• 17393 Citations
  • 61 h-Index
1992 …2019
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Research Output 1992 2019

3,4-Diaminopyridine induced hydrolysis of phosphoinositide in cultured neurons from embryo chick forebrain

Dong, Z. & Zhu, P. H., Jan 1 1995, In : Neuropharmacology. 34, 3, p. 297-302 6 p.

Research output: Contribution to journalArticle

Chick Embryo
Prosencephalon
Phosphatidylinositols
Hydrolysis
Neurons
1 Citation (Scopus)

Aberrant DNA methylation of mTOR pathway genes promotes inflammatory activation of immune cells in diabetic kidney disease

Chen, G., Chen, H., Ren, S., Xia, M., Zhu, J., Liu, Y., Zhang, L., Tang, L., Sun, L., Liu, H. & Dong, Z., Aug 2019, In : Kidney International. 96, 2, p. 409-420 12 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
DNA Methylation
Sirolimus
Methyltransferases
Cytosine
8 Citations (Scopus)

Acetylation of Ets-1 is the key to chromatin remodeling for miR-192 expression

Dong, Z., Jun 4 2013, In : Science Signaling. 6, 278, pe21.

Research output: Contribution to journalShort survey

Acetylation
Chromatin Assembly and Disassembly
MicroRNAs
Chromatin
Transforming Growth Factors
25 Citations (Scopus)

Acidic pH inhibits ATP depletion-induced tubular cell apoptosis by blocking caspase-9 activation in apoptosome

Brooks, C., Ketsawatsomkron, P., Sui, Y., Wang, J., Wang, C. Y., Yu, F. S. & Dong, Z., Aug 1 2005, In : American Journal of Physiology - Renal Physiology. 289, 2 58-2, p. F410-F419

Research output: Contribution to journalArticle

Apoptosomes
Caspase 9
Adenosine Triphosphate
Apoptosis
Caspases
149 Citations (Scopus)

Activation and involvement of p53 in cisplatin-induced nephrotoxicity

Wei, Q., Dong, G., Yang, T., Megyesi, J., Price, P. M. & Dong, Z., Oct 1 2007, In : American Journal of Physiology - Renal Physiology. 293, 4, p. F1282-F1291

Research output: Contribution to journalArticle

Cisplatin
Wild Animals
Apoptosis
Kidney
Acute Kidney Injury
294 Citations (Scopus)

A functional variant of SUMO4, a new IκBα modifier, is associated with type diabetes

Guo, D., Li, M., Zhang, Y., Yang, P., Eckenrode, S., Hopkins, D., Zheng, W., Purohit, S. B., Podolsky, R. H., Muir, A., Wang, J., Dong, Z., Brusko, T., Atkinson, M., Pozzilli, P., Zeidler, A., Raffel, L. J., Jacob, C. O., Park, Y., Serrano-Rios, M. & 7 others, Martinez Larrad, M. T., Zhang, Z., Garchon, H. J., Bach, J. F., Rotter, J. I., She, J-X. & Wang, C. Y., Aug 1 2004, In : Nature Genetics. 36, 8, p. 837-841 5 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Genes
Ubiquitin
Single Nucleotide Polymorphism
DNA
43 Citations (Scopus)

AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms

He, L., Wei, Q., Liu, J., Yi, M., Liu, Y., Liu, H., Sun, L., Peng, Y., Liu, F., Venkatachalam, M. A. & Dong, Z., Nov 2017, In : Kidney International. 92, 5, p. 1071-1083 13 p.

Research output: Contribution to journalReview article

Chronic Renal Insufficiency
Acute Kidney Injury
Wounds and Injuries
Autophagy
Transforming Growth Factors
68 Citations (Scopus)

Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury

Weinberg, J. M., Venkatachalam, M. A., Roeser, N. F., Saikumar, P., Dong, Z., Senter, R. A. & Nissim, I., Dec 7 2000, In : American Journal of Physiology - Renal Physiology. 279, 5 48-5

Research output: Contribution to journalArticle

Anaerobiosis
Succinic Acid
Citric Acid Cycle
Aspartic Acid
Wounds and Injuries
1 Citation (Scopus)

Analysis of apoptosis: Basic principles and protocols

Jiang, M., Brooks, C., Dong, G., Li, X., Ni, H. M., Yin, X. M. & Dong, Z., Jan 1 2009, Essentials of Apoptosis: A Guide for Basic and Clinical Research. Humana Press Inc., p. 691-711 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Apoptosis
Research Subjects
Biochemistry
Cell membranes
Cytosol
276 Citations (Scopus)

Apoptosis: Definition, mechanisms, and relevance to disease

Saikumar, P., Dong, Z., Mikhailov, V., Denton, M., Weinberg, J. M. & Venkatachalam, M. A., Nov 1999, In : American Journal of Medicine. 107, 5, p. 489-506 18 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-bcl-2
Lymphoproliferative Disorders
Graft Rejection
Virus Diseases
Caspases
3 Citations (Scopus)

Apoptosis in acute kidney injury

Pabla, N., Wei, Q. & Dong, Z., Jan 1 2009, Essentials of Apoptosis: A Guide for Basic and Clinical Research. Humana Press Inc., p. 565-579 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Acute Kidney Injury
Apoptosis
Cell death
Kidney Diseases
Research
75 Citations (Scopus)

Apoptosis-resistance of hypoxic cells: Multiple factors involved and a role for IAP-2

Dong, Z., Wang, J. Z., Yu, F. & Venkatachalam, M. A., Aug 1 2003, In : American Journal of Pathology. 163, 2, p. 663-671 9 p.

Research output: Contribution to journalArticle

Inhibitor of Apoptosis Proteins
Cytosol
Apoptosis
Caspases
Staurosporine
44 Citations (Scopus)

A stress-dependent SUMO4 sumoylation of its substrate proteins

Wei, W., Yang, P., Pang, J., Zhang, S., Wang, Y., Wang, M-H., Dong, Z., She, J-X. & Wang, C. Y., Oct 24 2008, In : Biochemical and Biophysical Research Communications. 375, 3, p. 454-459 6 p.

Research output: Contribution to journalArticle

Sumoylation
Small Ubiquitin-Related Modifier Proteins
Hydrolases
Substrates
Luciferases
191 Citations (Scopus)

ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis

Pabla, N., Huang, S., Mi, Q. S., Daniel, R. & Dong, Z., Mar 7 2008, In : Journal of Biological Chemistry. 283, 10, p. 6572-6583 12 p.

Research output: Contribution to journalArticle

Cisplatin
DNA Damage
Chemical activation
Apoptosis
DNA

ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis (Journal of Biological Chemistry (2008) 283, (6572-6583))

Pabla, N., Huang, S., Mi, Q. S., Daniel, R. & Dong, Z., May 30 2008, In : Journal of Biological Chemistry. 283, 22, 1 p.

Research output: Contribution to journalComment/debate

Cisplatin
DNA Damage
Chemical activation
Apoptosis
DNA
105 Citations (Scopus)

Autophagy: Molecular machinery, regulation, and implications for renal pathophysiology

Periyasamy-Thandavan, S., Jiang, M., Schoenlein, P. & Dong, Z., Aug 1 2009, In : American Journal of Physiology - Renal Physiology. 297, 2, p. F244-F256

Research output: Contribution to journalReview article

Autophagy
Kidney
Food
Starvation
Lysosomes
30 Citations (Scopus)

Autophagy and Tubular Cell Death in the Kidney

Havasi, A. & Dong, Z., May 1 2016, In : Seminars in Nephrology. 36, 3, p. 174-188 15 p.

Research output: Contribution to journalReview article

Autophagy
Cell Death
Kidney
Epithelial Cells
Poisons
54 Citations (Scopus)

Autophagy in acute kidney injury

Livingston, M. J. & Dong, Z., Jan 1 2014, In : Seminars in Nephrology. 34, 1, p. 17-26 10 p.

Research output: Contribution to journalReview article

Autophagy
Acute Kidney Injury
Cell Death
Gene Knockout Techniques
Wounds and Injuries
31 Citations (Scopus)

Autophagy in acute kidney injury and repair

He, L., Livingston, M. J. & Dong, Z., Apr 16 2014, In : Nephron - Clinical Practice. 127, 1-4, p. 56-60 5 p.

Research output: Contribution to journalArticle

Autophagy
Acute Kidney Injury
Kidney
Fibrosis
Kidney Diseases
19 Citations (Scopus)

Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential

Yang, D., Livingston, M. J., Liu, Z., Dong, G., Zhang, M., Chen, J. & Dong, Z., Feb 1 2018, In : Cellular and Molecular Life Sciences. 75, 4, p. 669-688 20 p.

Research output: Contribution to journalReview article

Autophagy
Diabetic Nephropathies
Therapeutics
Diabetes Complications
Organelles
2 Citations (Scopus)

Autophagy in podocytes

Lei, Z., Livingston, M. J., Chen, J. K. & Dong, Z., Jan 1 2014, In : Contributions to Nephrology. 183, p. 83-100 18 p.

Research output: Contribution to journalArticle

Podocytes
Autophagy
Physiology
Kidney Diseases
Pathology
228 Citations (Scopus)

Autophagy in proximal tubules protects against acute kidney injury

Jiang, M., Wei, Q., Dong, G., Komatsu, M., Su, Y. & Dong, Z., Dec 2 2012, In : Kidney International. 82, 12, p. 1271-1283 13 p.

Research output: Contribution to journalArticle

Autophagy
Acute Kidney Injury
Cisplatin
Knockout Mice
Kidney
29 Citations (Scopus)

Autophagy is activated to protect against endotoxic acute kidney injury

Mei, S., Livingston, M. J., Hao, J., Li, L., Mei, C. & Dong, Z., Feb 26 2016, In : Scientific Reports. 6, 22171.

Research output: Contribution to journalArticle

Autophagy
Acute Kidney Injury
Lipopolysaccharides
Kidney Tubules
Kidney
11 Citations (Scopus)

Autophagy is activated to protect against podocyte injury in adriamycin-induced nephropathy

Yi, M., Zhang, L., Liu, Y., Livingston, M. J., Chen, J., Nahman, N. S., Liu, F. & Dong, Z., Jan 1 2017, In : American Journal of Physiology - Renal Physiology. 313, 1, p. F74-F84

Research output: Contribution to journalArticle

Podocytes
Autophagy
Doxorubicin
Wounds and Injuries
Gene Knockout Techniques
244 Citations (Scopus)

Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury

Jiang, M., Liu, K., Luo, J. & Dong, Z., Mar 2010, In : American Journal of Pathology. 176, 3, p. 1181-1192 12 p.

Research output: Contribution to journalArticle

Autophagy
Reperfusion Injury
Kidney
Reperfusion
Ischemia
207 Citations (Scopus)

Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells

Periyasamy Thandavan, S., Livingston, M. J., Wei, Q., Smith, R., Yin, X. M. & Dong, Z., Sep 1 2008, In : Kidney International. 74, 5, p. 631-640 10 p.

Research output: Contribution to journalArticle

Autophagy
Cisplatin
Kidney
Wounds and Injuries
Apoptosis
234 Citations (Scopus)

Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins

Brooks, C., Wei, Q., Feng, L., Dong, G., Tao, Y., Mei, L., Xie, Z. J. & Dong, Z., Jul 10 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 28, p. 11649-11654 6 p.

Research output: Contribution to journalArticle

Apoptosis
Pathology
Mitochondrial Dynamics
Wounds and Injuries
Membranes
56 Citations (Scopus)

Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models

Wei, Q., Dong, G., Chen, J. K., Ramesh, G. & Dong, Z., Jul 2013, In : Kidney International. 84, 1, p. 138-148 11 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Knockout Mice
Kidney
Apoptosis
Gene Knockout Techniques
265 Citations (Scopus)

Bcl-2 Prevents Bax Oligomerization in the Mitochondrial Outer Membrane

Mikhailov, V., Mikhailova, M., Pulkrabek, D. J., Dong, Z., Venkatachalam, M. A. & Saikumar, P., Jan 25 2001, In : Journal of Biological Chemistry. 276, 21, p. 18361-18374 14 p.

Research output: Contribution to journalArticle

Oligomerization
Mitochondrial Membranes
Immunoprecipitation
Mitochondria
Adenosine Triphosphate
33 Citations (Scopus)

Bid activation in kidney cells following ATP depletion in vitro and ischemia in vivo

Wei, Q., Alam, M. M., Wang, M-H., Yu, F. & Dong, Z., Apr 1 2004, In : American Journal of Physiology - Renal Physiology. 286, 4 55-4

Research output: Contribution to journalArticle

Ischemia
Adenosine Triphosphate
Kidney
Azides
Mitochondria
50 Citations (Scopus)
Inbred C57BL Mouse
Renal Insufficiency
Kidney
Reperfusion
Ischemia

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H. G. & Dong, Z., Jul 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

Research output: Contribution to journalArticle

Mitochondrial Membranes
Apoptosis
Proteolysis
Mitochondrial Dynamics
Kidney
1 Citation (Scopus)

Blocking rpS6 phosphorylation exacerbates Tsc1 deletion–induced kidney growth

Wu, H., Chen, J., Xu, J., Dong, Z., Meyuhas, O. & Chen, J., Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 4, p. 1145-1158 14 p.

Research output: Contribution to journalArticle

Ribosomal Protein S6
Phosphorylation
Kidney
Growth
Carrier Proteins
158 Citations (Scopus)

Calcium in cell injury and death

Dong, Z., Saikumar, P., Weinberg, J. M. & Venkatachalam, M. A., Apr 19 2006, In : Annual Review of Pathology. 1, p. 405-434 30 p.

Research output: Contribution to journalReview article

Mitochondrial Membrane Potential
Cell Death
Calcium
Permeability
Wounds and Injuries
36 Citations (Scopus)

Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: Inactivation of its kinase activity toward p53

Wang, J., Pabla, N., Wang, C. Y., Wang, W., Schoenlein, P. V. & Dong, Z., Dec 14 2006, In : American Journal of Physiology - Renal Physiology. 291, 6, p. F1300-F1307

Research output: Contribution to journalArticle

Caspases
Cisplatin
Phosphotransferases
Apoptosis
Caspase Inhibitors
28 Citations (Scopus)

cDNA cloning and promoter analysis of rat caspase-9

Nishiyama, J., Yi, X., Venkatachalam, M. A. & Dong, Z., Nov 15 2001, In : Biochemical Journal. 360, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

Caspase 9
Cloning
Rats
Organism Cloning
Complementary DNA
51 Citations (Scopus)

Cellular and molecular mechanisms of AKI

Agarwal, A., Dong, Z., Harris, R., Murray, P., Parikh, S. M., Rosner, M. H., Kellum, J. A. & Ronco, C., May 2016, In : Journal of the American Society of Nephrology. 27, 5, p. 1288-1299 12 p.

Research output: Contribution to journalReview article

Clinical Trials
Cell Communication
Comorbidity
Industry
Theoretical Models
45 Citations (Scopus)

Changes in metabolic profiles during acute kidney injury and recovery following ischemia/reperfusion

Wei, Q., Xiao, X., Fogle, P. & Dong, Z., Sep 5 2014, In : PloS one. 9, 9, e106647.

Research output: Contribution to journalArticle

Metabolome
ischemia
Acute Kidney Injury
Reperfusion
Ischemia
8 Citations (Scopus)

Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells

Brooks, C., Wang, J., Yang, T. & Dong, Z., Jan 1 2007, In : American Journal of Physiology - Renal Physiology. 292, 1, p. F243-F252

Research output: Contribution to journalArticle

Clone Cells
Kidney
Azides
Apoptosis
Cytochromes c
5 Citations (Scopus)

Characterization of cell clones stably transfected with short form caspase-9: Apoptotic resistance and Bcl-XL expression

Yi, X., Wang, J., Seol, D. W. & Dong, Z., Jan 1 2006, In : Molecular and Cellular Biochemistry. 282, 1-2, p. 1-12 12 p.

Research output: Contribution to journalArticle

Clone cells
Caspase 9
Caspases
Clone Cells
Apoptosis
29 Citations (Scopus)
DNA Damage
Cell Cycle
Checkpoint Kinase 1
Phosphorylation
Cultured Tumor Cells
79 Citations (Scopus)

Checkpoint kinase 1 in DNA damage response and cell cycle regulation

Patil, M., Pabla, N. & Dong, Z., Nov 1 2013, In : Cellular and Molecular Life Sciences. 70, 21, p. 4009-4021 13 p.

Research output: Contribution to journalReview article

DNA Damage
Cell Cycle
Cell Cycle Checkpoints
DNA Repair
Checkpoint Kinase 1
67 Citations (Scopus)

Cisplatin-induced apoptosis in p53-deficient renal cells via the intrinsic mitochondrial pathway

Jiang, M., Wang, C. Y., Huang, S., Yang, T. & Dong, Z., May 1 2009, In : American Journal of Physiology - Renal Physiology. 296, 5, p. F983-F993

Research output: Contribution to journalArticle

Cisplatin
Apoptosis
Kidney
Cytochromes c
Caspase Inhibitors
909 Citations (Scopus)

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

Pabla, N. & Dong, Z., May 2008, In : Kidney International. 73, 9, p. 994-1007 14 p.

Research output: Contribution to journalReview article

Cisplatin
Platinum
Neoplasms
Cell Death
Inflammation
1 Citation (Scopus)

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

Livingston, M. J., Wang, J., Zhou, J., Wu, G., Ganley, I. G., Hill, J. A., Yin, X. M. & Dong, Z., Dec 2 2019, In : Autophagy. 15, 12, p. 2142-2162 21 p.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Degradation
Ischemic Preconditioning
Mitochondria
Autophagy
Kidney
30 Citations (Scopus)

Colfibrate attenuates blood pressure and sodium retention in DOCA-salt hypertension

Zhou, Y., Luo, P., Chang, H. H., Huang, H., Yang, T., Dong, Z., Wang, C. Y. & Wang, M-H., Oct 1 2008, In : Kidney International. 74, 8, p. 1040-1048 9 p.

Research output: Contribution to journalArticle

Desoxycorticosterone Acetate
Peroxisome Proliferator-Activated Receptors
Clofibrate
Salts
Sodium

Collapsing glomerulopathy with rare associated coxsackie virus infection: A case report

Zhu, X., Liu, H., Yuan, S., Xu, X., Dong, Z. & Liu, F., May 2016, In : Experimental and Therapeutic Medicine. 11, 5, p. 1871-1874 4 p.

Research output: Contribution to journalArticle

Coxsackievirus Infections
Satellite Viruses
Kidney
Biopsy
Enterovirus
7 Citations (Scopus)

Conditional ablation of HDAC3 in islet beta cells results in glucose intolerance and enhanced susceptibility to STZ-induced diabetes

Chen, W. B., Gao, L., Wang, J., Wang, Y. G., Dong, Z., Zhao, J., Mi, Q. S. & Zhou, L., Jan 1 2016, In : Oncotarget. 7, 36, p. 57485-57497 13 p.

Research output: Contribution to journalArticle

Glucose Intolerance
Experimental Diabetes Mellitus
Islets of Langerhans
Histone Deacetylases
Insulin
31 Citations (Scopus)

COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis

Shao, J., Teng, Y., Padia, R., Hong, S., Noh, H., Xie, X., Mumm, J. S., Dong, Z., Ding, H. F., Cowell, J., Kim, J., Han, J. & Huang, S., Sep 2013, In : Neoplasia (United States). 15, 9, p. 1075-1085 11 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Carcinogenesis
Breast Neoplasms
Proto-Oncogene Proteins c-jun
Proteins
18 Citations (Scopus)

Cordycepin inhibits albumin-induced epithelial-mesenchymal transition of renal tubular epithelial cells by reducing reactive oxygen species production

Xiao, L., Ge, Y., Sun, L., Xu, X., Xie, P., Zhan, M., Wang, M., Dong, Z., Li, J., Duan, S., Liu, F. & Xiao, P., Feb 1 2012, In : Free Radical Research. 46, 2, p. 174-183 10 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Albumins
Reactive Oxygen Species
Epithelial Cells
Kidney