• 17393 Citations
  • 61 h-Index
1992 …2019
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Research Output 1992 2019

2008
909 Citations (Scopus)

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

Pabla, N. & Dong, Z., May 2008, In : Kidney International. 73, 9, p. 994-1007 14 p.

Research output: Contribution to journalReview article

Cisplatin
Platinum
Neoplasms
Cell Death
Inflammation
30 Citations (Scopus)

Colfibrate attenuates blood pressure and sodium retention in DOCA-salt hypertension

Zhou, Y., Luo, P., Chang, H. H., Huang, H., Yang, T., Dong, Z., Wang, C. Y. & Wang, M-H., Oct 1 2008, In : Kidney International. 74, 8, p. 1040-1048 9 p.

Research output: Contribution to journalArticle

Desoxycorticosterone Acetate
Peroxisome Proliferator-Activated Receptors
Clofibrate
Salts
Sodium
35 Citations (Scopus)

Effects of targeted Bcl-2 expression in mitochondria or endoplasmic reticulum on renal tubular cell apoptosis

Bhatt, K., Feng, L., Pabla, N., Liu, K., Smith, S. & Dong, Z., Mar 1 2008, In : American Journal of Physiology - Renal Physiology. 294, 3, p. F499-F507

Research output: Contribution to journalArticle

Endoplasmic Reticulum
Mitochondria
Apoptosis
Kidney
Cytochromes c
82 Citations (Scopus)

Extracellular high-mobility group box 1 acts as an innate immune mediator to enhance autoimmune progression and diabetes onset in NOD mice

Han, J., Zhong, J., Wei, W., Wang, Y., Huang, Y., Yang, P., Purohit, S. B., Dong, Z., Wang, M-H., She, J-X., Gong, F., Stern, D. M. & Wang, C. Y., Aug 1 2008, In : Diabetes. 57, 8, p. 2118-2127 10 p.

Research output: Contribution to journalArticle

Inbred NOD Mouse
Type 1 Diabetes Mellitus
Dendritic Cells
Autoimmunity
T-Lymphocytes
31 Citations (Scopus)

Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agents

Dong, G., Wang, L., Wang, C. Y., Yang, T., Kumar, M. V. & Dong, Z., Jun 1 2008, In : Journal of Pharmacology and Experimental Therapeutics. 325, 3, p. 978-984 7 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Antineoplastic Agents
Apoptosis
Kidney
trichostatin A
42 Citations (Scopus)

Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress

Jia, Z., Guo, X., Zhang, H., Wang, M-H., Dong, Z. & Yang, T., Nov 1 2008, In : Hypertension. 52, 5, p. 952-959 8 p.

Research output: Contribution to journalArticle

Prostaglandin-Endoperoxide Synthases
Dinoprostone
Angiotensin II
Oxidative Stress
NADPH Oxidase
54 Citations (Scopus)

Nitro-oleic acid protects the mouse kidney from ischemia and reperfusion injury

Liu, H., Jia, Z., Soodvilai, S., Guan, G., Wang, M. H., Dong, Z., Symons, J. D. & Yang, T., Oct 2008, In : American Journal of Physiology - Renal Physiology. 295, 4, p. F942-F949

Research output: Contribution to journalArticle

Oleic Acid
Reperfusion Injury
Ischemia
Kidney
Reperfusion
54 Citations (Scopus)

Protein kinase Cα-CARMA3 signaling axis links Ras to NF-κB for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells

Mahanivong, C., Chen, H. M., Yee, S. W., Pan, Z. K., Dong, Z. & Huang, S., Feb 21 2008, In : Oncogene. 27, 9, p. 1273-1280 8 p.

Research output: Contribution to journalArticle

Complement Factor B
Plasminogen Activators
Urokinase-Type Plasminogen Activator
Ovarian Neoplasms
Protein Kinase C
97 Citations (Scopus)

Regulation and pathological role of p53 in cisplatin nephrotoxicity

Livingston, M. J. & Dong, Z., Nov 1 2008, In : Journal of Pharmacology and Experimental Therapeutics. 327, 2, p. 300-307 8 p.

Research output: Contribution to journalReview article

Cisplatin
Kidney
Neoplasms
Cell Death
Theoretical Models
2007
149 Citations (Scopus)

Activation and involvement of p53 in cisplatin-induced nephrotoxicity

Wei, Q., Dong, G., Yang, T., Megyesi, J., Price, P. M. & Dong, Z., Oct 1 2007, In : American Journal of Physiology - Renal Physiology. 293, 4, p. F1282-F1291

Research output: Contribution to journalArticle

Cisplatin
Wild Animals
Apoptosis
Kidney
Acute Kidney Injury
234 Citations (Scopus)

Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins

Brooks, C., Wei, Q., Feng, L., Dong, G., Tao, Y., Mei, L., Xie, Z. J. & Dong, Z., Jul 10 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 28, p. 11649-11654 6 p.

Research output: Contribution to journalArticle

Apoptosis
Pathology
Mitochondrial Dynamics
Wounds and Injuries
Membranes
8 Citations (Scopus)

Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells

Brooks, C., Wang, J., Yang, T. & Dong, Z., Jan 1 2007, In : American Journal of Physiology - Renal Physiology. 292, 1, p. F243-F252

Research output: Contribution to journalArticle

Clone Cells
Kidney
Azides
Apoptosis
Cytochromes c
7 Citations (Scopus)

Developmental regulation of calcineurin isoforms in the rodent kidney: Association with COX-2

Liu, H., Ye, W., Guan, G., Dong, Z., Jia, Z. & Yang, T., Dec 1 2007, In : American Journal of Physiology - Renal Physiology. 293, 6, p. F1898-F1904

Research output: Contribution to journalArticle

Calcineurin
Cyclooxygenase 2
Rodentia
Protein Isoforms
Kidney
122 Citations (Scopus)

Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity

Jiang, M., Wei, Q., Pabla, N., Dong, G., Wang, C. Y., Yang, T., Smith, S. B. & Dong, Z., May 1 2007, In : Biochemical Pharmacology. 73, 9, p. 1499-1510 12 p.

Research output: Contribution to journalArticle

Scavenging
Hydroxyl Radical
Cisplatin
Chemical activation
Apoptosis
38 Citations (Scopus)

IFN regulatory factor 8 mediates apoptosis in nonhemopoietic tumor cells via regulation of Fas expression

Yang, D., Thangaraju, M., Browning, D. D., Dong, Z., Korchin, B., Lev, D. C., Ganapathy, V. & Liu, K., Oct 1 2007, In : Journal of Immunology. 179, 7, p. 4775-4782 8 p.

Research output: Contribution to journalArticle

Apoptosis
Neoplasms
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Myeloid Cells
Sarcoma
78 Citations (Scopus)

Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation

Livingston, M. J., Pabla, N., Murphy, R. F., Yang, T., Yin, X. M., Degenhardt, K., White, E. & Dong, Z., Jan 26 2007, In : Journal of Biological Chemistry. 282, 4, p. 2636-2645 10 p.

Research output: Contribution to journalArticle

Cisplatin
Chemical activation
Kidney
Apoptosis
Oligomerization
4 Citations (Scopus)

Regulation and pathological role of bid in ischemic acute kidney injury

Wei, Q. & Dong, Z., Nov 1 2007, In : Renal Failure. 29, 8, p. 935-940 6 p.

Research output: Contribution to journalReview article

Acute Kidney Injury
Kidney
Reperfusion
Ischemia
Wounds and Injuries
81 Citations (Scopus)

Regulation of mitochondrial morphological dynamics during apoptosis by Bcl-2 family proteins: A key in Bak?

Brooks, C. & Dong, Z., Dec 15 2007, In : Cell Cycle. 6, 24, p. 3043-3047 5 p.

Research output: Contribution to journalReview article

Mitochondrial Dynamics
Staphylococcal Protein A
Apoptosis
Mitochondrial Membranes
Wounds and Injuries
150 Citations (Scopus)

The pathological role of Bax in cisplatin nephrotoxicity

Wei, Q., Dong, G., Franklin, J. & Dong, Z., Jul 1 2007, In : Kidney International. 72, 1, p. 53-62 10 p.

Research output: Contribution to journalArticle

Cisplatin
Cytochromes c
Apoptosis
Kidney
bcl-2-Associated X Protein
40 Citations (Scopus)

Tumor necrosis factor-α in cisplatin nephrotoxicity: A homebred foe?

Dong, Z. & Atherton, S. S., Jul 2007, In : Kidney International. 72, 1, p. 5-7 3 p.

Research output: Contribution to journalComment/debate

Cisplatin
Tumor Necrosis Factor-alpha
Kidney
Inflammation
Wounds and Injuries
36 Citations (Scopus)

Unique homologous siRNA blocks hypoxia-induced VEGF upregulation in human corneal cells and inhibits and regresses murine corneal neovascularization

Singh, N., Higgins, E., Amin, S., Jani, P., Richter, E., Patel, A., Kaur, R., Wang, J., Ambati, J., Dong, Z. & Ambati, B. K., Jan 1 2007, In : Cornea. 26, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

Corneal Neovascularization
Vascular Endothelial Growth Factor A
Small Interfering RNA
Up-Regulation
Plasmids
2006
50 Citations (Scopus)
Inbred C57BL Mouse
Renal Insufficiency
Kidney
Reperfusion
Ischemia
158 Citations (Scopus)

Calcium in cell injury and death

Dong, Z., Saikumar, P., Weinberg, J. M. & Venkatachalam, M. A., Apr 19 2006, In : Annual Review of Pathology. 1, p. 405-434 30 p.

Research output: Contribution to journalReview article

Mitochondrial Membrane Potential
Cell Death
Calcium
Permeability
Wounds and Injuries
36 Citations (Scopus)

Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: Inactivation of its kinase activity toward p53

Wang, J., Pabla, N., Wang, C. Y., Wang, W., Schoenlein, P. V. & Dong, Z., Dec 14 2006, In : American Journal of Physiology - Renal Physiology. 291, 6, p. F1300-F1307

Research output: Contribution to journalArticle

Caspases
Cisplatin
Phosphotransferases
Apoptosis
Caspase Inhibitors
5 Citations (Scopus)

Characterization of cell clones stably transfected with short form caspase-9: Apoptotic resistance and Bcl-XL expression

Yi, X., Wang, J., Seol, D. W. & Dong, Z., Jan 1 2006, In : Molecular and Cellular Biochemistry. 282, 1-2, p. 1-12 12 p.

Research output: Contribution to journalArticle

Clone cells
Caspase 9
Caspases
Clone Cells
Apoptosis
50 Citations (Scopus)
Cisplatin
Apoptosis
Hypoxia-Inducible Factor 1
Kidney
Electron Transport Complex III
79 Citations (Scopus)

Deletion of microsomal prostaglandin E synthase-1 increases sensitivity to salt loading and angiotensin II infusion

Jia, Z., Zhang, A., Zhang, H., Dong, Z. & Yang, T., Nov 1 2006, In : Circulation research. 99, 11, p. 1243-1251 9 p.

Research output: Contribution to journalArticle

Angiotensin II
Salts
Nitric Oxide Synthase
Dinoprostone
Nitrites
18 Citations (Scopus)

Epoxyeicosatrienoic acid inhibition alters renal hemodynamics during pregnancy

Huang, H., Chang, H. H., Xu, Y., Reddy, D. S., Du, J., Zhou, Y., Dong, Z., Falck, J. R. & Wang, M-H., Dec 2006, In : Experimental Biology and Medicine. 231, 11, p. 1744-1752 9 p.

Research output: Contribution to journalArticle

Hemodynamics
Rats
Kidney
Pregnancy
Acids
47 Citations (Scopus)

Expression, subcellular localization, and regulation of sigma receptor in retinal Müller cells

Jiang, G., Mysona, B., Dun, Y., Gnana-Prakasam, J. P., Pabla, N., Li, W., Dong, Z., Ganapathy, V. & Smith, S. B., Dec 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 12, p. 5576-5582 7 p.

Research output: Contribution to journalArticle

sigma Receptors
Pentazocine
Ligands
Reactive Oxygen Species
Nitric Oxide
42 Citations (Scopus)

Prostaglandin D2 inhibits TGF-β1-induced epithelial-to-mesenchymal transition in MDCK cells

Zhang, A., Dong, Z. & Yang, T., Dec 14 2006, In : American Journal of Physiology - Renal Physiology. 291, 6, p. F1332-F1342

Research output: Contribution to journalArticle

Prostaglandin D2
Madin Darby Canine Kidney Cells
Epithelial-Mesenchymal Transition
Epoprostenol
Thromboxane A2
54 Citations (Scopus)
Epithelial-Mesenchymal Transition
Hepatocyte Growth Factor
Dinoprostone
Cyclooxygenase 2
Transforming Growth Factors
147 Citations (Scopus)

Regulation of PUMA-α by p53 in cisplatin-induced renal cell apoptosis

Livingston, M. J., Wei, Q., Wang, J., Du, Q., Yu, J., Zhang, L. & Dong, Z., Jul 6 2006, In : Oncogene. 25, 29, p. 4056-4066 11 p.

Research output: Contribution to journalArticle

Cisplatin
Apoptosis
Kidney
Cytochromes c
Mitochondria
2005
25 Citations (Scopus)

Acidic pH inhibits ATP depletion-induced tubular cell apoptosis by blocking caspase-9 activation in apoptosome

Brooks, C., Ketsawatsomkron, P., Sui, Y., Wang, J., Wang, C. Y., Yu, F. S. & Dong, Z., Aug 1 2005, In : American Journal of Physiology - Renal Physiology. 289, 2 58-2, p. F410-F419

Research output: Contribution to journalArticle

Apoptosomes
Caspase 9
Adenosine Triphosphate
Apoptosis
Caspases
66 Citations (Scopus)

Differential gender differences in ischemic and nephrotoxic acute renal failure

Wei, Q., Wang, M. H. & Dong, Z., Sep 1 2005, In : American Journal of Nephrology. 25, 5, p. 491-499 9 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Cisplatin
Blood Urea Nitrogen
Kidney
Apoptosis
73 Citations (Scopus)

Flt-1 intraceptors inhibit hypoxia-induced VEGF expression in vitro and corneal neovascularization in vivo

Singhb, N., Amin, S., Richter, E., Rashid, S., Scoglietti, V., Jani, P. D., Wang, J., Kaur, R., Ambati, J., Dong, Z. & Ambati, B. K., Dec 1 2005, In : Investigative Ophthalmology and Visual Science. 46, 5, p. 1647-1652 6 p.

Research output: Contribution to journalArticle

Corneal Neovascularization
Vascular Endothelial Growth Factor A
Leukocytes
Plasmids
Epithelial Cells
37 Citations (Scopus)

Gender differences of renal CYP-derived eicosanoid synthesis in rats fed a high-fat diet

Zhou, Y., Lin, S., Chang, H. H., Du, J., Dong, Z., Dorrance, A. M., Brands, M. W. & Wang, M. H., Apr 2005, In : American journal of hypertension. 18, 4, p. 530-537 8 p.

Research output: Contribution to journalArticle

Eicosanoids
High Fat Diet
Cytochrome P-450 Enzyme System
Kidney
Fats
68 Citations (Scopus)

Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress

Guo, D., Han, J., Adam, B. L., Colburn, N. H., Wang, M-H., Dong, Z., Eizirik, D. L., She, J-X. & Wang, C. Y., Dec 2 2005, In : Biochemical and Biophysical Research Communications. 337, 4, p. 1308-1318 11 p.

Research output: Contribution to journalArticle

Sumoylation
HEK293 Cells
Starvation
Proteomics
Transcription Factors
14 Citations (Scopus)

Renal epoxyeicosatrienoic acid synthesis during pregnancy

Zhou, Y., Chang, H. H., Du, J., Wang, C. Y., Dong, Z. & Wang, M. H., Jan 1 2005, In : American Journal of Physiology - Renal Physiology. 288, 1 57-1, p. F221-F226

Research output: Contribution to journalArticle

Kidney
Pregnancy
Acids
Blood Pressure
Fetal Weight
2004
294 Citations (Scopus)

A functional variant of SUMO4, a new IκBα modifier, is associated with type diabetes

Guo, D., Li, M., Zhang, Y., Yang, P., Eckenrode, S., Hopkins, D., Zheng, W., Purohit, S. B., Podolsky, R. H., Muir, A., Wang, J., Dong, Z., Brusko, T., Atkinson, M., Pozzilli, P., Zeidler, A., Raffel, L. J., Jacob, C. O., Park, Y., Serrano-Rios, M. & 7 others, Martinez Larrad, M. T., Zhang, Z., Garchon, H. J., Bach, J. F., Rotter, J. I., She, J-X. & Wang, C. Y., Aug 1 2004, In : Nature Genetics. 36, 8, p. 837-841 5 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Genes
Ubiquitin
Single Nucleotide Polymorphism
DNA
33 Citations (Scopus)

Bid activation in kidney cells following ATP depletion in vitro and ischemia in vivo

Wei, Q., Alam, M. M., Wang, M-H., Yu, F. & Dong, Z., Apr 1 2004, In : American Journal of Physiology - Renal Physiology. 286, 4 55-4

Research output: Contribution to journalArticle

Ischemia
Adenosine Triphosphate
Kidney
Azides
Mitochondria

Erratum: A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes (Nature Genetics (2004) 36 (837-841))

Guo, D., Li, M., Zhang, Y., Yang, P., Eckenrode, S., Hopkins, D., Zheng, W., Purohit, S. B., Podolsky, R. H., Muir, A., Wang, J., Dong, Z., Brusko, T., Atkinson, M., Pozzilli, P., Zeidler, A., Raffel, L. J., Jacob, C. O., Park, Y., Serrano-Rios, M. & 7 others, Martinez Larrad, M. T., Zhang, Z., Garchon, H. J., Bach, J. F., Rotter, J. I., She, J-X. & Wang, C. Y., Sep 1 2004, In : Nature Genetics. 36, 9, 1 p.

Research output: Contribution to journalComment/debate

Type 1 Diabetes Mellitus
76 Citations (Scopus)

Hypoxia selection of death-resistant cells: A role for Bcl-XL

Dong, Z. & Wang, J., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 9215-9221 7 p.

Research output: Contribution to journalArticle

Cell Death
Apoptosis Regulatory Proteins
Mitochondria
Molecules
Staurosporine
21 Citations (Scopus)

Inhibition of apoptosis by Zn2+ in renal tubular cells following ATP depletion

Wei, Q., Wang, J., Wang, M. H., Yu, F. & Dong, Z., Sep 1 2004, In : American Journal of Physiology - Renal Physiology. 287, 3 56-3, p. F492-F500

Research output: Contribution to journalArticle

Adenosine Triphosphate
Apoptosis
Kidney
Caspases
Cytochromes c
216 Citations (Scopus)

Minocycline Up-regulates Bcl-2 and Protects against Cell Death in Mitochondria

Wang, J., Wei, Q., Wang, C. Y., Hill, W. D., Hess, D. C. & Dong, Z., May 7 2004, In : Journal of Biological Chemistry. 279, 19, p. 19948-19954 7 p.

Research output: Contribution to journalArticle

Minocycline
Mitochondria
Cell death
Cell Death
Up-Regulation
37 Citations (Scopus)

Molecular cloning and characterization of the mouse Acdp gene family

Wang, C. Y., Yang, P., Shi, J. D., Purohit, S., Guo, D., An, H., Gu, J. G., Ling, J., Dong, Z. & She, J. X., Jan 15 2004, In : BMC Genomics. 5, 7.

Research output: Contribution to journalArticle

Molecular Cloning
Genes
Proteins
Amino Acid Sequence
Nucleotides
36 Citations (Scopus)

Role of EGFR transactivation in preventing apoptosis in Pseudomonas aeruginosa-infected human corneal epithelial cells

Zhang, J., Li, H., Wang, J., Dong, Z., Mian, S. & Yu, F. S. X., Aug 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 8, p. 2569-2576 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Pseudomonas aeruginosa
Transcriptional Activation
Epithelial Cells
Apoptosis
116 Citations (Scopus)
Cisplatin
Apoptosis
Caspases
DNA Damage
Cell Death
117 Citations (Scopus)

Wound-induced HB-EGF ectodomain shedding and EGFR activation in corneal epithelial cells

Xu, K. P., Ding, Y., Ling, J., Dong, Z. & Yu, F. S. X., Mar 1 2004, In : Investigative Ophthalmology and Visual Science. 45, 3, p. 813-820 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Epidermal Growth Factor
Epithelial Cells
Wounds and Injuries
Matrix Metalloproteinase Inhibitors
2003
75 Citations (Scopus)

Apoptosis-resistance of hypoxic cells: Multiple factors involved and a role for IAP-2

Dong, Z., Wang, J. Z., Yu, F. & Venkatachalam, M. A., Aug 1 2003, In : American Journal of Pathology. 163, 2, p. 663-671 9 p.

Research output: Contribution to journalArticle

Inhibitor of Apoptosis Proteins
Cytosol
Apoptosis
Caspases
Staurosporine
25 Citations (Scopus)

Glycine protection of PC-12 cells against injury by ATP-depletion

Zhang, K., Weinberg, J. M., Venkatachalam, M. A. & Dong, Z., Jun 1 2003, In : Neurochemical Research. 28, 6, p. 893-901 9 p.

Research output: Contribution to journalArticle

Glycine
Glycine Receptors
Adenosine Triphosphate
Cytoprotection
Wounds and Injuries