• 19183 Citations
  • 65 h-Index
1992 …2020

Research output per year

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Research Output

Article

3,4-Diaminopyridine induced hydrolysis of phosphoinositide in cultured neurons from embryo chick forebrain

Dong, Z. & Zhu, P. H., Jan 1 1995, In : Neuropharmacology. 34, 3, p. 297-302 6 p.

Research output: Contribution to journalArticle

Aberrant DNA methylation of mTOR pathway genes promotes inflammatory activation of immune cells in diabetic kidney disease

Chen, G., Chen, H., Ren, S., Xia, M., Zhu, J., Liu, Y., Zhang, L., Tang, L., Sun, L., Liu, H. & Dong, Z., Aug 2019, In : Kidney International. 96, 2, p. 409-420 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Acidic pH inhibits ATP depletion-induced tubular cell apoptosis by blocking caspase-9 activation in apoptosome

Brooks, C., Ketsawatsomkron, P., Sui, Y., Wang, J., Wang, C. Y., Yu, F. S. & Dong, Z., Aug 1 2005, In : American Journal of Physiology - Renal Physiology. 289, 2 58-2, p. F410-F419

Research output: Contribution to journalArticle

25 Scopus citations

Activation and involvement of p53 in cisplatin-induced nephrotoxicity

Wei, Q., Dong, G., Yang, T., Megyesi, J., Price, P. M. & Dong, Z., Oct 2007, In : American Journal of Physiology - Renal Physiology. 293, 4, p. F1282-F1291

Research output: Contribution to journalArticle

156 Scopus citations

Activation of BNIP3-mediated mitophagy protects against renal ischemia–reperfusion injury

Tang, C., Han, H., Liu, Z., Liu, Y., Yin, L., Cai, J., He, L., Liu, Y., Chen, G., Zhang, Z., Yin, X. M. & Dong, Z., Sep 1 2019, In : Cell Death and Disease. 10, 9, 677.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

A functional variant of SUMO4, a new IκBα modifier, is associated with type diabetes

Guo, D., Li, M., Zhang, Y., Yang, P., Eckenrode, S., Hopkins, D., Zheng, W., Purohit, S. B., Podolsky, R. H., Muir, A., Wang, J., Dong, Z., Brusko, T., Atkinson, M., Pozzilli, P., Zeidler, A., Raffel, L. J., Jacob, C. O., Park, Y., Serrano-Rios, M. & 7 others, Martinez Larrad, M. T., Zhang, Z., Garchon, H. J., Bach, J. F., Rotter, J. I., She, J-X. & Wang, C. Y., Aug 1 2004, In : Nature Genetics. 36, 8, p. 837-841 5 p.

Research output: Contribution to journalArticle

299 Scopus citations

Anaerobic and aerobic pathways for salvage of proximal tubules from hypoxia-induced mitochondrial injury

Weinberg, J. M., Venkatachalam, M. A., Roeser, N. F., Saikumar, P., Dong, Z., Senter, R. A. & Nissim, I., 2000, In : American Journal of Physiology - Renal Physiology. 279, 5 48-5, p. F927-F943

Research output: Contribution to journalArticle

70 Scopus citations

Apoptosis: Definition, mechanisms, and relevance to disease

Saikumar, P., Dong, Z., Mikhailov, V., Denton, M., Weinberg, J. M. & Venkatachalam, M. A., Nov 1999, In : American Journal of Medicine. 107, 5, p. 489-506 18 p.

Research output: Contribution to journalArticle

280 Scopus citations

Apoptosis-resistance of hypoxic cells: Multiple factors involved and a role for IAP-2

Dong, Z., Wang, J. Z., Yu, F. & Venkatachalam, M. A., Aug 1 2003, In : American Journal of Pathology. 163, 2, p. 663-671 9 p.

Research output: Contribution to journalArticle

76 Scopus citations

A stress-dependent SUMO4 sumoylation of its substrate proteins

Wei, W., Yang, P., Pang, J., Zhang, S., Wang, Y., Wang, M-H., Dong, Z., She, J-X. & Wang, C. Y., Oct 24 2008, In : Biochemical and Biophysical Research Communications. 375, 3, p. 454-459 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis

Pabla, N., Huang, S., Mi, Q. S., Daniel, R. & Dong, Z., Mar 7 2008, In : Journal of Biological Chemistry. 283, 10, p. 6572-6583 12 p.

Research output: Contribution to journalArticle

193 Scopus citations

Autophagy in acute kidney injury and repair

He, L., Livingston, M. J. & Dong, Z., Apr 16 2014, In : Nephron - Clinical Practice. 127, 1-4, p. 56-60 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Autophagy in podocytes

Lei, Z., Livingston, M. J., Chen, J. K. & Dong, Z., Jan 1 2014, In : Contributions to Nephrology. 183, p. 83-100 18 p.

Research output: Contribution to journalArticle

2 Scopus citations

Autophagy in proximal tubules protects against acute kidney injury

Jiang, M., Wei, Q., Dong, G., Komatsu, M., Su, Y. & Dong, Z., Dec 2 2012, In : Kidney International. 82, 12, p. 1271-1283 13 p.

Research output: Contribution to journalArticle

253 Scopus citations

Autophagy is activated to protect against endotoxic acute kidney injury

Mei, S., Livingston, M. J., Hao, J., Li, L., Mei, C. & Dong, Z., Feb 26 2016, In : Scientific reports. 6, 22171.

Research output: Contribution to journalArticle

40 Scopus citations

Autophagy is activated to protect against podocyte injury in adriamycin-induced nephropathy

Yi, M., Zhang, L., Liu, Y., Livingston, M. J., Chen, J., Nahman, N. S., Liu, F. & Dong, Z., Jan 1 2017, In : American Journal of Physiology - Renal Physiology. 313, 1, p. F74-F84

Research output: Contribution to journalArticle

18 Scopus citations

Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury

Jiang, M., Liu, K., Luo, J. & Dong, Z., Mar 2010, In : American Journal of Pathology. 176, 3, p. 1181-1192 12 p.

Research output: Contribution to journalArticle

266 Scopus citations

Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells

Periyasamy-Thandavan, S., Jiang, M., Wei, Q., Smith, R., Yin, X. M. & Dong, Z., Sep 1 2008, In : Kidney International. 74, 5, p. 631-640 10 p.

Research output: Contribution to journalArticle

220 Scopus citations

Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins

Brooks, C., Wei, Q., Feng, L., Dong, G., Tao, Y., Mei, L., Xie, Z. J. & Dong, Z., Jul 10 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 28, p. 11649-11654 6 p.

Research output: Contribution to journalArticle

244 Scopus citations

Bax and Bak have critical roles in ischemic acute kidney injury in global and proximal tubule-specific knockout mouse models

Wei, Q., Dong, G., Chen, J. K., Ramesh, G. & Dong, Z., Jul 2013, In : Kidney International. 84, 1, p. 138-148 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

Bcl-2 Prevents Bax Oligomerization in the Mitochondrial Outer Membrane

Mikhailov, V., Mikhailova, M., Pulkrabek, D. J., Dong, Z., Venkatachalam, M. A. & Saikumar, P., Jan 25 2001, In : Journal of Biological Chemistry. 276, 21, p. 18361-18374 14 p.

Research output: Contribution to journalArticle

266 Scopus citations

Bid activation in kidney cells following ATP depletion in vitro and ischemia in vivo

Wei, Q., Alam, M. M., Wang, M-H., Yu, F. & Dong, Z., Apr 2004, In : American Journal of Physiology - Renal Physiology. 286, 4 55-4, p. F803-F809

Research output: Contribution to journalArticle

33 Scopus citations
51 Scopus citations

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H. G. & Dong, Z., Jul 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

Research output: Contribution to journalArticle

5 Scopus citations

Blocking rpS6 phosphorylation exacerbates Tsc1 deletion–induced kidney growth

Wu, H., Chen, J., Xu, J., Dong, Z., Meyuhas, O. & Chen, J., Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 4, p. 1145-1158 14 p.

Research output: Contribution to journalArticle

5 Scopus citations

Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats

Wang, Y., Zhang, H., Wang, Z., Wei, Y., Wang, M., Liu, M., Wang, X., Jiang, Y., Shi, G., Zhao, D., Yang, Z., Ren, Z., Li, J., Zhang, Z., Wang, Z., Zhang, B., Zong, B., Lou, X., Liu, C., Wang, Z. & 23 others, Zhang, H., Tao, N., Li, X., Zhang, X., Guo, Y., Ye, Y., Qi, Y., Li, H., Wang, M., Guo, R., Cheng, G., Li, S., Zhang, J., Liu, G., Chai, L., Lou, Q., Li, X., Cui, X., Gao, E., Dong, Z., Hu, Y., Chen, Y. H. & Ma, Y., Apr 22 2020, In : Science Translational Medicine. 12, 540, eaaw3172.

Research output: Contribution to journalArticle

Canagliflozin reduces cisplatin uptake and activates Akt to protect against cisplatin-induced nephrotoxicity

Song, Z., Zhu, J., Wei, Q., Dong, G. & Dong, Z., Apr 1 2020, In : American journal of physiology. Renal physiology. 318, 4, p. F1041-F1052

Research output: Contribution to journalArticle

Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: Inactivation of its kinase activity toward p53

Wang, J., Pabla, N., Wang, C. Y., Wang, W., Schoenlein, P. V. & Dong, Z., Dec 14 2006, In : American Journal of Physiology - Renal Physiology. 291, 6, p. F1300-F1307

Research output: Contribution to journalArticle

38 Scopus citations

cDNA cloning and promoter analysis of rat caspase-9

Nishiyama, J., Yi, X., Venkatachalam, M. A. & Dong, Z., Nov 15 2001, In : Biochemical Journal. 360, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Changes in metabolic profiles during acute kidney injury and recovery following ischemia/reperfusion

Wei, Q., Xiao, X., Fogle, P. & Dong, Z., Sep 5 2014, In : PloS one. 9, 9, e106647.

Research output: Contribution to journalArticle

51 Scopus citations

Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells

Brooks, C., Wang, J., Yang, T. & Dong, Z., Jan 1 2007, In : American Journal of Physiology - Renal Physiology. 292, 1, p. F243-F252

Research output: Contribution to journalArticle

8 Scopus citations

Characterization of cell clones stably transfected with short form caspase-9: Apoptotic resistance and Bcl-XL expression

Yi, X., Wang, J., Seol, D. W. & Dong, Z., Jan 1 2006, In : Molecular and Cellular Biochemistry. 282, 1-2, p. 1-12 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
33 Scopus citations

Chronic effects of repeated low-dose cisplatin treatment in mouse kidneys and renal tubular cells

Fu, Y., Cai, J., Li, F., Liu, Z., Shu, S., Wang, Y., Liu, Y., Tang, C. & Dong, Z., 2019, In : American Journal of Physiology - Renal Physiology. 317, 6, p. F1582-F1592

Research output: Contribution to journalArticle

Cisplatin-induced apoptosis in p53-deficient renal cells via the intrinsic mitochondrial pathway

Jiang, M., Wang, C. Y., Huang, S., Yang, T. & Dong, Z., May 1 2009, In : American Journal of Physiology - Renal Physiology. 296, 5, p. F983-F993

Research output: Contribution to journalArticle

71 Scopus citations

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

Livingston, M. J., Wang, J., Zhou, J., Wu, G., Ganley, I. G., Hill, J. A., Yin, X. M. & Dong, Z., Dec 2 2019, In : Autophagy. 15, 12, p. 2142-2162 21 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Colfibrate attenuates blood pressure and sodium retention in DOCA-salt hypertension

Zhou, Y., Luo, P., Chang, H. H., Huang, H., Yang, T., Dong, Z., Wang, C. Y. & Wang, M. H., Oct 1 2008, In : Kidney International. 74, 8, p. 1040-1048 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Collapsing glomerulopathy with rare associated coxsackie virus infection: A case report

Zhu, X., Liu, H., Yuan, S., Xu, X., Dong, Z. & Liu, F., May 2016, In : Experimental and Therapeutic Medicine. 11, 5, p. 1871-1874 4 p.

Research output: Contribution to journalArticle

Conditional ablation of HDAC3 in islet beta cells results in glucose intolerance and enhanced susceptibility to STZ-induced diabetes

Chen, W. B., Gao, L., Wang, J., Wang, Y. G., Dong, Z., Zhao, J., Mi, Q. S. & Zhou, L., 2016, In : Oncotarget. 7, 36, p. 57485-57497 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis

Shao, J., Teng, Y., Padia, R., Hong, S., Noh, H., Xie, X., Mumm, J. S., Dong, Z., Ding, H. F., Cowell, J., Kim, J., Han, J. & Huang, S., Sep 2013, In : Neoplasia (United States). 15, 9, p. 1075-1085 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Cordycepin inhibits albumin-induced epithelial-mesenchymal transition of renal tubular epithelial cells by reducing reactive oxygen species production

Xiao, L., Ge, Y., Sun, L., Xu, X., Xie, P., Zhan, M., Wang, M., Dong, Z., Li, J., Duan, S., Liu, F. & Xiao, P., Feb 1 2012, In : Free Radical Research. 46, 2, p. 174-183 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Curtailing side effects in chemotherapy: A tale of PKCδ in cisplatin treatment

Pabla, N. & Dong, Z., Jan 2012, In : Oncotarget. 3, 1, p. 107-111 5 p.

Research output: Contribution to journalArticle

38 Scopus citations

Cyclic 3′,5′-guanosine monophosphate-dependent protein kinase inhibits colon cancer cell adaptation to hypoxia

Kwon, I. K., Wang, R., Prakash, N., Bozard, R., Baudino, T. A., Liu, K., Thangaraju, M., Dong, Z. & Browning, D. D., Dec 1 2011, In : Cancer. 117, 23, p. 5282-5293 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression

Yang, L., Fang, D., Chen, H., Lu, Y., Dong, Z., Ding, H. F., Jing, Q., Su, S. B. & Huang, S., 2015, In : Oncotarget. 6, 25, p. 20801-20812 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels

Venkatachalam, M. A., Weinberg, J. M., Patel, Y., Saikumar, P. & Dong, Z., Jan 1 1996, In : Kidney International. 49, 2, p. 449-460 12 p.

Research output: Contribution to journalArticle

40 Scopus citations
52 Scopus citations

Deletion of microRNA miR-223 increases Langerhans cell cross-presentation

Mi, Q. S., Xu, Y. P., Wang, H., Qi, R. Q., Dong, Z. & Zhou, L., Feb 1 2013, In : International Journal of Biochemistry and Cell Biology. 45, 2, p. 395-400 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Deletion of microsomal prostaglandin E synthase-1 increases sensitivity to salt loading and angiotensin II infusion

Jia, Z., Zhang, A., Zhang, H., Dong, Z. & Yang, T., Nov 1 2006, In : Circulation research. 99, 11, p. 1243-1251 9 p.

Research output: Contribution to journalArticle

82 Scopus citations
3 Scopus citations

Developmental regulation of calcineurin isoforms in the rodent kidney: Association with COX-2

Liu, H., Ye, W., Guan, G., Dong, Z., Jia, Z. & Yang, T., Dec 1 2007, In : American Journal of Physiology - Renal Physiology. 293, 6, p. F1898-F1904

Research output: Contribution to journalArticle

7 Scopus citations