• 19552 Citations
  • 66 h-Index
1992 …2020

Research output per year

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Research Output

3,4-Diaminopyridine induced hydrolysis of phosphoinositide in cultured neurons from embryo chick forebrain

Dong, Z. & Zhu, P. H., Jan 1 1995, In : Neuropharmacology. 34, 3, p. 297-302 6 p.

Research output: Contribution to journalArticle

Aberrant DNA methylation of mTOR pathway genes promotes inflammatory activation of immune cells in diabetic kidney disease

Chen, G., Chen, H., Ren, S., Xia, M., Zhu, J., Liu, Y., Zhang, L., Tang, L., Sun, L., Liu, H. & Dong, Z., Aug 2019, In : Kidney International. 96, 2, p. 409-420 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Acetylation of Ets-1 is the key to chromatin remodeling for miR-192 expression

Dong, Z., Jun 4 2013, In : Science Signaling. 6, 278, pe21.

Research output: Contribution to journalShort survey

8 Scopus citations

Acidic pH inhibits ATP depletion-induced tubular cell apoptosis by blocking caspase-9 activation in apoptosome

Brooks, C., Ketsawatsomkron, P., Sui, Y., Wang, J., Wang, C. Y., Yu, F. S. & Dong, Z., Aug 1 2005, In : American Journal of Physiology - Renal Physiology. 289, 2 58-2, p. F410-F419

Research output: Contribution to journalArticle

25 Scopus citations

Activation and involvement of p53 in cisplatin-induced nephrotoxicity

Wei, Q., Dong, G., Yang, T., Megyesi, J., Price, P. M. & Dong, Z., Oct 2007, In : American Journal of Physiology - Renal Physiology. 293, 4, p. F1282-F1291

Research output: Contribution to journalArticle

157 Scopus citations

Activation of BNIP3-mediated mitophagy protects against renal ischemia–reperfusion injury

Tang, C., Han, H., Liu, Z., Liu, Y., Yin, L., Cai, J., He, L., Liu, Y., Chen, G., Zhang, Z., Yin, X. M. & Dong, Z., Sep 1 2019, In : Cell Death and Disease. 10, 9, 677.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

A functional variant of SUMO4, a new IκBα modifier, is associated with type diabetes

Guo, D., Li, M., Zhang, Y., Yang, P., Eckenrode, S., Hopkins, D., Zheng, W., Purohit, S. B., Podolsky, R. H., Muir, A., Wang, J., Dong, Z., Brusko, T., Atkinson, M., Pozzilli, P., Zeidler, A., Raffel, L. J., Jacob, C. O., Park, Y., Serrano-Rios, M. & 7 others, Martinez Larrad, M. T., Zhang, Z., Garchon, H. J., Bach, J. F., Rotter, J. I., She, J-X. & Wang, C. Y., Aug 2004, In : Nature Genetics. 36, 8, p. 837-841 5 p.

Research output: Contribution to journalArticle

301 Scopus citations

AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms

He, L., Wei, Q., Liu, J., Yi, M., Liu, Y., Liu, H., Sun, L., Peng, Y., Liu, F., Venkatachalam, M. A. & Dong, Z., Nov 2017, In : Kidney International. 92, 5, p. 1071-1083 13 p.

Research output: Contribution to journalReview article

68 Scopus citations

Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury

Weinberg, J. M., Venkatachalam, M. A., Roeser, N. F., Saikumar, P., Dong, Z., Senter, R. A. & Nissim, I., 2000, In : American Journal of Physiology - Renal Physiology. 279, 5 48-5, p. F927-F943

Research output: Contribution to journalArticle

70 Scopus citations

Analysis of apoptosis: Basic principles and protocols

Jiang, M., Brooks, C., Dong, G., Li, X., Ni, H. M., Yin, X. M. & Dong, Z., Jan 1 2009, Essentials of Apoptosis: A Guide for Basic and Clinical Research. Humana Press Inc., p. 691-711 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Apoptosis: Definition, mechanisms, and relevance to disease

Saikumar, P., Dong, Z., Mikhailov, V., Denton, M., Weinberg, J. M. & Venkatachalam, M. A., Nov 1999, In : American Journal of Medicine. 107, 5, p. 489-506 18 p.

Research output: Contribution to journalArticle

283 Scopus citations

Apoptosis in acute kidney injury

Pabla, N., Wei, Q. & Dong, Z., Jan 1 2009, Essentials of Apoptosis: A Guide for Basic and Clinical Research. Humana Press Inc., p. 565-579 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Apoptosis-resistance of hypoxic cells: Multiple factors involved and a role for IAP-2

Dong, Z., Wang, J. Z., Yu, F. & Venkatachalam, M. A., Aug 1 2003, In : American Journal of Pathology. 163, 2, p. 663-671 9 p.

Research output: Contribution to journalArticle

76 Scopus citations

A stress-dependent SUMO4 sumoylation of its substrate proteins

Wei, W., Yang, P., Pang, J., Zhang, S., Wang, Y., Wang, M-H., Dong, Z., She, J-X. & Wang, C. Y., Oct 24 2008, In : Biochemical and Biophysical Research Communications. 375, 3, p. 454-459 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis

Pabla, N., Huang, S., Mi, Q. S., Daniel, R. & Dong, Z., Mar 7 2008, In : Journal of Biological Chemistry. 283, 10, p. 6572-6583 12 p.

Research output: Contribution to journalArticle

193 Scopus citations

ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis (Journal of Biological Chemistry (2008) 283, (6572-6583))

Pabla, N., Huang, S., Mi, Q. S., Daniel, R. & Dong, Z., May 30 2008, In : Journal of Biological Chemistry. 283, 22, 1 p.

Research output: Contribution to journalComment/debate

Autophagy: Molecular machinery, regulation, and implications for renal pathophysiology

Periyasamy-Thandavan, S., Jiang, M., Schoenlein, P. & Dong, Z., Aug 2009, In : American Journal of Physiology - Renal Physiology. 297, 2, p. F244-F256

Research output: Contribution to journalReview article

115 Scopus citations

Autophagy and Tubular Cell Death in the Kidney

Havasi, A. & Dong, Z., May 1 2016, In : Seminars in Nephrology. 36, 3, p. 174-188 15 p.

Research output: Contribution to journalReview article

40 Scopus citations

Autophagy in acute kidney injury

Livingston, M. J. & Dong, Z., Jan 2014, In : Seminars in Nephrology. 34, 1, p. 17-26 10 p.

Research output: Contribution to journalReview article

59 Scopus citations

Autophagy in acute kidney injury and repair

He, L., Livingston, M. J. & Dong, Z., Apr 16 2014, In : Nephron - Clinical Practice. 127, 1-4, p. 56-60 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential

Yang, D., Livingston, M. J., Liu, Z., Dong, G., Zhang, M., Chen, J. K. & Dong, Z., Feb 1 2018, In : Cellular and Molecular Life Sciences. 75, 4, p. 669-688 20 p.

Research output: Contribution to journalReview article

47 Scopus citations

Autophagy inhibition by chloroquine and hydroxychloroquine could adversely affect acute kidney injury and other organ injury in critically ill patients with COVID-19

Edelstein, C. L., Venkatachalam, M. A. & Dong, Z., Jul 2020, In : Kidney International. 98, 1, p. 234-235 2 p.

Research output: Contribution to journalLetter

Open Access
2 Scopus citations

Autophagy in kidney homeostasis and disease

Tang, C., Livingston, M. J., Liu, Z. & Dong, Z., 2020, (Accepted/In press) In : Nature Reviews Nephrology.

Research output: Contribution to journalReview article

Autophagy in podocytes

Lei, Z., Livingston, M. J., Chen, J. K. & Dong, Z., Jan 1 2014, In : Contributions to Nephrology. 183, p. 83-100 18 p.

Research output: Contribution to journalArticle

2 Scopus citations

Autophagy in proximal tubules protects against acute kidney injury

Jiang, M., Wei, Q., Dong, G., Komatsu, M., Su, Y. & Dong, Z., Dec 2 2012, In : Kidney International. 82, 12, p. 1271-1283 13 p.

Research output: Contribution to journalArticle

259 Scopus citations

Autophagy is activated to protect against endotoxic acute kidney injury

Mei, S., Livingston, M. J., Hao, J., Li, L., Mei, C. & Dong, Z., Feb 26 2016, In : Scientific reports. 6, 22171.

Research output: Contribution to journalArticle

42 Scopus citations

Autophagy is activated to protect against podocyte injury in adriamycin-induced nephropathy

Yi, M., Zhang, L., Liu, Y., Livingston, M. J., Chen, J., Nahman, N. S., Liu, F. & Dong, Z., 2017, In : American Journal of Physiology - Renal Physiology. 313, 1, p. F74-F84

Research output: Contribution to journalArticle

18 Scopus citations

Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury

Jiang, M., Liu, K., Luo, J. & Dong, Z., Mar 2010, In : American Journal of Pathology. 176, 3, p. 1181-1192 12 p.

Research output: Contribution to journalArticle

269 Scopus citations

Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells

Periyasamy-Thandavan, S., Jiang, M., Wei, Q., Smith, R., Yin, X. M. & Dong, Z., Sep 1 2008, In : Kidney International. 74, 5, p. 631-640 10 p.

Research output: Contribution to journalArticle

223 Scopus citations

Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins

Brooks, C., Wei, Q., Feng, L., Dong, G., Tao, Y., Mei, L., Xie, Z. J. & Dong, Z., Jul 10 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 28, p. 11649-11654 6 p.

Research output: Contribution to journalArticle

246 Scopus citations

Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models

Wei, Q., Dong, G., Chen, J. K., Ramesh, G. & Dong, Z., Jul 2013, In : Kidney International. 84, 1, p. 138-148 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

Bcl-2 Prevents Bax Oligomerization in the Mitochondrial Outer Membrane

Mikhailov, V., Mikhailova, M., Pulkrabek, D. J., Dong, Z., Venkatachalam, M. A. & Saikumar, P., Jan 25 2001, In : Journal of Biological Chemistry. 276, 21, p. 18361-18374 14 p.

Research output: Contribution to journalArticle

267 Scopus citations

Bid activation in kidney cells following ATP depletion in vitro and ischemia in vivo

Wei, Q., Alam, M. M., Wang, M-H., Yu, F. & Dong, Z., Apr 2004, In : American Journal of Physiology - Renal Physiology. 286, 4 55-4, p. F803-F809

Research output: Contribution to journalArticle

33 Scopus citations
51 Scopus citations

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H. G. & Dong, Z., Jul 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

Research output: Contribution to journalArticle

5 Scopus citations

Blocking rpS6 phosphorylation exacerbates Tsc1 deletion–induced kidney growth

Wu, H., Chen, J., Xu, J., Dong, Z., Meyuhas, O. & Chen, J., 2016, In : Journal of the American Society of Nephrology. 27, 4, p. 1145-1158 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats

Wang, Y., Zhang, H., Wang, Z., Wei, Y., Wang, M., Liu, M., Wang, X., Jiang, Y., Shi, G., Zhao, D., Yang, Z., Ren, Z., Li, J., Zhang, Z., Wang, Z., Zhang, B., Zong, B., Lou, X., Liu, C., Wang, Z. & 23 others, Zhang, H., Tao, N., Li, X., Zhang, X., Guo, Y., Ye, Y., Qi, Y., Li, H., Wang, M., Guo, R., Cheng, G., Li, S., Zhang, J., Liu, G., Chai, L., Lou, Q., Li, X., Cui, X., Gao, E., Dong, Z., Hu, Y., Chen, Y. H. & Ma, Y., Apr 22 2020, In : Science Translational Medicine. 12, 540, eaaw3172.

Research output: Contribution to journalArticle

Calcium in cell injury and death

Dong, Z., Saikumar, P., Weinberg, J. M. & Venkatachalam, M. A., Apr 19 2006, In : Annual Review of Pathology. 1, p. 405-434 30 p.

Research output: Contribution to journalReview article

167 Scopus citations

Canagliflozin reduces cisplatin uptake and activates Akt to protect against cisplatin-induced nephrotoxicity

Song, Z., Zhu, J., Wei, Q., Dong, G. & Dong, Z., Apr 1 2020, In : American journal of physiology. Renal physiology. 318, 4, p. F1041-F1052

Research output: Contribution to journalArticle

Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: Inactivation of its kinase activity toward p53

Wang, J., Pabla, N., Wang, C. Y., Wang, W., Schoenlein, P. V. & Dong, Z., Dec 14 2006, In : American Journal of Physiology - Renal Physiology. 291, 6, p. F1300-F1307

Research output: Contribution to journalArticle

38 Scopus citations

cDNA cloning and promoter analysis of rat caspase-9

Nishiyama, J., Yi, X., Venkatachalam, M. A. & Dong, Z., Nov 15 2001, In : Biochemical Journal. 360, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Cell Apoptosis and Autophagy in Renal Fibrosis

Zhao, X. C., Livingston, M. J., Liang, X. L. & Dong, Z., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 557-584 28 p. (Advances in Experimental Medicine and Biology; vol. 1165).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Cellular and molecular mechanisms of AKI

Agarwal, A., Dong, Z., Harris, R., Murray, P., Parikh, S. M., Rosner, M. H., Kellum, J. A. & Ronco, C., May 2016, In : Journal of the American Society of Nephrology. 27, 5, p. 1288-1299 12 p.

Research output: Contribution to journalReview article

68 Scopus citations

Changes in metabolic profiles during acute kidney injury and recovery following ischemia/reperfusion

Wei, Q., Xiao, X., Fogle, P. & Dong, Z., Sep 5 2014, In : PloS one. 9, 9, e106647.

Research output: Contribution to journalArticle

52 Scopus citations

Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells

Brooks, C., Wang, J., Yang, T. & Dong, Z., Jan 1 2007, In : American Journal of Physiology - Renal Physiology. 292, 1, p. F243-F252

Research output: Contribution to journalArticle

8 Scopus citations

Characterization of cell clones stably transfected with short form caspase-9: Apoptotic resistance and Bcl-XL expression

Yi, X., Wang, J., Seol, D. W. & Dong, Z., Jan 1 2006, In : Molecular and Cellular Biochemistry. 282, 1-2, p. 1-12 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
33 Scopus citations

Checkpoint kinase 1 in DNA damage response and cell cycle regulation

Patil, M., Pabla, N. & Dong, Z., Nov 2013, In : Cellular and Molecular Life Sciences. 70, 21, p. 4009-4021 13 p.

Research output: Contribution to journalReview article

100 Scopus citations

Chronic effects of repeated low-dose cisplatin treatment in mouse kidneys and renal tubular cells

Fu, Y., Cai, J., Li, F., Liu, Z., Shu, S., Wang, Y., Liu, Y., Tang, C. & Dong, Z., 2019, In : American Journal of Physiology - Renal Physiology. 317, 6, p. F1582-F1592

Research output: Contribution to journalArticle

2 Scopus citations

Cisplatin-induced apoptosis in p53-deficient renal cells via the intrinsic mitochondrial pathway

Jiang, M., Wang, C. Y., Huang, S., Yang, T. & Dong, Z., May 2009, In : American Journal of Physiology - Renal Physiology. 296, 5, p. F983-F993

Research output: Contribution to journalArticle

74 Scopus citations