• 16949 Citations
  • 60 h-Index
1992 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1992 2019

2019
1 Citation (Scopus)

Aberrant DNA methylation of mTOR pathway genes promotes inflammatory activation of immune cells in diabetic kidney disease

Chen, G., Chen, H., Ren, S., Xia, M., Zhu, J., Liu, Y., Zhang, L., Tang, L., Sun, L., Liu, H. & Dong, Z., Aug 2019, In : Kidney International. 96, 2, p. 409-420 12 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
DNA Methylation
Sirolimus
Methyltransferases
Cytosine

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H. G. & Dong, Z., Jul 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

Research output: Contribution to journalArticle

Mitochondrial Membranes
Apoptosis
Proteolysis
Mitochondrial Dynamics
Kidney

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

Livingston, M. J., Wang, J., Zhou, J., Wu, G., Ganley, I. G., Hill, J. A., Yin, X. M. & Dong, Z., Dec 2 2019, In : Autophagy. 15, 12, p. 2142-2162 21 p.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Degradation
Ischemic Preconditioning
Mitochondria
Autophagy
Kidney
4 Citations (Scopus)

Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications

Guo, C., Dong, G., Liang, X. & Dong, Z., Apr 1 2019, In : Nature Reviews Nephrology. 15, 4, p. 220-239 20 p.

Research output: Contribution to journalReview article

Acute Kidney Injury
Epigenomics
Kidney
DNA Methylation
MicroRNAs
1 Citation (Scopus)

Epigenetic Regulation in Kidney Toxicity: Insights From Cisplatin Nephrotoxicity

Xiang, X., Guo, C., Tang, C., Cai, J. & Dong, Z., Mar 2019, In : Seminars in Nephrology. 39, 2, p. 152-158 7 p.

Research output: Contribution to journalReview article

Epigenomics
Cisplatin
Kidney
Histone Code
Untranslated RNA

Erratum: HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers(J Clin Invest. (2018)128:6(2419–2435) DOI: 10.1172/JCI91814)

Khambu, B., Huda, N., Chen, X., Antoine, D. J., Li, Y., Dai, G., Köhler, U. A., Zong, W. X., Waguri, S., Werner, S., Oury, T. D., Dong, Z. & Yin, X. M., May 1 2019, In : Journal of Clinical Investigation. 129, 5, 1 p.

Research output: Contribution to journalComment/debate

HMGB1 Protein
Autophagy
Mass Spectrometry
Carcinogenesis
Liver
Glycolysis
Fibrosis
Fibroblasts
Kidney
Ureteral Obstruction
2 Citations (Scopus)

Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury

Khambu, B., Li, T., Yan, S., Yu, C., Chen, X., Goheen, M., Li, Y., Lin, J., Cummings, O. W., Lee, Y. A., Friedman, S., Dong, Z., Feng, G. S., Wu, S. & Yin, X. M., May 1 2019, In : Hepatology. 69, 5, p. 2196-2213 18 p.

Research output: Contribution to journalArticle

Autophagy
Liver
Wounds and Injuries
Bile Acids and Salts
Genes

Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation

Yang, L., Zha, Y., Ding, J., Ye, B., Liu, M., Yan, C., Dong, Z., Cui, H. & Ding, H. F., Jan 1 2019, In : Oncogenesis. 8, 1, 3.

Research output: Contribution to journalArticle

Histone Demethylases
Neuroblastoma
Epigenomics
Cell Differentiation
Histones

Identification of key biomarkers in diabetic nephropathy via bioinformatic analysis

Zeng, M., Liu, J., Yang, W., Zhang, S., Liu, F., Dong, Z., Peng, Y., Sun, L. & Xiao, L., May 1 2019, In : Journal of cellular biochemistry. 120, 5, p. 8676-8688 13 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Biomarkers
Bioinformatics
Computational Biology
Genes

Multiple-microarray analysis for identification of hub genes involved in tubulointerstial injury in diabetic nephropathy

Zeng, M., Liu, J., Yang, W., Zhang, S., Liu, F., Dong, Z., Peng, Y., Sun, L. & Xiao, L., Sep 1 2019, In : Journal of Cellular Physiology. 234, 9, p. 16447-16462 16 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Microarray Analysis
Microarrays
Genes
Wounds and Injuries

Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation

Zheng, M., Cai, J., Liu, Z., Shu, S., Wang, Y., Tang, C. & Dong, Z., Jun 2019, In : Journal of Cellular and Molecular Medicine. 23, 6, p. 3995-4004 10 p.

Research output: Contribution to journalArticle

Open Access
Niacinamide
Fibrosis
Inflammation
Kidney
Wounds and Injuries
3 Citations (Scopus)

P53 in kidney injury and repair: Mechanism and therapeutic potentials

Tang, C., Ma, Z., Zhu, J., Liu, Z., Liu, Y., Liu, Y., Cai, J. & Dong, Z., Mar 2019, In : Pharmacology and Therapeutics. 195, p. 5-12 8 p.

Research output: Contribution to journalReview article

Acute Kidney Injury
Kidney
Wounds and Injuries
Chronic Renal Insufficiency
Therapeutics
1 Citation (Scopus)

RNA interference may suppress stress granule formation by preventing argonaute 2 recruitment

Lou, Q., Hu, Y., Ma, Y. & Dong, Z., Jan 1 2019, In : American Journal of Physiology - Cell Physiology. 316, 1, p. C81-C91

Research output: Contribution to journalArticle

RNA-Induced Silencing Complex
RNA Interference
Hypoxia-Inducible Factor 1
Clustered Regularly Interspaced Short Palindromic Repeats
Heat-Shock Proteins
1 Citation (Scopus)

Specific TBC Domain-Containing Proteins Control the ER-Golgi-Plasma Membrane Trafficking of GPCRs

Wei, Z., Zhang, M., Li, C., Huang, W., Fan, Y., Guo, J., Khater, M., Fukuda, M., Dong, Z., Hu, G. & Wu, G., Jul 9 2019, In : Cell Reports. 28, 2, p. 554-566.e4

Research output: Contribution to journalArticle

Open Access
Cell membranes
G-Protein-Coupled Receptors
Cell Membrane
Proteins
GTPase-Activating Proteins
Physiological Stress
Cell Survival
Kidney
Wounds and Injuries
Reperfusion
2018
17 Citations (Scopus)

Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential

Yang, D., Livingston, M. J., Liu, Z., Dong, G., Zhang, M., Chen, J. & Dong, Z., Feb 1 2018, In : Cellular and Molecular Life Sciences. 75, 4, p. 669-688 20 p.

Research output: Contribution to journalReview article

Autophagy
Diabetic Nephropathies
Therapeutics
Diabetes Complications
Organelles
Receptor-Interacting Protein Serine-Threonine Kinases
Muromegalovirus
Photoreceptor Cells
Cytomegalovirus Infections
Protein Kinases
1 Citation (Scopus)
Proximal Kidney Tubule
Fibrosis
Up-Regulation
Kidney
Wounds and Injuries

Embryonic Fate Mapping Uncovers the Critical Role of microRNAs in the Development of Epidermal γδ T Cells

Yao, Y., Liu, Q., Martin, C., Yin, C., Dong, Z., Mi, Q. S. & Zhou, L., Jan 1 2018, In : Journal of Investigative Dermatology. 138, 1, p. 236-239 4 p.

Research output: Contribution to journalArticle

DEAD-box RNA Helicases
Granulocyte-Macrophage Colony-Stimulating Factor Receptors
Antigen Receptors, T-Cell, gamma-delta
Ribonuclease III
T-cells
9 Citations (Scopus)

Endoplasmic reticulum stress in ischemic and nephrotoxic acute kidney injury

Yan, M., Shu, S., Guo, C., Tang, C. & Dong, Z., Jul 4 2018, In : Annals of Medicine. 50, 5, p. 381-390 10 p.

Research output: Contribution to journalReview article

Endoplasmic Reticulum Stress
Acute Kidney Injury
Unfolded Protein Response
Kidney
Protein Unfolding
4 Citations (Scopus)

Endoplasmic reticulum stress is activated in post-ischemic kidneys to promote chronic kidney disease

Shu, S., Zhu, J., Liu, Z., Tang, C., Cai, J. & Dong, Z., Nov 2018, In : EBioMedicine. 37, p. 269-280 12 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Chronic Renal Insufficiency
Acute Kidney Injury
Kidney
Transcription Factor CHOP
6 Citations (Scopus)

FGF21 is induced in cisplatin nephrotoxicity to protect against kidney tubular cell injury

Li, F., Liu, Z., Tang, C., Cai, J. & Dong, Z., Jun 1 2018, In : FASEB Journal. 32, 6, p. 3423-3433 11 p.

Research output: Contribution to journalArticle

Cisplatin
Kidney
Wounds and Injuries
Acute Kidney Injury
fibroblast growth factor 21
17 Citations (Scopus)

Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells

Liu, J., Livingston, M. J., Dong, G., Tang, C., Su, Y., Wu, G., Yin, X. M. & Dong, Z., Mar 1 2018, In : Cell Death and Disease. 9, 3, 322.

Research output: Contribution to journalArticle

trichostatin A
Histone Deacetylase Inhibitors
Autophagy
Acute Kidney Injury
Cisplatin
16 Citations (Scopus)

HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers

Khambu, B., Huda, N., Chen, X., Antoine, D. J., Li, Y., Dai, G., Köhler, U. A., Zong, W. X., Waguri, S., Werner, S., Oury, T. D., Dong, Z. & Yin, X. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2419-2435 17 p.

Research output: Contribution to journalArticle

Autophagy
Carcinogenesis
Hepatocytes
Liver
Inflammasomes

Inflammation and outer blood-retina barrier (BRB) compromise following choroidal murine cytomegalovirus (MCMV) infections

Xu, J., Liu, X., Mo, J., Marshall, B., Perry, L., Dong, Z. & Zhang, M., May 18 2018, In : Molecular Vision. 24, p. 379-394 16 p.

Research output: Contribution to journalArticle

Muromegalovirus
Cytomegalovirus Infections
Retina
Inflammation
Bruch Membrane
7 Citations (Scopus)

MicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in ischemic acute kidney injury

Wei, Q., Sun, H., Song, S., Liu, Y., Liu, P., Livingston, M. J., Wang, J., Liang, M., Mi, Q. S., Huo, Y., Nahman, N. S., Mei, C. & Dong, Z., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5448-5464 17 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Mitochondrial Proteins
MicroRNAs
Acute Kidney Injury
Kidney
1 Citation (Scopus)

Micro RNAs are required for Langerhans cell, skin- and lung-resident macrophage ontogeny

Yao, Y., Martin, C., Yin, C., Guo, C., Dong, Z., Zhou, L. & Mi, Q. S., Sep 1 2018, In : Journal of Allergy and Clinical Immunology. 142, 3, p. 976-978.e2

Research output: Contribution to journalArticle

Langerhans Cells
MicroRNAs
Macrophages
Lung
Skin

Neutrophil extracellular traps in ischemic AKI: new way to kill

Liu, J. & Dong, Z., Feb 2018, In : Kidney International. 93, 2, p. 303-305 3 p.

Research output: Contribution to journalComment/debate

Infection
Kidney
Acute Kidney Injury
Neutrophils
Inflammation
8 Citations (Scopus)

PINK1/Parkin-mediated mitophagy is activated in cisplatin nephrotoxicity to protect against kidney injury

Wang, Y., Tang, C., Cai, J., Chen, G., Zhang, D., Zhang, Z. & Dong, Z., Nov 1 2018, In : Cell Death and Disease. 9, 11, 1113.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Degradation
Cisplatin
Kidney
Wounds and Injuries
Autophagy
25 Citations (Scopus)

PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury

Tang, C., Han, H., Yan, M., Zhu, S., Liu, J., Liu, Z., He, L., Tan, J., Liu, Y., Liu, H., Sun, L., Duan, S., Peng, Y., Liu, F., Yin, X. M., Zhang, Z. & Dong, Z., May 4 2018, In : Autophagy. 14, 5, p. 880-897 18 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Reperfusion Injury
Kidney
Acute Kidney Injury
Reactive Oxygen Species
5 Citations (Scopus)

PKCδ-mediated Nox2 activation promotes fluid-phase pinocytosis of antigens by immature dendritic cells

Singla, B., Ghoshal, P., Lin, H., Wei, Q., Dong, Z. & Csányi, G., Mar 26 2018, In : Frontiers in immunology. 9, MAR, 537.

Research output: Contribution to journalArticle

Pinocytosis
NADPH Oxidase
Dendritic Cells
Protein Kinase C
Antigens
1 Citation (Scopus)

Protective effect of the BET protein inhibitor JQ1 in cisplatin-induced nephrotoxicity

Sun, L., Liu, J., Yuan, Y., Zhang, I. & Dong, Z., Sep 1 2018, In : American Journal of Physiology - Renal Physiology. 315, 3, p. F469-F478

Research output: Contribution to journalArticle

Cisplatin
Proteins
Kidney
Acetylation
Apoptosis
11 Citations (Scopus)

Rodent models of AKI-CKD transition

Fu, Y., Tang, C., Cai, J., Chen, G., Zhang, D. & Dong, Z., Oct 5 2018, In : American Journal of Physiology - Renal Physiology. 315, 4, p. F1098-F1106

Research output: Contribution to journalReview article

Chronic Renal Insufficiency
Acute Kidney Injury
Rodentia
Reperfusion Injury
Diphtheria Toxin
7 Citations (Scopus)

Serum sclerostin in vascular calcification and clinical outcome in chronic kidney disease

Zeng, C., Guo, C., Cai, J., Tang, C. & Dong, Z., Mar 1 2018, In : Diabetes and Vascular Disease Research. 15, 2, p. 99-105 7 p.

Research output: Contribution to journalReview article

Vascular Calcification
Chronic Renal Insufficiency
Serum
Osteocytes
Wnt Signaling Pathway
3 Citations (Scopus)
STAT1 Transcription Factor
effectors
ischemia
kidneys
Reperfusion Injury
2017
36 Citations (Scopus)

AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms

He, L., Wei, Q., Liu, J., Yi, M., Liu, Y., Liu, H., Sun, L., Peng, Y., Liu, F., Venkatachalam, M. A. & Dong, Z., Nov 2017, In : Kidney International. 92, 5, p. 1071-1083 13 p.

Research output: Contribution to journalReview article

Chronic Renal Insufficiency
Acute Kidney Injury
Wounds and Injuries
Autophagy
Transforming Growth Factors
11 Citations (Scopus)

Autophagy is activated to protect against podocyte injury in adriamycin-induced nephropathy

Yi, M., Zhang, L., Liu, Y., Livingston, M. J., Chen, J., Nahman, N. S., Liu, F. & Dong, Z., Jan 1 2017, In : American Journal of Physiology - Renal Physiology. 313, 1, p. F74-F84

Research output: Contribution to journalArticle

Podocytes
Autophagy
Doxorubicin
Wounds and Injuries
Gene Knockout Techniques
8 Citations (Scopus)

DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8

Guo, C., Pei, L., Xiao, X., Wei, Q., Chen, J., Ding, H., Huang, S., Fan, G., Shi, H. & Dong, Z., Nov 2017, In : Kidney International. 92, 5, p. 1194-1205 12 p.

Research output: Contribution to journalArticle

DNA Methylation
Cisplatin
Acute Kidney Injury
Kidney
Wounds and Injuries
5 Citations (Scopus)
Urethral Obstruction
Proximal Kidney Tubule
Fibrosis
Apoptosis
Kidney
12 Citations (Scopus)

Exosome production and its regulation of EGFR during wound healing in renal tubular cells

Zhou, X., Zhang, W., Yao, Q., Zhang, H., Dong, G., Zhang, M., Liu, Y., Chen, J. & Dong, Z., Jan 1 2017, In : American Journal of Physiology - Renal Physiology. 312, 6, p. F963-F970

Research output: Contribution to journalArticle

Exosomes
Wound Healing
Kidney
Epidermal Growth Factor
Growth Factor Receptors
3 Citations (Scopus)

Genetic or pharmacologic inhibition of EGFR ameliorates sepsisinduced AKI

Xu, X., Wang, J., Yang, R., Dong, Z. & Zhang, D., Jan 1 2017, In : Oncotarget. 8, 53, p. 91577-91592 16 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Apoptosis
Cytokines
Kidney
Endotoxemia
16 Citations (Scopus)

HIF-1-mediated production of exosomes during hypoxia is protective in renal tubular cells

Zhang, W., Zhou, X., Yao, Q., Liu, Y., Zhang, H. & Dong, Z., Oct 2017, In : American Journal of Physiology - Renal Physiology. 313, 4, p. F906-F913

Research output: Contribution to journalArticle

Exosomes
Hypoxia-Inducible Factor 1
Kidney
Hypoxia
Adenosine Triphosphate
17 Citations (Scopus)

Hypoxia, HIF, and associated signaling networks in chronic kidney disease

Liu, J., Wei, Q., Guo, C., Dong, G., Liu, Y., Tang, C. & Dong, Z., May 2017, In : International journal of molecular sciences. 18, 5, 950.

Research output: Contribution to journalReview article

kidney diseases
hypoxia
Chronic Renal Insufficiency
anemias
pathogenesis
21 Citations (Scopus)

Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6

Hao, J., Wei, Q., Mei, S., Li, L., Su, Y., Mei, C. & Dong, Z., Jan 1 2017, In : Kidney International. 91, 1, p. 106-118 13 p.

Research output: Contribution to journalArticle

Death Domain Receptors
Reperfusion Injury
MicroRNAs
Kidney
Acute Kidney Injury
9 Citations (Scopus)

MBD2 upregulates MIR-301a-5p to induce kidney cell apoptosis during vancomycin-induced AKI

Wang, J., Li, H., Qiu, S., Dong, Z., Xiang, X. & Zhang, D., Oct 12 2017, In : Cell Death and Disease. 8, 10, e3120.

Research output: Contribution to journalArticle

Vancomycin
Acute Kidney Injury
Up-Regulation
Apoptosis
Kidney
12 Citations (Scopus)

MicroRNA-375 is induced in cisplatin nephrotoxicity to repress hepatocyte nuclear factor 1-β

Hao, J., Lou, Q., Wei, Q., Mei, S., Li, L., Wu, G., Mi, Q. S., Mei, C. & Dong, Z., Mar 17 2017, In : Journal of Biological Chemistry. 292, 11, p. 4571-4582 12 p.

Research output: Contribution to journalArticle

Hepatocyte Nuclear Factor 1
MicroRNAs
Cisplatin
Homeobox Genes
Kidney
3 Citations (Scopus)

miRNA miR-17-92 cluster is differentially regulated in the imiqumod-treated skin but is not required for imiqumod-induced psoriasis-like dermatitis in mice

Wu, D., Bi, X., Qu, L., Han, L., Yin, C., Deng, J., Dong, Z., Mi, Q. S. & Zhou, L., Jan 1 2017, In : Experimental Dermatology. 26, 1, p. 82-84 3 p.

Research output: Contribution to journalLetter

Dermatitis
imiquimod
MicroRNAs
Psoriasis
Skin
16 Citations (Scopus)

P53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in UUO

Yang, R., Xu, X., Li, H., Chen, J., Xiang, X., Dong, Z. & Zhang, D., Feb 27 2017, In : Scientific Reports. 7, 43409.

Research output: Contribution to journalArticle

Urethral Obstruction
Fibrosis
Kidney
Vimentin
Collagen
9 Citations (Scopus)

PRKCD/PKCδ contributes to nephrotoxicity during cisplatin chemotherapy by suppressing autophagy

Zhang, D., Xu, X. & Dong, Z., Mar 4 2017, In : Autophagy. 13, 3, p. 631-632 2 p.

Research output: Contribution to journalComment/debate

Autophagy
Cisplatin
Drug Therapy
Protein Kinase C-delta
Platinum Compounds