• 3676 Citations
  • 33 h-Index
19952019
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Research Output 1995 2019

  • 3676 Citations
  • 33 h-Index
  • 51 Article
  • 3 Review article
  • 1 Comment/debate
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Article
2019
5 Citations (Scopus)

Adiponectin modulates ventral tegmental area dopamine neuron activity and anxiety-related behavior through AdipoR1

Sun, F., Lei, Y., You, J., Li, C., Sun, L., Garza, J., Zhang, D., Guo, M., Scherer, P. E., Lodge, D. & Lu, X., Jan 1 2019, In : Molecular Psychiatry. 24, 1, p. 126-144 19 p.

Research output: Contribution to journalArticle

Adiponectin Receptors
Ventral Tegmental Area
Dopaminergic Neurons
Adiponectin
Anxiety

Enhancer of zeste homolog 2 (EZH2) regulates adipocyte lipid metabolism independent of adipogenic differentiation: Role of apolipoprotein e

Yiew, N. K. H., Greenway, C., Zarzour, A., Ahmadieh, S., Goo, B., Kim, D., Benson, T. W., Ogbi, M., Tang, Y. L., Chen, W., Stepp, D., Patel, V., Hilton, R., Lu, X. Y., Hui, D. Y., Kim, H. W. & Weintraub, N. L., Jan 1 2019, In : Journal of Biological Chemistry. 294, 21, p. 8577-8591 15 p.

Research output: Contribution to journalArticle

Apolipoproteins
Lipid Metabolism
Adipocytes
Lipids
Lipoproteins
3 Citations (Scopus)
Sirtuin 1
Prosencephalon
Prefrontal Cortex
Synaptic Transmission
Depression
2018
3 Citations (Scopus)

Remote Effects of Transplanted Perivascular Adipose Tissue on Endothelial Function and Atherosclerosis

Horimatsu, T., Patel, A. S., Prasad, R., Reid, L. E., Benson, T. W., Zarzour, A., Ogbi, M., Bruder do Nascimento, T., Belin de Chantemele, E. J., Stansfield, B. K., Lu, X., Kim, H. W. & Weintraub, N. L., Oct 1 2018, In : Cardiovascular Drugs and Therapy. 32, 5, p. 503-510 8 p.

Research output: Contribution to journalArticle

Adipose Tissue
Atherosclerosis
Tissue Transplantation
Abdominal Aorta
Obesity
2017
27 Citations (Scopus)

Adiponectin regulates contextual fear extinction and intrinsic excitability of dentate gyrus granule neurons through AdipoR2 receptors

Zhang, D., Wang, X., Wang, B., Garza, J. C., Fang, X., Wang, J., Scherer, P. E., Brenner, R., Zhang, W. & Lu, X. Y., Jul 1 2017, In : Molecular Psychiatry. 22, 7, p. 1044-1055 12 p.

Research output: Contribution to journalArticle

Adiponectin
Dentate Gyrus
Fear
Neurons
Post-Traumatic Stress Disorders
24 Citations (Scopus)

Role of the adipose PPARÎ 3-adiponectin axis in susceptibility to stress and depression/anxiety-related behaviors

Guo, M., Li, C., Lei, Y., Xu, S., Zhao, D. & Lu, X., Jul 1 2017, In : Molecular Psychiatry. 22, 7, p. 1056-1068 13 p.

Research output: Contribution to journalArticle

rosiglitazone
PPAR gamma
Adiponectin
Anxiety
Depression
2016
29 Citations (Scopus)

Adiponectin exerts neurotrophic effects on dendritic arborization, spinogenesis, and neurogenesis of the dentate gyrus of male mice

Zhang, D., Wang, X. & Lu, X. Y., Jul 2016, In : Endocrinology. 157, 7, p. 2853-2869 17 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Adiponectin
Neurogenesis
Dentate Gyrus
Neurons
13 Citations (Scopus)

Leptin/LepRb in the ventral tegmental area mediates anxiety-related behaviors

Liu, J., Guo, M. & Lu, X., Jan 1 2016, In : International Journal of Neuropsychopharmacology. 19, 2, p. 1-11 11 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Leptin
Anxiety
Anti-Anxiety Agents
Light
2015
20 Citations (Scopus)

Dentate gyrus-CA3 glutamate release/NMDA transmission mediates behavioral despair and antidepressant-like responses to leptin

Wang, X., Zhang, D. & Lu, X. Y., Apr 2 2015, In : Molecular Psychiatry. 20, 4, p. 509-519 11 p.

Research output: Contribution to journalArticle

Hindlimb Suspension
Dentate Gyrus
N-Methylaspartate
Leptin
Antidepressive Agents
5 Citations (Scopus)

Sex-specific and estrous cycle-dependent antidepressant-like effects and hippocampal Akt signaling of leptin

Carrier, N., Wang, X., Sun, L. & Lu, X. Y., Oct 1 2015, In : Endocrinology. 156, 10, p. 3695-3705 11 p.

Research output: Contribution to journalArticle

Estrous Cycle
Leptin
Antidepressive Agents
Depression
Diestrus
2014

Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced b-cell apoptosis

Zhang, J., Zhang, N., Liu, M., Li, X., Zhou, L., Huang, W., Xu, Z., Liu, J., Musi, N., DeFronzo, R. A., Cunningham, J. M., Zhou, Z., Lu, X. & Liu, F., May 10 2014, In : Veterinary Record. 174, 19, p. 3189-3198 10 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
streptozotocin
Streptozocin
pancreas
growth factors
38 Citations (Scopus)
Leptin Receptors
Desipramine
Fluoxetine
Antidepressive Agents
Glycogen Synthase Kinase 3
2013
35 Citations (Scopus)
Receptor, Melanocortin, Type 4
Anorexia
Corticosterone
Amygdala
Psychological Stress
47 Citations (Scopus)

Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours

Guo, M., Huang, T. Y., Garza, J. C., Chua, S. C. & Lu, X. Y., May 1 2013, In : International Journal of Neuropsychopharmacology. 16, 4, p. 857-867 11 p.

Research output: Contribution to journalArticle

Leptin Receptors
Hippocampus
Dependovirus
Depression
Anxiety
2012
80 Citations (Scopus)

Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity

Liu, J., Guo, M., Zhang, D., Cheng, S. Y., Liu, M., Ding, J., Scherer, P. E., Liu, F. & Lu, X., Jul 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 30, p. 12248-12253 6 p.

Research output: Contribution to journalArticle

Adiponectin
Antidepressive Agents
Learned Helplessness
Depression
Anhedonia
22 Citations (Scopus)

Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis

Zhang, J., Zhang, N., Liu, M., Li, X., Zhou, L., Huang, W., Xu, Z., Liu, J., Musi, N., DeFronzo, R. A., Cunningham, J. M., Zhou, Z., Lu, X. & Liu, F., Dec 1 2012, In : Diabetes. 61, 12, p. 3189-3198 10 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Streptozocin
Pancreas
Carrier Proteins
Cell Proliferation
48 Citations (Scopus)

Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression

Guo, M., Lu, Y., Garza, J. C., Li, Y., Chua, S. C., Zhang, W., Lu, B. & Lu, X., Mar 15 2012, In : Translational Psychiatry. 2, e83.

Research output: Contribution to journalArticle

Leptin Receptors
Prosencephalon
Leptin
Long-Term Synaptic Depression
Depression
112 Citations (Scopus)
Glycogen Synthase Kinase 3
Catenins
Neurogenesis
Leptin
Glucocorticoids
2011
82 Citations (Scopus)
Glycogen Synthase Kinase 3
Catenins
Neural Stem Cells
Adiponectin
p38 Mitogen-Activated Protein Kinases
76 Citations (Scopus)

Cognitive and neural correlates of depression-like behaviour in socially defeated mice: An animal model of depression with cognitive dysfunction

Yu, T., Guo, M., Garza, J., Rendon, S., Sun, X. L., Zhang, W. & Lu, X., Apr 1 2011, In : International Journal of Neuropsychopharmacology. 14, 3, p. 303-317 15 p.

Research output: Contribution to journalArticle

Animal Models
Depression
Fear
Anhedonia
Gyrus Cinguli
61 Citations (Scopus)

Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala

Liu, J., Perez, S. M., Zhang, W., Lodge, D. J. & Lu, X., Oct 1 2011, In : Molecular Psychiatry. 16, 10, p. 1024-1038 15 p.

Research output: Contribution to journalArticle

Leptin Receptors
Dopaminergic Neurons
Amygdala
Mesencephalon
Dopamine
2010
107 Citations (Scopus)

Acute administration of leptin produces anxiolytic-like effects: A comparison with fluoxetine

Liu, J., Garza, J. C., Bronner, J., Kim, C. S., Zhang, W. & Lu, X., Jan 1 2010, In : Psychopharmacology. 207, 4, p. 535-545 11 p.

Research output: Contribution to journalArticle

Fluoxetine
Anti-Anxiety Agents
Leptin
Antidepressive Agents
Anxiety
15 Citations (Scopus)

Loss of polyubiquitin gene Ubb leads to metabolic and sleep abnormalities in mice

Ryu, K. Y., Fujiki, N., Kazantzis, M., Garza, J. C., Bouley, D. M., Stahl, A., Lu, X. Y., Nishino, S. & Kopito, R. R., Jun 2010, In : Neuropathology and Applied Neurobiology. 36, 4, p. 285-299 15 p.

Research output: Contribution to journalArticle

Polyubiquitin
Sleep
Ubiquitin
Knockout Mice
Genes
2008
52 Citations (Scopus)

Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity

Garza, J. C., Kim, C. S., Liu, J., Zhang, W. & Lu, X., Jun 1 2008, In : Journal of Endocrinology. 197, 3, p. 471-482 12 p.

Research output: Contribution to journalArticle

Receptor, Melanocortin, Type 4
Hyperphagia
Dependovirus
Paraventricular Hypothalamic Nucleus
High Fat Diet
62 Citations (Scopus)

Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene

Ryu, K. Y., Garza, J. C., Lu, X. Y., Barsh, G. S. & Kopito, R. R., Mar 25 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 10, p. 4016-4021 6 p.

Research output: Contribution to journalArticle

Polyubiquitin
Ubiquitin
Obesity
Genes
Neurons
158 Citations (Scopus)

Leptin increases adult hippocampal neurogenesis in vivo and in vitro

Garza, J. C., Guo, M., Zhang, W. & Lu, X., Jun 27 2008, In : Journal of Biological Chemistry. 283, 26, p. 18238-18247 10 p.

Research output: Contribution to journalArticle

Neurogenesis
Leptin
Stem Cells
Dentate Gyrus
Cell proliferation
2007
13 Citations (Scopus)

Genetic analysis of attractin homologs

Walker, W. P., Aradhya, S., Hu, C. L., Shen, S., Zhang, W., Azarani, A., Lu, X., Barsh, G. S. & Gunn, T. M., Dec 1 2007, In : Genesis. 45, 12, p. 744-756 13 p.

Research output: Contribution to journalArticle

Body Weight
Biological Phenomena
Mutation
Adiposity
Pigmentation
83 Citations (Scopus)

The melanocortinergic pathway is rapidly recruited by emotional stress and contributes to stress-induced anorexia and anxiety-like behavior

Liu, J., Garza, J. C., Truong, H. V., Henschel, J., Zhang, W. & Lu, X., Nov 1 2007, In : Endocrinology. 148, 11, p. 5531-5540 10 p.

Research output: Contribution to journalArticle

Anorexia
Psychological Stress
Anxiety
Agouti-Related Protein
Melanocortin Receptors
23 Citations (Scopus)

The neuroprotective role of attractin in neurodegeneration

Paz, J., Yao, H., Lim, H. S., Lu, X. Y. & Zhang, W., Sep 1 2007, In : Neurobiology of Aging. 28, 9, p. 1446-1456 11 p.

Research output: Contribution to journalArticle

Cell Death
1-Methyl-4-phenylpyridinium
Apoptosis Inducing Factor
Dopaminergic Neurons
Neurotoxins
2006
304 Citations (Scopus)

Leptin: A potential novel antidepressant

Lu, X., Kim, C. S., Fraser, A. & Zhang, W., Jan 31 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 5, p. 1593-1598 6 p.

Research output: Contribution to journalArticle

Leptin
Antidepressive Agents
Hippocampus
Body Weight
Leptin Receptors
2005
33 Citations (Scopus)

Diurnal rhythmic expression of the rhythm-related genes, rPeriod1, rPeriod2, and rClock, in the rat brain

Shieh, K. R., Yang, S. C., Lu, X. Y., Akil, H. & Watson, S. J., Jan 1 2005, In : Journal of Biomedical Science. 12, 1, p. 209-217 9 p.

Research output: Contribution to journalArticle

Rats
Brain
Genes
Messenger RNA
Suprachiasmatic Nucleus
91 Citations (Scopus)

Relation between the Hypothalamic-Pituitary-Thyroid (HPT) axis and the Hypothalamic-Pituitary-Adrenal (HPA) axis during repeated stress

Helmreich, D. L., Parfitt, D. B., Lu, X., Akil, H. & Watson, S. J., Aug 29 2005, In : Neuroendocrinology. 81, 3, p. 183-192 10 p.

Research output: Contribution to journalArticle

Agouti-Related Protein
Corticosterone
Thyroid Gland
Messenger RNA
Foot
2004
185 Citations (Scopus)

Glucocorticoid receptor overexpression in forebrain: A mouse model of increased emotional lability

Wei, Q., Lu, X., Liu, L., Schafer, G., Shieh, K. R., Burke, S., Robinson, T. E., Watson, S. J., Seasholtz, A. F. & Akil, H., Aug 10 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 32, p. 11851-11856 6 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Prosencephalon
Norepinephrine Plasma Membrane Transport Proteins
Gene Expression
Serotonin Plasma Membrane Transport Proteins
34 Citations (Scopus)

Transcriptional regulation of Agouti-related protein (Agrp) in transgenic mice

Kaelin, C. B., Xu, A. W., Lu, X. Y. & Barsh, G. S., Dec 1 2004, In : Endocrinology. 145, 12, p. 5798-5806 9 p.

Research output: Contribution to journalArticle

Agouti-Related Protein
Transgenic Mice
Bacterial Artificial Chromosomes
Neurons
Food Deprivation
2003
173 Citations (Scopus)

Interaction between α-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses

Lu, X. Y., Barsh, G. S., Akil, H. & Watson, S. J., Aug 27 2003, In : Journal of Neuroscience. 23, 21, p. 7863-7872 10 p.

Research output: Contribution to journalArticle

Melanocyte-Stimulating Hormones
Corticotropin-Releasing Hormone
Melanocortins
Paraventricular Hypothalamic Nucleus
Receptor, Melanocortin, Type 4
108 Citations (Scopus)

Spongiform degeneration in mahoganoid mutant mice

He, L., Lu, X. Y., Jolly, A. F., Eldridge, A. G., Watson, S. J., Jackson, P. K., Barsh, G. S. & Gunn, T. M., Jan 31 2003, In : Science. 299, 5607, p. 710-712 3 p.

Research output: Contribution to journalArticle

Mutation
Phenotype
Prion Diseases
Ubiquitin-Protein Ligases
Genes
2002
66 Citations (Scopus)

Diurnal rhythm of agouti-related protein and its relation to corticosterone and food intake

Xin-Yun, L. U., Shieh, K. R., Kabbaj, M., Barsh, G. S., Akil, H. & Watson, S. J., Oct 1 2002, In : Endocrinology. 143, 10, p. 3905-3915 11 p.

Research output: Contribution to journalArticle

Agouti-Related Protein
Corticosterone
Circadian Rhythm
Eating
Messenger RNA
2001
109 Citations (Scopus)

A biochemical function for attractin in agouti-induced pigmentation and obesity

He, L., Gunn, T. M., Bouley, D. M., Lu, X., Watson, S. J., Schlossman, S. F., Duke-Cohan, J. S. & Barsh, G. S., Jan 20 2001, In : Nature Genetics. 27, 1, p. 40-47 8 p.

Research output: Contribution to journalArticle

Pigmentation
Agouti Signaling Protein
Agouti-Related Protein
Obesity
Paracrine Communication
47 Citations (Scopus)

Time course of short-term and long-term orexigenic effects of Agouti-related protein (86-132)

Lu, X. Y., Nicholson, J. R., Akil, H. & Watson, S. J., May 8 2001, In : NeuroReport. 12, 6, p. 1281-1284 4 p.

Research output: Contribution to journalArticle

Agouti-Related Protein
Curriculum
Eating
Melanocortin Receptors
Intraventricular Infusions
2000
217 Citations (Scopus)

Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting

Lu, X. Y., Bagnol, D., Burke, S., Akil, H. & Watson, S. J., Jun 2000, In : Hormones and Behavior. 37, 4, p. 335-344 10 p.

Research output: Contribution to journalArticle

Orexin Receptors
Fasting
Messenger RNA
Brain
Amygdala
8 Citations (Scopus)

Neuroendocrine regulation by the Agouti/Agrp-melanocortin system

Barsh, G., Gunn, T., He, L., Wilson, B., Lu, X., Gantz, I. & Watson, S., Jan 1 2000, In : Endocrine Research. 26, 4, 1 p.

Research output: Contribution to journalArticle

Paracrine Communication
Melanocortins
Melanocyte-Stimulating Hormones
Neurosecretory Systems
Intercellular Signaling Peptides and Proteins
1999
261 Citations (Scopus)

Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain.

Bagnol, D., Lu, X., Kaelin, C. B., Day, H. E., Ollmann, M., Gantz, I., Akil, H., Barsh, G. S. & Watson, S. J., Jan 1 1999, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 19, 18

Research output: Contribution to journalArticle

Agouti-Related Protein
Melanocortins
Pro-Opiomelanocortin
Receptor, Melanocortin, Type 3
Anatomy
35 Citations (Scopus)

Distribution of Mahogany/Attractin mRNA in the rat central nervous system

Lu, X. Y., Gunn, T. M., Shieh, K. R., Barsh, G. S., Akil, H. & Watson, S. J., Nov 26 1999, In : FEBS Letters. 462, 1-2, p. 101-107 7 p.

Research output: Contribution to journalArticle

Neurology
Rats
Central Nervous System
Genes
Messenger RNA
29 Citations (Scopus)

Expression of glutamate receptor subunit/subtype messenger RNAS for NMDAR1, GLuR1, GLuR2 and mGLuR5 by accumbal projection neurons

Lu, X., Behnam Ghasemzadeh, M. & Kalivas, P. W., Jan 8 1999, In : Molecular Brain Research. 63, 2, p. 287-296 10 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Ventral Tegmental Area
Neurons
Nucleus Accumbens
Messenger RNA
114 Citations (Scopus)

Neuroadaptations in ionotropic and metabotropic glutamate receptor mRNA produced by cocaine treatment

Ghasemzadeh, M. B., Nelson, L. C., Lu, X. & Kalivas, P. W., Jan 11 1999, In : Journal of Neurochemistry. 72, 1, p. 157-165 9 p.

Research output: Contribution to journalArticle

Ionotropic Glutamate Receptors
Metabotropic Glutamate Receptors
Cocaine
Messenger RNA
Nucleus Accumbens
39 Citations (Scopus)

Regional distribution and cellular localization of γ-aminobutyric acid subtype 1 receptor mRNA in the rat brain

Lu, X. Y., Ghasemzadeh, M. B. & Kalivas, P. W., May 3 1999, In : Journal of Comparative Neurology. 407, 2, p. 166-182 17 p.

Research output: Contribution to journalArticle

Aminobutyrates
GABA Receptors
Neurons
Messenger RNA
Brain
1997
213 Citations (Scopus)

Expression of D1 receptor, D2 receptor, substance P and enkephalin messenger RNAs in the neurons projecting from the nucleus accumbens

Lu, X., Ghasemzadeh, M. B. & Kalivas, P. W., Oct 24 1997, In : Neuroscience. 82, 3, p. 767-780 14 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Enkephalins
Nucleus Accumbens
Ventral Tegmental Area
Neurons
75 Citations (Scopus)

Expression of D1 receptor mRNA in projections from the forebrain to the ventral tegmental area

Lu, X., Churchill, L. & Kalivas, P. W., Feb 1 1997, In : Synapse. 25, 2, p. 205-214 10 p.

Research output: Contribution to journalArticle

Ventral Tegmental Area
Prosencephalon
Messenger RNA
Nucleus Accumbens
Prefrontal Cortex
1995
4 Citations (Scopus)
Angiotensin Receptors
Freezing
Angiotensin II
Rats
Tissue
14 Citations (Scopus)

Pharmacological characterization of angiotensin II AT2 receptor subtype heterogeneity in the rat adrenal cortex and medulla

Lu, X., Grove, K. L., Zhang, W. & Speth, R. C., Apr 1 1995, In : Endocrine. 3, 4, p. 255-261 7 p.

Research output: Contribution to journalArticle

Angiotensin Type 2 Receptor
Angiotensin Receptors
Adrenal Medulla
Adrenal Cortex
Binding Sites