• 644 Citations
  • 15 h-Index
19972018
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Research Output 1997 2018

  • 644 Citations
  • 15 h-Index
  • 38 Article
  • 2 Review article
  • 1 Conference contribution
  • 1 Paper
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Article
2018
1 Citation (Scopus)

Estrogen enhances tumor growth and angiogenesis indirectly via mediation of bone marrow-derived cells as well as directly through stimulation of tumor and endothelial cells

Zhuo, Y., Li, X., Zheng, Q., Fan, X., Ma, W., Chen, J., Zhao, X., Zhao, P., Liu, X., Tang, F., Cheng, K. & Feng, W., Oct 2018, In : Oncology Reports. 40, 4, p. 2147-2156 10 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
Estrogens
Endothelial Cells
Growth
Neoplasms
4 Citations (Scopus)

Reactive cysteine residues in the oxidative dimerization and Cu2+ induced aggregation of human γD-crystallin: Implications for age-related cataract

Ramkumar, S., Fan, X., Wang, B., Yang, S. & Monnier, V. M., Nov 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 11, p. 3595-3604 10 p.

Research output: Contribution to journalArticle

Crystallins
Dimerization
Cataract
Cysteine
Disulfides
2017
3 Citations (Scopus)

Gclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration

Feng, W., Rosca, M., Fan, Y., Hu, Y., Feng, P., Lee, H. G., Monnier, V. M. & Fan, X., Apr 1 2017, In : Human Molecular Genetics. 26, 7, p. 1376-1390 15 p., ddx040.

Research output: Contribution to journalArticle

Central Nervous System
Nesting Behavior
Ligases
Breeding
Glutathione
3 Citations (Scopus)

Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins

Whitson, J. A., Wilmarth, P. A., Klimek, J., Monnier, V. M., David, L. & Fan, X., Dec 1 2017, In : Free Radical Biology and Medicine. 113, p. 84-96 13 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Heat-Shock Proteins
Proteomics
Lenses
Glutathione
5 Citations (Scopus)

Reduced Glutathione Level Promotes Epithelial-Mesenchymal Transition in Lens Epithelial Cells via a Wnt/β-Catenin–Mediated Pathway: Relevance for Cataract Therapy

Wei, Z., Caty, J., Whitson, J., Zhang, A. D., Srinivasagan, R., Kavanagh, T. J., Yan, H. & Fan, X., Nov 2017, In : American Journal of Pathology. 187, 11, p. 2399-2412 14 p.

Research output: Contribution to journalArticle

Wnt Signaling Pathway
Epithelial-Mesenchymal Transition
Cataract
Lenses
Glutathione
13 Citations (Scopus)

The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling

Wang, B., Hom, G., Zhou, S., Guo, M., Li, B., Yang, J., Monnier, V. M. & Fan, X., Apr 1 2017, In : Aging Cell. 16, 2, p. 244-261 18 p.

Research output: Contribution to journalArticle

Proteome
Sulfhydryl Compounds
Disulfides
Lenses
Crystallins
4 Citations (Scopus)

Transcriptome of the GSH-Depleted lens reveals changes in detoxification and EMT signaling genes, transport systems, and lipid homeostasis

Whitson, J. A., Zhang, X., Medvedovic, M., Chen, J., Wei, Z., Monnier, V. M. & Fan, X., May 2017, In : Investigative Ophthalmology and Visual Science. 58, 5, p. 2666-2684 19 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Transcriptome
Lenses
Homeostasis
Lipids
2016
5 Citations (Scopus)

Evidence of dual mechanisms of glutathione uptake in the rodent lens: A novel role for vitreous humor in lens glutathione homeostasis

Whitson, J. A., Sell, D. R., Goodman, M. C., Monnier, V. M. & Fan, X., Jul 2016, In : Investigative Ophthalmology and Visual Science. 57, 8, p. 3914-3925 12 p.

Research output: Contribution to journalArticle

Vitreous Body
Lenses
Glutathione
Rodentia
Homeostasis
13 Citations (Scopus)

Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients

Zhang, L., Li, Y., Payne, J., Srivastava, S., Fan, X., Fung, J., Li, X., Kern, T. S. & Lin, F., Feb 3 2016, In : Scientific Reports. 6, 20341.

Research output: Contribution to journalArticle

Pericytes
Diabetic Retinopathy
Autoantibodies
Complement Activation
Serum
2015
14 Citations (Scopus)

Evidence of highly conserved β-crystallin disulfidome that can be mimicked by in Vitro oxidation in age-related human cataract and glutathione depleted mouse lens

Fan, X., Zhou, S., Wang, B., Hom, G., Guo, M., Li, B., Yang, J., Vaysburg, D. & Monnier, V. M., Dec 2015, In : Molecular and Cellular Proteomics. 14, 12, p. 3211-3223 13 p.

Research output: Contribution to journalArticle

Crystallins
Disulfides
Cataract
Lenses
Glutathione
2014
36 Citations (Scopus)

UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: Implications for human lens aging and cataract formation

Linetsky, M., Raghavan, C. T., Johar, K., Fan, X., Monnier, V. M., Vasavada, A. R. & Nagaraj, R. H., Jun 13 2014, In : Journal of Biological Chemistry. 289, 24, p. 17111-17123 13 p.

Research output: Contribution to journalArticle

Kynurenine
Crystallins
Advanced Glycosylation End Products
Cataract
Lenses
2012
19 Citations (Scopus)

The LEGSKO Mouse: A Mouse Model of Age-Related Nuclear Cataract Based on Genetic Suppression of Lens Glutathione Synthesis

Fan, X., Liu, X., Hao, S., Wang, B., Robinson, M. L. & Monnier, V. M., Nov 30 2012, In : PloS one. 7, 11, e50832.

Research output: Contribution to journalArticle

Genetic Suppression
cataract
Lens
Lenses
Glutathione
2011
16 Citations (Scopus)

Topical application of L-arginine blocks advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice

Fan, X., Xiaoqin, L., Potts, B., Strauch, C. M., Nemet, I. & Monnier, V. M., Sep 26 2011, In : Molecular Vision. 17, p. 2221-2227 7 p.

Research output: Contribution to journalArticle

Transgenic Mice
Lenses
Ascorbic Acid
Arginine
Acetylcysteine
2010
43 Citations (Scopus)

Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysis

Fan, X., Sell, D. R., Zhang, J., Nemet, I., Theves, M., Lu, J., Strauch, C., Halushka, M. K. & Monnier, V. M., Sep 1 2010, In : Free Radical Biology and Medicine. 49, 5, p. 847-856 10 p.

Research output: Contribution to journalArticle

Skin Aging
Medical problems
Oxidants
Lenses
Skin
2009
39 Citations (Scopus)

Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes

Fan, X., Zhang, J., Theves, M., Strauch, C., Nemet, I., Liu, X., Qian, J., Giblin, F. J. & Monnier, V. M., Dec 11 2009, In : Journal of Biological Chemistry. 284, 50, p. 34618-34627 10 p.

Research output: Contribution to journalArticle

2-Aminoadipic Acid
Crystallins
Medical problems
Lenses
Lysine
2008
16 Citations (Scopus)

Binding of recombinant but not endogenous prion protein to DNA Causes DNA internalization and expression in mammalian cells

Yin, S., Fan, X., Yu, S., Li, C. & Sy, M. S., Sep 12 2008, In : Journal of Biological Chemistry. 283, 37, p. 25446-25454 9 p.

Research output: Contribution to journalArticle

Cells
DNA
PrPC Proteins
Pinocytosis
Endopeptidase K
25 Citations (Scopus)

Identification of glucose-derived cross-linking sites in ribonuclease A

Dai, Z., Wang, B., Sun, G., Fan, X., Anderson, V. E. & Monnier, V. M., Jul 1 2008, In : Journal of Proteome Research. 7, 7, p. 2756-2768 13 p.

Research output: Contribution to journalArticle

Pancreatic Ribonuclease
Glucose
Aging of materials
Proteins
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
14 Citations (Scopus)

Inhibition of crystallin ascorbylation by nucleophilic compounds in the hSVCT2 mouse model of lenticular aging

Fan, X. & Monnier, V. M., Nov 1 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 4945-4952 8 p.

Research output: Contribution to journalArticle

Crystallins
Ascorbic Acid
Gas Chromatography-Mass Spectrometry
Lenses
Pyridoxamine
2007
18 Citations (Scopus)

Effects of advanced glycation end product modification on proximal tubule epithelial cell processing of albumin

Ozdemir, A. M., Hopfer, U., Rosca, M. V., Fan, X., Monnier, V. M. & Weiss, M. F., Nov 1 2007, In : American Journal of Nephrology. 28, 1, p. 14-24 11 p.

Research output: Contribution to journalArticle

Advanced Glycosylation End Products
Albumins
Epithelial Cells
Pyruvaldehyde
Proximal Kidney Tubule
2006
6 Citations (Scopus)

Relative suppression of the sodium-dependent Vitamin C transport in mouse versus human lens epithelial cells

Obrenovich, M. E., Fan, X., Satake, M., Jarvis, S. M., Reneker, L., Reddan, J. R. & Monnier, V. M., Dec 1 2006, In : Molecular and Cellular Biochemistry. 293, 1-2, p. 53-62 10 p.

Research output: Contribution to journalArticle

Lenses
Ascorbic Acid
Epithelial Cells
Sodium
Night Vision
77 Citations (Scopus)

Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model

Fan, X., Reneker, L. W., Obrenovich, M. E., Strauch, C., Cheng, R., Jams, S. M., Ortwerth, B. J. & Monnier, V. M., Nov 7 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 45, p. 16912-16917 6 p.

Research output: Contribution to journalArticle

Maillard Reaction
Crystallins
Lenses
Ascorbic Acid
Pigmentation
2003
64 Citations (Scopus)
Pyruvaldehyde
Bovine Serum Albumin
Mitogens
Protein Kinases
Reactive Oxygen Species
2002
33 Citations (Scopus)

Cellular oxidant stress and advanced glycation endproducts of albumin: Caveats of the dichlorofluorescein assay

Subramaniam, R., Fan, X., Scivittaro, V., Yang, J., Ha, C. E., Petersen, C. E., Surewicz, W. K., Bhagavan, N. V., Weiss, M. F. & Monnier, V. M., Apr 1 2002, In : Archives of Biochemistry and Biophysics. 400, 1, p. 15-25 11 p., 92776.

Research output: Contribution to journalArticle

Oxidants
Albumins
Assays
Fluorescence
Phenylglyoxal

Cellular oxidant stress mediated by advanced glycation endproducts: The role of native albumin

Subramaniam, R., Fan, X., Yang, J., Ha, C. E., Petersen, C. E., Bhagavan, N. V., Weiss, M. F. & Monnier, V. M., Nov 1 2002, In : International Congress Series. 1245, C, p. 65-71 7 p.

Research output: Contribution to journalArticle

Oxidants
Albumins
Fluorescence
Diabetes Complications
Bovine Serum Albumin
2001

Determination of human PDGF-B promoter binding nuclear protein by capillary electrophoresis

Fan, X., Liu, J., Jin, Y. X. & Wang, D. B., Jan 1 2001, In : Se pu = Chinese journal of chromatography / Zhongguo hua xue hui. 19, 2, p. 170-172 3 p.

Research output: Contribution to journalArticle

Capillary electrophoresis
Boric acid
Ethylenediaminetetraacetic acid
DNA-Binding Proteins
Capillary Electrophoresis
2000
3 Citations (Scopus)

Determination of PyPuPu (PyPuPy) intermolecular triple-stranded DNA by capillary electrophoresis

Fan, X., Liu, J., Tang, H., Jin, Y. & Wang, D. B., Jan 1 2000, In : Analytical Biochemistry. 287, 1, p. 95-101 7 p.

Research output: Contribution to journalArticle

Capillary electrophoresis
Capillary Electrophoresis
DNA
Oligonucleotides
Magnesium
6 Citations (Scopus)

Esterification by microwave irradiation on activated carbon

Fan, X., Yuant, K., Li, N., Tan, G., Yu, X. & Hao, C., Jun 2000, In : Organic Preparations and Procedures International. 32, 3, p. 287-290 4 p.

Research output: Contribution to journalArticle

Microwave irradiation
Esterification
Activated carbon
8 Citations (Scopus)

Rapid n-alkylation of carbazole, phenothiazlne and acridone under microwave irradiation

Fan, X., You, J., Jiao, T., Tan, G. & Yu, X., Jan 1 2000, In : Organic Preparations and Procedures International. 32, 3, p. 284-287 4 p.

Research output: Contribution to journalArticle

Microwave irradiation
Alkylation
carbazole
acridone
1999
24 Citations (Scopus)

High performance liquid chromatographic determination of N- nitrosoamines by pre-column fluorescence derivatization with acridone-N- acetyl chloride

You, J., Fan, X., Lao, W., Ou, Q. & Zhu, Q., Jan 1 1999, In : Talanta. 48, 2, p. 437-449 13 p.

Research output: Contribution to journalArticle

AIDS-Related Complex
Fluorescence
Derivatives
Amines
Liquids
2 Citations (Scopus)
Cyclodextrins
Fluorescent Dyes
Fluorescence
Acids
AIDS-Related Complex
1998

Amidated synthesis of one kind of substituted propane catalyzed by PPh 3/NBS

Fan, X., Tan, G., Wang, M. & Yu, X., Dec 1 1998, In : Chemistry Bulletin / Huaxue Tongbao. 5, p. 53-54 2 p.

Research output: Contribution to journalArticle

Propane
11 Citations (Scopus)
glycyl-glycyl-glycine
Glycylglycine
Oligopeptides
Rain
Signal-To-Noise Ratio

High-performance liquid chromatographic determination of amino acids by pre-column fluorescence derivatization with three new fluorescent agents

You, J., Fan, X., Ou, Q., Zhu, Q. & Jia, X., Dec 1 1998, In : Fenxi Huaxue. 26, 10, p. 1199-1200 2 p.

Research output: Contribution to journalArticle

Fluorescent Dyes
Fluorescence
Amino Acids
Liquids
Derivatives
17 Citations (Scopus)
Acridines
peptide
acetate
Acetates
fluorescence

Liquid chromatography determination of amino acids by precolumn fluorescence derivatization with acridone-N-acetyl chloride

You, J. M., Fan, X., Ou, Q. Y. & Zhu, Q. C., Dec 1 1998, In : Chinese Chemical Letters. 9, 7, p. 657-660 4 p.

Research output: Contribution to journalArticle

Liquid chromatography
Fluorescence
Amino Acids
Derivatives
Liquids
45 Citations (Scopus)

New reagents for determination of amino acids by liquid chromatography with pre-column fluorescence derivatization

Fan, X., You, J., Kang, J., Ou, Q. & Zhu, Q., Jul 3 1998, In : Analytica Chimica Acta. 367, 1-3, p. 81-91 11 p.

Research output: Contribution to journalArticle

Liquid chromatography
Liquid Chromatography
liquid chromatography
fluorescence
amino acid
4 Citations (Scopus)

Progress in microwave-organic reaction enhancement chemistry

Fan, X., You, J., Tan, G., Yu, X. & Jiao, T., Dec 1 1998, In : Progress in Chemistry. 10, 3

Research output: Contribution to journalArticle

Microwave irradiation
Microwaves
1997

HPLC of amino acids and oligopeptides by pre-column fluorescence derivatization with 9-acridine formyl chloride

You, J. M., Fan, X. & Ou, Q. Y., Dec 1 1997, In : Chinese Chemical Letters. 8, 10, p. 875-878 4 p.

Research output: Contribution to journalArticle

Acridines
Oligopeptides
glycyl-glycyl-glycine
Chlorides
Fluorescence