• 17393 Citations
  • 61 h-Index
1992 …2019
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Research Output 1992 2019

1992
4 Citations (Scopus)

Effect of high K+ exposure on phosphoinositide metabolism in frog skeletal muscle

Dong, Z., Chen, K. Y. & Zhu, P. H., Jan 31 1992, In : Biochemical and Biophysical Research Communications. 182, 2, p. 767-772 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Metabolism
Anura
Labeling
Muscle
1994
3 Citations (Scopus)

Effects of 3,4-diaminopyridine on myoplasmic calcium and phosphoinositide hydrolysis in frog sartorius muscle fibers

Xu, Z. M., Dong, Z. & Zhu, P. H., Jan 1 1994, In : Acta Pharmacologica Sinica. 15, 2, p. 139-141 3 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Anura
Muscle
Hydrolysis
Calcium
1995

3,4-Diaminopyridine induced hydrolysis of phosphoinositide in cultured neurons from embryo chick forebrain

Dong, Z. & Zhu, P. H., Jan 1 1995, In : Neuropharmacology. 34, 3, p. 297-302 6 p.

Research output: Contribution to journalArticle

Chick Embryo
Prosencephalon
Phosphatidylinositols
Hydrolysis
Neurons
1996
40 Citations (Scopus)

Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels

Venkatachalam, M. A., Weinberg, J. M., Patel, Y., Saikumar, P. & Dong, Z., Jan 1 1996, In : Kidney International. 49, 2, p. 449-460 12 p.

Research output: Contribution to journalArticle

Chloride Channels
Cytoprotection
Glycine
Epithelial Cells
Kidney
2 Citations (Scopus)

Effect of caffeine on phosphoinositide metabolism in frog skeletal muscle

Dong, Z. & Zhu, P. H., Dec 1 1996, In : Chinese Journal of Physiological Sciences. 12, 2, p. 123-128 6 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Caffeine
Anura
Skeletal Muscle
Inositol
1 Citation (Scopus)

The accumulation of diacylglycerol and activation of protein kinase C induced by high K+ exposure in the frog skeletal muscle

Sun, J. H., Dong, Z. & Zhu, P. H., Dec 1 1996, In : Acta Biochimica et Biophysica Sinica. 28, 5, p. 574-575 2 p.

Research output: Contribution to journalArticle

Diglycerides
Anura
Protein Kinase C
Muscle
Skeletal Muscle
1997
2 Citations (Scopus)
Dantrolene
Phosphatidylinositols
Anura
Skeletal Muscle
Calcium
207 Citations (Scopus)

Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death: Involvement of serine but not cysteine proteases

Dong, Z., Saikumar, P., Weinberg, J. M. & Venkatachalam, M. A., Nov 1 1997, In : American Journal of Pathology. 151, 5, p. 1205-1213 9 p.

Research output: Contribution to journalArticle

DNA Cleavage
Cysteine Proteases
Serine
DNA Fragmentation
Cell Death
1998
64 Citations (Scopus)

Development of porous defects in plasma membranes of adenosine triphosphate-depleted madin-darby canine kidney cells and its inhibition by glycine

Dong, Z., Patel, Y., Saikumar, P., Weinberg, J. M. & Venkatachalam, M. A., Jun 1 1998, In : Laboratory Investigation. 78, 6, p. 657-668 12 p.

Research output: Contribution to journalArticle

Madin Darby Canine Kidney Cells
Glycine
Dextrans
Adenosine Triphosphate
Cell Membrane
26 Citations (Scopus)

Intracellular Ca2+ thresholds that determine survival or death of energy-deprived cells

Dong, Z., Saikumar, P., Griess, G. A., Weinberg, J. M. & Venkatachalam, M. A., Jan 1 1998, In : American Journal of Pathology. 152, 1, p. 231-240 10 p.

Research output: Contribution to journalArticle

Adenosine Triphosphate
Glycine
Cell Death
Cell Survival
Cell Membrane
220 Citations (Scopus)

Mechanisms of cell death in hypoxia/reoxygenation injury

Saikumar, P., Dong, Z., Weinberg, J. M. & Venkatachalam, M. A., Jan 1 1998, In : Oncogene. 17, 25, p. 3341-3349 9 p.

Research output: Contribution to journalArticle

Cell Death
Wounds and Injuries
Apoptosis Regulatory Proteins
Caspase Inhibitors
Caspases
242 Citations (Scopus)

Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury

Saikumar, P., Dong, Z., Patel, Y., Hall, K., Hopfer, U., Weinberg, J. M. & Venkatachalam, M. A., Dec 31 1998, In : Oncogene. 17, 26, p. 3401-3415 15 p.

Research output: Contribution to journalArticle

Cytochromes c
Adenosine Triphosphate
Wounds and Injuries
Cell Death
Protein Transport
1999
276 Citations (Scopus)

Apoptosis: Definition, mechanisms, and relevance to disease

Saikumar, P., Dong, Z., Mikhailov, V., Denton, M., Weinberg, J. M. & Venkatachalam, M. A., Nov 1999, In : American Journal of Medicine. 107, 5, p. 489-506 18 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-bcl-2
Lymphoproliferative Disorders
Graft Rejection
Virus Diseases
Caspases
1 Citation (Scopus)
Giant Cell Tumor of Bone
Recurrence
Curettage
2000
68 Citations (Scopus)

Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury

Weinberg, J. M., Venkatachalam, M. A., Roeser, N. F., Saikumar, P., Dong, Z., Senter, R. A. & Nissim, I., Dec 7 2000, In : American Journal of Physiology - Renal Physiology. 279, 5 48-5

Research output: Contribution to journalArticle

Anaerobiosis
Succinic Acid
Citric Acid Cycle
Aspartic Acid
Wounds and Injuries
55 Citations (Scopus)

Heme oxygenase-1 in tissue pathology: The Yin and Yang

Dong, Z., Lavrovsky, Y., Venkatachalam, M. A. & Roy, A. K., Jan 1 2000, In : American Journal of Pathology. 156, 5, p. 1485-1488 4 p.

Research output: Contribution to journalComment/debate

Yin-Yang
Heme Oxygenase-1
Pathology
67 Citations (Scopus)

Serine protease inhibitors suppress cytochrome c-mediated caspase-9 activation and apoptosis during hypoxia-reoxygenation

Dong, Z., Saikumar, P., Patel, Y., Weinberg, J. M. & Venkatachalam, M. A., May 1 2000, In : Biochemical Journal. 347, 3, p. 669-677 9 p.

Research output: Contribution to journalArticle

Serine Proteinase Inhibitors
Caspase 9
Caspases
Cytochromes c
Chemical activation
2001
265 Citations (Scopus)

Bcl-2 Prevents Bax Oligomerization in the Mitochondrial Outer Membrane

Mikhailov, V., Mikhailova, M., Pulkrabek, D. J., Dong, Z., Venkatachalam, M. A. & Saikumar, P., Jan 25 2001, In : Journal of Biological Chemistry. 276, 21, p. 18361-18374 14 p.

Research output: Contribution to journalArticle

Oligomerization
Mitochondrial Membranes
Immunoprecipitation
Mitochondria
Adenosine Triphosphate
28 Citations (Scopus)

cDNA cloning and promoter analysis of rat caspase-9

Nishiyama, J., Yi, X., Venkatachalam, M. A. & Dong, Z., Nov 15 2001, In : Biochemical Journal. 360, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

Caspase 9
Cloning
Rats
Organism Cloning
Complementary DNA
31 Citations (Scopus)

Protection of ATP-depleted cells by impermeant strychnine derivatives: Implications for glycine cytoprotection

Dong, Z., Venkatachalam, M. A., Weinberg, J. M., Saikumar, P. & Patel, Y., Jan 1 2001, In : American Journal of Pathology. 158, 3, p. 1021-1028 8 p.

Research output: Contribution to journalArticle

Strychnine
Cytoprotection
Glycine
Adenosine Triphosphate
Fluorescein
129 Citations (Scopus)

Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia: HIF-1-independent mechanisms

Dong, Z., Venkatachalam, M. A., Wang, J., Patel, Y., Saikumar, P., Semenza, G. L., Force, T. & Nishiyama, J., Jun 1 2001, In : Journal of Biological Chemistry. 276, 22, p. 18702-18709 8 p.

Research output: Contribution to journalArticle

Inhibitor of Apoptosis Proteins
Up-Regulation
Genes
Apoptosis
Transcription
2002
32 Citations (Scopus)

Gene promoter of apoptosis inhibitory protein IAP2: Identification of enhancer elements and activation by severe hypoxia

Dong, Z., Nishiyama, J., Yi, X., Venkatachalam, M. A., Denton, M., Gu, S., Li, S. & Qiang, M., Jun 1 2002, In : Biochemical Journal. 364, 2, p. 413-421 9 p.

Research output: Contribution to journalArticle

Inhibitor of Apoptosis Proteins
Genes
Chemical activation
Apoptosis
Rats
35 Citations (Scopus)

Role of glutathione metabolism of Treponema denticola in bacterial growth and virulence expression

Chu, L., Dong, Z., Xu, X., Cochran, D. L. & Ebersole, J. L., Mar 4 2002, In : Infection and Immunity. 70, 3, p. 1113-1120 8 p.

Research output: Contribution to journalArticle

Treponema denticola
Glutathione
Virulence
Periodontal Pocket
cysteinylglycine
2003
75 Citations (Scopus)

Apoptosis-resistance of hypoxic cells: Multiple factors involved and a role for IAP-2

Dong, Z., Wang, J. Z., Yu, F. & Venkatachalam, M. A., Aug 1 2003, In : American Journal of Pathology. 163, 2, p. 663-671 9 p.

Research output: Contribution to journalArticle

Inhibitor of Apoptosis Proteins
Cytosol
Apoptosis
Caspases
Staurosporine
25 Citations (Scopus)

Glycine protection of PC-12 cells against injury by ATP-depletion

Zhang, K., Weinberg, J. M., Venkatachalam, M. A. & Dong, Z., Jun 1 2003, In : Neurochemical Research. 28, 6, p. 893-901 9 p.

Research output: Contribution to journalArticle

Glycine
Glycine Receptors
Adenosine Triphosphate
Cytoprotection
Wounds and Injuries
103 Citations (Scopus)

Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed

Yi, X., Yin, X. M. & Dong, Z., May 9 2003, In : Journal of Biological Chemistry. 278, 19, p. 16992-16999 8 p.

Research output: Contribution to journalArticle

Oligomerization
Apoptosis
Membranes
Mitochondrial Membranes
Cytochromes c
18 Citations (Scopus)

Postmitochondrial regulation of apoptosis by bicarbonate

Dong, Z., Wang, J. & Zhong, Q., Aug 15 2003, In : Experimental Cell Research. 288, 2, p. 301-312 12 p.

Research output: Contribution to journalArticle

Bicarbonates
Apoptosis
Cytochromes c
Caspases
Chloride-Bicarbonate Antiporters
15 Citations (Scopus)

Role for recombinant γ-glutamyltransferase from Treponema denticola in glutathione metabolism

Chu, L., Xu, X., Dong, Z., Cappelli, D. & Ebersole, J. L., Jan 1 2003, In : Infection and Immunity. 71, 1, p. 335-342 8 p.

Research output: Contribution to journalArticle

Treponema denticola
Glutathione
Bacteria
Pyruvic Acid
Ammonia
2004
294 Citations (Scopus)

A functional variant of SUMO4, a new IκBα modifier, is associated with type diabetes

Guo, D., Li, M., Zhang, Y., Yang, P., Eckenrode, S., Hopkins, D., Zheng, W., Purohit, S. B., Podolsky, R. H., Muir, A., Wang, J., Dong, Z., Brusko, T., Atkinson, M., Pozzilli, P., Zeidler, A., Raffel, L. J., Jacob, C. O., Park, Y., Serrano-Rios, M. & 7 others, Martinez Larrad, M. T., Zhang, Z., Garchon, H. J., Bach, J. F., Rotter, J. I., She, J-X. & Wang, C. Y., Aug 1 2004, In : Nature Genetics. 36, 8, p. 837-841 5 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Genes
Ubiquitin
Single Nucleotide Polymorphism
DNA
33 Citations (Scopus)

Bid activation in kidney cells following ATP depletion in vitro and ischemia in vivo

Wei, Q., Alam, M. M., Wang, M-H., Yu, F. & Dong, Z., Apr 1 2004, In : American Journal of Physiology - Renal Physiology. 286, 4 55-4

Research output: Contribution to journalArticle

Ischemia
Adenosine Triphosphate
Kidney
Azides
Mitochondria

Erratum: A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes (Nature Genetics (2004) 36 (837-841))

Guo, D., Li, M., Zhang, Y., Yang, P., Eckenrode, S., Hopkins, D., Zheng, W., Purohit, S. B., Podolsky, R. H., Muir, A., Wang, J., Dong, Z., Brusko, T., Atkinson, M., Pozzilli, P., Zeidler, A., Raffel, L. J., Jacob, C. O., Park, Y., Serrano-Rios, M. & 7 others, Martinez Larrad, M. T., Zhang, Z., Garchon, H. J., Bach, J. F., Rotter, J. I., She, J-X. & Wang, C. Y., Sep 1 2004, In : Nature Genetics. 36, 9, 1 p.

Research output: Contribution to journalComment/debate

Type 1 Diabetes Mellitus
76 Citations (Scopus)

Hypoxia selection of death-resistant cells: A role for Bcl-XL

Dong, Z. & Wang, J., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 9215-9221 7 p.

Research output: Contribution to journalArticle

Cell Death
Apoptosis Regulatory Proteins
Mitochondria
Molecules
Staurosporine
21 Citations (Scopus)

Inhibition of apoptosis by Zn2+ in renal tubular cells following ATP depletion

Wei, Q., Wang, J., Wang, M. H., Yu, F. & Dong, Z., Sep 1 2004, In : American Journal of Physiology - Renal Physiology. 287, 3 56-3, p. F492-F500

Research output: Contribution to journalArticle

Adenosine Triphosphate
Apoptosis
Kidney
Caspases
Cytochromes c
216 Citations (Scopus)

Minocycline Up-regulates Bcl-2 and Protects against Cell Death in Mitochondria

Wang, J., Wei, Q., Wang, C. Y., Hill, W. D., Hess, D. C. & Dong, Z., May 7 2004, In : Journal of Biological Chemistry. 279, 19, p. 19948-19954 7 p.

Research output: Contribution to journalArticle

Minocycline
Mitochondria
Cell death
Cell Death
Up-Regulation
37 Citations (Scopus)

Molecular cloning and characterization of the mouse Acdp gene family

Wang, C. Y., Yang, P., Shi, J. D., Purohit, S., Guo, D., An, H., Gu, J. G., Ling, J., Dong, Z. & She, J. X., Jan 15 2004, In : BMC Genomics. 5, 7.

Research output: Contribution to journalArticle

Molecular Cloning
Genes
Proteins
Amino Acid Sequence
Nucleotides
36 Citations (Scopus)

Role of EGFR transactivation in preventing apoptosis in Pseudomonas aeruginosa-infected human corneal epithelial cells

Zhang, J., Li, H., Wang, J., Dong, Z., Mian, S. & Yu, F. S. X., Aug 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 8, p. 2569-2576 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Pseudomonas aeruginosa
Transcriptional Activation
Epithelial Cells
Apoptosis
116 Citations (Scopus)
Cisplatin
Apoptosis
Caspases
DNA Damage
Cell Death
117 Citations (Scopus)

Wound-induced HB-EGF ectodomain shedding and EGFR activation in corneal epithelial cells

Xu, K. P., Ding, Y., Ling, J., Dong, Z. & Yu, F. S. X., Mar 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 3, p. 813-820 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Epithelial Cells
Wounds and Injuries
Matrix Metalloproteinase Inhibitors
2005
25 Citations (Scopus)

Acidic pH inhibits ATP depletion-induced tubular cell apoptosis by blocking caspase-9 activation in apoptosome

Brooks, C., Ketsawatsomkron, P., Sui, Y., Wang, J., Wang, C. Y., Yu, F. S. & Dong, Z., Aug 1 2005, In : American Journal of Physiology - Renal Physiology. 289, 2 58-2, p. F410-F419

Research output: Contribution to journalArticle

Apoptosomes
Caspase 9
Adenosine Triphosphate
Apoptosis
Caspases
66 Citations (Scopus)

Differential gender differences in ischemic and nephrotoxic acute renal failure

Wei, Q., Wang, M. H. & Dong, Z., Sep 1 2005, In : American Journal of Nephrology. 25, 5, p. 491-499 9 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Cisplatin
Blood Urea Nitrogen
Kidney
Apoptosis
73 Citations (Scopus)

Flt-1 intraceptors inhibit hypoxia-induced VEGF expression in vitro and corneal neovascularization in vivo

Singhb, N., Amin, S., Richter, E., Rashid, S., Scoglietti, V., Jani, P. D., Wang, J., Kaur, R., Ambati, J., Dong, Z. & Ambati, B. K., Dec 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 5, p. 1647-1652 6 p.

Research output: Contribution to journalArticle

Corneal Neovascularization
Vascular Endothelial Growth Factor A
Leukocytes
Plasmids
Epithelial Cells
37 Citations (Scopus)

Gender differences of renal CYP-derived eicosanoid synthesis in rats fed a high-fat diet

Zhou, Y., Lin, S., Chang, H. H., Du, J., Dong, Z., Dorrance, A. M., Brands, M. W. & Wang, M. H., Apr 2005, In : American journal of hypertension. 18, 4, p. 530-537 8 p.

Research output: Contribution to journalArticle

Eicosanoids
High Fat Diet
Cytochrome P-450 Enzyme System
Kidney
Fats
68 Citations (Scopus)

Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress

Guo, D., Han, J., Adam, B. L., Colburn, N. H., Wang, M-H., Dong, Z., Eizirik, D. L., She, J-X. & Wang, C. Y., Dec 2 2005, In : Biochemical and Biophysical Research Communications. 337, 4, p. 1308-1318 11 p.

Research output: Contribution to journalArticle

Sumoylation
HEK293 Cells
Starvation
Proteomics
Transcription Factors
14 Citations (Scopus)

Renal epoxyeicosatrienoic acid synthesis during pregnancy

Zhou, Y., Chang, H. H., Du, J., Wang, C. Y., Dong, Z. & Wang, M. H., Jan 1 2005, In : American Journal of Physiology - Renal Physiology. 288, 1 57-1, p. F221-F226

Research output: Contribution to journalArticle

Kidney
Pregnancy
Acids
Blood Pressure
Fetal Weight
2006
50 Citations (Scopus)
Inbred C57BL Mouse
Renal Insufficiency
Kidney
Reperfusion
Ischemia
158 Citations (Scopus)

Calcium in cell injury and death

Dong, Z., Saikumar, P., Weinberg, J. M. & Venkatachalam, M. A., Apr 19 2006, In : Annual Review of Pathology. 1, p. 405-434 30 p.

Research output: Contribution to journalReview article

Mitochondrial Membrane Potential
Cell Death
Calcium
Permeability
Wounds and Injuries
36 Citations (Scopus)

Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: Inactivation of its kinase activity toward p53

Wang, J., Pabla, N., Wang, C. Y., Wang, W., Schoenlein, P. V. & Dong, Z., Dec 14 2006, In : American Journal of Physiology - Renal Physiology. 291, 6, p. F1300-F1307

Research output: Contribution to journalArticle

Caspases
Cisplatin
Phosphotransferases
Apoptosis
Caspase Inhibitors
5 Citations (Scopus)

Characterization of cell clones stably transfected with short form caspase-9: Apoptotic resistance and Bcl-XL expression

Yi, X., Wang, J., Seol, D. W. & Dong, Z., Jan 1 2006, In : Molecular and Cellular Biochemistry. 282, 1-2, p. 1-12 12 p.

Research output: Contribution to journalArticle

Clone cells
Caspase 9
Caspases
Clone Cells
Apoptosis
50 Citations (Scopus)
Cisplatin
Apoptosis
Hypoxia-Inducible Factor 1
Kidney
Electron Transport Complex III
79 Citations (Scopus)

Deletion of microsomal prostaglandin E synthase-1 increases sensitivity to salt loading and angiotensin II infusion

Jia, Z., Zhang, A., Zhang, H., Dong, Z. & Yang, T., Nov 1 2006, In : Circulation research. 99, 11, p. 1243-1251 9 p.

Research output: Contribution to journalArticle

Angiotensin II
Salts
Nitric Oxide Synthase
Dinoprostone
Nitrites