Yutaka Itokazu

Senior Research Scientist

  • 2098 Citations
  • 16 h-Index
20002019
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Research Output 2000 2019

  • 2098 Citations
  • 16 h-Index
  • 26 Article
  • 3 Chapter
  • 2 Review article
  • 1 Comment/debate
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Article
2019
Open Access
Intraventricular Infusions
Adult Stem Cells
Neural Stem Cells
Gangliosides
Brain
2018
14 Citations (Scopus)

Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes

Kong, J. N., Zhu, Z., Itokazu, Y., Wang, G., Dinkins, M. B., Zhong, L., Lin, H. P., Elsherbini, A., Leanhart, S., Jiang, X., Qin, H., Zhi, W., Spassieva, S. D. & Bieberich, E., Jan 1 2018, In : Journal of Lipid Research. 59, 3, p. 488-506 19 p.

Research output: Contribution to journalArticle

Ceramides
Astrocytes
Adenosine Triphosphate
Tubulin
Mitochondria
2016
2 Citations (Scopus)

A2B5+/GFAP+ Cells of Rat Spinal Cord Share a Similar Lipid Profile with Progenitor Cells: A Comparative Lipidomic Study

Itokazu, Y., Tajima, N., Kerosuo, L., Somerharju, P., Sariola, H., Yu, R. K. & Käkelä, R., Jul 1 2016, In : Neurochemical Research. 41, 7, p. 1527-1544 18 p.

Research output: Contribution to journalArticle

Glial Fibrillary Acidic Protein
Rats
Spinal Cord
Stem Cells
Cells
13 Citations (Scopus)

GM1 ganglioside is involved in epigenetic activation loci of neuronal cells

Tsai, Y. T., Itokazu, Y. & Yu, R. K., Oct 24 2016, In : Neurochemical Research. 41, 1-2, p. 107-115 9 p.

Research output: Contribution to journalArticle

G(M1) Ganglioside
Epigenomics
Histones
Gangliosides
Genes
2015
5 Citations (Scopus)

Ganglioside-dependent neural stem cell proliferation in alzheimer’s disease model mice

Koon, N. A., Itokazu, Y. & Yu, R. K., Nov 9 2015, In : ASN Neuro. 7, 6

Research output: Contribution to journalArticle

Neural Stem Cells
Gangliosides
Alzheimer Disease
Cell Proliferation
Glycoconjugates
7 Citations (Scopus)

Novel GM1 ganglioside-like peptide mimics prevent the association of cholera toxin to human intestinal epithelial cells in vitro

Yu, R. K., Usuki, S., Itokazu, Y. & Wu, H. C., Jun 11 2015, In : Glycobiology. 26, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

G(M1) Ganglioside
Cholera Toxin
Epithelial Cells
Peptides
Vibrio cholerae
2014
16 Citations (Scopus)
Fucosyltransferases
Neural Stem Cells
Amyloid
Up-Regulation
Peptides
2 Citations (Scopus)

Gill tissue lipids of salmon (Salmo salar L.) presmolts and smolts from anadromous and landlocked populations

Itokazu, Y., Käkelä, R., Piironen, J., Guan, X. L., Kiiskinen, P. & Vornanen, M., Jan 1 2014, In : Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 172, p. 39-45 7 p.

Research output: Contribution to journalArticle

Salmo salar
Salmon
Phosphatidylcholines
Tissue
Lipids

Glycolipid and glycoprotein expression during neural development

Yu, R. K. & Itokazu, Y., 2014, In : Advances in neurobiology. 9, p. 185-222 38 p.

Research output: Contribution to journalArticle

Neural Tube
Neural Crest
Glycolipids
Neurology
Glycoproteins
23 Citations (Scopus)

Reduced GM1 ganglioside in CFTR-deficient human airway cells results in decreased β1-integrin signaling and delayed wound repair

Itokazu, Y., Pagano, R. E., Schroeder, A. S., O'Grady, S. M., Limper, A. H. & Marks, D. L., May 1 2014, In : American Journal of Physiology - Cell Physiology. 306, 9, p. C819-C830

Research output: Contribution to journalArticle

G(M1) Ganglioside
Integrins
Wounds and Injuries
Sphingolipids
Glycosphingolipids
2013
15 Citations (Scopus)

Brain gangliosides of a transgenic mouse model of Alzheimer's disease with deficiency in GD3-synthase: Expression of elevated levels of a cholinergic-specific ganglioside, GT1aα

Ariga, T., Itokazu, Y., McDonald, M. P., Hirabayashi, Y., Ando, S. & Yu, R. K., Aug 7 2013, In : ASN Neuro. 5, 2, p. 141-148 8 p.

Research output: Contribution to journalArticle

Gangliosides
Cholinergic Agents
Transgenic Mice
Alzheimer Disease
Brain
10 Citations (Scopus)

Effects of amyloid β-peptides and gangliosides on mouse neural stem cells

Itokazu, Y., Kato-Negishi, M., Nakatani, Y., Ariga, T. & Yu, R. K., Oct 1 2013, In : Neurochemical Research. 38, 10, p. 2019-2027 9 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Gangliosides
Stem cells
Amyloid
Peptides
2011
31 Citations (Scopus)

Activity of BKCa channel is modulated by membrane cholesterol content and association with Na+/K+-ATPase in human melanoma IGR39 cells

Tajima, N., Itokazu, Y., Korpi, E. R., Somerharju, P. & Käkelä, R., Feb 18 2011, In : Journal of Biological Chemistry. 286, 7, p. 5624-5638 15 p.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Melanoma
Cholesterol
Membranes
Large-Conductance Calcium-Activated Potassium Channels
2010
81 Citations (Scopus)

Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration

Wakao, S., Hayashi, T., Kitada, M., Kohama, M., Matsue, D., Teramoto, N., Ose, T., Itokazu, Y., Koshino, K., Watabe, H., Iida, H., Takamoto, T., Tabata, Y. & Dezawa, M., Jun 1 2010, In : Experimental Neurology. 223, 2, p. 537-547 11 p.

Research output: Contribution to journalArticle

Nerve Regeneration
Schwann Cells
Cell Transplantation
Mesenchymal Stromal Cells
Peripheral Nerves
13 Citations (Scopus)

Transplantation of cultured choroid plexus epithelial cells via cerebrospinal fluid shows prominent neuroprotective effects against acute ischemic brain injury in the rat

Matsumoto, N., Taguchi, A., Kitayama, H., Watanabe, Y., Ohta, M., Yoshihara, T., Itokazu, Y., Dezawa, M., Suzuki, Y., Sugimoto, H., Noda, M. & Ide, C., Jan 29 2010, In : Neuroscience Letters. 469, 3, p. 283-288 6 p.

Research output: Contribution to journalArticle

Choroid Plexus
Neuroprotective Agents
Brain Injuries
Cerebrospinal Fluid
Transplantation
2009
73 Citations (Scopus)

Committed neural progenitor cells derived from genetically modified bone marrow stromal cells ameliorate deficits in a rat model of stroke

Hayase, M., Kitada, M., Wakao, S., Itokazu, Y., Nozaki, K., Hashimoto, N., Takagi, Y. & Dezawa, M., Aug 1 2009, In : Journal of Cerebral Blood Flow and Metabolism. 29, 8, p. 1409-1420 12 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Stromal Cells
Stem Cells
Stroke
Bone Marrow
123 Citations (Scopus)

Isolation and characterization of patient-derived, toxic, high mass Amyloid β-protein (Aβ) assembly from Alzheimer disease brains

Noguchi, A., Matsumura, S., Dezawa, M., Tada, M., Yanazawa, M., Ito, A., Akioka, M., Kikuchi, S., Sato, M., Noda, M., Fukunari, A., Muramatsu, S. I., Itokazu, Y., Sato, K., Takahashi, H., Teplow, D. B., Nabeshima, Y. I., Kakita, A., Imahori, K. & Hoshi, M., Nov 20 2009, In : Journal of Biological Chemistry. 284, 47, p. 32895-32905 11 p.

Research output: Contribution to journalArticle

Patient Isolation
Serum Amyloid A Protein
Poisons
Brain
Alzheimer Disease
2007
52 Citations (Scopus)

Neuroprotective effect of bone marrow-derived mononuclear cells promoting functional recovery from spinal cord injury

Yoshihara, T., Ohta, M., Itokazu, Y., Matsumoto, N., Dezawa, M., Suzuki, Y., Taguchi, A., Watanabe, Y., Adachi, Y., Ikehara, S., Sugimoto, H. & Ide, C., Jun 1 2007, In : Journal of Neurotrauma. 24, 6, p. 1026-1036 11 p.

Research output: Contribution to journalArticle

Neuroprotective Agents
Spinal Cord Injuries
Bone Marrow
Cerebrospinal Fluid
Cell Transplantation
120 Citations (Scopus)

Peripheral nerve regeneration by the in vitro differentiated-human bone marrow stromal cells with Schwann cell property

Shimizu, S., Kitada, M., Ishikawa, H., Itokazu, Y., Wakao, S. & Dezawa, M., Aug 10 2007, In : Biochemical and Biophysical Research Communications. 359, 4, p. 915-920 6 p.

Research output: Contribution to journalArticle

Nerve Regeneration
Schwann Cells
Mesenchymal Stromal Cells
Peripheral Nerves
Stromal Cells
2006
36 Citations (Scopus)

Choroid plexus ependymal cells host neural progenitor cells in the rat

Itokazu, Y., Kitada, M., Dezawa, M., Mizoguchi, A., Matsumoto, N., Shimizu, A. & Ide, C., Jan 1 2006, In : Glia. 53, 1, p. 32-42 11 p.

Research output: Contribution to journalArticle

Choroid Plexus
Stem Cells
Glial Fibrillary Acidic Protein
Fibroblast Growth Factor 2
Epidermal Growth Factor
19 Citations (Scopus)

Effects of vibration and hyaluronic acid on activation of three-dimensional cultured chondrocytes

Takeuchi, R., Saito, T., Ishikawa, H., Takigami, H., Dezawa, M., Ide, C., Itokazu, Y., Ikeda, M., Shiraishi, T. & Morishita, S., Jun 1 2006, In : Arthritis and Rheumatism. 54, 6, p. 1897-1905 9 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Chondrocytes
Vibration
Chondroitin Sulfates
Porifera
2005
25 Citations (Scopus)

Conditioned medium of the primary culture of rat choroid plexus epithelial (modified ependymal) cells enhances neurite outgrowth and survival of hippocampal neurons

Watanabe, Y., Matsumoto, N., Dezawa, M., Itokazu, Y., Yoshihara, T. & Ide, C., May 13 2005, In : Neuroscience Letters. 379, 3, p. 158-163 6 p.

Research output: Contribution to journalArticle

Choroid Plexus
Conditioned Culture Medium
Cerebrospinal Fluid
Neurons
Central Nervous System
482 Citations (Scopus)

Developmental biology: Bone marrow stromal cells generate muscle cells and repair muscle degeneration

Dezawa, M., Ishikawa, H., Itokazu, Y., Yoshihara, T., Hoshino, M., Takeda, S. I., Ide, C. & Nabeshima, Y. I., Jul 8 2005, In : Science. 309, 5732, p. 314-317 4 p.

Research output: Contribution to journalArticle

Developmental Biology
Mesenchymal Stromal Cells
Muscle Cells
Muscles
Bone Marrow
235 Citations (Scopus)

Neurogenesis in the ependymal layer of the adult rat 3rd ventricle

Xu, Y., Tamamaki, N., Noda, T., Kimura, K., Itokazu, Y., Matsumoto, N., Dezawa, M. & Ide, C., Apr 2005, In : Experimental Neurology. 192, 2, p. 251-264 14 p.

Research output: Contribution to journalArticle

Third Ventricle
Neurogenesis
Stem Cells
Bromodeoxyuridine
Hypothalamus
2004
613 Citations (Scopus)

Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation

Dezawa, M., Kanno, H., Hoshino, M., Cho, H., Matsumoto, N., Itokazu, Y., Tajima, N., Yamada, H., Sawada, H., Ishikawa, H., Mimura, T., Kitada, M., Suzuki, Y. & Ide, C., Jun 1 2004, In : Journal of Clinical Investigation. 113, 12, p. 1701-1710 10 p.

Research output: Contribution to journalArticle

Autologous Transplantation
Mesenchymal Stromal Cells
Stromal Cells
Glial Cell Line-Derived Neurotrophic Factor
Bone Marrow
2000
36 Citations (Scopus)

Atomic force microscopy with carbon nanotube probe resolves the subunit organization of protein complexes

Hohmura, K. I., Itokazu, Y., Yoshimura, S. H., Mizuguchi, G., Masamura, Y. S., Takeyasu, K., Shiomi, Y., Tsurimoto, T., Nishijima, H., Akita, S. & Nakayama, Y., 2000, In : Journal of Electron Microscopy. 49, 3, p. 415-21 7 p.

Research output: Contribution to journalArticle

Carbon Nanotubes
Atomic Force Microscopy
Protein Subunits
Atomic force microscopy
Carbon nanotubes