• 3845 Citations
  • 34 h-Index
19952020

Research output per year

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Research Output

  • 3845 Citations
  • 34 h-Index
  • 52 Article
  • 3 Review article
  • 1 Comment/debate
2020

Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons

Li, C., Meng, F., Garza, J. C., Liu, J., Lei, Y., Kirov, S. A., Guo, M. & Lu, X. Y., Jan 1 2020, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex

Lei, Y., Wang, J., Wang, D., Li, C., Liu, B., Fang, X., You, J., Guo, M. & Lu, X., May 1 2020, In : Molecular Psychiatry. 25, 5, p. 1094-1111 18 p.

Research output: Contribution to journalArticle

7 Scopus citations
2019

Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1

Sun, F., Lei, Y., You, J., Li, C., Sun, L., Garza, J., Zhang, D., Guo, M., Scherer, P. E., Lodge, D. & Lu, X. Y., Jan 1 2019, In : Molecular Psychiatry. 24, 1, p. 126-144 19 p.

Research output: Contribution to journalArticle

10 Scopus citations

Enhancer of zeste homolog 2 (EZH2) regulates adipocyte lipid metabolism independent of adipogenic differentiation: Role of apolipoprotein e

Yiew, N. K. H., Greenway, C., Zarzour, A., Ahmadieh, S., Goo, B., Kim, D., Benson, T. W., Ogbi, M., Tang, Y. L., Chen, W., Stepp, D., Patel, V., Hilton, R., Lu, X. Y., Hui, D. Y., Kim, H. W. & Weintraub, N. L., May 24 2019, In : Journal of Biological Chemistry. 294, 21, p. 8577-8591 15 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Remote Effects of Transplanted Perivascular Adipose Tissue on Endothelial Function and Atherosclerosis

Horimatsu, T., Patel, A. S., Prasad, R., Reid, L. E., Benson, T. W., Zarzour, A., Ogbi, M., Bruder do Nascimento, T., Belin de Chantemele, E., Stansfield, B. K., Lu, X. Y., Kim, H. W. & Weintraub, N. L., Oct 1 2018, In : Cardiovascular Drugs and Therapy. 32, 5, p. 503-510 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors

Zhang, D., Wang, X., Wang, B., Garza, J. C., Fang, X., Wang, J., Scherer, P. E., Brenner, R., Zhang, W. & Lu, X. Y., Jul 1 2017, In : Molecular Psychiatry. 22, 7, p. 1044-1055 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Role of the adipose PPARÎ 3-adiponectin axis in susceptibility to stress and depression/anxiety-related behaviors

Guo, M., Li, C., Lei, Y., Xu, S., Zhao, D. & Lu, X., Jul 1 2017, In : Molecular Psychiatry. 22, 7, p. 1056-1068 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
2016

Adiponectin exerts neurotrophic effects on dendritic arborization, spinogenesis, and neurogenesis of the dentate gyrus of male mice

Zhang, D., Wang, X. & Lu, X. Y., Jul 2016, In : Endocrinology. 157, 7, p. 2853-2869 17 p.

Research output: Contribution to journalArticle

36 Scopus citations

Leptin/LepRb in the ventral tegmental area mediates anxiety-related behaviors

Liu, J., Guo, M. & Lu, X., 2016, In : International Journal of Neuropsychopharmacology. 19, 2, p. 1-11 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Dentate gyrus-CA3 glutamate release/NMDA transmission mediates behavioral despair and antidepressant-like responses to leptin

Wang, X., Zhang, D. & Lu, X. Y., Apr 2 2015, In : Molecular Psychiatry. 20, 4, p. 509-519 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Sex-specific and estrous cycle-dependent antidepressant-like effects and hippocampal Akt signaling of leptin

Carrier, N., Wang, X., Sun, L. & Lu, X. Y., Oct 1 2015, In : Endocrinology. 156, 10, p. 3695-3705 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced b-cell apoptosis

Zhang, J., Zhang, N., Liu, M., Li, X., Zhou, L., Huang, W., Xu, Z., Liu, J., Musi, N., DeFronzo, R. A., Cunningham, J. M., Zhou, Z., Lu, X. & Liu, F., May 10 2014, In : Veterinary Record. 174, 19, p. 3189-3198 10 p.

Research output: Contribution to journalArticle

39 Scopus citations
2013
40 Scopus citations

Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours

Guo, M., Huang, T. Y., Garza, J. C., Chua, S. C. & Lu, X. Y., May 2013, In : International Journal of Neuropsychopharmacology. 16, 4, p. 857-867 11 p.

Research output: Contribution to journalArticle

49 Scopus citations
2012

Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity

Liu, J., Guo, M., Zhang, D., Cheng, S. Y., Liu, M., Ding, J., Scherer, P. E., Liu, F. & Lu, X., Jul 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 30, p. 12248-12253 6 p.

Research output: Contribution to journalArticle

88 Scopus citations

Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis

Zhang, J., Zhang, N., Liu, M., Li, X., Zhou, L., Huang, W., Xu, Z., Liu, J., Musi, N., DeFronzo, R. A., Cunningham, J. M., Zhou, Z., Lu, X. & Liu, F., Dec 1 2012, In : Diabetes. 61, 12, p. 3189-3198 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression

Guo, M., Lu, Y., Garza, J. C., Li, Y., Chua, S. C., Zhang, W., Lu, B. & Lu, X., Mar 15 2012, In : Translational Psychiatry. 2, e83.

Research output: Contribution to journalArticle

50 Scopus citations
123 Scopus citations
2011
89 Scopus citations

Cognitive and neural correlates of depression-like behaviour in socially defeated mice: An animal model of depression with cognitive dysfunction

Yu, T., Guo, M., Garza, J., Rendon, S., Sun, X. L., Zhang, W. & Lu, X., Apr 1 2011, In : International Journal of Neuropsychopharmacology. 14, 3, p. 303-317 15 p.

Research output: Contribution to journalArticle

83 Scopus citations

Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala

Liu, J., Perez, S. M., Zhang, W., Lodge, D. J. & Lu, X., Oct 1 2011, In : Molecular Psychiatry. 16, 10, p. 1024-1038 15 p.

Research output: Contribution to journalArticle

65 Scopus citations
2010

Acute administration of leptin produces anxiolytic-like effects: A comparison with fluoxetine

Liu, J., Garza, J. C., Bronner, J., Kim, C. S., Zhang, W. & Lu, X., Jan 1 2010, In : Psychopharmacology. 207, 4, p. 535-545 11 p.

Research output: Contribution to journalArticle

113 Scopus citations

Loss of polyubiquitin gene Ubb leads to metabolic and sleep abnormalities in mice

Ryu, K. Y., Fujiki, N., Kazantzis, M., Garza, J. C., Bouley, D. M., Stahl, A., Lu, X. Y., Nishino, S. & Kopito, R. R., Jun 2010, In : Neuropathology and Applied Neurobiology. 36, 4, p. 285-299 15 p.

Research output: Contribution to journalArticle

15 Scopus citations

Rapid changes in night eating: Considering mechanisms

Stunkard, A. & Lu, X. Y., Jan 1 2010, In : Eating and Weight Disorders. 15, 1-2, p. e2-e8

Research output: Contribution to journalReview article

11 Scopus citations

Rapid changes in night eating: Considering mechanisms (Eating and Weight Disorders (2010) 15, (e2-e8))

Stunkard, A. & Lu, X., Sep 1 2010, In : Eating and Weight Disorders. 15, 3

Research output: Contribution to journalComment/debate

2008

Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity

Garza, J. C., Kim, C. S., Liu, J., Zhang, W. & Lu, X., Jun 1 2008, In : Journal of Endocrinology. 197, 3, p. 471-482 12 p.

Research output: Contribution to journalArticle

53 Scopus citations

Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene

Ryu, K. Y., Garza, J. C., Lu, X. Y., Barsh, G. S. & Kopito, R. R., Mar 25 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 10, p. 4016-4021 6 p.

Research output: Contribution to journalArticle

64 Scopus citations

Leptin increases adult hippocampal neurogenesis in vivo and in vitro

Garza, J. C., Guo, M., Zhang, W. & Lu, X. Y., Jun 27 2008, In : Journal of Biological Chemistry. 283, 26, p. 18238-18247 10 p.

Research output: Contribution to journalArticle

165 Scopus citations
2007

Genetic analysis of attractin homologs

Walker, W. P., Aradhya, S., Hu, C. L., Shen, S., Zhang, W., Azarani, A., Lu, X. Y., Barsh, G. S. & Gunn, T. M., Dec 2007, In : Genesis. 45, 12, p. 744-756 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

The leptin hypothesis of depression: a potential link between mood disorders and obesity?

Lu, X., Dec 1 2007, In : Current Opinion in Pharmacology. 7, 6, p. 648-652 5 p.

Research output: Contribution to journalReview article

188 Scopus citations

The melanocortinergic pathway is rapidly recruited by emotional stress and contributes to stress-induced anorexia and anxiety-like behavior

Liu, J., Garza, J. C., Truong, H. V., Henschel, J., Zhang, W. & Lu, X., Nov 2007, In : Endocrinology. 148, 11, p. 5531-5540 10 p.

Research output: Contribution to journalArticle

85 Scopus citations

The neuroprotective role of attractin in neurodegeneration

Paz, J., Yao, H., Lim, H. S., Lu, X. Y. & Zhang, W., Sep 1 2007, In : Neurobiology of Aging. 28, 9, p. 1446-1456 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2006

Leptin: A potential novel antidepressant

Lu, X., Kim, C. S., Fraser, A. & Zhang, W., Jan 31 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 5, p. 1593-1598 6 p.

Research output: Contribution to journalArticle

313 Scopus citations
2005

Diurnal rhythmic expression of the rhythm-related genes, rPeriod1, rPeriod2, and rClock, in the rat brain

Shieh, K. R., Yang, S. C., Lu, X. Y., Akil, H. & Watson, S. J., Jan 1 2005, In : Journal of Biomedical Science. 12, 1, p. 209-217 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Relation between the Hypothalamic-Pituitary-Thyroid (HPT) axis and the Hypothalamic-Pituitary-Adrenal (HPA) axis during repeated stress

Helmreich, D. L., Parfitt, D. B., Lu, X. Y., Akil, H. & Watson, S. J., Aug 29 2005, In : Neuroendocrinology. 81, 3, p. 183-192 10 p.

Research output: Contribution to journalArticle

95 Scopus citations
2004

Glucocorticoid receptor overexpression in forebrain: A mouse model of increased emotional lability

Wei, Q., Lu, X., Liu, L., Schafer, G., Shieh, K. R., Burke, S., Robinson, T. E., Watson, S. J., Seasholtz, A. F. & Akil, H., Aug 10 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 32, p. 11851-11856 6 p.

Research output: Contribution to journalArticle

195 Scopus citations

Transcriptional regulation of Agouti-related protein (Agrp) in transgenic mice

Kaelin, C. B., Xu, A. W., Lu, X. Y. & Barsh, G. S., Dec 2004, In : Endocrinology. 145, 12, p. 5798-5806 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
2003

Interaction between α-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses

Lu, X. Y., Barsh, G. S., Akil, H. & Watson, S. J., Aug 27 2003, In : Journal of Neuroscience. 23, 21, p. 7863-7872 10 p.

Research output: Contribution to journalArticle

Open Access
176 Scopus citations

Spongiform degeneration in mahoganoid mutant mice

He, L., Lu, X. Y., Jolly, A. F., Eldridge, A. G., Watson, S. J., Jackson, P. K., Barsh, G. S. & Gunn, T. M., Jan 31 2003, In : Science. 299, 5607, p. 710-712 3 p.

Research output: Contribution to journalArticle

109 Scopus citations
2002

Diurnal rhythm of agouti-related protein and its relation to corticosterone and food intake

Xin-Yun, L. U., Shieh, K. R., Kabbaj, M., Barsh, G. S., Akil, H. & Watson, S. J., Oct 1 2002, In : Endocrinology. 143, 10, p. 3905-3915 11 p.

Research output: Contribution to journalArticle

67 Scopus citations
2001

A biochemical function for attractin in agouti-induced pigmentation and obesity

He, L., Gunn, T. M., Bouley, D. M., Lu, X. Y., Watson, S. J., Schlossman, S. F., Duke-Cohan, J. S. & Barsh, G. S., Jan 20 2001, In : Nature Genetics. 27, 1, p. 40-47 8 p.

Research output: Contribution to journalArticle

110 Scopus citations

Role of central melanocortin signaling in eating disorders.

Lu, X., Sep 1 2001, In : Psychopharmacology Bulletin. 35, 4, p. 45-65 21 p.

Research output: Contribution to journalReview article

20 Scopus citations

Time course of short-term and long-term orexigenic effects of Agouti-related protein (86-132)

Lu, X. Y., Nicholson, J. R., Akil, H. & Watson, S. J., May 8 2001, In : NeuroReport. 12, 6, p. 1281-1284 4 p.

Research output: Contribution to journalArticle

47 Scopus citations
2000

Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting

Lu, X. Y., Bagnol, D., Burke, S., Akil, H. & Watson, S. J., Jun 2000, In : Hormones and Behavior. 37, 4, p. 335-344 10 p.

Research output: Contribution to journalArticle

225 Scopus citations

Neuroendocrine regulation by the Agouti/Agrp-melanocortin system

Barsh, G., Gunn, T., He, L., Wilson, B., Lu, X., Gantz, I. & Watson, S., Jan 1 2000, In : Endocrine Research. 26, 4, 1 p.

Research output: Contribution to journalArticle

9 Scopus citations
1999

Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain.

Bagnol, D., Lu, X., Kaelin, C. B., Day, H. E., Ollmann, M., Gantz, I., Akil, H., Barsh, G. S. & Watson, S. J., Sep 15 1999, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 19, 18, p. RC26

Research output: Contribution to journalArticle

Open Access
267 Scopus citations

Distribution of Mahogany/Attractin mRNA in the rat central nervous system

Lu, X. Y., Gunn, T. M., Shieh, K. R., Barsh, G. S., Akil, H. & Watson, S. J., Nov 26 1999, In : FEBS Letters. 462, 1-2, p. 101-107 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Expression of glutamate receptor subunit/subtype messenger RNAS for NMDAR1, GLuR1, GLuR2 and mGLuR5 by accumbal projection neurons

Lu, X. Y., Behnam Ghasemzadeh, M. & Kalivas, P. W., Jan 8 1999, In : Molecular Brain Research. 63, 2, p. 287-296 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Neuroadaptations in ionotropic and metabotropic glutamate receptor mRNA produced by cocaine treatment

Ghasemzadeh, M. B., Nelson, L. C., Lu, X. Y. & Kalivas, P. W., Jan 11 1999, In : Journal of Neurochemistry. 72, 1, p. 157-165 9 p.

Research output: Contribution to journalArticle

114 Scopus citations