• 2988 Citations
  • 27 h-Index
1989 …2020

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Article
2020

Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling

He, Y., Zuo, C., Jia, D., Bai, P., Kong, D., Chen, D., Liu, G., Li, J., Wang, Y., Chen, G., Yan, S., Xiao, B., Zhang, J., Piao, L., Li, Y., Deng, Y., Li, B., Roux, P. P., Andreasson, K. I., Breyer, R. M. & 5 others, Su, Y., Wang, J., Lyu, A., Shen, Y. & Yu, Y., May 15 2020, In : American journal of respiratory and critical care medicine. 201, 10, p. 1263-1276 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia

Wang, L., Cao, Y., Gorshkov, B., Zhou, Y., Yang, Q., Xu, J., Ma, Q., Zhang, X., Wang, J., Mao, X., Zeng, X., Su, Y., Verin, A. D., Hong, M., Liu, Z. & Huo, Y., Aug 2019, In : Pharmacological Research. 146, 104292.

Research output: Contribution to journalArticle

2 Scopus citations

Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis

Barman, S. A., Li, X., Haigh, S., Kondrikov, D., Mahboubi, K., Bordan, Z., Stepp, D. W., Zhou, J., Wang, Y., Weintraub, D. S., Traber, P., Snider, W., Jonigk, D., Sullivan, J., Ryan Crislip, G., Butcher, J. T., Thompson, J., Su, Y., Chen, F. & Fulton, D. J. R., May 2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 316, 5, p. L784-L797

Research output: Contribution to journalArticle

5 Scopus citations

PFKFB3 in smooth muscle promotes vascular remodeling in pulmonary arterial hypertension

Kovacs, L., Cao, Y., Han, W., Meadows, L., Kovacs-Kasa, A., Kondrikov, D., Verin, A. D., Barman, S. A., Dong, Z., Huo, Y. & Su, Y., Sep 1 2019, In : American journal of respiratory and critical care medicine. 200, 5, p. 617-627 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension

Cao, Y., Zhang, X., Wang, L., Yang, Q., Ma, Q., Xu, J., Wang, J., Kovacs, L., Ayon, R. J., Liu, Z., Zhang, M., Zhou, Y., Zeng, X., Xu, Y., Wang, Y., Fulton, D. J., Weintraub, N. L., Lucas, R., Dong, Z., Yuan, J. X. J. & 8 others, Sullivan, J. C., Meadows, L., Barman, S. A., Wu, C., Quan, J., Hong, M., Su, Y. & Huo, Y., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 27, p. 13394-13403 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
1 Scopus citations
2018

Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells

Liu, J., Livingston, M. J., Dong, G., Tang, C., Su, Y., Wu, G., Yin, X. M. & Dong, Z., Mar 1 2018, In : Cell Death and Disease. 9, 3, 322.

Research output: Contribution to journalArticle

24 Scopus citations

Hsp70 suppresses mitochondrial reactive oxygen species and preserves pulmonary microvascular barrier integrity following exposure to bacterial toxins

Li, X., Yu, Y., Gorshkov, B., Haigh, S., Bordan, Z., Weintraub, D., Rudic, R. D., Chakraborty, T., Barman, S. A., Verin, A. D., Su, Y., Lucas, R., Stepp, D. W., Chen, F. & Fulton, D. J., Jun 12 2018, In : Frontiers in immunology. 9, JUN, 1309.

Research output: Contribution to journalArticle

11 Scopus citations

Inhibition of angiotensin II and calpain attenuates pleural fibrosis

Song, L. J., Xiang, F., Ye, H., Huang, H., Yang, J., Yu, F., Xiong, L., Xu, J. J., Greer, P. A., Shi, H. Z., Xin, J. B., Su, Y. & Ma, W. L., Feb 2018, In : Pulmonary Pharmacology and Therapeutics. 48, p. 46-52 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle

Luo, X., Xue, L., Xu, H., Zhao, Q. Y., Wang, Q., She, Y. S., Zang, D. A., Shen, J., Peng, Y. B., Zhao, P., Yu, M. F., Chen, W., Ma, L. Q., Chen, S., Chen, S., Fu, X., Hu, S., Nie, X., Shen, C., Zou, C. & 7 others, Qin, G., Dai, J., Ji, G., Su, Y., Hu, S., Chen, J. & Liu, Q. H., Dec 1 2018, In : Scientific reports. 8, 1, 3114.

Research output: Contribution to journalArticle

6 Scopus citations
2017
5 Scopus citations

Calpain-activated mTORC2/Akt pathway mediates airway smooth muscle remodelling in asthma

Rao, S. S., Mu, Q., Zeng, Y., Cai, P. C., Liu, F., Yang, J., Xia, Y., Zhang, Q., Song, L. J., Zhou, L. L., Li, F. Z., Lin, Y. X., Fang, J., Greer, P. A., Shi, H. Z., Ma, W. L., Su, Y. & Ye, H., Feb 1 2017, In : Clinical and Experimental Allergy. 47, 2, p. 176-189 14 p.

Research output: Contribution to journalArticle

12 Scopus citations
8 Scopus citations

Epithelial sodium channel-α mediates the protective effect of the TNF-derived TIP peptide in pneumolysin-induced endothelial barrier dysfunction

Czikora, I., Alli, A. A., Sridhar, S., Matthay, M. A., Pillich, H., Hudel, M., Berisha, B., Gorshkov, B. A., Romero Lucas, M. J., Gonzales, J. N., Wu, G., Huo, Y., Su, Y., Verin, A. D., Fulton, D. J., Chakraborty, T., Eaton, D. C. & Lucas, R., Jul 21 2017, In : Frontiers in immunology. 8, JUL, 842.

Research output: Contribution to journalArticle

12 Scopus citations

Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6

Hao, J., Wei, Q., Mei, S., Li, L., Su, Y., Mei, C. & Dong, Z., Jan 1 2017, In : Kidney International. 91, 1, p. 106-118 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

miR-18a-5p Inhibits Sub-pleural Pulmonary Fibrosis by Targeting TGF-β Receptor II

Zhang, Q., Ye, H., Xiang, F., Song, L. J., Zhou, L. L., Cai, P. C., Zhang, J. C., Yu, F., Shi, H. Z., Su, Y., Xin, J. B. & Ma, W. L., Mar 1 2017, In : Molecular Therapy. 25, 3, p. 728-738 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4/signal transducer and activator of transcription 6/transcription factor EC/IL-4 receptor α positive feedback loop in M2 macrophages

Wang, Y., Zhu, J., Zhang, L., Zhang, Z., He, L., Mou, Y., Deng, Y., Cao, Y., Yang, P., Su, Y., Zhao, J., Zhang, S., Yu, Q., Hu, J., Chen, Z., Ning, Q., Xiang, X., Xu, Y., Wang, C. Y. & Xiong, W., Dec 2017, In : Journal of Allergy and Clinical Immunology. 140, 6, p. 1550-1561.e8

Research output: Contribution to journalArticle

23 Scopus citations

The GTPase Rab43 Controls the Anterograde ER-Golgi Trafficking and Sorting of GPCRs

Li, C., Wei, Z., Fan, Y., Huang, W., Su, Y., Li, H., Dong, Z., Fukuda, M., Khater, M. & Wu, G., Oct 24 2017, In : Cell Reports. 21, 4, p. 1089-1101 13 p.

Research output: Contribution to journalArticle

15 Scopus citations
2016

Activation of calpain-2 by mediators in pulmonary vascular remodeling of pulmonary arterial hypertension

Kovacs, L., Han, W., Rafikov, R., Bagi, Z., Offermanns, S., Saido, T. C., Black, S. M. & Su, Y., Mar 2016, In : American journal of respiratory cell and molecular biology. 54, 3, p. 384-393 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Activation of calpain by renin-angiotensin system in pleural mesothelial cells mediates tuberculous pleural fibrosis

Yang, J., Xiang, F., Cai, P. C., Lu, Y. Z., Xu, X. X., Yu, F., Li, F. Z., Greer, P. A., Shi, H. Z., Zhou, Q., Xin, J. B., Ye, H., Su, Y. & Ma, W. L., Jul 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 311, 1, p. L145-L153

Research output: Contribution to journalArticle

10 Scopus citations

Calpain-2 activates Akt via TGF-β1-mTORC2 pathway in pulmonary artery smooth muscle cells

Abeyrathna, P., Kovacs, L., Han, W. & Su, Y., Jul 1 2016, In : American Journal of Physiology - Cell Physiology. 311, 1, p. C24-C34

Research output: Contribution to journalArticle

10 Scopus citations

Chop deficiency protects mice against bleomycin-induced pulmonary fibrosis by attenuating M2 macrophage production

Yao, Y., Wang, Y., Zhang, Z., He, L., Zhu, J., Zhang, M., He, X., Cheng, Z., Ao, Q., Cao, Y., Yang, P., Su, Y., Zhao, J., Zhang, S., Yu, Q., Ning, Q., Xiang, X., Xiong, W., Wang, C. Y. & Xu, Y., May 1 2016, In : Molecular Therapy. 24, 5, p. 915-925 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Preexisting smooth muscle cells contribute to neointimal cell repopulation at an incidence varying widely among individual lesions

Yang, P., Hong, M. S., Fu, C., Schmit, B. M., Su, Y., Berceli, S. A. & Jiang, Z., Feb 1 2016, In : Surgery (United States). 159, 2, p. 602-612 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Bleomycin induced epithelial-mesenchymal transition (EMT) in pleural mesothelial cells

Chen, L. J., Ye, H., Zhang, Q., Li, F. Z., Song, L. J., Yang, J., Mu, Q., Rao, S. S., Cai, P. C., Xiang, F., Zhang, J. C., Su, Y., Xin, J. B. & Ma, W. L., Mar 1 2015, In : Toxicology and Applied Pharmacology. 283, 2, p. 75-82 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

CAT-1 as a novel CAM stabilizes endothelial integrity and mediates the protective actions of l-Arg via a NO-independent mechanism

Guo, L., Tian, S., Chen, Y., Mao, Y., Cui, S., Hu, A., Zhang, J., Xia, S. L., Su, Y., Du, J., Block, E. R., Wang, X. L. & Cui, Z., Oct 1 2015, In : Journal of molecular and cellular cardiology. 87, p. 180-191 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Crosstalk between calpain activation and TGF-β1 augments collagen-I synthesis in pulmonary fibrosis

Li, F. Z., Cai, P. C., Song, L. J., Zhou, L. L., Zhang, Q., Rao, S. S., Xia, Y., Xiang, F., Xin, J. B., Greer, P. A., Shi, H. Z., Su, Y., Ma, W. L. & Ye, H., Sep 1 2015, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 9, p. 1796-1804 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling

Lu, A., Zuo, C., He, Y., Chen, G., Piao, L., Zhang, J., Xiao, B., Shen, Y., Tang, J., Kong, D., Alberti, S., Chen, D., Zuo, S., Zhang, Q., Yan, S., Fei, X., Yuan, F., Zhou, B., Duan, S., Yu, Y. & 5 others, Lazarus, M., Su, Y., Breyer, R. M., Funk, C. D. & Yu, Y., Mar 2 2015, In : Journal of Clinical Investigation. 125, 3, p. 1228-1242 15 p.

Research output: Contribution to journalArticle

37 Scopus citations
8 Scopus citations
69 Scopus citations

Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways

Wang, S., Livingston, M. J., Su, Y. & Dong, Z., Jan 1 2015, In : Autophagy. 11, 4, p. 607-616 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

SUMOylation occurs in acute kidney injury and plays a cytoprotective role

Guo, C., Wei, Q., Su, Y. & Dong, Z., Mar 1 2015, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 3, p. 482-489 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Toll-like receptor 4 signaling inhibits malignant pleural effusion by altering Th1/Th17 responses

Xu, Q. Q., Zhou, Q., Xu, L. L., Lin, H., Wang, X. J., Ma, W. L., Zhai, K., Tong, Z. H., Su, Y. & Shi, H. Z., Oct 1 2015, In : Cell Biology International. 39, 10, p. 1120-1130 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2014

Caveolin-1 is a negative regulator of NADPH oxidase-derived reactive oxygen species

Chen, F., Barman, S., Yu, Y., Haigh, S., Wang, Y., Dou, H., Bagi, Z., Han, W., Su, Y. & Fulton, D. J. R., Aug 2014, In : Free Radical Biology and Medicine. 73, p. 201-213 13 p.

Research output: Contribution to journalArticle

43 Scopus citations

Cotinine concentration in serum correlates with tobacco smoke-induced emphysema in mice

Xu, X., Su, Y. & Fan, Z. H., Jan 27 2014, In : Scientific reports. 4, 3864.

Research output: Contribution to journalArticle

7 Scopus citations

Dissociation of FK506-binding protein 12.6 kD from ryanodine receptor in bronchial smooth muscle cells in airway hyperresponsiveness in asthma

Du, Y., Zhao, J., Li, X., Jin, S., Ma, W. L., Mu, Q., Xu, S., Yang, J., Rao, S., Zhu, L., Xin, J., Cai, P. C., Su, Y. & Ye, H., Feb 1 2014, In : American journal of respiratory cell and molecular biology. 50, 2, p. 398-408 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Endothelial PFKFB3 plays a critical role in angiogenesis

Xu, Y., An, X., Guo, X., Habtetsion, T. G., Wang, Y., Xu, X., Kandala, S., Li, Q., Li, H., Zhang, C., Caldwell, R. B., Fulton, D. J., Su, Y., Hoda, MD. N., Zhou, G., Wu, C. & Huo, Y., Jun 2014, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 6, p. 1231-1239 9 p.

Research output: Contribution to journalArticle

93 Scopus citations

Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase

Sun, X., Kumar, S., Sharma, S., Aggarwal, S., Lu, Q., Gross, C., Rafikova, O., Lee, S. G., Dasarathy, S., Hou, Y., Meadows, M. L., Han, W., Su, Y., Fineman, J. R. & Black, S. M., Jun 2014, In : American journal of respiratory cell and molecular biology. 50, 6, p. 1084-1095 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Increasing muscle mass improves vascular function in obese (DB/DB) Mice

Qiu, S., Mintz, J. D., Salet, C. D., Han, W., Giannis, A., Chen, F., Yu, Y., Su, Y., Fulton, D. J. & Stepp, D. W., Jan 1 2014, In : Journal of the American Heart Association. 3, 3, 000854.

Research output: Contribution to journalArticle

17 Scopus citations

NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling

Barman, S. A., Chen, F., Su, Y., Dimitropoulou, C., Wang, Y., Catravas, J. D., Han, W., Orfi, L., Szantai-Kis, C., Keri, G., Szabadkai, I., Barabutis, N., Rafikova, O., Rafikov, R., Black, S. M., Jonigk, D., Giannis, A., Asmis, R., Stepp, D. W., Ramesh, G. & 1 others, Fulton, D. J., Aug 2014, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 8, p. 1704-1715 12 p.

Research output: Contribution to journalArticle

72 Scopus citations

Novel peptide for attenuation of hyperoxia-induced disruption of lung endothelial barrier and pulmonary edema via modulating peroxynitrite formation

Kondrikov, D., Gross, C., Black, S. M. & Su, Y., Nov 28 2014, In : Journal of Biological Chemistry. 289, 48, p. 33355-33363 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Regulation of endothelial nitric oxide synthase activity by protein-protein interaction

Su, Y., Jan 1 2014, In : Current Pharmaceutical Design. 20, 22, p. 3514-3520 7 p.

Research output: Contribution to journalArticle

19 Scopus citations
2013

Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function

Toque, H. A., Nunes, K. P., Yao, L., Xu, Z., Kondrikov, D., Su, Y., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Jan 1 2013, In : PloS one. 8, 8, p. e72277

Research output: Contribution to journalArticle

20 Scopus citations

SUMO1 regulates endothelial function by modulating the overall signals in favor of angiogenesis and homeostatic responses

Yang, P., Zhang, Y., Xu, J., Zhang, S., Yu, Q., Pang, J., Rao, X., Kuczma, M., Marrero, M. B., Fulton, D. J., Kraj, P., Su, Y. & Wang, C. Y., Jan 1 2013, In : American Journal of Translational Research. 5, 4, p. 427-440 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

The role of RhoA and cytoskeleton in myofibroblast transformation in hyperoxic lung fibrosis

Ni, J., Dong, Z., Han, W., Kondrikov, D. & Su, Y., Apr 25 2013, In : Free Radical Biology and Medicine. 61, p. 26-39 14 p.

Research output: Contribution to journalArticle

23 Scopus citations
2012

Autophagy in proximal tubules protects against acute kidney injury

Jiang, M., Wei, Q., Dong, G., Komatsu, M., Su, Y. & Dong, Z., Dec 2 2012, In : Kidney International. 82, 12, p. 1271-1283 13 p.

Research output: Contribution to journalArticle

249 Scopus citations

Calpain 2-dependent IκBα degradation mediates CPT-11 secondary resistance in colorectal cancer xenografts

Fenouille, N., Grosso, S., Su, Y., Didier, M., Pontier-Bres, R., Imbert, V., Czerucka, D., Caroli-Bosc, F. X., Peyron, J. F. & Lagadec, P., May 2012, In : Journal of Pathology. 227, 1, p. 118-129 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
2011

Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease

Ma, W., Han, W., Greer, P. A., Tuder, R. M., Toque, H. A., Wang, K. K. W., Caldwell, R. W. & Su, Y., Nov 1 2011, In : Journal of Clinical Investigation. 121, 11, p. 4548-4566 19 p.

Research output: Contribution to journalArticle

70 Scopus citations

Collagen IV contributes to nitric oxide-induced angiogenesis of lung endothelial cells

Wang, H. & Su, Y., May 1 2011, In : American Journal of Physiology - Cell Physiology. 300, 5, p. C979-C988

Research output: Contribution to journalArticle

12 Scopus citations
38 Scopus citations