• 19552 Citations
  • 66 h-Index
1992 …2020

Research output per year

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Research Output

1992

Effect of high K+ exposure on phosphoinositide metabolism in frog skeletal muscle

Dong, Z., Chen, K. Y. & Zhu, P. H., Jan 31 1992, In : Biochemical and Biophysical Research Communications. 182, 2, p. 767-772 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
1994

Effects of 3,4-diaminopyridine on myoplasmic calcium and phosphoinositide hydrolysis in frog sartorius muscle fibers

Xu, Z. M., Dong, Z. & Zhu, P. H., Jan 1 1994, In : Acta Pharmacologica Sinica. 15, 2, p. 139-141 3 p.

Research output: Contribution to journalArticle

3 Scopus citations
1995

3,4-Diaminopyridine induced hydrolysis of phosphoinositide in cultured neurons from embryo chick forebrain

Dong, Z. & Zhu, P. H., Jan 1 1995, In : Neuropharmacology. 34, 3, p. 297-302 6 p.

Research output: Contribution to journalArticle

1996

Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels

Venkatachalam, M. A., Weinberg, J. M., Patel, Y., Saikumar, P. & Dong, Z., Jan 1 1996, In : Kidney International. 49, 2, p. 449-460 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Effect of caffeine on phosphoinositide metabolism in frog skeletal muscle

Dong, Z. & Zhu, P. H., Dec 1 1996, In : Chinese Journal of Physiological Sciences. 12, 2, p. 123-128 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

The accumulation of diacylglycerol and activation of protein kinase C induced by high K+ exposure in the frog skeletal muscle

Sun, J. H., Dong, Z. & Zhu, P. H., Dec 1 1996, In : Acta Biochimica et Biophysica Sinica. 28, 5, p. 574-575 2 p.

Research output: Contribution to journalArticle

1 Scopus citations
1997
2 Scopus citations

Internucleosomal DNA cleavage triggered by plasma membrane damage during necrotic cell death: Involvement of serine but not cysteine proteases

Dong, Z., Saikumar, P., Weinberg, J. M. & Venkatachalam, M. A., Nov 1997, In : American Journal of Pathology. 151, 5, p. 1205-1213 9 p.

Research output: Contribution to journalArticle

208 Scopus citations
1998

Development of porous defects in plasma membranes of adenosine triphosphate-depleted madin-darby canine kidney cells and its inhibition by glycine

Dong, Z., Patel, Y., Saikumar, P., Weinberg, J. M. & Venkatachalam, M. A., Jun 1998, In : Laboratory Investigation. 78, 6, p. 657-668 12 p.

Research output: Contribution to journalArticle

66 Scopus citations

Intracellular Ca2+ thresholds that determine survival or death of energy-deprived cells

Dong, Z., Saikumar, P., Griess, G. A., Weinberg, J. M. & Venkatachalam, M. A., Jan 1998, In : American Journal of Pathology. 152, 1, p. 231-240 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Mechanisms of cell death in hypoxia/reoxygenation injury

Saikumar, P., Dong, Z., Weinberg, J. M. & Venkatachalam, M. A., Jan 1 1998, In : Oncogene. 17, 25, p. 3341-3349 9 p.

Research output: Contribution to journalArticle

223 Scopus citations

Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury

Saikumar, P., Dong, Z., Patel, Y., Hall, K., Hopfer, U., Weinberg, J. M. & Venkatachalam, M. A., Dec 31 1998, In : Oncogene. 17, 26, p. 3401-3415 15 p.

Research output: Contribution to journalArticle

244 Scopus citations
1999

Apoptosis: Definition, mechanisms, and relevance to disease

Saikumar, P., Dong, Z., Mikhailov, V., Denton, M., Weinberg, J. M. & Venkatachalam, M. A., Nov 1999, In : American Journal of Medicine. 107, 5, p. 489-506 18 p.

Research output: Contribution to journalArticle

283 Scopus citations
1 Scopus citations
2000

Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury

Weinberg, J. M., Venkatachalam, M. A., Roeser, N. F., Saikumar, P., Dong, Z., Senter, R. A. & Nissim, I., 2000, In : American Journal of Physiology - Renal Physiology. 279, 5 48-5, p. F927-F943

Research output: Contribution to journalArticle

70 Scopus citations

Heme oxygenase-1 in tissue pathology: The Yin and Yang

Dong, Z., Lavrovsky, Y., Venkatachalam, M. A. & Roy, A. K., 2000, In : American Journal of Pathology. 156, 5, p. 1485-1488 4 p.

Research output: Contribution to journalComment/debate

55 Scopus citations

Serine protease inhibitors suppress cytochrome c-mediated caspase-9 activation and apoptosis during hypoxia-reoxygenation

Dong, Z., Saikumar, P., Patel, Y., Weinberg, J. M. & Venkatachalam, M. A., May 1 2000, In : Biochemical Journal. 347, 3, p. 669-677 9 p.

Research output: Contribution to journalArticle

69 Scopus citations
2001

Bcl-2 Prevents Bax Oligomerization in the Mitochondrial Outer Membrane

Mikhailov, V., Mikhailova, M., Pulkrabek, D. J., Dong, Z., Venkatachalam, M. A. & Saikumar, P., Jan 25 2001, In : Journal of Biological Chemistry. 276, 21, p. 18361-18374 14 p.

Research output: Contribution to journalArticle

267 Scopus citations

cDNA cloning and promoter analysis of rat caspase-9

Nishiyama, J., Yi, X., Venkatachalam, M. A. & Dong, Z., Nov 15 2001, In : Biochemical Journal. 360, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Protection of ATP-depleted cells by impermeant strychnine derivatives: Implications for glycine cytoprotection

Dong, Z., Venkatachalam, M. A., Weinberg, J. M., Saikumar, P. & Patel, Y., 2001, In : American Journal of Pathology. 158, 3, p. 1021-1028 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia: HIF-1-independent mechanisms

Dong, Z., Venkatachalam, M. A., Wang, J., Patel, Y., Saikumar, P., Semenza, G. L., Force, T. & Nishiyama, J., Jun 1 2001, In : Journal of Biological Chemistry. 276, 22, p. 18702-18709 8 p.

Research output: Contribution to journalArticle

129 Scopus citations
2002

Gene promoter of apoptosis inhibitory protein IAP2: Identification of enhancer elements and activation by severe hypoxia

Dong, Z., Nishiyama, J., Yi, X., Venkatachalam, M. A., Denton, M., Gu, S., Li, S. & Qiang, M., Jun 1 2002, In : Biochemical Journal. 364, 2, p. 413-421 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Role of glutathione metabolism of Treponema denticola in bacterial growth and virulence expression

Chu, L., Dong, Z., Xu, X., Cochran, D. L. & Ebersole, J. L., 2002, In : Infection and Immunity. 70, 3, p. 1113-1120 8 p.

Research output: Contribution to journalArticle

37 Scopus citations
2003

Apoptosis-resistance of hypoxic cells: Multiple factors involved and a role for IAP-2

Dong, Z., Wang, J. Z., Yu, F. & Venkatachalam, M. A., Aug 1 2003, In : American Journal of Pathology. 163, 2, p. 663-671 9 p.

Research output: Contribution to journalArticle

76 Scopus citations

Glycine protection of PC-12 cells against injury by ATP-depletion

Zhang, K., Weinberg, J. M., Venkatachalam, M. A. & Dong, Z., Jun 1 2003, In : Neurochemical Research. 28, 6, p. 893-901 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed

Yi, X., Yin, X. M. & Dong, Z., May 9 2003, In : Journal of Biological Chemistry. 278, 19, p. 16992-16999 8 p.

Research output: Contribution to journalArticle

105 Scopus citations

Postmitochondrial regulation of apoptosis by bicarbonate

Dong, Z., Wang, J. & Zhong, Q., Aug 15 2003, In : Experimental Cell Research. 288, 2, p. 301-312 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Role for recombinant γ-glutamyltransferase from Treponema denticola in glutathione metabolism

Chu, L., Xu, X., Dong, Z., Cappelli, D. & Ebersole, J. L., Jan 1 2003, In : Infection and Immunity. 71, 1, p. 335-342 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2004

A functional variant of SUMO4, a new IκBα modifier, is associated with type diabetes

Guo, D., Li, M., Zhang, Y., Yang, P., Eckenrode, S., Hopkins, D., Zheng, W., Purohit, S. B., Podolsky, R. H., Muir, A., Wang, J., Dong, Z., Brusko, T., Atkinson, M., Pozzilli, P., Zeidler, A., Raffel, L. J., Jacob, C. O., Park, Y., Serrano-Rios, M. & 7 others, Martinez Larrad, M. T., Zhang, Z., Garchon, H. J., Bach, J. F., Rotter, J. I., She, J-X. & Wang, C. Y., Aug 2004, In : Nature Genetics. 36, 8, p. 837-841 5 p.

Research output: Contribution to journalArticle

301 Scopus citations

Bid activation in kidney cells following ATP depletion in vitro and ischemia in vivo

Wei, Q., Alam, M. M., Wang, M-H., Yu, F. & Dong, Z., Apr 2004, In : American Journal of Physiology - Renal Physiology. 286, 4 55-4, p. F803-F809

Research output: Contribution to journalArticle

33 Scopus citations

Erratum: A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes (Nature Genetics (2004) 36 (837-841))

Guo, D., Li, M., Zhang, Y., Yang, P., Eckenrode, S., Hopkins, D., Zheng, W., Purohit, S. B., Podolsky, R. H., Muir, A., Wang, J., Dong, Z., Brusko, T., Atkinson, M., Pozzilli, P., Zeidler, A., Raffel, L. J., Jacob, C. O., Park, Y., Serrano-Rios, M. & 7 others, Martinez Larrad, M. T., Zhang, Z., Garchon, H. J., Bach, J. F., Rotter, J. I., She, J-X. & Wang, C. Y., Sep 2004, In : Nature Genetics. 36, 9, p. 1024 1 p.

Research output: Contribution to journalComment/debate

Open Access

Hypoxia selection of death-resistant cells: A role for Bcl-XL

Dong, Z. & Wang, J., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 9215-9221 7 p.

Research output: Contribution to journalArticle

77 Scopus citations

Inhibition of apoptosis by Zn2+ in renal tubular cells following ATP depletion

Wei, Q., Wang, J., Wang, M. H., Yu, F. & Dong, Z., Sep 1 2004, In : American Journal of Physiology - Renal Physiology. 287, 3 56-3, p. F492-F500

Research output: Contribution to journalArticle

21 Scopus citations

Minocycline Up-regulates Bcl-2 and Protects against Cell Death in Mitochondria

Wang, J., Wei, Q., Wang, C. Y., Hill, W. D., Hess, D. C. & Dong, Z., May 7 2004, In : Journal of Biological Chemistry. 279, 19, p. 19948-19954 7 p.

Research output: Contribution to journalArticle

220 Scopus citations

Molecular cloning and characterization of the mouse Acdp gene family

Wang, C. Y., Yang, P., Shi, J. D., Purohit, S., Guo, D., An, H., Gu, J. G., Ling, J., Dong, Z. & She, J. X., Jan 15 2004, In : BMC Genomics. 5, 7.

Research output: Contribution to journalArticle

37 Scopus citations

Role of EGFR transactivation in preventing apoptosis in Pseudomonas aeruginosa-infected human corneal epithelial cells

Zhang, J., Li, H., Wang, J., Dong, Z., Mian, S. & Yu, F. S. X., Aug 2004, In : Investigative Ophthalmology and Visual Science. 45, 8, p. 2569-2576 8 p.

Research output: Contribution to journalArticle

38 Scopus citations
122 Scopus citations

Wound-induced HB-EGF ectodomain shedding and EGFR activation in corneal epithelial cells

Xu, K. P., Ding, Y., Ling, J., Dong, Z. & Yu, F. S. X., Mar 2004, In : Investigative Ophthalmology and Visual Science. 45, 3, p. 813-820 8 p.

Research output: Contribution to journalArticle

118 Scopus citations
2005

Acidic pH inhibits ATP depletion-induced tubular cell apoptosis by blocking caspase-9 activation in apoptosome

Brooks, C., Ketsawatsomkron, P., Sui, Y., Wang, J., Wang, C. Y., Yu, F. S. & Dong, Z., Aug 1 2005, In : American Journal of Physiology - Renal Physiology. 289, 2 58-2, p. F410-F419

Research output: Contribution to journalArticle

25 Scopus citations

Differential gender differences in ischemic and nephrotoxic acute renal failure

Wei, Q., Wang, M. H. & Dong, Z., Sep 1 2005, In : American Journal of Nephrology. 25, 5, p. 491-499 9 p.

Research output: Contribution to journalArticle

71 Scopus citations

Flt-1 intraceptors inhibit hypoxia-induced VEGF expression in vitro and corneal neovascularization in vivo

Singhb, N., Amin, S., Richter, E., Rashid, S., Scoglietti, V., Jani, P. D., Wang, J., Kaur, R., Ambati, J., Dong, Z. & Ambati, B. K., Dec 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 5, p. 1647-1652 6 p.

Research output: Contribution to journalArticle

75 Scopus citations

Gender differences of renal CYP-derived eicosanoid synthesis in rats fed a high-fat diet

Zhou, Y., Lin, S., Chang, H. H., Du, J., Dong, Z., Dorrance, A. M., Brands, M. W. & Wang, M. H., Apr 2005, In : American journal of hypertension. 18, 4, p. 530-537 8 p.

Research output: Contribution to journalArticle

37 Scopus citations

Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress

Guo, D., Han, J., Adam, B. L., Colburn, N. H., Wang, M-H., Dong, Z., Eizirik, D. L., She, J-X. & Wang, C. Y., Dec 2 2005, In : Biochemical and Biophysical Research Communications. 337, 4, p. 1308-1318 11 p.

Research output: Contribution to journalArticle

70 Scopus citations

Renal epoxyeicosatrienoic acid synthesis during pregnancy

Zhou, Y., Chang, H. H., Du, J., Wang, C. Y., Dong, Z. & Wang, M. H., Jan 1 2005, In : American Journal of Physiology - Renal Physiology. 288, 1 57-1, p. F221-F226

Research output: Contribution to journalArticle

15 Scopus citations
2006
51 Scopus citations

Calcium in cell injury and death

Dong, Z., Saikumar, P., Weinberg, J. M. & Venkatachalam, M. A., Apr 19 2006, In : Annual Review of Pathology. 1, p. 405-434 30 p.

Research output: Contribution to journalReview article

167 Scopus citations

Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: Inactivation of its kinase activity toward p53

Wang, J., Pabla, N., Wang, C. Y., Wang, W., Schoenlein, P. V. & Dong, Z., Dec 14 2006, In : American Journal of Physiology - Renal Physiology. 291, 6, p. F1300-F1307

Research output: Contribution to journalArticle

38 Scopus citations

Characterization of cell clones stably transfected with short form caspase-9: Apoptotic resistance and Bcl-XL expression

Yi, X., Wang, J., Seol, D. W. & Dong, Z., Jan 1 2006, In : Molecular and Cellular Biochemistry. 282, 1-2, p. 1-12 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
53 Scopus citations

Deletion of microsomal prostaglandin E synthase-1 increases sensitivity to salt loading and angiotensin II infusion

Jia, Z., Zhang, A., Zhang, H., Dong, Z. & Yang, T., Nov 2006, In : Circulation research. 99, 11, p. 1243-1251 9 p.

Research output: Contribution to journalArticle

82 Scopus citations