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Research Output 2007 2019

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Article
2019
1 Citation (Scopus)
Exosomes
Endothelial cells
MicroRNAs
Stem Cells
Myocardial Infarction

Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

Fulzele, S. T., Mendhe, B., Khayrullin, A., Johnson, M. H., Kaiser, H., Liu, Y., Isales, C. M. & Hamrick, M. W., Mar 31 2019, In : Aging. 11, 6, p. 1791-1803 13 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
Stem Cells
Muscles
Mesenchymal Stromal Cells
MicroRNAs
2018
2 Citations (Scopus)

Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

Gharahkhani, P., Burdon, K. P., Cooke Bailey, J. N., Hewitt, A. W., Law, M. H., Pasquale, L. R., Kang, J. H., Haines, J. L., Souzeau, E., Zhou, T., Siggs, O. M., Landers, J., Awadalla, M., Sharma, S., Mills, R. A., Ridge, B., Lynn, D., Casson, R., Graham, S. L., Goldberg, I. & 45 others, White, A., Healey, P. R., Grigg, J., Lawlor, M., Mitchell, P., Ruddle, J., Coote, M., Walland, M., Best, S., Vincent, A., Gale, J., Radfordsmith, G., Whiteman, D. C., Montgomery, G. W., Martin, N. G., MacKey, D. A., Wiggs, J. L., MacGregor, S., Craig, J. E., Allingham, R. R., Brilliant, M., Budenz, D. L., Fingert, J. H., Gaasterland, D., Gaasterland, T., Hark, L., Hauser, M., Igo, R. P., Kraft, P., Lee, R. K., Lichter, P. R., Liu, Y., Moroi, S., Pericak-Vance, M., Realini, A., Rhee, D., Richards, J. E., Ritch, R., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Wollstein, G. & Zack, D. J., Dec 1 2018, In : Scientific Reports. 8, 1, 3124.

Research output: Contribution to journalArticle

Open Angle Glaucoma
Glaucoma
Genome-Wide Association Study
Eye Diseases
Chromosome Mapping
1 Citation (Scopus)

A Novel Cx50 Insert Mutation from a Chinese Congenital Cataract Family Impairs Its Cellular Membrane Localization and Function

Cui, X., Zhou, Z., Zhu, K., Feng, R., Han, J., Li, M., Wang, S., Li, J., Zhang, J., Jiang, Q., Zhang, W., Mu, H., Liu, Y. & Hu, Y., May 1 2018, In : DNA and cell biology. 37, 5, p. 449-456 8 p.

Research output: Contribution to journalArticle

Cataract
Lenses
Mutation
Membranes
Gap Junctions
4 Citations (Scopus)

Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Iglesias, A. I., Mishra, A., Vitart, V., Bykhovskaya, Y., Höhn, R., Springelkamp, H., Cuellar-Partida, G., Gharahkhani, P., Bailey, J. N. C., Willoughby, C. E., Li, X., Yazar, S., Nag, A., Khawaja, A. P., Polašek, O., Siscovick, D., Mitchell, P., Tham, Y. C., Haines, J. L., Kearns, L. S. & 124 others, Hayward, C., Shi, Y., Van Leeuwen, E. M., Taylor, K. D., Wang, J. J., Rochtchina, E., Attia, J., Scott, R., Holliday, E. G., Baird, P. N., Xie, J., Inouye, M., Viswanathan, A., Sim, X., Bonnemaijer, P., Rotter, J. I., Martin, N. G., Zeller, T., Mills, R. A., Staffieri, S. E., Jonas, J. B., Schmidtmann, I., Boutin, T., Kang, J. H., Lucas, S. E. M., Wong, T. Y., Beutel, M. E., Wilson, J. F., Allingham, R. R., Brilliant, M. H., Budenz, D. L., Christen, W. G., Fingert, J., Friedman, D. S., Gaasterland, D., Gaasterland, T., Hauser, M. A., Kraft, P., Lee, R. K., Lichter, P. R., Liu, Y., Loomis, S. J., Moroi, S. E., Pericak-Vance, M. A., Realini, A., Richards, J. E., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Weinreb, R. N., Wollstein, G., Zack, D. J., Zhang, K., Donnelly, P., Barroso, I., Blackwell, J. M., Bramon, E., Brown, M. A., Casas, J. P., Corvin, A., Deloukas, P., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Wood, N. W., Spencer, C. C. A., Band, G., Bellenguez, C., Freeman, C., Hellenthal, G., Giannoulatou, E., Pirinen, M., Pearson, R., Strange, A., Su, Z., Vukcevic, D., Langford, C., Hunt, S. E., Edkins, S., Gwilliam, R., Blackburn, H., Bumpstead, S. J., Dronov, S., Gillman, M., Gray, E., Hammond, N., Jayakumar, A., McCann, O. T., Liddle, J., Potter, S. C., Ravindrarajah, R., Ricketts, M., Waller, M., Weston, P., Widaa, S., Whittaker, P., Uitterlinden, A. G., Vithana, E. N., Foster, P. J., Hysi, P. G., Hewitt, A. W., Khor, C. C., Pasquale, L. R., Montgomery, G. W., Klaver, C. C. W., Aung, T., Pfeiffer, N., MacKey, D. A., Hammond, C. J., Cheng, C. Y., Craig, J. E., Rabinowitz, Y. S., Wiggs, J. L., Burdon, K. P., Van Duijn, C. M. & MacGregor, S., Dec 1 2018, In : Nature Communications. 9, 1, 1864.

Research output: Contribution to journalArticle

eye diseases
Eye Diseases
genome
Genome-Wide Association Study
Keratoconus
5 Citations (Scopus)

Differential expression of coding and long noncoding rnas in keratoconus-affected corneas

Khaled, M. L., Bykhovskaya, Y., Yablonski, S. E. R., Li, H., Drewry, M. D., Aboobakar, I. F., Estes, A. J., Gao, X. R., Stamer, W. D., Xu, H., Allingham, R. R., Hauser, M. A., Rabinowitz, Y. S. & Liu, Y., Jun 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 7, p. 2717-2728 12 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Keratoconus
Cornea
RNA
Cell Movement
5 Citations (Scopus)

Differentially expressed microRNAs in the aqueous humor of patients with exfoliation glaucoma or primary open-angle glaucoma

Drewry, M. D., Challa, P., Kuchtey, J. G., Navarro, I., Helwa, I., Hu, Y., Mu, H., Stamer, W. D., Kuchtey, R. W. & Liu, Y., Apr 1 2018, In : Human Molecular Genetics. 27, 7, p. 1263-1275 13 p.

Research output: Contribution to journalArticle

Exfoliation Syndrome
Aqueous Humor
MicroRNAs
Glaucoma
Primary Open Angle Glaucoma
5 Citations (Scopus)

Epigenetic modifications in hyperhomocysteinemia; potential role in diabetic retinopathy and age-related macular degeneration

Elmasry, K., Mohamed, R., Sharma, I., Elsherbiny, N. M., Liu, Y., Al-Shabrawey, M. & Tawfik, A. M., Jan 1 2018, In : Oncotarget. 9, 16, p. 12562-12590 29 p.

Research output: Contribution to journalArticle

Hyperhomocysteinemia
Macular Degeneration
Diabetic Retinopathy
MicroRNAs
Epigenomics
2 Citations (Scopus)

Exosome-Derived Dystrophin from Allograft Myogenic Progenitors Improves Cardiac Function in Duchenne Muscular Dystrophic Mice

Su, X., Jin, Y., Shen, Y., Ju, C., Cai, J., Liu, Y., Kim, I., Wang, Y., Yu, H., Weintraub, N. L., Jiang, M. & Tang, Y. L., Jan 1 2018, (Accepted/In press) In : Journal of Cardiovascular Translational Research.

Research output: Contribution to journalArticle

Exosomes
Dystrophin
Allografts
Stem Cells
Duchenne Muscular Dystrophy
9 Citations (Scopus)

Exosomes from Suxiao Jiuxin pill-treated cardiac mesenchymal stem cells decrease H3K27 demethylase UTX expression in mouse cardiomyocytes in vitro

Ruan, X. F., Li, Y. J., Ju, C. W., Shen, Y., Lei, W., Chen, C., Li, Y., Yu, H., Liu, Y., Kim, I., Wang, X. L., Weintraub, N. L. & Tang, Y. L., Apr 1 2018, In : Acta Pharmacologica Sinica. 39, 4, p. 579-586 8 p.

Research output: Contribution to journalArticle

Exosomes
Mesenchymal Stromal Cells
Cardiac Myocytes
Epigenomics
Chromatin Assembly and Disassembly
2 Citations (Scopus)

Extracellular vesicle-mediated long-range communication in stressed retinal pigment epithelial cell monolayers

Shah, N., Ishii, M., Brandon, C., Ablonczy, Z., Cai, J., Liu, Y., Chou, C. J. & Rohrer, B., Aug 1 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 8, p. 2610-2622 13 p.

Research output: Contribution to journalArticle

Retinal Pigments
Epithelial Cells
Retinal Pigment Epithelium
Extracellular Vesicles
Tight Junctions
1 Citation (Scopus)

Family-based genome-wide association study of south Indian pedigrees supports WNT7B as a central corneal thickness locus

Fan, B. J., Chen, X., Sondhi, N., Sharmila, P. F., Soumittra, N., Sripriya, S., Sacikala, S., Asokan, R., Friedman, D. S., Pasquale, L. R., Gao, X. R., Vijaya, L., Bailey, J. C., Vitart, V., Macgregor, S., Hammond, C. J., Khor, C. C., Haines, J. L., George, R., Wiggs, J. L. & 70 others, Allingham, R. R., Gao, X. R., Gauderman, J., Hauser, M., Rotter, J. I., Varma, R., Wiggs, J., Aung, T., Burdon, K. P., Cheng, C. Y., Craig, J. E., Cree, A. J., Gharahkhani, P., Hewitt, A. W., Höhn, R., Hysi, P., Iglesias Gonzalez, A. I., Jonas, J., Khawaja, A., Khor, C. C., Klaver, C. C. W., Pasutto, F., Macgregor, S., Mackey, D., Mitchell, P., Mishra, A., Pang, C., Pasquale, L. R., Pasutto, F., Springelkamp, H., Thorleifsson, G., Thorsteinsdottir, U., van Duijn, C. M., Viswanathan, A., Vitart, V., Wiggs, J. L., Wojciechowski, R., Wong, T., Young, T. L., Zeller, T., Allingham, R., Brilliant, M., Budenz, D., Bailey, J. C., Fingert, J., Gaasterland, D., Gaasterland, T., Haines, J. L., Hauser, M., Igo, R., Kang, J. H., Kraft, P., Lee, R., Lichter, P., Liu, Y., Moroi, S., Pasquale, L. R., Realini, A., Rhee, D., Richards, J. R., Ritch, R., Schuman, J., Scott, W. K., Singh, K., Sit, A., Vollrath, D., Weinreb, R. N., Wiggs, J. L., Wollstein, G. & Zack, D., May 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 6, p. 2495-2502 8 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Pedigree
Single Nucleotide Polymorphism
Hispanic Americans
Population
3 Citations (Scopus)

Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma

International Glaucoma Genetics Consortium & NEIGHBORHOOD Consortium, Jan 1 2018, In : PLoS Genetics. 14, 1, e1007145.

Research output: Contribution to journalArticle

glaucoma
Glaucoma
genomics
risk factor
Quantitative Trait Loci
6 Citations (Scopus)

Suxiao Jiuxin pill promotes exosome secretion from mouse cardiac mesenchymal stem cells in vitro

Ruan, X. F., Ju, C. W., Shen, Y., Liu, Y., Kim, I., Yu, H., Weintraub, N. L., Wang, X. L. & Tang, Y. L., Apr 1 2018, In : Acta Pharmacologica Sinica. 39, 4, p. 569-578 10 p.

Research output: Contribution to journalArticle

Exosomes
Mesenchymal Stromal Cells
Sphingomyelin Phosphodiesterase
GTP Phosphohydrolases
Therapeutics
2 Citations (Scopus)

Testosterone pathway genetic polymorphisms in relation to primary open-angle glaucoma: An analysis in two large datasets

Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG) Consortium, Feb 2018, In : Investigative Ophthalmology and Visual Science. 59, 2, p. 629-636 8 p.

Research output: Contribution to journalArticle

Genetic Polymorphisms
Testosterone
Genes
Single Nucleotide Polymorphism
Low Tension Glaucoma
2 Citations (Scopus)

Transplantation of Cardiac Mesenchymal Stem Cell-Derived Exosomes for Angiogenesis

Ju, C., Li, Y., Shen, Y., Liu, Y., Cai, J., Liu, N., Ma, G. & Tang, Y. L., Jan 1 2018, (Accepted/In press) In : Journal of Cardiovascular Translational Research.

Research output: Contribution to journalArticle

Mesenchymal Stem Cell Transplantation
Exosomes
Extremities
MicroRNAs
Perfusion
6 Citations (Scopus)

Transplantation of Cardiac Mesenchymal Stem Cell-Derived Exosomes Promotes Repair in Ischemic Myocardium

Ju, C., Shen, Y., Ma, G., Liu, Y., Cai, J., Kim, I., Weintraub, N. L., Liu, N. & Tang, Y. L., Jan 1 2018, (Accepted/In press) In : Journal of Cardiovascular Translational Research.

Research output: Contribution to journalArticle

Mesenchymal Stem Cell Transplantation
Exosomes
Myocardium
Myocardial Infarction
Cardiac Myocytes
2017
123 Citations (Scopus)

A comparative study of serum exosome isolation using differential ultracentrifugation and three commercial reagents

Helwa, I., Cai, J., Drewry, M. D., Zimmerman, A., Dinkins, M. B., Khaled, M. L., Seremwe, M., Dismuke, W. M., Bieberich, E., Stamer, W. D., Hamrick, M. W. & Liu, Y., Jan 2017, In : PloS one. 12, 1, e0170628.

Research output: Contribution to journalArticle

exosomes
Exosomes
ultracentrifugation
Ultracentrifugation
RNA
2 Citations (Scopus)

Age at natural menopause genetic risk score in relation to age at natural menopause and primary open-angle glaucoma in a US-based sample

Pasquale, L. R., Aschard, H., Kang, J. H., Bailey, J. N. C., Lindström, S., Chasman, D. I., Christen, W. G., Allingham, R. R., Ashley-Koch, A., Lee, R. K., Moroi, S. E., Brilliant, M. H., Wollstein, G., Schuman, J. S., Fingert, J., Budenz, D. L., Realini, T., Gaasterland, T., Gaasterland, D., Scott, W. K. & 21 others, Singh, K., Sit, A. J., Igo, R. P., Song, Y. E., Hark, L., Ritch, R., Rhee, D. J., Gulati, V., Havens, S., Vollrath, D., Zack, D. J., Medeiros, F., Weinreb, R. N., Pericak-Vance, M. A., Liu, Y., Kraft, P., Richards, J. E., Rosner, B. A., Hauser, M. A., Haines, J. L. & Wiggs, J. L., Jan 1 2017, In : Menopause. 24, 2, p. 150-156 7 p.

Research output: Contribution to journalArticle

Menopause
Odds Ratio
Confidence Intervals
National Eye Institute (U.S.)
Primary Open Angle Glaucoma
12 Citations (Scopus)

Exosome production and its regulation of EGFR during wound healing in renal tubular cells

Zhou, X., Zhang, W., Yao, Q., Zhang, H., Dong, G., Zhang, M., Liu, Y., Chen, J. & Dong, Z., Jan 1 2017, In : American Journal of Physiology - Renal Physiology. 312, 6, p. F963-F970

Research output: Contribution to journalArticle

Exosomes
Wound Healing
Kidney
Epidermal Growth Factor
Growth Factor Receptors
2 Citations (Scopus)

Further evidence for a role of the ADRB2 gene in risk for posttraumatic stress disorder

Hauser, M. A., Garrett, M. E., Liu, Y., Dennis, M. F., Kimbrel, N. A., Veterans Affairs Mid-Atlantic Mental Illness Research, Education, A. M-A. M. I. R. E., Beckham, J. C. & Ashley-Koch, A. E., Jan 1 2017, In : Journal of Psychiatric Research. 84, p. 59-61 3 p.

Research output: Contribution to journalArticle

Post-Traumatic Stress Disorders
Adrenergic Receptors
Genes
Wounds and Injuries
Veterans
36 Citations (Scopus)

Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis

Kolhe, R. B., Hunter, D. M., Liu, S., Jadeja, R. N., Pundkar, C., Mondal, A. K., Mendhe, B., Drewry, M., Rojiani, M. V., Liu, Y., Isales, C. M., Guldberg, R. E., Hamrick, M. W. & Fulzele, S. T., Dec 1 2017, In : Scientific Reports. 7, 1, 2029.

Research output: Contribution to journalArticle

Synovial Fluid
MicroRNAs
Osteoarthritis
Exosomes
Encyclopedias
26 Citations (Scopus)

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Aung, T., Ozaki, M., Lee, M. C., Schlötzer-Schrehardt, U., Thorleifsson, G., Mizoguchi, T., Igo, R. P., Haripriya, A., Williams, S. E., Astakhov, Y. S., Orr, A. C., Burdon, K. P., Nakano, S., Mori, K., Abu-Amero, K., Hauser, M., Li, Z., Prakadeeswari, G., Bailey, J. N. C., Cherecheanu, A. P. & 269 others, Kang, J. H., Nelson, S., Hayashi, K., Manabe, S. I., Kazama, S., Zarnowski, T., Inoue, K., Irkec, M., Coca-Prados, M., Sugiyama, K., Järvelä, I., Schlottmann, P., Lerner, S. F., Lamari, H., Nilgün, Y., Bikbov, M., Park, K. H., Cha, S. C., Yamashiro, K., Zenteno, J. C., Jonas, J. B., Kumar, R. S., Perera, S. A., Chan, A. S. Y., Kobakhidze, N., George, R., Vijaya, L., Do, T., Edward, D. P., De Juan Marcos, L., Pakravan, M., Moghimi, S., Ideta, R., Bach-Holm, D., Kappelgaard, P., Wirostko, B., Thomas, S., Gaston, D., Bedard, K., Greer, W. L., Yang, Z., Chen, X., Huang, L., Sang, J., Jia, H., Jia, L., Qiao, C., Zhang, H., Liu, X., Zhao, B., Wang, Y. X., Xu, L., Leruez, S., Reynier, P., Chichua, G., Tabagari, S., Uebe, S., Zenkel, M., Berner, D., Mossböck, G., Weisschuh, N., Hoja, U., Welge-Luessen, U. C., Mardin, C., Founti, P., Chatzikyriakidou, A., Pappas, T., Anastasopoulos, E., Lambropoulos, A., Ghosh, A., Shetty, R., Porporato, N., Saravanan, V., Venkatesh, R., Shivkumar, C., Kalpana, N., Sarangapani, S., Kanavi, M. R., Beni, A. N., Yazdani, S., Lashay, A., Naderifar, H., Khatibi, N., Fea, A., Lavia, C., Dallorto, L., Rolle, T., Frezzotti, P., Paoli, D., Salvi, E., Manunta, P., Mori, Y., Miyata, K., Higashide, T., Chihara, E., Ishiko, S., Yoshida, A., Yanagi, M., Kiuchi, Y., Ohashi, T., Sakurai, T., Sugimoto, T., Chuman, H., Aihara, M., Inatani, M., Miyake, M., Gotoh, N., Matsuda, F., Yoshimura, N., Ikeda, Y., Ueno, M., Sotozono, C., Jeoung, J. W., Sagong, M., Park, K. H., Ahn, J., Cruz-Aguilar, M., Ezzouhairi, S. M., Rafei, A., Chong, Y. F., Ng, X. Y., Goh, S. R., Chen, Y., Yong, V. H. K., Khan, M. I., Olawoye, O. O., Ashaye, A. O., Ugbede, I., Onakoya, A., Kizor-Akaraiwe, N., Teekhasaenee, C., Suwan, Y., Supakontanasan, W., Okeke, S., Uche, N. J., Asimadu, I., Ayub, H., Akhtar, F., Kosior-Jarecka, E., Lukasik, U., Lischinsky, I., Castro, V., Grossmann, R. P., Megevand, G. S., Roy, S., Dervan, E., Silke, E., Rao, A., Sahay, P., Fornero, P., Cuello, O., Sivori, D., Zompa, T., Mills, R. A., Souzeau, E., Mitchell, P., Wang, J. J., Hewitt, A. W., Coote, M., Crowston, J. G., Astakhov, S. Y., Akopov, E. L., Emelyanov, A., Vysochinskaya, V., Kazakbaeva, G., Fayzrakhmanov, R., Al-Obeidan, S. A., Owaidhah, O., Aljasim, L. A., Chowbay, B., Foo, J. N., Soh, R. Q., Sim, K. S., Xie, Z., Cheong, A. W. O., Mok, S. Q., Soo, H. M., Chen, X. Y., Peh, S. Q., Heng, K. K., Husain, R., Ho, S. L., Hillmer, A. M., Cheng, C. Y., Escudero-Domínguez, F. A., González-Sarmiento, R., Martinon-Torres, F., Salas, A., Pathanapitoon, K., Hansapinyo, L., Wanichwecharugruang, B., Kitnarong, N., Sakuntabhai, A., Nguyn, H. X., Nguyn, G. T. T., Nguyn, T. V., Zenz, W., Binder, A., Klobassa, D. S., Hibberd, M. L., Davila, S., Herms, S., Nöthen, M. M., Moebus, S., Rautenbach, R. M., Ziskind, A., Carmichael, T. R., Ramsay, M., Álvarez, L., García, M., González-Iglesias, H., Rodríguez-Calvo, P. P., Cueto, L. F. V., Oguz, Ç., Tamcelik, N., Atalay, E., Batu, B., Aktas, D., Kaslm, B., Wilson, M. R., Coleman, A. L., Liu, Y., Challa, P., Herndon, L., Kuchtey, R. W., Kuchtey, J., Curtin, K., Chaya, C. J., Crandall, A., Zangwill, L. M., Wong, T. Y., Nakano, M., Kinoshita, S., Den Hollander, A. I., Vesti, E., Fingert, J. H., Lee, R. K., Sit, A. J., Shingleton, B. J., Wang, N., Cusi, D., Qamar, R., Kraft, P., Pericak-Vance, M. A., Raychaudhuri, S., Heegaard, S., Kivelä, T., Reis, A., Kruse, F. E., Weinreb, R. N., Pasquale, L. R., Haines, J. L., Thorsteinsdottir, U., Jonasson, F., Allingham, R. R., Milea, D., Ritch, R., Kubota, T., Tashiro, K., Vithana, E. N., Micheal, S., Topouzis, F., Craig, J. E., Dubina, M., Sundaresan, P., Stefansson, K., Wiggs, J. L., Pasutto, F. & Khor, C. C., Jul 1 2017, In : Nature Genetics. 49, 7, p. 993-1004 12 p.

Research output: Contribution to journalArticle

Exfoliation Syndrome
Genome-Wide Association Study
Genetic Association Studies
Blindness
Glaucoma
4 Citations (Scopus)

Genetic correlations between intraocular pressure, blood pressure and primary open-angle glaucoma: A multi-cohort analysis

Aschard, H., Kang, J. H., Iglesias, A. I., Hysi, P., Cooke Bailey, J. N., Khawaja, A. P., Allingham, R. R., Ashley-Koch, A., Lee, R. K., Moroi, S. E., Brilliant, M. H., Wollstein, G., Schuman, J. S., Fingert, J. H., Budenz, D. L., Realini, T., Gaasterland, T., Scott, W. K., Singh, K., Sit, A. J. & 25 others, Igo, R. P., Song, Y. E., Hark, L., Ritch, R., Rhee, D. J., Gulati, V., Haven, S., Vollrath, D., Zack, D. J., Medeiros, F., Weinreb, R. N., Cheng, C. Y., Chasman, D. I., Christen, W. G., Pericak-Vance, M. A., Liu, Y., Kraft, P., Richards, J. E., Rosner, B. A., Hauser, M. A., Klaver, C. C. W., Vanduijn, C. M., Haines, J., Wiggs, J. L. & Pasquale, L. R., Nov 1 2017, In : European Journal of Human Genetics. 25, 11, p. 1261-1267 7 p.

Research output: Contribution to journalArticle

Intraocular Pressure
Cohort Studies
Blood Pressure
Genome
Linkage Disequilibrium
16 Citations (Scopus)

HIF-1-mediated production of exosomes during hypoxia is protective in renal tubular cells

Zhang, W., Zhou, X., Yao, Q., Liu, Y., Zhang, H. & Dong, Z., Oct 2017, In : American Journal of Physiology - Renal Physiology. 313, 4, p. F906-F913

Research output: Contribution to journalArticle

Exosomes
Hypoxia-Inducible Factor 1
Kidney
Hypoxia
Adenosine Triphosphate
7 Citations (Scopus)

Isolation of Extracellular Vesicles from Stem Cells

Chen, Z., Li, Y., Yu, H., Shen, Y., Ju, C., Ma, G., Liu, Y., Kim, I., Weintraub, N. L. & Tang, Y. L., Jan 1 2017, In : Methods in molecular biology (Clifton, N.J.). 1660, p. 389-394 6 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Stem Cells
Tissue Survival
Untranslated RNA
Myocardial Reperfusion
29 Citations (Scopus)
Cell Aging
Cell proliferation
Stem cells
MicroRNAs
Mesenchymal Stromal Cells
3 Citations (Scopus)

Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

Chintalapudi, S. R., Maria, D., Di Wang, X., Bailey, J. N. C., Allingham, R., Brilliant, M., Budenz, D., Fingert, J., Gaasterland, D., Gaasterland, T., Haines, J. L., Hark, L., Hauser, M., Igo, R., Hee Kang, J., Kraft, P., Lee, R., Lichter, P., Liu, Y., Moroi, S. & 43 others, Pasquale, L. R., Pericak-Vance, M., Realini, A., Rhee, D., Richards, J. R., Ritch, R., Schuman, J., Scott, W. K., Singh, K., Sit, A., Vollrath, D., Wollstein, G., Zack, D., Aung, T., Bonnemaijer, P., Cheng, C. Y., Craig, J., Van Duijn, C., Gharahkhani, P., Iglesias Gonzalez, A., Hammond, C. J., Hewitt, A., Hoehn, R., Jonansson, F., Khawaja, A., Chuen Khor, C., Klaver, C. C. W., Lotery, A., MacKey, D., MacGregor, S., Pang, C., Pasutto, F., Stefansson, K., Thorleifsson, G., Thorsteinsdottir, U., Vitart, V., Vithana, E., Young, T., Zeller, T., Hysi, P. G., Wiggs, J. L., Williams, R. W. & Jablonski, M. M., Dec 1 2017, In : Nature Communications. 8, 1, 1755.

Research output: Contribution to journalArticle

intraocular pressure
glaucoma
Intraocular Pressure
Glaucoma
magnetic permeability

TSC1 mutations in Keratoconus Patients with or without tuberous sclerosis

Bykhovskaya, Y., Fardaei, M., Khaled, M. L., Nejabat, M., Salouti, R., Dastsooz, H., Liu, Y., Inaloo, S. & Rabinowitz, Y. S., Dec 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 14, p. 6462-6469 8 p.

Research output: Contribution to journalArticle

Keratoconus
Tuberous Sclerosis
Mutation
Exome
Cornea
2016
12 Citations (Scopus)

A common variant in MIR182 is associated with primary open-angle glaucoma in the NEIGHBORHOOD consortium

Liu, Y., Bailey, J. C., Helwa, I., Dismuke, W. M., Cai, J., Drewry, M., Brilliant, M. H., Budenz, D. L., Christen, W. G., Chasman, D. I., Fingert, J. H., Gaasterland, D., Gaasterland, T., Gordon, M. O., Igo, R. P., Kang, J. H., Kass, M. A., Kraft, P., Lee, R. K., Lichter, P. & 25 others, Moroi, S. E., Realini, A., Richards, J. E., Ritch, R., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Song, Y. E., Vollrath, D., Weinreb, R., Medeiros, F., Wollstein, G., Zack, D. J., Zhang, K., Pericak-Vance, M. A., Gonzalez, P., Stamer, W. D., Kuchtey, J., Kuchtey, R. W., Allingham, R. R., Hauser, M. A., Pasquale, L. R., Haines, J. L. & Wiggs, J. L., Aug 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 10, p. 4528-4535 8 p.

Research output: Contribution to journalArticle

MicroRNAs
Trabecular Meshwork
Glaucoma
Aqueous Humor
Exosomes
13 Citations (Scopus)

Assessing the association of mitochondrial genetic variation with primary open-angle glaucoma using gene-set analyses

Khawaja, A. P., Cooke Bailey, J. N., Kang, J. H., Rand Allingham, R., Hauser, M. A., Brilliant, M., Budenz, D. L., Christen, W. G., Fingert, J., Gaasterland, D., Gaasterland, T., Kraft, P., Lee, R. K., Lichter, P. R., Liu, Y., Medeiros, F., Moroi, S. E., Richards, J. E., Realini, T., Ritch, R. & 13 others, Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Vollrath, D., Wollstein, G., Zack, D. J., Zhang, K., Pericak-Vance, M., Weinreb, R. N., Haines, J. L., Pasquale, L. R. & Wiggs, J. L., Sep 2016, In : Investigative Ophthalmology and Visual Science. 57, 11, p. 5046-5052 7 p.

Research output: Contribution to journalArticle

Low Tension Glaucoma
Mitochondrial Proteins
Encyclopedias
Genes
Carbohydrate Metabolism
15 Citations (Scopus)

Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium

eMERGE Network & NEIGHBOR Consortium, Sep 1 2016, In : PLoS Genetics. 12, 9, e1006186.

Research output: Contribution to journalArticle

Genetic Epistasis
glaucoma
Electronic Health Records
epistasis
Genomics
6 Citations (Scopus)

Gene signatures of postoperative atrial fibrillation in atrial tissue after coronary artery bypass grafting surgery in patients receiving β-blockers

for the Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team, Mar 1 2016, In : Journal of molecular and cellular cardiology. 92, p. 109-115 7 p.

Research output: Contribution to journalArticle

Coronary Artery Bypass
Atrial Fibrillation
Quantitative Trait Loci
Genes
Atrial Appendage
88 Citations (Scopus)

Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

Bailey, J. N. C., Loomis, S. J., Kang, J. H., Allingham, R. R., Gharahkhani, P., Khor, C. C., Burdon, K. P., Aschard, H., Chasman, D. I., Igo, R. P., Hysi, P. G., Glastonbury, C. A., Ashley-Koch, A., Brilliant, M., Brown, A. A., Budenz, D. L., Buil, A., Cheng, C. Y., Choi, H., Christen, W. G. & 60 others, Curhan, G., De Vivo, I., Fingert, J. H., Foster, P. J., Fuchs, C., Gaasterland, D., Gaasterland, T., Hewitt, A. W., Hu, F., Hunter, D. J., Khawaja, A. P., Lee, R. K., Li, Z., Lichter, P. R., Mackey, D. A., McGuffin, P., Mitchell, P., Moroi, S. E., Perera, S. A., Pepper, K. W., Qi, Q., Realini, T., Richards, J. E., Ridker, P. M., Rimm, E., Ritch, R., Ritchie, M., Schuman, J. S., Scott, W. K., Singh, K., Sit, A. J., Song, Y. E., Tamimi, R. M., Topouzis, F., Viswanathan, A. C., Verma, S. S., Vollrath, D., Wang, J. J., Weisschuh, N., Wissinger, B., Wollstein, G., Wong, T. Y., Yaspan, B. L., Zack, D. J., Zhang, K., Weinreb, R. N., Pericak-Vance, M. A., Small, K., Hammond, C. J., Aung, T., Liu, Y., Vithana, E. N., MacGregor, S., Craig, J. E., Kraft, P., Howell, G., Hauser, M. A., Pasquale, L. R., Haines, J. L. & Wiggs, J. L., Feb 1 2016, In : Nature Genetics. 48, 2, p. 189-194 6 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Odds Ratio
Single Nucleotide Polymorphism
Meta-Analysis
Retinal Ganglion Cells
8 Citations (Scopus)

Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor-initiating stem cells

Khater, M. K., Perucho, A. M., Mohamed, S. A., Laknaur, A., Lebedyeva, I., Liu, Y., Diamond, M. P. & Al-Hendy, A. A., Jun 2016, In : Fertility and Sterility. 105, 6, p. 1638-1648.e8

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Leiomyoma
Adenoviridae
Genetic Therapy
Nanoparticles
13 Citations (Scopus)

miRNA profile in three different normal human ocular tissues by miRNA-seq

Drewry, M., Helwa, I., Allingham, R. R., Hauser, M. A. & Liu, Y., Jul 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 8, p. 3731-3739 9 p.

Research output: Contribution to journalArticle

MicroRNAs
Trabecular Meshwork
Keratoconus
Ciliary Body
Human Body
58 Citations (Scopus)

Neutral sphingomyelinase-2 deficiency ameliorates Alzheimer’s disease pathology and improves cognition in the 5XFAD mouse

Dinkins, M. B., Enasko, J., Hernandez, C. M., Wang, G., Kong, J., Helwa, I., Liu, Y., Terry, A. V. & Bieberich, E., Aug 17 2016, In : Journal of Neuroscience. 36, 33, p. 8653-8667 15 p.

Research output: Contribution to journalArticle

Type A Niemann-Pick Disease
Exosomes
Cognition
Alzheimer Disease
Pathology
2015
39 Citations (Scopus)

A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Aung, T., Ozaki, M., Mizoguchi, T., Allingham, R. R., Li, Z., Haripriya, A., Nakano, S., Uebe, S., Harder, J. M., Chan, A. S. Y., Lee, M. C., Burdon, K. P., Astakhov, Y. S., Abu-Amero, K. K., Zenteno, J. C., Nilgün, Y., Zarnowski, T., Pakravan, M., Safieh, L. A., Jia, L. & 141 others, Wang, Y. X., Williams, S., Paoli, D., Schlottmann, P. G., Huang, L., Sim, K. S., Foo, J. N., Nakano, M., Ikeda, Y., Kumar, R. S., Ueno, M., Manabe, S. I., Hayashi, K., Kazama, S., Ideta, R., Mori, Y., Miyata, K., Sugiyama, K., Higashide, T., Chihara, E., Inoue, K., Ishiko, S., Yoshida, A., Yanagi, M., Kiuchi, Y., Aihara, M., Ohashi, T., Sakurai, T., Sugimoto, T., Chuman, H., Matsuda, F., Yamashiro, K., Gotoh, N., Miyake, M., Astakhov, S. Y., Osman, E. A., Al-Obeidan, S. A., Owaidhah, O., Al-Jasim, L., Shahwan, S. A., Fogarty, R. A., Leo, P., Yetkin, Y., Ouz, Ç., Kanavi, M. R., Beni, A. N., Yazdani, S., Akopov, E. L., Toh, K. Y., Howell, G. R., Orr, A. C., Goh, Y., Meah, W. Y., Peh, S. Q., Kosior-Jarecka, E., Lukasik, U., Krumbiegel, M., Vithana, E. N., Wong, T. Y., Liu, Y., Koch, A. E. A., Challa, P., Rautenbach, R. M., Mackey, D. A., Hewitt, A. W., Mitchell, P., Wang, J. J., Ziskind, A., Carmichael, T., Ramakrishnan, R., Narendran, K., Venkatesh, R., Vijayan, S., Zhao, P., Chen, X., Guadarrama-Vallejo, D., Cheng, C. Y., Perera, S. A., Husain, R., Ho, S. L., Welge-Luessen, U. C., Mardin, C., Schloetzer-Schrehardt, U., Hillmer, A. M., Herms, S., Moebus, S., Nöthen, M. M., Weisschuh, N., Shetty, R., Ghosh, A., Teo, Y. Y., Brown, M. A., Lischinsky, I., Crowston, J. G., Coote, M., Zhao, B., Sang, J., Zhang, N., You, Q., Vysochinskaya, V., Founti, P., Chatzikyriakidou, A., Lambropoulos, A., Anastasopoulos, E., Coleman, A. L., Wilson, M. R., Rhee, D. J., Kang, J. H., May-Bolchakova, I., Heegaard, S., Mori, K., Alward, W. L. M., Jonas, J. B., Xu, L., Liebmann, J. M., Chowbay, B., Schaeffeler, E., Schwab, M., Lerner, F., Wang, N., Yang, Z., Frezzotti, P., Kinoshita, S., Fingert, J. H., Inatani, M., Tashiro, K., Reis, A., Edward, D. P., Pasquale, L. R., Kubota, T., Wiggs, J. L., Pasutto, F., Topouzis, F., Dubina, M., Craig, J. E., Yoshimura, N., Sundaresan, P., John, S. W. M., Ritch, R., Hauser, M. A. & Khor, C. C., Apr 28 2015, In : Nature Genetics. 47, 4, p. 387-392 6 p.

Research output: Contribution to journalArticle

Exfoliation Syndrome
Odds Ratio
Alleles
Genome
Genetic Loci
45 Citations (Scopus)

A common variant near TGFBR3 is associated with primary open angle glaucoma

Li, Z., Allingham, R. R., Nakano, M., Jia, L., Chen, Y., Ikeda, Y., Mani, B., Chen, L. J., Kee, C., Garway-Heath, D. F., Sripriya, S., Fuse, N., Abu-Amero, K. K., Huang, C., Namburi, P., Burdon, K., Perera, S. A., Gharahkhani, P., Lin, Y., Ueno, M. & 91 others, Ozaki, M., Mizoguchi, T., Krishnadas, S. R., Osman, E. A., Lee, M. C., Chan, A. S. Y., Tajudin, L. S. A., Do, T., Goncalves, A., Reynier, P., Zhang, H., Bourne, R., Goh, D., Broadway, D., Husain, R., Negi, A. K., Su, D. H., Ho, C. L., Blanco, A. A., Leung, C. K. S., Wong, T. T., Yakub, A., Liu, Y., Nongpiur, M. E., Han, J. C., Hon, D. N., Shantha, B., Zhao, B., Sang, J., Zhang, N. H., Sato, R., Yoshii, K., Panda-Jonas, S., Ashley Koch, A. E., Herndon, L. W., Moroi, S. E., Challa, P., Foo, J. N., Bei, J. X., Zeng, Y. X., Simmons, C. P., Bich Chau, T. N., Sharmila, P. F., Chew, M., Lim, B., Tam, P. O. S., Chua, E., Ng, X. Y., Yong, V. H. K., Chong, Y. F., Meah, W. Y., Vijayan, S., Seongsoo, S., Xu, W., Teo, Y. Y., Cooke Bailey, J. N., Kang, J. H., Haines, J. L., Cheng, C. Y., Saw, S. M., Tai, E. S., Richards, J. E., Ritch, R., Gaasterland, D. E., Pasquale, L. R., Liu, J., Jonas, J. B., Milea, D., George, R., Al-Obeidan, S. A., Mori, K., Macgregor, S., Hewitt, A. W., Girkin, C. A., Zhang, M., Sundaresan, P., Vijaya, L., Mackey, D. A., Wong, T. Y., Craig, J. E., Sun, X., Kinoshita, S., Wiggs, J. L., Khor, C. C., Yang, Z., Pang, C. P., Wang, N., Hauser, M. A., Tashiro, K., Aung, T. & Vithana, E. N., Jul 1 2015, In : Human Molecular Genetics. 24, 13, p. 3880-3892 13 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Exome
Optic Disk
Blindness
Glaucoma
18 Citations (Scopus)

An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. Veterans

VA Mid-Atlantic MIRECC Registry Workgroup, Mar 20 2015, In : PloS one. 10, 3, e0119998.

Research output: Contribution to journalArticle

Combat Disorders
veterans
Veterans
Post-Traumatic Stress Disorders
Genes
9 Citations (Scopus)

Case-control association between CCT-associated variants and keratoconus in a Saudi Arabian population

Abu-Amero, K. K., Helwa, I., Al-Muammar, A., Strickland, S., Hauser, M. A., Allingham, R. R. & Liu, Y., Jun 4 2015, In : Journal of Negative Results in BioMedicine. 14, 1, 29.

Research output: Contribution to journalArticle

Keratoconus
Polymorphism
Single Nucleotide Polymorphism
Nucleotides
Association reactions
4 Citations (Scopus)

Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder

Kimbrel, N. A., Garrett, M. E., Dennis, M. F., Liu, Y., Patanam, I., Ashley-Koch, A. E., Hauser, M. A., Beckham, J. C., Mason, J., Miller-Mumford, M., McDonald, S. D., Pickett, T., Hurley, R. A., Rowland, J., Taber, K. H., Yoash-Gantz, R. E., Brancu, M., Calhoun, P. S., Dedert, E. A., Elbogen, E. B. & 17 others, Fairbank, J. A., Green, K. T., Kilts, J. D., Kirby, A. C., Marx, C. E., McCarthy, G., Moore, S. D., Morey, R. A., Naylor, J., Runnals, J. J., Szabo, S. T., Straits-Tröster, K. A., Tupler, L. A., Van Voorhees, E. E., Wagner, R. H., Weiner, R. D. & VA Mid-Atlantic MIRECC Workgroup, M-A. MIRECC. W., Sep 30 2015, In : Psychiatry Research. 229, 1-2, p. 326-331 6 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Post-Traumatic Stress Disorders
Cholinergic Receptors
Smoking
Genes
13 Citations (Scopus)

Effect of the APOE ε4 allele and combat exposure on PTSD among Iraq/Afghanistan-era veterans

Kimbrel, N. A., Hauser, M. A., Garrett, M., Ashley-Koch, A., Liu, Y., Dennis, M. F., Klein, R. C. & Beckham, J. C., May 1 2015, In : Depression and Anxiety. 32, 5, p. 307-315 9 p.

Research output: Contribution to journalArticle

Apolipoprotein E4
Afghanistan
Iraq
Veterans
Post-Traumatic Stress Disorders
140 Citations (Scopus)

Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium

Wang, Y., Zhang, L., Li, Y., Chen, L., Wang, X., Guo, W., Zhang, X., Qin, G., He, S. H., Zimmerman, A., Liu, Y., Kim, I., Weintraub, N. L. & Tang, Y. L., Jun 9 2015, In : International Journal of Cardiology. 192, p. 61-69 9 p.

Research output: Contribution to journalArticle

Exosomes
Induced Pluripotent Stem Cells
MicroRNAs
Cardiac Myocytes
Myocardium
10 Citations (Scopus)

Expression profiling of human Schlemm’s canal endothelial cells from eyes with and without glaucoma

Cai, J., Perkumas, K. M., Qin, X., Hauser, M. A., Daniel Stamer, W. & Liu, Y., Oct 1 2015, In : Investigative Ophthalmology and Visual Science. 56, 11, p. 6747-6753 7 p.

Research output: Contribution to journalArticle

Glaucoma
Endothelial Cells
Genes
Gene Ontology
Software
31 Citations (Scopus)

Genetic variants and cellular stressors associated with exfoliation syndrome modulate promoter activity of a lncRNA within the LOXL1 locus

Hauser, M. A., Aboobakar, I. F., Liu, Y., Miura, S., Whigham, B. T., Challa, P., Wheeler, J., Williams, A., Santiago-Turla, C., Qin, X., Rautenbach, R. M., Ziskind, A., Ramsay, M., Uebe, S., Song, L., Safi, A., Vithana, E. N., Mizoguchi, T., Nakano, S., Kubota, T. & 17 others, Hayashi, K., Manabe, S. I., Kazama, S., Mori, Y., Miyata, K., Yoshimura, N., Reis, A., Crawford, G. E., Pasutto, F., Carmichael, T. R., Susan, S. E., Ozaki, M., Aung, T., Khor, C. C., Stamer, W. D., Ashley-Koch, A. E. & Allingham, R. R., Jan 1 2015, In : Human Molecular Genetics. 24, 22, p. 6552-6563 12 p.

Research output: Contribution to journalArticle

Exfoliation Syndrome
Protein-Lysine 6-Oxidase
Long Noncoding RNA
Population
Mechanical Stress
45 Citations (Scopus)

Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq-Afghanistan era veterans

Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, Jun 25 2015, In : Journal of Affective Disorders. 184, p. 225-234 10 p., 7362.

Research output: Contribution to journalArticle

Afghanistan
Iraq
Genome-Wide Association Study
Veterans
Post-Traumatic Stress Disorders
36 Citations (Scopus)

Human aqueous humor exosomes

Dismuke, W. M., Challa, P., Navarro, I., Stamer, W. D. & Liu, Y., Mar 1 2015, In : Experimental eye research. 132, p. 73-77 5 p.

Research output: Contribution to journalArticle

Exosomes
Aqueous Humor
RNA
MicroRNAs
Communication
3 Citations (Scopus)

Independent origin of c.57 C > T mutation in MIR184 associated with inherited corneal and lens abnormalities

Bykhovskaya, Y., Seldin, M. F., Liu, Y., Ransom, M., Li, X. & Rabinowitz, Y. S., Mar 1 2015, In : Ophthalmic Genetics. 36, 1, p. 95-97 3 p.

Research output: Contribution to journalArticle

DNA Mutational Analysis
Genotyping Techniques
Keratoconus
Genetic Linkage
Germ-Line Mutation
29 Citations (Scopus)

Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology

NEIGHBORHOOD Consortium, Mar 1 2015, In : Genetic Epidemiology. 39, 3, p. 207-216 10 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Optic Disk
Glaucoma
Meta-Analysis
Optic Nerve Diseases