• 692 Citations
  • 16 h-Index
19972020

Research output per year

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Research Output

  • 692 Citations
  • 16 h-Index
  • 39 Article
  • 2 Review article
  • 1 Conference contribution
  • 1 Paper
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Article
2020

Vitamin C is a source of oxoaldehyde and glycative stress in age-related cataract and neurodegenerative diseases

Fan, X., Sell, D. R., Hao, C., Liu, S., Wang, B., Wesson, D. W., Siedlak, S., Zhu, X., Kavanagh, T. J., Harrison, F. E. & Monnier, V. M., Jul 1 2020, In : Aging Cell. 19, 7, ACEL13176.

Research output: Contribution to journalArticle

Open Access
2018

Estrogen enhances tumor growth and angiogenesis indirectly via mediation of bone marrow-derived cells as well as directly through stimulation of tumor and endothelial cells

Zhuo, Y., Li, X., Zheng, Q., Fan, X., Ma, W., Chen, J., Zhao, X., Zhao, P., Liu, X., Tang, F., Cheng, K. & Feng, W., Oct 2018, In : Oncology Reports. 40, 4, p. 2147-2156 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Reactive cysteine residues in the oxidative dimerization and Cu2+ induced aggregation of human γD-crystallin: Implications for age-related cataract

Ramkumar, S., Fan, X., Wang, B., Yang, S. & Monnier, V. M., Nov 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 11, p. 3595-3604 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Gclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration

Feng, W., Rosca, M., Fan, Y., Hu, Y., Feng, P., Lee, H. G., Monnier, V. M. & Fan, X., Apr 1 2017, In : Human Molecular Genetics. 26, 7, p. 1376-1390 15 p., ddx040.

Research output: Contribution to journalArticle

6 Scopus citations

Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins

Whitson, J. A., Wilmarth, P. A., Klimek, J., Monnier, V. M., David, L. & Fan, X., Dec 2017, In : Free Radical Biology and Medicine. 113, p. 84-96 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Reduced Glutathione Level Promotes Epithelial-Mesenchymal Transition in Lens Epithelial Cells via a Wnt/β-Catenin–Mediated Pathway: Relevance for Cataract Therapy

Wei, Z., Caty, J., Whitson, J., Zhang, A. D., Srinivasagan, R., Kavanagh, T. J., Yan, H. & Fan, X., Nov 2017, In : American Journal of Pathology. 187, 11, p. 2399-2412 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling

Wang, B., Hom, G., Zhou, S., Guo, M., Li, B., Yang, J., Monnier, V. M. & Fan, X., Apr 1 2017, In : Aging Cell. 16, 2, p. 244-261 18 p.

Research output: Contribution to journalArticle

16 Scopus citations

Transcriptome of the GSH-Depleted lens reveals changes in detoxification and EMT signaling genes, transport systems, and lipid homeostasis

Whitson, J. A., Zhang, X., Medvedovic, M., Chen, J., Wei, Z., Monnier, V. M. & Fan, X., May 2017, In : Investigative Ophthalmology and Visual Science. 58, 5, p. 2666-2684 19 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Evidence of dual mechanisms of glutathione uptake in the rodent lens: A novel role for vitreous humor in lens glutathione homeostasis

Whitson, J. A., Sell, D. R., Goodman, M. C., Monnier, V. M. & Fan, X., Jul 2016, In : Investigative Ophthalmology and Visual Science. 57, 8, p. 3914-3925 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Presence of retinal pericyte-reactive autoantibodies in diabetic retinopathy patients

Zhang, L., Li, Y., Payne, J., Srivastava, S., Fan, X., Fung, J., Li, X., Kern, T. S. & Lin, F., Feb 3 2016, In : Scientific reports. 6, 20341.

Research output: Contribution to journalArticle

16 Scopus citations
2015

Evidence of highly conserved β-crystallin disulfidome that can be mimicked by in Vitro oxidation in age-related human cataract and glutathione depleted mouse lens

Fan, X., Zhou, S., Wang, B., Hom, G., Guo, M., Li, B., Yang, J., Vaysburg, D. & Monnier, V. M., Dec 2015, In : Molecular and Cellular Proteomics. 14, 12, p. 3211-3223 13 p.

Research output: Contribution to journalArticle

16 Scopus citations
2014

UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: Implications for human lens aging and cataract formation

Linetsky, M., Raghavan, C. T., Johar, K., Fan, X., Monnier, V. M., Vasavada, A. R. & Nagaraj, R. H., Jun 13 2014, In : Journal of Biological Chemistry. 289, 24, p. 17111-17123 13 p.

Research output: Contribution to journalArticle

40 Scopus citations
2012

The LEGSKO Mouse: A Mouse Model of Age-Related Nuclear Cataract Based on Genetic Suppression of Lens Glutathione Synthesis

Fan, X., Liu, X., Hao, S., Wang, B., Robinson, M. L. & Monnier, V. M., Nov 30 2012, In : PloS one. 7, 11, e50832.

Research output: Contribution to journalArticle

21 Scopus citations
2011

Topical application of L-arginine blocks advanced glycation by ascorbic acid in the lens of hSVCT2 transgenic mice

Fan, X., Xiaoqin, L., Potts, B., Strauch, C. M., Nemet, I. & Monnier, V. M., Sep 26 2011, In : Molecular Vision. 17, p. 2221-2227 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
2010

Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysis

Fan, X., Sell, D. R., Zhang, J., Nemet, I., Theves, M., Lu, J., Strauch, C., Halushka, M. K. & Monnier, V. M., Sep 2010, In : Free Radical Biology and Medicine. 49, 5, p. 847-856 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2009

Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes

Fan, X., Zhang, J., Theves, M., Strauch, C., Nemet, I., Liu, X., Qian, J., Giblin, F. J. & Monnier, V. M., Dec 11 2009, In : Journal of Biological Chemistry. 284, 50, p. 34618-34627 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
2008

Binding of recombinant but not endogenous prion protein to DNA Causes DNA internalization and expression in mammalian cells

Yin, S., Fan, X., Yu, S., Li, C. & Sy, M. S., Sep 12 2008, In : Journal of Biological Chemistry. 283, 37, p. 25446-25454 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Identification of glucose-derived cross-linking sites in ribonuclease A

Dai, Z., Wang, B., Sun, G., Fan, X., Anderson, V. E. & Monnier, V. M., Jul 2008, In : Journal of Proteome Research. 7, 7, p. 2756-2768 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Inhibition of crystallin ascorbylation by nucleophilic compounds in the hSVCT2 mouse model of lenticular aging

Fan, X. & Monnier, V. M., Nov 2008, In : Investigative Ophthalmology and Visual Science. 49, 11, p. 4945-4952 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
2007

Effects of advanced glycation end product modification on proximal tubule epithelial cell processing of albumin

Ozdemir, A. M., Hopfer, U., Rosca, M. V., Fan, X. J., Monnier, V. M. & Weiss, M. F., Nov 1 2007, In : American Journal of Nephrology. 28, 1, p. 14-24 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2006

Relative suppression of the sodium-dependent Vitamin C transport in mouse versus human lens epithelial cells

Obrenovich, M. E., Fan, X., Satake, M., Jarvis, S. M., Reneker, L., Reddan, J. R. & Monnier, V. M., Dec 1 2006, In : Molecular and Cellular Biochemistry. 293, 1-2, p. 53-62 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Vitamin C mediates chemical aging of lens crystallins by the Maillard reaction in a humanized mouse model

Fan, X., Reneker, L. W., Obrenovich, M. E., Strauch, C., Cheng, R., Jams, S. M., Ortwerth, B. J. & Monnier, V. M., Nov 7 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 45, p. 16912-16917 6 p.

Research output: Contribution to journalArticle

81 Scopus citations
2003
68 Scopus citations
2002

Cellular oxidant stress and advanced glycation endproducts of albumin: Caveats of the dichlorofluorescein assay

Subramaniam, R., Fan, X., Scivittaro, V., Yang, J., Ha, C. E., Petersen, C. E., Surewicz, W. K., Bhagavan, N. V., Weiss, M. F. & Monnier, V. M., Apr 1 2002, In : Archives of Biochemistry and Biophysics. 400, 1, p. 15-25 11 p., 92776.

Research output: Contribution to journalArticle

33 Scopus citations

Cellular oxidant stress mediated by advanced glycation endproducts: The role of native albumin

Subramaniam, R., Fan, X., Yang, J., Ha, C. E., Petersen, C. E., Bhagavan, N. V., Weiss, M. F. & Monnier, V. M., Nov 1 2002, In : International Congress Series. 1245, C, p. 65-71 7 p.

Research output: Contribution to journalArticle

2001

Determination of human PDGF-B promoter binding nuclear protein by capillary electrophoresis

Fan, X., Liu, J., Jin, Y. X. & Wang, D. B., Jan 1 2001, In : Se pu = Chinese journal of chromatography / Zhongguo hua xue hui. 19, 2, p. 170-172 3 p.

Research output: Contribution to journalArticle

2000

Determination of PyPuPu (PyPuPy) intermolecular triple-stranded DNA by capillary electrophoresis

Fan, X., Liu, J., Tang, H., Jin, Y. & Wang, D. B., 2000, In : Analytical Biochemistry. 287, 1, p. 95-101 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Esterification by microwave irradiation on activated carbon

Fan, X., Yuant, K., Li, N., Tan, G., Yu, X. & Hao, C., Jun 2000, In : Organic Preparations and Procedures International. 32, 3, p. 287-290 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Rapid n-alkylation of carbazole, phenothiazlne and acridone under microwave irradiation

Fan, X., You, J., Jiao, T., Tan, G. & Yu, X., Jan 1 2000, In : Organic Preparations and Procedures International. 32, 3, p. 284-287 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
1999

High performance liquid chromatographic determination of N- nitrosoamines by pre-column fluorescence derivatization with acridone-N- acetyl chloride

You, J., Fan, X., Lao, W., Ou, Q. & Zhu, Q., Jan 1 1999, In : Talanta. 48, 2, p. 437-449 13 p.

Research output: Contribution to journalArticle

24 Scopus citations
2 Scopus citations
1998

Amidated synthesis of one kind of substituted propane catalyzed by PPh 3/NBS

Fan, X., Tan, G., Wang, M. & Yu, X., Dec 1 1998, In : Chemistry Bulletin / Huaxue Tongbao. 5, p. 53-54 2 p.

Research output: Contribution to journalArticle

11 Scopus citations

High-performance liquid chromatographic determination of amino acids by pre-column fluorescence derivatization with three new fluorescent agents

You, J., Fan, X., Ou, Q., Zhu, Q. & Jia, X., Dec 1 1998, In : Fenxi Huaxue. 26, 10, p. 1199-1200 2 p.

Research output: Contribution to journalArticle

17 Scopus citations

Liquid chromatography determination of amino acids by precolumn fluorescence derivatization with acridone-N-acetyl chloride

You, J. M., Fan, X., Ou, Q. Y. & Zhu, Q. C., Dec 1 1998, In : Chinese Chemical Letters. 9, 7, p. 657-660 4 p.

Research output: Contribution to journalArticle

New reagents for determination of amino acids by liquid chromatography with pre-column fluorescence derivatization

Fan, X., You, J., Kang, J., Ou, Q. & Zhu, Q., Jul 3 1998, In : Analytica Chimica Acta. 367, 1-3, p. 81-91 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Progress in microwave-organic reaction enhancement chemistry

Fan, X., You, J., Tan, G., Yu, X. & Jiao, T., Dec 1 1998, In : Progress in Chemistry. 10, 3

Research output: Contribution to journalArticle

4 Scopus citations
1997

HPLC of amino acids and oligopeptides by pre-column fluorescence derivatization with 9-acridine formyl chloride

You, J. M., Fan, X. J. & Ou, Q. Y., Dec 1 1997, In : Chinese Chemical Letters. 8, 10, p. 875-878 4 p.

Research output: Contribution to journalArticle