Vollenweider, P., Wagenknecht, L. E., Wain, L. V., Wang, X., Wang, T. J., Wareham, N. J., Watkins, H., Weder, A. B., Whincup, P. H., Wiggins, K. L., Witteman, J. C. M., Wong, A., Wu, Y., Yajnik, C. S., Yao, J., Young, J. H., Zelenika, D., Zhai, G., Zhang, W., Zhang, F., Zhao, J. H., Zhu, H., Zhu, X., Zitting, P., Zukowska-Szczechowska, E., Okada, Y., Wu, J. Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S. C., Wong, T. Y., Liu, J., Young, T. L., Aung, T., Teo, Y. Y., Kim, Y. J., Kang, D., Chen, C. H., Tsai, F. J., Chang, L. C., Fann, S. J. C., Mei, H., Hixson, J. E., Chen, S., Katsuya, T., Isono, M., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, Y. T., Tanaka, T., Reilly, M. P., Schunkert, H., Assimes, T. L., Hall, A., Hengstenberg, C., König, I. R., Laaksonen, R., McPherson, R., Thompson, J. R., Thorsteinsdottir, U., Ziegler, A., Absher, D., Chen, L., Cupples, L. A., Halperin, E., Li, M., Musunuru, K., Preuss, M., Schillert, A., Thorleifsson, G., Wells, G. A., Holm, H., Roberts, R., Stewart, A. F. R., Fortmann, S., Go, A., Hlatky, M., Iribarren, C., Knowles, J., Myers, R., Quertermous, T., Sidney, S., Risch, N., Tang, H., Blankenberg, S., Schnabel, R., Sinning, C., Lackner, K. J., Tiret, L., Nicaud, V., Cambien, F., Bickel, C., Rupprecht, H. J., Perret, C., Proust, C., Münzel, T. F., Barbalic, M., Chen, I. Y. D., Demissie-Banjaw, S., Folsom, A., Lumley, T., Marciante, K., Taylor, K. D., Volcik, K., Gretarsdottir, S., Gulcher, J. R., Kong, A., Stefansson, K., Thorgeirsson, G., Andersen, K., Fischer, M., Grosshennig, A., Linsel-Nitschke, P., Stark, K., Schreiber, S., Aherrahrou, Z., Bruse, P., Doering, A., Klopp, N., Diemert, P., Loley, C., Medack, A., Nahrstedt, J., Peters, A., Wagner, A. K., Willenborg, C., Böhm, B. O., Dobnig, H., Grammer, T. B., Hoffmann, M. M., Meinitzer, A., Winkelmann, B. R., Pilz, S., Renner, W., Scharnagl, H., Stojakovic, T., Tomaschitz, A., Winkler, K., Guiducci, C., Burtt, N., Gabriel, S. B., Dandona, S., Jarinova, O., Qu, L., Wilensky, R., Matthai, W., Hakonarson, H. H., Devaney, J., Burnett, M. S., Pichard, A. D., Kent, K. M., Satler, L., Lindsay, J. M., Waksman, R., Knouff, C. W., Waterworth, D. M., Walker, M. C., Epstein, S. E., Rader, D. J., Nelson, C. P., Wright, B. J., Balmforth, A. J., Ball, S. G., Loehr, L. R., Rosamond, W. D., Benjamin, E., Haritunians, T., Couper, D., Murabito, J., Wang, Y. A., Stricker, B. H., Chang, P. P., Willerson, J. T., Felix, S. B., Watzinger, N., Aragam, J., Zweiker, R., Lind, L., Rodeheffer, R. J., Greiser, K. H., Deckers, J. W., Stritzke, J., Ingelsson, E., Kullo, I., Haerting, J., Reffelmann, T., Redfield, M. M., Werdan, K., Mitchell, G. F., Arnett, D. K., Gottdiener, J. S., Blettner, M., Friedrich, N., Kovacs, P., Wild, P. S., Froguel, P., Rettig, R., Mägi, R., Biffar, R., Schmidt, R., Middelberg, R. P. S., Carroll, R. J., Penninx, B. W., Scott, R. J., Katz, R., Sedaghat, S., Wild, S. H., Kardia, S. L. R., Ulivi, S., Hwang, S. J., Enroth, S., Kloiber, S., Trompet, S., Stengel, B., Hancock, S. J., Turner, S. T., Rosas, S. E., Stracke, S., Harris, T. B., Zeller, T., Zemunik, T., Lehtimäki, T., Illig, T., Aspelund, T., Nikopensius, T., Esko, T., Tanaka, T., Gyllensten, U., Völker, U., Emilsson, V., Vitart, V., Aalto, V., Gudnason, V., Chouraki, V., Chen, W. M., Igl, W., März, W., Koenig, W., Lieb, W., Loos, R. J. F., Liu, Y., Snieder, H., Pramstaller, P. P., Parsa, A., O'Connell, J. R., Susztak, K., Hamet, P., Tremblay, J., De Boer, I. H., Böger, C. A., Goessling, W., Chasman, D. I., Köttgen, A., Kao, W. H. L. & Fox, C. S., Jan 21 2016, In : Nature Communications. 7, 10023.

Research output: Contribution to journalArticle

kidneys
loci
Glomerular Filtration Rate
Kidney
cells
2 Citations (Scopus)

Growth of Carotid Intima-Media Thickness in Black and White Young Adults

Hao, G., Wang, X., Treiber, F. A., Davis, H., Leverett, S., Su, S. & Kapuku, K. G., Dec 1 2016, In : Journal of the American Heart Association. 5, 12, e004147.

Research output: Contribution to journalArticle

Carotid Intima-Media Thickness
Young Adult
Growth
Body Mass Index
Cerebrovascular Disorders
15 Citations (Scopus)

Phenotypic alteration of CD8+ T cells in chronic lymphocytic leukemia is associated with epigenetic reprogramming

Wu, J., Xu, X., Lee, E. J., Shull, A. Y., Pei, L., Awan, F., Wang, X., Choi, J-H., Deng, L., Xin, H. B., Zhong, W., Liang, J., Miao, Y., Wu, Y., Fan, L., Li, J., Xu, W. & Shi, H., Jan 1 2016, In : Oncotarget. 7, 26, p. 40558-40570 13 p.

Research output: Contribution to journalArticle

T-Cell Prolymphocytic Leukemia
Epigenomics
B-Cell Chronic Lymphocytic Leukemia
T-Lymphocytes
DNA Methylation
7 Citations (Scopus)

Pulse wave velocity in elastic and muscular arteries: Tracking stability and association with anthropometric and hemodynamic measurements

Ye, C., Pan, Y., Xu, X., Su, S., Snieder, H., Treiber, F., Kapuku, G. & Wang, X., Nov 1 2016, In : Hypertension Research. 39, 11, p. 786-791 6 p.

Research output: Contribution to journalArticle

Pulse Wave Analysis
Arteries
Hemodynamics
Blood Pressure
Obesity
2015
48 Citations (Scopus)

Adverse childhood experiences and blood pressure trajectories from childhood to young adulthood: the Georgia stress and Heart study

Su, S., Wang, X., Pollock, J. S., Treiber, F. A., Xu, X., Snieder, H., McCall, W. V., Stefanek, M. & Harshfield, G. A., May 12 2015, In : Circulation. 131, 19, p. 1674-81 8 p.

Research output: Contribution to journalArticle

Blood Pressure
Social Class
Health Behavior
Street Drugs
Risk-Taking
54 Citations (Scopus)

A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension

EchoGen consortium, CHARGE-HF consortium, International Consortium for Blood Pressure GWAS (ICBP), CARDIoGRAM consortium, CKDGen Consortium & KidneyGen Consortium, Mar 18 2015, In : PLoS Genetics. 11, 3, e1005035.

Research output: Contribution to journalArticle

hypertension
meta-analysis
Transcriptome
gene expression
blood pressure
11 Citations (Scopus)

Berardinelli-Seip congenital lipodystrophy 2 regulates adipocyte lipolysis, browning, and energy balance in adult animals

Zhou, H., Lei, X., Benson, T., Mintz, J., Xu, X., Harris, R. B., Weintraub, N. L., Wang, X. & Chen, W., Oct 1 2015, In : Journal of Lipid Research. 56, 10, p. 1912-1925 14 p.

Research output: Contribution to journalArticle

Congenital Generalized Lipodystrophy
Lipolysis
Energy balance
Adipocytes
Adipose Tissue
81 Citations (Scopus)

DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring

Küpers, L. K., Xu, X., Jankipersadsing, S. A., Vaez, A., La Bastide-van Gemert, S., Scholtens, S., Nolte, I. M., Richmond, R. C., Relton, C. L., Felix, J. F., Duijts, L., Van Meurs, J. B., Tiemeier, H., Jaddoe, V. W., Wang, X., Corpeleijn, E. & Snieder, H., Aug 2015, In : International Journal of Epidemiology. 44, 4, p. 1224-1237 14 p.

Research output: Contribution to journalArticle

DNA Methylation
Smoking
Mothers
Pregnancy
Methylation
8 Citations (Scopus)

Familial aggregation and childhood blood pressure

Wang, X., Xu, X., Su, S. & Snieder, H., Jan 1 2015, In : Current Hypertension Reports. 17, 1, p. 509 1 p.

Research output: Contribution to journalArticle

Blood Pressure
Twin Studies
Genome-Wide Association Study
Birth Weight
Social Class
21 Citations (Scopus)

Obesity is associated with more activated neutrophils in African American male youth

Xu, X., Su, S., Wang, X., Barnes, V. A., De Miguel, C., Ownby, D. R., Pollock, J., Snieder, H. & Chen, W., Jan 10 2015, In : International Journal of Obesity. 39, 1, p. 26-32 7 p.

Research output: Contribution to journalArticle

African Americans
Neutrophils
Obesity
Neutrophil Activation
Leukocytes
4 Citations (Scopus)

Specific genetic influences on nighttime blood pressure

Xu, X., Su, S., Treiber, F. A., Vlietinck, R., Fagard, R., Derom, C., Gielen, M., Loos, R. J. F., Snieder, H. & Wang, X., Apr 1 2015, In : American journal of hypertension. 28, 4, p. 440-443 4 p.

Research output: Contribution to journalArticle

Blood Pressure
Twin Studies
Meta-Analysis
Embryonic and Fetal Development
Genes
2014
3 Citations (Scopus)

A 2-step penalized regression method for family-based next-generation sequencing association studies

Ding, X., Su, S., Nandakumar, K., Wang, X. & Fardo, D. W., Jun 17 2014, In : BMC Proceedings. 8, S25.

Research output: Contribution to journalArticle

Pedigree
40 Citations (Scopus)

Adverse childhood experiences are associated with detrimental hemodynamics and elevated circulating endothelin-1 in adolescents and young adults

Su, S., Wang, X., Kapuku, K. G., Treiber, F. A., Pollock, D. M., Harshfield, G. A., McCall, W. V. & Pollock, J. S., Jan 1 2014, In : Hypertension. 64, 1, p. 201-207 7 p.

Research output: Contribution to journalArticle

Endothelin-1
Psychological Stress
Vascular Resistance
Young Adult
Hemodynamics
57 Citations (Scopus)

Dietary sodium, adiposity, and inflammation in healthy adolescents

Zhu, H., Pollock, N. K., Kotak, I., Gutin, B., Wang, X., Bhagatwala, J., Parikh, S., Harshfield, G. A. & Dong, Y., Jan 1 2014, In : Pediatrics. 133, 3

Research output: Contribution to journalArticle

Dietary Sodium
Adiposity
Sodium
Abdominal Subcutaneous Fat
Inflammation
22 Citations (Scopus)

DNA methylation of the LY86 gene is associated with obesity, insulin resistance, and inflammation

Su, S., Zhu, H., Xu, X., Wang, X., Wang, X., Dong, Y., Kapuku, K. G., Treiber, F., Gutin, B., Harshfield, G. A. & Snieder, H., Jun 2014, In : Twin Research and Human Genetics. 17, 3, p. 183-191 9 p.

Research output: Contribution to journalArticle

Methylation
Insulin Resistance
Obesity
Lymphocytes
Inflammation
5 Citations (Scopus)

Identifying genetic variants for heart rate variability in the acetylcholine pathway

Riese, H., Muñoz, L. M., Hartman, C. A., Ding, X., Su, S., Oldehinkel, A. J., Van Roon, A. M., Van Der Most, P. J., Lefrt, J., Gansevoort, R. T., Van Der Harst, P., Verweij, N., Licht, C. M. M., Boomsma, D. I., Hottenga, J. J., Willemsen, G., Penninx, B. W. J. H., Nolte, I. M., De Geus, E. J. C., Wang, X. & 1 others, Snieder, H., Nov 10 2014, In : PloS one. 9, 11, e112476.

Research output: Contribution to journalArticle

acetylcholine
Acetylcholine
heart rate
Heart Rate
Genes
2013
46 Citations (Scopus)

A genome-wide methylation study of severe vitamin d deficiency in African American adolescents

Zhu, H., Wang, X., Shi, H., Su, S., Harshfield, G. A., Gutin, B., Snieder, H. & Dong, Y., Jan 1 2013, In : Journal of Pediatrics. 162, 5

Research output: Contribution to journalArticle

Avitaminosis
African Americans
Methylation
Vitamin D Deficiency
Genome
43 Citations (Scopus)

A Genome-Wide Methylation Study on Essential Hypertension in Young African American Males

Wang, X., Falkner, B., Zhu, H., Shi, H., Su, S., Xu, X., Sharma, A. K., Dong, Y., Treiber, F., Gutin, B., Harshfield, G. A. & Snieder, H., Jan 17 2013, In : PloS one. 8, 1, e53938.

Research output: Contribution to journalArticle

Methylation
African Americans
methylation
hypertension
DNA Methylation
95 Citations (Scopus)

A genome-wide methylation study on obesity: Differential variability and differential methylation

Xu, X., Su, S., Barnes, V. A., De Miguel, C., Pollock, J., Ownby, D. R., Shi, H., Zhu, H., Snieder, H. & Wang, X., Jan 1 2013, In : Epigenetics. 8, 5, p. 522-533 12 p.

Research output: Contribution to journalArticle

Methylation
Obesity
Genome
Neoplasms
Genes
13 Citations (Scopus)

A Method to Detect Differentially Methylated Loci With Next-Generation Sequencing

Xu, H., Podolsky, R. H., Ryu, D., Wang, X., Su, S., Shi, H. & George, V., May 1 2013, In : Genetic Epidemiology. 37, 4, p. 377-382 6 p.

Research output: Contribution to journalArticle

Methylation
Alleles
DNA Methylation
B-Cell Chronic Lymphocytic Leukemia
Epigenomics
11 Citations (Scopus)

Effect of oral ALA supplementation on oxidative stress and insulin sensitivity among overweight/obese adults: A double-blinded, randomized, controlled, cross-over intervention trial

Yan, W., Li, N., Hu, X., Huang, Y., Zhang, W., Wang, Q., Wang, F., Wang, C., Zhai, X., Xu, R., Yan, K., Ding, X. & Wang, X., Jul 31 2013, In : International Journal of Cardiology. 167, 2, p. 602-603 2 p.

Research output: Contribution to journalArticle

alpha-Linolenic Acid
Double-Blind Method
Cross-Over Studies
Oral Administration
Insulin Resistance
13 Citations (Scopus)

Genetic and environmental influences on blood pressure variability: A study in twins

Xu, X., Ding, X., Zhang, X., Su, S., Treiber, F. A., Vlietinck, R., Fagard, R., Derom, C., Gielen, M., Loos, R. J. F., Snieder, H. & Wang, X., Apr 1 2013, In : Journal of hypertension. 31, 4, p. 690-697 8 p.

Research output: Contribution to journalArticle

Twin Studies
Blood Pressure
Antihypertensive Agents
Meta-Analysis
Young Adult
432 Citations (Scopus)

Identification of seven loci affecting mean telomere length and their association with disease

Codd, V., Nelson, C. P., Albrecht, E., Mangino, M., Deelen, J., Buxton, J. L., Hottenga, J. J., Fischer, K., Esko, T., Surakka, I., Broer, L., Nyholt, D. R., Leach, I. M., Salo, P., Hägg, S., Matthews, M. K., Palmen, J., Norata, G. D., O'Reilly, P. F., Saleheen, D. & 79 others, Amin, N., Balmforth, A. J., Beekman, M., De Boer, R. A., Böhringer, S., Braund, P. S., Burton, P. R., Craen, A. J. M., Denniff, M., Dong, Y., Douroudis, K., Dubinina, E., Eriksson, J. G., Garlaschelli, K., Guo, D., Hartikainen, A. L., Henders, A. K., Houwing-Duistermaat, J. J., Kananen, L., Karssen, L. C., Kettunen, J., Klopp, N., Lagou, V., Van Leeuwen, E. M., Madden, P. A., Mägi, R., Magnusson, P. K. E., Männistö, S., McCarthy, M. I., Medland, S. E., Mihailov, E., Montgomery, G. W., Oostra, B. A., Palotie, A., Peters, A., Pollard, H., Pouta, A., Prokopenko, I., Ripatti, S., Salomaa, V., Suchiman, H. E. D., Valdes, A. M., Verweij, N., Viñuela, A., Wang, X., Wichmann, H. E., Widen, E., Willemsen, G., Wright, M. J., Xia, K., Xiao, X., Van Veldhuisen, D. J., Catapano, A. L., Tobin, M. D., Hall, A. S., Blakemore, A. I. F., Van Gilst, W. H., Zhu, H., Erdmann, J., Reilly, M. P., Kathiresan, S., Schunkert, H., Talmud, P. J., Pedersen, N. L., Perola, M., Ouwehand, W., Kaprio, J., Martin, N. G., Van Duijn, C. M., Hovatta, I., Gieger, C., Metspalu, A., Boomsma, D. I., Jarvelin, M. R., Slagboom, P. E., Thompson, J. R., Spector, T. D., Van Der Harst, P. & Samani, N. J., Apr 1 2013, In : Nature Genetics. 45, 4, p. 422-427 6 p.

Research output: Contribution to journalArticle

Telomere
Leukocytes
Coronary Artery Disease
Idiopathic Pulmonary Fibrosis
Single Nucleotide Polymorphism

Reply to manuscript IJC-D-12-04197 entitled "Does alpha-lipoic acid treatment play a role on oxidative stress and insulin resistance in overweight/obese patients?" by MD Turgay Ulas

Yan, W., Li, N., Hu, X., Huang, Y., Zhang, W., Wang, Q., Wang, F., Wang, C., Zhai, X., Xu, R., Yan, K., Ding, X. & Wang, X., Sep 30 2013, In : International Journal of Cardiology. 168, 2, 1 p.

Research output: Contribution to journalArticle

Thioctic Acid
alpha-Linolenic Acid
Manuscripts
Insulin Resistance
Oxidative Stress
1 Citation (Scopus)

Urinary prostasin excretion is associated with adiposity in nonhypertensive African-American adolescents

Guo, D. H., Parikh, S. J., Chao, J., Pollock, N. K., Wang, X., Snieder, H., Navis, G., Wilson, J. G., Bhagatwala, J., Zhu, H. & Dong, Y., Aug 1 2013, In : Pediatric research. 74, 2, p. 206-210 5 p.

Research output: Contribution to journalArticle

Adiposity
African Americans
Blood Pressure
Aldosterone
Adipose Tissue

Urinary prostasin excretion is associated with adiposity in non-hypertensive African American adolescents

Guo, D-H., Parikh, S., Chao, J., Pollock, N. K., Wang, X., Snieder, H., Navis, G., Bhagatwala, J., Zhu, H. & Dong, Y., 2013, In : Pediatric Research. In Press

Research output: Contribution to journalArticle

2011
4 Citations (Scopus)

[The effect of oral alpha-lipoic acid in overweight/obese individuals on brachial-ankle pulse wave velocity and supine blood pressure: a randomized, crossover, double-blind, placebo-controlled trial].

Huang, Y. D., Li, N., Zhang, W. G., Hu, X. J., Wang, Q., Wang, C. C., Xu, R. W., Yan, K., Hou, X. Y., Naerkeze, Wang, X. & Yan, W. L., Jan 1 2011, In : Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi. 32, 3, p. 290-296 7 p.

Research output: Contribution to journalArticle

Thioctic Acid
Pulse Wave Analysis
Ankle
Arm
Placebos
20 Citations (Scopus)

Beyond genome-wide association studies: New strategies for identifying genetic determinants of hypertension

Wang, X., Prins, B. P., Sõber, S., Laan, M. & Snieder, H., Dec 1 2011, In : Current Hypertension Reports. 13, 6, p. 442-451 10 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Hypertension
Blood Pressure
Genes
Histone Code
20 Citations (Scopus)

Genetic and environmental influences on blood pressure and body mass index in Han Chinese: A twin study

Wu, T., Snieder, H., Li, L., Cao, W., Zhan, S., Lv, J., Gao, W., Wang, X., Ding, X. & Hu, Y., Feb 1 2011, In : Hypertension Research. 34, 2, p. 173-179 7 p.

Research output: Contribution to journalArticle

Twin Studies
Body Mass Index
Blood Pressure
Obesity
Genes
20 Citations (Scopus)

Genetic influence on blood pressure measured in the office, under laboratory stress and during real life

Wang, X., Ding, X., Su, S., Harshfield, G. A., Treiber, F. & Snieder, H., Feb 1 2011, In : Hypertension Research. 34, 2, p. 239-244 6 p.

Research output: Contribution to journalArticle

Blood Pressure
Genes
Video Games
Genetic Models
African Americans
1248 Citations (Scopus)

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Ehret, G. B., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., Chasman, D. I., Smith, A. V., Tobin, M. D., Verwoert, G. C., Hwang, S. J., Pihur, V., Vollenweider, P., O'Reilly, P. F., Amin, N., Bragg-Gresham, J. L., Teumer, A., Glazer, N. L., Launer, L., Zhao, J. H., Aulchenko, Y. & 326 others, Heath, S., Sober, S., Parsa, A., Luan, J., Arora, P., Dehghan, A., Zhang, F., Lucas, G., Hicks, A. A., Jackson, A. U., Peden, J. F., Tanaka, T., Wild, S. H., Rudan, I., Igl, W., Milaneschi, Y., Parker, A. N., Fava, C., Chambers, J. C., Fox, E. R., Kumari, M., Go, M. J., van der Harst, P., Kao, W. H. L., Sjögren, M., Vinay, D. G., Alexander, M., Tabara, Y., Shaw-Hawkins, S., Whincup, P. H., Liu, Y., Shi, G., Kuusisto, J., Tayo, B., Seielstad, M., Sim, X., Hoang Nguyen, K. D., Lehtimäki, T., Matullo, G., Wu, Y., Gaunt, T. R., Charlotte Onland-Moret, N., Cooper, M. N., Platou, C. G. P., Org, E., Hardy, R., Dahgam, S., Palmen, J., Vitart, V., Braund, P. S., Kuznetsova, T., Uiterwaal, C. S. P. M., Adeyemo, A., Palmas, W., Campbell, H., Ludwig, B., Tomaszewski, M., Tzoulaki, I., Palmer, N. D., Aspelund, T., Garcia, M., Chang, Y. P. C., O'Connell, J. R., Steinle, N. I., Grobbee, D. E., Arking, D. E., Kardia, S. L., Morrison, A. C., Hernandez, D., Najjar, S., McArdle, W. L., Hadley, D., Brown, M. J., Connell, J. M., Hingorani, A. D., Day, I. N. M., Lawlor, D. A., Beilby, J. P., Lawrence, R. W., Clarke, R., Hopewell, J. C., Ongen, H., Dreisbach, A. W., Li, Y., Hunter Young, J., Bis, J. C., Kähönen, M., Viikari, J., Adair, L. S., Lee, N. R., Chen, M. H., Olden, M., Pattaro, C., Bolton, J. A. H., Köttgen, A., Bergmann, S., Mooser, V., Chaturvedi, N., Frayling, T. M., Islam, M., Jafar, T. H., Erdmann, J., Kulkarni, S. R., Bornstein, S. R., Grässler, J., Groop, L., Voight, B. F., Kettunen, J., Howard, P., Taylor, A., Guarrera, S., Ricceri, F., Emilsson, V., Plump, A., Barroso, I., Khaw, K. T., Weder, A. B., Hunt, S. C., Sun, Y. V., Bergman, R. N., Collins, F. S., Bonnycastle, L. L., Scott, L. J., Stringham, H. M., Peltonen, L., Perola, M., Vartiainen, E., Brand, S. M., Staessen, J. A., Wang, T. J., Burton, P. R., Artigas, M. S., Dong, Y., Snieder, H., Wang, X., Zhu, H., Lohman, K. K., Rudock, M. E., Heckbert, S. R., Smith, N. L., Wiggins, K. L., Doumatey, A., Shriner, D., Veldre, G., Viigimaa, M., Kinra, S., Prabhakaran, D., Tripathy, V., Langefeld, C. D., Rosengren, A., Thelle, D. S., Corsi, A. M., Singleton, A., Forrester, T., Hilton, G., McKenzie, C. A., Salako, T., Iwai, N., Kita, Y., Ogihara, T., Ohkubo, T., Okamura, T., Ueshima, H., Umemura, S., Eyheramendy, S., Meitinger, T., Wichmann, H. E., Cho, Y. S., Kim, H. L., Lee, J. Y., Scott, J., Sehmi, J. S., Zhang, W., Hedblad, B., Nilsson, P., Smith, G. D., Wong, A., Narisu, N., Stančáková, A., Raffel, L. J., Yao, J., Kathiresan, S., O'Donnell, C. J., Schwartz, S. M., Arfan Ikram, M., Longstreth, W. T., Mosley, T. H., Seshadri, S., Shrine, N. R. G., Wain, L. V., Morken, M. A., Swift, A. J., Laitinen, J., Prokopenko, I., Zitting, P., Cooper, J. A., Humphries, S. E., Danesh, J., Rasheed, A., Goel, A., Hamsten, A., Watkins, H., Bakker, S. J. L., van Gilst, W. H., Janipalli, C. S., Radha Mani, K., Yajnik, C. S., Hofman, A., Mattace-Raso, F. U. S., Oostra, B. A., Demirkan, A., Isaacs, A., Rivadeneira, F., Lakatta, E. G., Orru, M., Scuteri, A., Ala-Korpela, M., Kangas, A. J., Lyytikäinen, L. P., Soininen, P., Tukiainen, T., Würtz, P., Twee-HeeOng, R., Dörr, M., Kroemer, H. K., Völker, U., Völzke, H., Galan, P., Hercberg, S., Lathrop, M., Zelenika, D., Deloukas, P., Mangino, M., Spector, T. D., Zhai, G., Meschia, J. F., Nalls, M. A., Sharma, P., Terzic, J., Kranthi Kumar, M. V., Denniff, M., Zukowska-Szczechowska, E., Wagenknecht, L. E., Fowkes, F. G. R., Charchar, F. J., Schwarz, P. E. H., Hayward, C., Guo, X., Rotimi, C., Bots, M. L., Brand, E., Samani, N. J., Polasek, O., Talmud, P. J., Nyberg, F., Kuh, D., Laan, M., Hveem, K., Palmer, L. J., van der Schouw, Y. T., Casas, J. P., Mohlke, K. L., Vineis, P., Raitakari, O., Ganesh, S. K., Wong, T. Y., Shyong Tai, E., Cooper, R. S., Laakso, M., Rao, D. C., Harris, T. B., Morris, R. W., Dominiczak, A. F., Kivimaki, M., Marmot, M. G., Miki, T., Saleheen, D., Chandak, G. R., Coresh, J., Navis, G., Salomaa, V., Han, B. G., Zhu, X., Kooner, J. S., Melander, O., Ridker, P. M., Bandinelli, S., Gyllensten, U. B., Wright, A. F., Wilson, J. F., Ferrucci, L., Farrall, M., Tuomilehto, J., Pramstaller, P. P., Elosua, R., Soranzo, N., Sijbrands, E. J. G., Altshuler, D., Loos, R. J. F., Shuldiner, A. R., Gieger, C., Meneton, P., Uitterlinden, A. G., Wareham, N. J., Gudnason, V., Rotter, J. I., Rettig, R., Uda, M., Strachan, D. P., Witteman, J. C. M., Hartikainen, A. L., Beckmann, J. S., Boerwinkle, E., Vasan, R. S., Boehnke, M., Larson, M. G., Järvelin, M. R., Psaty, B. M., Abecasis, G. R., Chakravarti, A., Elliott, P., van Duijn, C. M., Newton-Cheh, C., Levy, D., Caulfield, M. J. & Johnson, T., Oct 6 2011, In : Nature. 478, 7367, p. 103-109 7 p.

Research output: Contribution to journalArticle

Hematologic Diseases
Cardiovascular Diseases
Blood Pressure
Blood Physiological Phenomena
Furin
90 Citations (Scopus)

Leukocyte telomere length in healthy caucasian and african-american adolescents: Relationships with race, sex, adiposity, adipokines, and physical activity

Zhu, H., Wang, X., Gutin, B., Davis, C. L., Keeton, D., Thomas, J., Stallmann-Jorgensen, I., Mooken, G., Bundy, V., Snieder, H., Van Der Harst, P. & Dong, Y., Feb 1 2011, In : Journal of Pediatrics. 158, 2, p. 215-220 6 p.

Research output: Contribution to journalArticle

Adipokines
Telomere
Adiposity
African Americans
Leukocytes
2010
38 Citations (Scopus)

A longitudinal study of blood pressure variability in African-American and European American youth

Li, Z., Snieder, H., Su, S., Harshfield, G. A., Treiber, F. A. & Wang, X., Apr 1 2010, In : Journal of hypertension. 28, 4, p. 715-722 8 p.

Research output: Contribution to journalArticle

African Americans
Longitudinal Studies
Blood Pressure
Hypertension
Adiposity
139 Citations (Scopus)

Obesity related methylation changes in DNA of peripheral blood leukocytes

Wang, X., Zhu, H., Snieder, H., Su, S., Munn, D. H., Harshfield, G. A., Maria, B. L., Dong, Y., Treiber, F., Gutin, B. & Shi, H., Dec 21 2010, In : BMC Medicine. 8, 87.

Research output: Contribution to journalArticle

Methylation
Leukocytes
Obesity
DNA
Genes
2009
41 Citations (Scopus)

A 15-year longitudinal study on ambulatory blood pressure tracking from childhood to early adulthood

Li, Z., Snieder, H., Harshfield, G. A., Treiber, F. A. & Wang, X., Aug 12 2009, In : Hypertension Research. 32, 5, p. 404-410 7 p.

Research output: Contribution to journalArticle

Longitudinal Studies
Blood Pressure
Reading
Ambulatory Blood Pressure Monitoring
African Americans