• 2411 Citations
  • 24 h-Index
1989 …2020

Research output per year

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Research Output

  • 2411 Citations
  • 24 h-Index
  • 40 Article
  • 9 Review article
  • 3 Comment/debate
  • 1 Chapter
2020

Engineering T cells for immunotherapy of primary human hepatocellular carcinoma

Caraballo Galva, L. D., Cai, L., Shao, Y. & He, Y., Jan 20 2020, In : Journal of Genetics and Genomics. 47, 1, p. 1-15 15 p.

Research output: Contribution to journalReview article

2019

Vaccinia virus-mediated cancer immunotherapy: Cancer vaccines and oncolytics

Guo, Z. S., Lu, B., Guo, Z., Giehl, E., Feist, M., Dai, E., Liu, W., Storkus, W. J., He, Y., Liu, Z. & Bartlett, D. L., Jan 9 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, 6.

Research output: Contribution to journalReview article

14 Scopus citations
2018

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B. H., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

28 Scopus citations

Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice

Wang, Z., He, Y., Deng, W., Lang, L., Yang, H., Jin, B., Kolhe, R. B., Ding, H., Zhang, J., Hai, T. & Yan, C., Jan 4 2018, In : Oncogene. 37, 1, p. 18-27 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy

Cai, J., Li, R., Xu, X., Zhang, L., Lian, R., Fang, L., Huang, Y., Feng, X., Liu, X., Li, X., Zhu, X., Zhang, H., Wu, J., Zeng, M., Song, E., He, Y., Yin, Y., Li, J. & Li, M., Apr 1 2018, In : Nature Cell Biology. 20, 4, p. 465-478 14 p.

Research output: Contribution to journalArticle

19 Scopus citations

Erratum: Publisher Correction: Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC (Nature communications (2017) 8 (15870))

Cai, J., Fang, L., Huang, Y., Li, R., Xu, X., Hu, Z., Zhang, L., Yang, Y., Zhu, X., Zhang, H., Wu, J., Huang, Y., Li, J., Zeng, M., Song, E., He, Y., Zhang, L. & Li, M., Mar 30 2018, In : Nature communications. 9, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Harnessing the CD8+ T-cell subsets with stemness for tumor immunotherapy

Wang, W., He, Y. & Wu, S., Oct 2018, In : Future Oncology. 14, 24, p. 2433-2436 4 p.

Research output: Contribution to journalReview article

Identification of α-fetoprotein-specific T-cell receptors for hepatocellular carcinoma immunotherapy

Zhu, W., Peng, Y., Wang, L., Hong, Y., Jiang, X., Li, Q., Liu, H., Huang, L., Wu, J., Celis, E., Merchen, T. D., Kruse, E. J. & He, Y., Aug 2018, In : Hepatology. 68, 2, p. 574-589 16 p.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Simultaneous overactivation of Wnt/β-catenin and TGFβ signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

Zhang, L., Cai, J., Fang, L., Huang, Y., Li, R., Xu, X., Hu, Z., Zhang, L., Yang, Y., Zhu, X., Zhang, H., Wu, J., Huang, Y., Li, J., Zeng, M., Song, E., He, Y. & Li, M., Jun 19 2017, In : Nature communications. 8, 15870.

Research output: Contribution to journalArticle

56 Scopus citations

The antitumor effects of vaccine-activated CD8+ T cells associate with weak TCR signaling and induction of stem-like memory T cells

Wu, S., Zhu, W., Peng, Y., Wang, L., Hong, Y., Huang, L., Dong, D., Xie, J., Merchen, T. D., Kruse, E. J., Guo, Z. S., Bartlett, D., Fu, N. & He, Y., Oct 2017, In : Cancer Immunology Research. 5, 10, p. 908-919 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2016

Deletion of LRP5 and LRP6 in dendritic cells enhances antitumor immunity

Hong, Y., Manoharan, I., Suryawanshi, A., Shanmugam, A., Swafford, D., Ahmad, S., Chinnadurai, R., Manicassamy, B., He, Y., Mellor, A. L., Thangaraju, M., Munn, D. H. & Manicassamy, S., Apr 2 2016, In : OncoImmunology. 5, 4

Research output: Contribution to journalArticle

24 Scopus citations

Engineering alpha-fetoprotein to develop vaccines and T cell immunotherapies for hepatocellular carcinoma: From preclinical studies to future perspectives

He, Y. & Wu, S., Jan 1 2016, Alpha-Fetoprotein: Functions and Clinical Applications. Nova Science Publishers, Inc., p. 375-391 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

Epstein-Barr virus-induced gene 3-deficiency leads to impaired antitumor T-cell responses and accelerated tumor growth

Liu, Z., Liu, J. Q., Shi, Y., Zhu, X., Liu, Z., Li, M. S., Yu, J., Wu, L. C., He, Y., Zhang, G. & Bai, X. F., Jan 1 2015, In : OncoImmunology. 4, 7, p. 1-10 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2014

Engineering α-fetoprotein-based gene vaccines to prevent and treat hepatocellular carcinoma: Review and future prospects

He, Y., Hong, Y. & Mizejewski, G. J., Jan 1 2014, In : Immunotherapy. 6, 6, p. 725-736 12 p.

Research output: Contribution to journalReview article

10 Scopus citations

Epitope-optimized alpha-fetoprotein genetic vaccines prevent carcinogen-induced murine autochthonous hepatocellular carcinoma

Hong, Y., Peng, Y., Guo, Z. S., Guevara-Patino, J., Pang, J., Butterfield, L. H., Mivechi, N. F., Munn, D. H., Bartlett, D. L. & He, Y., Apr 2014, In : Hepatology. 59, 4, p. 1448-1458 11 p.

Research output: Contribution to journalArticle

25 Scopus citations
2013

Local administration of TLR ligands rescues the function of tumor-infiltrating CD8 T cells and enhances the antitumor effect of lentivector immunization

Xiao, H., Peng, Y., Hong, Y., Huang, L., Guo, Z. S., Bartlett, D. L., Fu, N., Munn, D. H., Mellor, A. & He, Y., Jun 1 2013, In : Journal of Immunology. 190, 11, p. 5866-5873 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Oncolytic viruses as therapeutic cancer vaccines

Bartlett, D. L., Liu, Z., Sathaiah, M., Ravindranathan, R., Guo, Z., He, Y. & Guo, Z. S., Sep 11 2013, In : Molecular cancer. 12, 1, 103.

Research output: Contribution to journalReview article

160 Scopus citations
2012

Immunoglobulin Fc fragment tagging allows strong activation of endogenous CD4 T cells to reshape the tumor milieu and enhance the antitumor effect of lentivector immunization

Hong, Y., Peng, Y., Xiao, H., Mi, C., Munn, D. & He, Y., May 15 2012, In : Journal of Immunology. 188, 10, p. 4819-4827 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Melanoma cell expression of CD200 inhibits tumor formation and lung metastasis via inhibition of myeloid cell functions

Talebian, F., Liu, J. Q., Liu, Z., Khattabi, M., He, Y., Ganju, R. & Bai, X. F., Feb 3 2012, In : PloS one. 7, 2, e31442.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Induction of antitumor immune responses with recombinant lentivector: Role of skin derived DCs

Zhou, Q. & He, Y., Nov 1 2011, In : Current Cancer Therapy Reviews. 7, 4, p. 261-266 6 p.

Research output: Contribution to journalReview article

Lentivector expressing HBsAG and immunoglobulin Fc fusion antigen induces potent immune responses and results in seroconversion in HBsAG transgenic mice

Hong, Y., Peng, Y., Mi, M., Xiao, H., Munn, D. H., Wang, G. Q. & He, Y., May 17 2011, In : Vaccine. 29, 22, p. 3909-3916 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Lentivector prime and vaccinia virus vector boost generate high-quality CD8 memory T cells and prevent autochthonous mouse melanoma

Xiao, H., Peng, Y., Hong, Y., Liu, Y., Guo, Z. S., Bartlett, D. L., Fu, N. & He, Y., Aug 15 2011, In : Journal of Immunology. 187, 4, p. 1788-1796 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
2010

Blockade of programmed death-1 pathway rescues the effector function of tumor-infiltrating T cells and enhances the antitumor efficacy of lentivector immunization

Zhou, Q., Xiao, H., Liu, Y., Peng, Y., Hong, Y., Yagita, H., Chandler, P., Munn, D. H., Mellor, A., Fu, N. & He, Y., Nov 1 2010, In : Journal of Immunology. 185, 9, p. 5082-5092 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Reprogrammed Foxp3+ Regulatory T Cells Provide Essential Help to Support Cross-presentation and CD8+ T Cell Priming in Naive Mice

Sharma, M. D., Hou, D. Y., Baban, B., Koni, P. A., He, Y., Chandler, P. R., Blazar, B. R., Mellor, A. L. & Munn, D. H., Dec 14 2010, In : Immunity. 33, 6, p. 942-954 13 p.

Research output: Contribution to journalArticle

134 Scopus citations
2009

Gadd45b and Gadd45g are important for anti-tumor immune responses

Ju, S., Zhu, Y., Liu, L., Dai, S., Li, C., Chen, E., He, Y., Zhang, X. & Lu, B., Nov 1 2009, In : European Journal of Immunology. 39, 11, p. 3010-3018 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes

Sharma, M. D., Hou, D. Y., Liu, Y., Koni, P. A., Metz, R., Chandler, P., Mellor, A. L., He, Y. & Munn, D. H., Nov 19 2009, In : Blood. 113, 24, p. 6102-6111 10 p.

Research output: Contribution to journalArticle

260 Scopus citations

Lentivector immunization stimulates potent CD8 T cell responses against melanoma self-antigen tyrosinase-related protein 1 and generates antitumor immunity in mice

Liu, Y., Peng, Y., Mi, M., Guevara-Patino, J., Munn, D. H., Fu, N. & He, Y., May 15 2009, In : Journal of Immunology. 182, 10, p. 5960-5969 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2008

Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma

Piao, G. H., Piao, W. H., He, Y., Zhang, H. H., Wang, G. Q. & Piao, Z., Dec 1 2008, In : Histology and Histopathology. 23, 10, p. 1171-1175 5 p.

Research output: Contribution to journalArticle

19 Scopus citations
2007

Lentivirus as a potent and mechanistically distinct vector for genetic immunization

He, Y. & Falo, L. D., Oct 19 2007, In : Current Opinion in Molecular Therapeutics. 9, 5, p. 439-446 8 p.

Research output: Contribution to journalReview article

31 Scopus citations

Mechanisms of the actions of interferons

Zhu, Y. F. & He, Y., Jan 1 2007, In : Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. 15, 11, p. 845-846 2 p.

Research output: Contribution to journalArticle

Recombinant lentivector as a genetic immunization vehicle for antitumor immunity

He, Y., Munn, D. & Falo, L. D., Dec 1 2007, In : Expert Review of Vaccines. 6, 6, p. 913-924 12 p.

Research output: Contribution to journalReview article

23 Scopus citations
2006

Induction of T cell immunity by cutaneous genetic immunization with recombinant lentivector

He, Y. & Falo, L. D., Sep 1 2006, In : Immunologic Research. 36, 1-3, p. 101-117 17 p.

Research output: Contribution to journalReview article

11 Scopus citations

Phagocytosis induces lysosome remodeling and regulated presentation of particulate antigens by activated dendritic cells

Nayak, J. V., Hokey, D. A., Larregina, A., He, Y., Salter, R. D., Watkins, S. C. & Falo, L. D., Dec 15 2006, In : Journal of Immunology. 177, 12, p. 8493-8503 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Skin-Derived Dendritic Cells Induce Potent CD8+ T Cell Immunity in Recombinant Lentivector-Mediated Genetic Immunization

He, Y., Zhang, J., Donahue, C. & Falo, L. D., May 1 2006, In : Immunity. 24, 5, p. 643-656 14 p.

Research output: Contribution to journalArticle

148 Scopus citations
2005

Immunization with lentiviral vector-transduced dendritic cells induces strong and long-lasting T cell responses and therapeutic immunity

He, Y., Zhang, J., Mi, Z., Robbins, P. & Falo, L. D., Mar 15 2005, In : Journal of Immunology. 174, 6, p. 3808-3817 10 p.

Research output: Contribution to journalArticle

117 Scopus citations

Inhibition of HIV derived lentiviral production by TAR RNA binding domain of TAT protein

Mi, M. Y., Zhang, J. & He, Y., Nov 17 2005, In : Retrovirology. 2, 71.

Research output: Contribution to journalArticle

5 Scopus citations
2002

Systemic administration of naked DNA encoding interleukin 12 for the treatment of human papillomavirus DNA-positive tumor

Lui, V. W. Y., He, Y., Falo, L. & Huang, L., Mar 4 2002, In : Human Gene Therapy. 13, 2, p. 177-185 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
2001

Regression of human mammary adenocarcinoma by systemic administration of a recombinant gene encoding the hFlex-TRAIL fusion protein

Wu, X., He, Y., Falo, L. D., Hui, K. M. & Huang, L., Jan 1 2001, In : Molecular Therapy. 3, 3, p. 368-374 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Specific down-regulation of HER-2/neu mediated by a chimeric U6 hammerhead ribozyme results in growth inhibition of human ovarian carcinoma

Lui, V. W. Y., He, Y., Goyaland, K. & Huang, L., Jan 1 2001, In : Molecular Therapy. 3, 2, p. 169-177 9 p.

Research output: Contribution to journalArticle

27 Scopus citations
2000

Constitutive activation of stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

Grandis, J. R., Drenning, S. D., Zeng, Q., Watkins, S. C., Melhem, M. F., Endo, S., Johnson, D. E., Huang, L., He, Y. & Kim, J. D., Apr 11 2000, In : Proceedings of the National Academy of Sciences of the United States of America. 97, 8, p. 4227-4232 6 p.

Research output: Contribution to journalArticle

524 Scopus citations

Intravenous injection of naked DNA encoding secreted flt3 ligand dramatically increases the number of dendritic cells and natural killer cells in vivo

He, Y., Pimenov, A. A., Nayak, J. V., Plowey, J., Falo, L. D. & Huang, L., Mar 16 2000, In : Human Gene Therapy. 11, 4, p. 547-554 8 p.

Research output: Contribution to journalArticle

67 Scopus citations

TGF-α antisense gene therapy inhibits head and neck squamous cell carcinoma growth in vivo

Endo, S., Zeng, Q., Burke, N. A., He, Y., Melhem, M. F., Watkins, S. F., Lango, M. N., Drenning, S. D., Huang, L. & Rubin Grandis, J., Jan 1 2000, In : Gene Therapy. 7, 22, p. 1906-1914 9 p.

Research output: Contribution to journalArticle

37 Scopus citations
1999

A novel T7 RNA polymerase autogene for efficient cytoplasmic expression of target genes

Brisson, M., He, Y., Li, S., Yang, J. P. & Huang, L., Feb 1 1999, In : Gene Therapy. 6, 2, p. 263-270 8 p.

Research output: Contribution to journalArticle

45 Scopus citations
1998

Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter

He, Y., Zeng, Q., Drenning, S. D., Melhem, M. F., Tweardy, D. J., Huang, L. & Grandis, J. R., Jul 15 1998, In : Journal of the National Cancer Institute. 90, 14, p. 1080-1087 8 p.

Research output: Contribution to journalArticle

123 Scopus citations

Potentiation of E7 antisense RNA-induced antitumor immunity by co-delivery of IL-12 gene in HPV16 DNA-positive mouse tumor

He, Y., Lui, V. W. Y., Baar, J., Wang, L., Shurin, M., Almonte, C., Watkins, S. C. & Huang, L., Jan 1 1998, In : Gene Therapy. 5, 11, p. 1462-1471 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
1997

Delivery of a PCR amplified DNA fragment into cells: A model for using synthetic genes for gene therapy

Li, S., Brisson, M., He, Y. & Huang, L., Jan 1 1997, In : Gene Therapy. 4, 5, p. 449-454 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Growth inhibition of human papillomavirus 16 DNA-positive mouse tumor by antisense RNA transcribed from U6 promoter

He, Y. & Huang, L., Sep 15 1997, In : Cancer Research. 57, 18, p. 3993-3999 7 p.

Research output: Contribution to journalArticle

34 Scopus citations
1996

Novel HPV types present in oral papillomatous lesions from patients with HIV infection

Völter, C., He, Y., Delius, H., Roy-Burman, A., Greenspan, J. S., Greenspan, D. & De Villiers, E. M., May 16 1996, In : International Journal of Cancer. 66, 4, p. 453-456 4 p.

Research output: Contribution to journalArticle

82 Scopus citations