• 3089 Citations
  • 29 h-Index
1989 …2020

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Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia

Wang, L., Cao, Y., Gorshkov, B., Zhou, Y., Yang, Q., Xu, J., Ma, Q., Zhang, X., Wang, J., Mao, X., Zeng, X., Su, Y., Verin, A. D., Hong, M., Liu, Z. & Huo, Y., Aug 2019, In : Pharmacological Research. 146, 104292.

Research output: Contribution to journalArticle

3 Scopus citations

Activation of calpain-2 by mediators in pulmonary vascular remodeling of pulmonary arterial hypertension

Kovacs, L., Han, W., Rafikov, R., Bagi, Z., Offermanns, S., Saido, T. C., Black, S. M. & Su, Y., Mar 2016, In : American journal of respiratory cell and molecular biology. 54, 3, p. 384-393 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Activation of calpain by renin-angiotensin system in pleural mesothelial cells mediates tuberculous pleural fibrosis

Yang, J., Xiang, F., Cai, P. C., Lu, Y. Z., Xu, X. X., Yu, F., Li, F. Z., Greer, P. A., Shi, H. Z., Zhou, Q., Xin, J. B., Ye, H., Su, Y. & Ma, W. L., Jul 1 2016, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 311, 1, p. L145-L153

Research output: Contribution to journalArticle

11 Scopus citations

Acute hypoxia increases intracellular L-arginine content in cultured porcine pulmonary artery enclothelial cells

Su, Y. & Block, E. R., May 1996, In : Journal of Cellular Physiology. 167, 2, p. 349-353 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function

Toque, H. A., Nunes, K. P., Yao, L., Xu, Z., Kondrikov, D., Su, Y., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., 2013, In : PloS one. 8, 8, p. e72277

Research output: Contribution to journalArticle

20 Scopus citations

Autophagy in proximal tubules protects against acute kidney injury

Jiang, M., Wei, Q., Dong, G., Komatsu, M., Su, Y. & Dong, Z., Dec 2 2012, In : Kidney International. 82, 12, p. 1271-1283 13 p.

Research output: Contribution to journalArticle

259 Scopus citations

Bleomycin induced epithelial-mesenchymal transition (EMT) in pleural mesothelial cells

Chen, L. J., Ye, H., Zhang, Q., Li, F. Z., Song, L. J., Yang, J., Mu, Q., Rao, S. S., Cai, P. C., Xiang, F., Zhang, J. C., Su, Y., Xin, J. B. & Ma, W. L., Mar 1 2015, In : Toxicology and Applied Pharmacology. 283, 2, p. 75-82 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
6 Scopus citations

Calpain-2 activates Akt via TGF-β1-mTORC2 pathway in pulmonary artery smooth muscle cells

Abeyrathna, P., Kovacs, L., Han, W. & Su, Y., Jul 1 2016, In : American Journal of Physiology - Cell Physiology. 311, 1, p. C24-C34

Research output: Contribution to journalArticle

10 Scopus citations

Calpain 2-dependent IκBα degradation mediates CPT-11 secondary resistance in colorectal cancer xenografts

Fenouille, N., Grosso, S., Su, Y., Didier, M., Pontier-Bres, R., Imbert, V., Czerucka, D., Caroli-Bosc, F. X., Peyron, J. F. & Lagadec, P., May 2012, In : Journal of Pathology. 227, 1, p. 118-129 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Calpain-2 regulation of VEGF-mediated angiogenesis

Su, Y., Cui, Z., Li, Z. & Block, E. R., Jul 2006, In : FASEB Journal. 20, 9, p. 1443-1451 9 p.

Research output: Contribution to journalArticle

64 Scopus citations

Calpain-activated mTORC2/Akt pathway mediates airway smooth muscle remodelling in asthma

Rao, S. S., Mu, Q., Zeng, Y., Cai, P. C., Liu, F., Yang, J., Xia, Y., Zhang, Q., Song, L. J., Zhou, L. L., Li, F. Z., Lin, Y. X., Fang, J., Greer, P. A., Shi, H. Z., Ma, W. L., Su, Y. & Ye, H., Feb 1 2017, In : Clinical and Experimental Allergy. 47, 2, p. 176-189 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease

Ma, W., Han, W., Greer, P. A., Tuder, R. M., Toque, H. A., Wang, K. K. W., Caldwell, R. W. & Su, Y., Nov 1 2011, In : Journal of Clinical Investigation. 121, 11, p. 4548-4566 19 p.

Research output: Contribution to journalArticle

71 Scopus citations

CAT-1 as a novel CAM stabilizes endothelial integrity and mediates the protective actions of l-Arg via a NO-independent mechanism

Guo, L., Tian, S., Chen, Y., Mao, Y., Cui, S., Hu, A., Zhang, J., Xia, S. L., Su, Y., Du, J., Block, E. R., Wang, X. L. & Cui, Z., Oct 1 2015, In : Journal of molecular and cellular cardiology. 87, p. 180-191 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Caveolin-1 is a negative regulator of NADPH oxidase-derived reactive oxygen species

Chen, F., Barman, S., Yu, Y., Haigh, S., Wang, Y., Dou, H., Bagi, Z., Han, W., Su, Y. & Fulton, D. J. R., Aug 2014, In : Free Radical Biology and Medicine. 73, p. 201-213 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

cGMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor of the soluble guanylyl cyclase

Moro, M. A., Russell, R. J., Cellek, S., Lizasoain, I., Su, Y., Darley-Usmar, V. M., Radomski, M. W. & Moncada, S., Feb 20 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 4, p. 1480-1485 6 p.

Research output: Contribution to journalArticle

403 Scopus citations

Chop deficiency protects mice against bleomycin-induced pulmonary fibrosis by attenuating M2 macrophage production

Yao, Y., Wang, Y., Zhang, Z., He, L., Zhu, J., Zhang, M., He, X., Cheng, Z., Ao, Q., Cao, Y., Yang, P., Su, Y., Zhao, J., Zhang, S., Yu, Q., Ning, Q., Xiang, X., Xiong, W., Wang, C. Y. & Xu, Y., May 1 2016, In : Molecular Therapy. 24, 5, p. 915-925 11 p.

Research output: Contribution to journalArticle

53 Scopus citations

Cigarette smoke extract inhibits angiogenesis of pulmonary artery endothelial cells: The role of calpain

Su, Y., Cao, W., Han, Z. & Block, E. R., Oct 2004, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 287, 4 31-4, p. L794-L800

Research output: Contribution to journalArticle

48 Scopus citations

Collagen IV contributes to nitric oxide-induced angiogenesis of lung endothelial cells

Wang, H. & Su, Y., May 2011, In : American Journal of Physiology - Cell Physiology. 300, 5, p. C979-C988

Research output: Contribution to journalArticle

14 Scopus citations

Cotinine concentration in serum correlates with tobacco smoke-induced emphysema in mice

Xu, X., Su, Y. & Fan, Z. H., Jan 27 2014, In : Scientific reports. 4, 3864.

Research output: Contribution to journalArticle

7 Scopus citations

Crosstalk between calpain activation and TGF-β1 augments collagen-I synthesis in pulmonary fibrosis

Li, F. Z., Cai, P. C., Song, L. J., Zhou, L. L., Zhang, Q., Rao, S. S., Xia, Y., Xiang, F., Xin, J. B., Greer, P. A., Shi, H. Z., Su, Y., Ma, W. L. & Ye, H., Sep 1 2015, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1852, 9, p. 1796-1804 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Dissociation of FK506-binding protein 12.6 kD from ryanodine receptor in bronchial smooth muscle cells in airway hyperresponsiveness in asthma

Du, Y., Zhao, J., Li, X., Jin, S., Ma, W. L., Mu, Q., Xu, S., Yang, J., Rao, S., Zhu, L., Xin, J., Cai, P. C., Su, Y. & Ye, H., Feb 2014, In : American journal of respiratory cell and molecular biology. 50, 2, p. 398-408 11 p.

Research output: Contribution to journalArticle

8 Scopus citations
8 Scopus citations

Effect of cigarette smoke extract on nitric oxide synthase in pulmonary artery endothelial cells

Su, Y., Han, W., Giraldo, C., De Li, Y. & Block, E. R., 1998, In : American journal of respiratory cell and molecular biology. 19, 5, p. 819-825 7 p.

Research output: Contribution to journalArticle

270 Scopus citations
1 Scopus citations
2 Scopus citations

Endothelial PFKFB3 plays a critical role in angiogenesis

Xu, Y., An, X., Guo, X., Habtetsion, T. G., Wang, Y., Xu, X., Kandala, S., Li, Q., Li, H., Zhang, C., Caldwell, R. B., Fulton, D. J., Su, Y., Hoda, MD. N., Zhou, G., Wu, C. & Huo, Y., Jun 2014, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 6, p. 1231-1239 9 p.

Research output: Contribution to journalArticle

95 Scopus citations

Endothelin-1 induces a glycolytic switch in pulmonary arterial endothelial cells via the mitochondrial translocation of endothelial nitric oxide synthase

Sun, X., Kumar, S., Sharma, S., Aggarwal, S., Lu, Q., Gross, C., Rafikova, O., Lee, S. G., Dasarathy, S., Hou, Y., Meadows, M. L., Han, W., Su, Y., Fineman, J. R. & Black, S. M., Jun 2014, In : American journal of respiratory cell and molecular biology. 50, 6, p. 1084-1095 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

eNOS-β-actin interaction contributes to increased peroxynitrite formation during hyperoxia in pulmonary artery endothelial cells and mouse lungs

Kondrikov, D., Elms, S., Fulton, D. & Su, Y., Nov 12 2010, In : Journal of Biological Chemistry. 285, 46, p. 35479-35487 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling

Lu, A., Zuo, C., He, Y., Chen, G., Piao, L., Zhang, J., Xiao, B., Shen, Y., Tang, J., Kong, D., Alberti, S., Chen, D., Zuo, S., Zhang, Q., Yan, S., Fei, X., Yuan, F., Zhou, B., Duan, S., Yu, Y. & 5 others, Lazarus, M., Su, Y., Breyer, R. M., Funk, C. D. & Yu, Y., Mar 2 2015, In : Journal of Clinical Investigation. 125, 3, p. 1228-1242 15 p.

Research output: Contribution to journalArticle

39 Scopus citations

Epithelial sodium channel-α mediates the protective effect of the TNF-derived TIP peptide in pneumolysin-induced endothelial barrier dysfunction

Czikora, I., Alli, A. A., Sridhar, S., Matthay, M. A., Pillich, H., Hudel, M., Berisha, B., Gorshkov, B. A., Romero Lucas, M. J., Gonzales, J. N., Wu, G., Huo, Y., Su, Y., Verin, A. D., Fulton, D. J., Chakraborty, T., Eaton, D. C. & Lucas, R., Jul 21 2017, In : Frontiers in immunology. 8, JUL, 842.

Research output: Contribution to journalArticle

13 Scopus citations

Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis

Barman, S. A., Li, X., Haigh, S., Kondrikov, D., Mahboubi, K., Bordan, Z., Stepp, D. W., Zhou, J., Wang, Y., Weintraub, D. S., Traber, P., Snider, W., Jonigk, D., Sullivan, J., Ryan Crislip, G., Butcher, J. T., Thompson, J., Su, Y., Chen, F. & Fulton, D. J. R., May 2019, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 316, 5, p. L784-L797

Research output: Contribution to journalArticle

7 Scopus citations
28 Scopus citations
9 Scopus citations
39 Scopus citations

Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells

Liu, J., Livingston, M. J., Dong, G., Tang, C., Su, Y., Wu, G., Yin, X. M. & Dong, Z., Mar 1 2018, In : Cell Death and Disease. 9, 3, 322.

Research output: Contribution to journalArticle

25 Scopus citations

Hsp70 suppresses mitochondrial reactive oxygen species and preserves pulmonary microvascular barrier integrity following exposure to bacterial toxins

Li, X., Yu, Y., Gorshkov, B., Haigh, S., Bordan, Z., Weintraub, D., Rudic, R. D., Chakraborty, T., Barman, S. A., Verin, A. D., Su, Y., Lucas, R., Stepp, D. W., Chen, F. & Fulton, D. J., Jun 12 2018, In : Frontiers in immunology. 9, JUN, 1309.

Research output: Contribution to journalArticle

11 Scopus citations

Hydrogen sulfide ameliorates tobacco smoke-induced oxidative stress and emphysema in mice

Han, W., Dong, Z., Dimitropoulou, C. & Su, Y., Oct 15 2011, In : Antioxidants and Redox Signaling. 15, 8, p. 2121-2134 14 p.

Research output: Contribution to journalArticle

67 Scopus citations
71 Scopus citations
35 Scopus citations
8 Scopus citations

Increasing muscle mass improves vascular function in obese (DB/DB) Mice

Qiu, S., Mintz, J. D., Salet, C. D., Han, W., Giannis, A., Chen, F., Yu, Y., Su, Y., Fulton, D. J. & Stepp, D. W., 2014, In : Journal of the American Heart Association. 3, 3, 000854.

Research output: Contribution to journalArticle

17 Scopus citations

Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6

Hao, J., Wei, Q., Mei, S., Li, L., Su, Y., Mei, C. & Dong, Z., Jan 1 2017, In : Kidney International. 91, 1, p. 106-118 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Inhibition of angiotensin II and calpain attenuates pleural fibrosis

Song, L. J., Xiang, F., Ye, H., Huang, H., Yang, J., Yu, F., Xiong, L., Xu, J. J., Greer, P. A., Shi, H. Z., Xin, J. B., Su, Y. & Ma, W. L., Feb 2018, In : Pulmonary Pharmacology and Therapeutics. 48, p. 46-52 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Involvement of calpain-calpastatin in cigarette smoke-induced inhibition of lung endothelial nitric oxide synthase

Cui, Z., Han, Z., Li, Z., Hu, H., Patel, J. M., Antony, V., Block, E. R. & Su, Y., Nov 2005, In : American journal of respiratory cell and molecular biology. 33, 5, p. 513-520 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling

He, Y., Zuo, C., Jia, D., Bai, P., Kong, D., Chen, D., Liu, G., Li, J., Wang, Y., Chen, G., Yan, S., Xiao, B., Zhang, J., Piao, L., Li, Y., Deng, Y., Li, B., Roux, P. P., Andreasson, K. I., Breyer, R. M. & 5 others, Su, Y., Wang, J., Lyu, A., Shen, Y. & Yu, Y., May 15 2020, In : American journal of respiratory and critical care medicine. 201, 10, p. 1263-1276 14 p.

Research output: Contribution to journalArticle

1 Scopus citations

miR-18a-5p Inhibits Sub-pleural Pulmonary Fibrosis by Targeting TGF-β Receptor II

Zhang, Q., Ye, H., Xiang, F., Song, L. J., Zhou, L. L., Cai, P. C., Zhang, J. C., Yu, F., Shi, H. Z., Su, Y., Xin, J. B. & Ma, W. L., Mar 1 2017, In : Molecular Therapy. 25, 3, p. 728-738 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP)

Wang, C. Y., Shi, J. D., Yang, P., Kumar, P. G., Li, Q. Z., Run, Q. G., Su, Y. C., Scott, H. S., Kao, K. J. & She, J. X., Mar 13 2003, In : Gene. 306, 1-2, p. 37-44 8 p.

Research output: Contribution to journalArticle

72 Scopus citations

NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling

Barman, S. A., Chen, F., Su, Y., Dimitropoulou, C., Wang, Y., Catravas, J. D., Han, W., Orfi, L., Szantai-Kis, C., Keri, G., Szabadkai, I., Barabutis, N., Rafikova, O., Rafikov, R., Black, S. M., Jonigk, D., Giannis, A., Asmis, R., Stepp, D. W., Ramesh, G. & 1 others, Fulton, D. J., Aug 2014, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 8, p. 1704-1715 12 p.

Research output: Contribution to journalArticle

73 Scopus citations

Novel peptide for attenuation of hyperoxia-induced disruption of lung endothelial barrier and pulmonary edema via modulating peroxynitrite formation

Kondrikov, D., Gross, C., Black, S. M. & Su, Y., Nov 28 2014, In : Journal of Biological Chemistry. 289, 48, p. 33355-33363 9 p.

Research output: Contribution to journalArticle

7 Scopus citations