• 17193 Citations
  • 61 h-Index
1992 …2019
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Research Output 1992 2019

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Article
2019
1 Citation (Scopus)

Aberrant DNA methylation of mTOR pathway genes promotes inflammatory activation of immune cells in diabetic kidney disease

Chen, G., Chen, H., Ren, S., Xia, M., Zhu, J., Liu, Y., Zhang, L., Tang, L., Sun, L., Liu, H. & Dong, Z., Aug 2019, In : Kidney International. 96, 2, p. 409-420 12 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
DNA Methylation
Sirolimus
Methyltransferases
Cytosine

Bif-1 interacts with prohibitin-2 to regulate mitochondrial inner membrane during cell stress and apoptosis

Cho, S. G., Xiao, X., Wang, S., Gao, H., Rafikov, R., Black, S., Huang, S., Ding, H. F., Yoon, Y., Kirken, R. A., Yin, X. M., Wang, H. G. & Dong, Z., Jul 2019, In : Journal of the American Society of Nephrology. 30, 7, p. 1174-1191 18 p.

Research output: Contribution to journalArticle

Mitochondrial Membranes
Apoptosis
Proteolysis
Mitochondrial Dynamics
Kidney

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

Livingston, M. J., Wang, J., Zhou, J., Wu, G., Ganley, I. G., Hill, J. A., Yin, X. M. & Dong, Z., Dec 2 2019, In : Autophagy. 15, 12, p. 2142-2162 21 p.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Degradation
Ischemic Preconditioning
Mitochondria
Autophagy
Kidney
Glycolysis
Fibrosis
Fibroblasts
Kidney
Ureteral Obstruction
3 Citations (Scopus)

Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury

Khambu, B., Li, T., Yan, S., Yu, C., Chen, X., Goheen, M., Li, Y., Lin, J., Cummings, O. W., Lee, Y. A., Friedman, S., Dong, Z., Feng, G. S., Wu, S. & Yin, X. M., May 1 2019, In : Hepatology. 69, 5, p. 2196-2213 18 p.

Research output: Contribution to journalArticle

Autophagy
Liver
Wounds and Injuries
Bile Acids and Salts
Genes

Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation

Yang, L., Zha, Y., Ding, J., Ye, B., Liu, M., Yan, C., Dong, Z., Cui, H. & Ding, H. F., Jan 1 2019, In : Oncogenesis. 8, 1, 3.

Research output: Contribution to journalArticle

Histone Demethylases
Neuroblastoma
Epigenomics
Cell Differentiation
Histones

Identification of key biomarkers in diabetic nephropathy via bioinformatic analysis

Zeng, M., Liu, J., Yang, W., Zhang, S., Liu, F., Dong, Z., Peng, Y., Sun, L. & Xiao, L., May 1 2019, In : Journal of cellular biochemistry. 120, 5, p. 8676-8688 13 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Biomarkers
Bioinformatics
Computational Biology
Genes

Multiple-microarray analysis for identification of hub genes involved in tubulointerstial injury in diabetic nephropathy

Zeng, M., Liu, J., Yang, W., Zhang, S., Liu, F., Dong, Z., Peng, Y., Sun, L. & Xiao, L., Sep 1 2019, In : Journal of Cellular Physiology. 234, 9, p. 16447-16462 16 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Microarray Analysis
Microarrays
Genes
Wounds and Injuries
1 Citation (Scopus)

Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation

Zheng, M., Cai, J., Liu, Z., Shu, S., Wang, Y., Tang, C. & Dong, Z., Jun 2019, In : Journal of Cellular and Molecular Medicine. 23, 6, p. 3995-4004 10 p.

Research output: Contribution to journalArticle

Open Access
Niacinamide
Fibrosis
Inflammation
Kidney
Wounds and Injuries
1 Citation (Scopus)

RNA interference may suppress stress granule formation by preventing argonaute 2 recruitment

Lou, Q., Hu, Y., Ma, Y. & Dong, Z., Jan 1 2019, In : American Journal of Physiology - Cell Physiology. 316, 1, p. C81-C91

Research output: Contribution to journalArticle

RNA-Induced Silencing Complex
RNA Interference
Hypoxia-Inducible Factor 1
Clustered Regularly Interspaced Short Palindromic Repeats
Heat-Shock Proteins
1 Citation (Scopus)

Specific TBC Domain-Containing Proteins Control the ER-Golgi-Plasma Membrane Trafficking of GPCRs

Wei, Z., Zhang, M., Li, C., Huang, W., Fan, Y., Guo, J., Khater, M., Fukuda, M., Dong, Z., Hu, G. & Wu, G., Jul 9 2019, In : Cell Reports. 28, 2, p. 554-566.e4

Research output: Contribution to journalArticle

Open Access
Cell membranes
G-Protein-Coupled Receptors
Cell Membrane
Proteins
GTPase-Activating Proteins
Physiological Stress
Cell Survival
Kidney
Wounds and Injuries
Reperfusion
2018
1 Citation (Scopus)
Receptor-Interacting Protein Serine-Threonine Kinases
Muromegalovirus
Photoreceptor Cells
Cytomegalovirus Infections
Protein Kinases
2 Citations (Scopus)
Proximal Kidney Tubule
Fibrosis
Up-Regulation
Kidney
Wounds and Injuries

Embryonic Fate Mapping Uncovers the Critical Role of microRNAs in the Development of Epidermal γδ T Cells

Yao, Y., Liu, Q., Martin, C., Yin, C., Dong, Z., Mi, Q. S. & Zhou, L., Jan 1 2018, In : Journal of Investigative Dermatology. 138, 1, p. 236-239 4 p.

Research output: Contribution to journalArticle

DEAD-box RNA Helicases
Granulocyte-Macrophage Colony-Stimulating Factor Receptors
Antigen Receptors, T-Cell, gamma-delta
Ribonuclease III
T-cells
6 Citations (Scopus)

Endoplasmic reticulum stress is activated in post-ischemic kidneys to promote chronic kidney disease

Shu, S., Zhu, J., Liu, Z., Tang, C., Cai, J. & Dong, Z., Nov 2018, In : EBioMedicine. 37, p. 269-280 12 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Chronic Renal Insufficiency
Acute Kidney Injury
Kidney
Transcription Factor CHOP
8 Citations (Scopus)

FGF21 is induced in cisplatin nephrotoxicity to protect against kidney tubular cell injury

Li, F., Liu, Z., Tang, C., Cai, J. & Dong, Z., Jun 2018, In : FASEB Journal. 32, 6, p. 3423-3433 11 p.

Research output: Contribution to journalArticle

Cisplatin
Kidney
Wounds and Injuries
Acute Kidney Injury
fibroblast growth factor 21
18 Citations (Scopus)

Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells

Liu, J., Livingston, M. J., Dong, G., Tang, C., Su, Y., Wu, G., Yin, X. M. & Dong, Z., Mar 1 2018, In : Cell Death and Disease. 9, 3, 322.

Research output: Contribution to journalArticle

trichostatin A
Histone Deacetylase Inhibitors
Autophagy
Acute Kidney Injury
Cisplatin
17 Citations (Scopus)

HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers

Khambu, B., Huda, N., Chen, X., Antoine, D. J., Li, Y., Dai, G., Köhler, U. A., Zong, W. X., Waguri, S., Werner, S., Oury, T. D., Dong, Z. & Yin, X. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2419-2435 17 p.

Research output: Contribution to journalArticle

Autophagy
Carcinogenesis
Hepatocytes
Liver
Inflammasomes

Inflammation and outer blood-retina barrier (BRB) compromise following choroidal murine cytomegalovirus (MCMV) infections

Xu, J., Liu, X., Mo, J., Marshall, B., Perry, L., Dong, Z. & Zhang, M., May 18 2018, In : Molecular Vision. 24, p. 379-394 16 p.

Research output: Contribution to journalArticle

Muromegalovirus
Cytomegalovirus Infections
Retina
Inflammation
Bruch Membrane
9 Citations (Scopus)

MicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in ischemic acute kidney injury

Wei, Q., Sun, H., Song, S., Liu, Y., Liu, P., Livingston, M. J., Wang, J., Liang, M., Mi, Q. S., Huo, Y., Nahman, N. S., Mei, C. & Dong, Z., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5448-5464 17 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Mitochondrial Proteins
MicroRNAs
Acute Kidney Injury
Kidney
1 Citation (Scopus)

Micro RNAs are required for Langerhans cell, skin- and lung-resident macrophage ontogeny

Yao, Y., Martin, C., Yin, C., Guo, C., Dong, Z., Zhou, L. & Mi, Q. S., Sep 2018, In : Journal of Allergy and Clinical Immunology. 142, 3, p. 976-978.e2

Research output: Contribution to journalArticle

Langerhans Cells
MicroRNAs
Macrophages
Lung
Skin
8 Citations (Scopus)

PINK1/Parkin-mediated mitophagy is activated in cisplatin nephrotoxicity to protect against kidney injury

Wang, Y., Tang, C., Cai, J., Chen, G., Zhang, D., Zhang, Z. & Dong, Z., Nov 1 2018, In : Cell Death and Disease. 9, 11, 1113.

Research output: Contribution to journalArticle

Open Access
Mitochondrial Degradation
Cisplatin
Kidney
Wounds and Injuries
Autophagy
27 Citations (Scopus)

PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury

Tang, C., Han, H., Yan, M., Zhu, S., Liu, J., Liu, Z., He, L., Tan, J., Liu, Y., Liu, H., Sun, L., Duan, S., Peng, Y., Liu, F., Yin, X. M., Zhang, Z. & Dong, Z., May 4 2018, In : Autophagy. 14, 5, p. 880-897 18 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Reperfusion Injury
Kidney
Acute Kidney Injury
Reactive Oxygen Species
5 Citations (Scopus)

PKCδ-mediated Nox2 activation promotes fluid-phase pinocytosis of antigens by immature dendritic cells

Singla, B., Ghoshal, P., Lin, H., Wei, Q., Dong, Z. & Csányi, G., Mar 26 2018, In : Frontiers in immunology. 9, MAR, 537.

Research output: Contribution to journalArticle

Pinocytosis
NADPH Oxidase
Dendritic Cells
Protein Kinase C
Antigens
2 Citations (Scopus)

Protective effect of the BET protein inhibitor JQ1 in cisplatin-induced nephrotoxicity

Sun, L., Liu, J., Yuan, Y., Zhang, I. & Dong, Z., Sep 2018, In : American Journal of Physiology - Renal Physiology. 315, 3, p. F469-F478

Research output: Contribution to journalArticle

Cisplatin
Proteins
Kidney
Acetylation
Apoptosis
3 Citations (Scopus)
STAT1 Transcription Factor
effectors
ischemia
kidneys
Reperfusion Injury
2017
11 Citations (Scopus)

Autophagy is activated to protect against podocyte injury in adriamycin-induced nephropathy

Yi, M., Zhang, L., Liu, Y., Livingston, M. J., Chen, J., Nahman, N. S., Liu, F. & Dong, Z., Jan 1 2017, In : American Journal of Physiology - Renal Physiology. 313, 1, p. F74-F84

Research output: Contribution to journalArticle

Podocytes
Autophagy
Doxorubicin
Wounds and Injuries
Gene Knockout Techniques
8 Citations (Scopus)

DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes, including interferon regulatory factor 8

Guo, C., Pei, L., Xiao, X., Wei, Q., Chen, J., Ding, H., Huang, S., Fan, G., Shi, H. & Dong, Z., Nov 2017, In : Kidney International. 92, 5, p. 1194-1205 12 p.

Research output: Contribution to journalArticle

DNA Methylation
Cisplatin
Acute Kidney Injury
Kidney
Wounds and Injuries
6 Citations (Scopus)
Urethral Obstruction
Proximal Kidney Tubule
Fibrosis
Apoptosis
Kidney
12 Citations (Scopus)

Exosome production and its regulation of EGFR during wound healing in renal tubular cells

Zhou, X., Zhang, W., Yao, Q., Zhang, H., Dong, G., Zhang, M., Liu, Y., Chen, J. & Dong, Z., Jan 1 2017, In : American Journal of Physiology - Renal Physiology. 312, 6, p. F963-F970

Research output: Contribution to journalArticle

Exosomes
Wound Healing
Kidney
Epidermal Growth Factor
Growth Factor Receptors
3 Citations (Scopus)

Genetic or pharmacologic inhibition of EGFR ameliorates sepsisinduced AKI

Xu, X., Wang, J., Yang, R., Dong, Z. & Zhang, D., Jan 1 2017, In : Oncotarget. 8, 53, p. 91577-91592 16 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Apoptosis
Cytokines
Kidney
Endotoxemia
17 Citations (Scopus)

HIF-1-mediated production of exosomes during hypoxia is protective in renal tubular cells

Zhang, W., Zhou, X., Yao, Q., Liu, Y., Zhang, H. & Dong, Z., Oct 2017, In : American Journal of Physiology - Renal Physiology. 313, 4, p. F906-F913

Research output: Contribution to journalArticle

Exosomes
Hypoxia-Inducible Factor 1
Kidney
Hypoxia
Adenosine Triphosphate
22 Citations (Scopus)

Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6

Hao, J., Wei, Q., Mei, S., Li, L., Su, Y., Mei, C. & Dong, Z., Jan 1 2017, In : Kidney International. 91, 1, p. 106-118 13 p.

Research output: Contribution to journalArticle

Death Domain Receptors
Reperfusion Injury
MicroRNAs
Kidney
Acute Kidney Injury
10 Citations (Scopus)

MBD2 upregulates MIR-301a-5p to induce kidney cell apoptosis during vancomycin-induced AKI

Wang, J., Li, H., Qiu, S., Dong, Z., Xiang, X. & Zhang, D., Oct 12 2017, In : Cell Death and Disease. 8, 10, e3120.

Research output: Contribution to journalArticle

Vancomycin
Acute Kidney Injury
Up-Regulation
Apoptosis
Kidney
12 Citations (Scopus)

MicroRNA-375 is induced in cisplatin nephrotoxicity to repress hepatocyte nuclear factor 1-β

Hao, J., Lou, Q., Wei, Q., Mei, S., Li, L., Wu, G., Mi, Q. S., Mei, C. & Dong, Z., Mar 17 2017, In : Journal of Biological Chemistry. 292, 11, p. 4571-4582 12 p.

Research output: Contribution to journalArticle

Hepatocyte Nuclear Factor 1
MicroRNAs
Cisplatin
Homeobox Genes
Kidney
17 Citations (Scopus)

P53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in UUO

Yang, R., Xu, X., Li, H., Chen, J., Xiang, X., Dong, Z. & Zhang, D., Feb 27 2017, In : Scientific Reports. 7, 43409.

Research output: Contribution to journalArticle

Urethral Obstruction
Fibrosis
Kidney
Vimentin
Collagen
20 Citations (Scopus)

Protein kinase Cd suppresses autophagy to induce kidney cell apoptosis in cisplatin nephrotoxicity

Zhang, D., Pan, J., Xiang, X., Liu, Y., Dong, G., Livingston, M. J., Chen, J., Yin, X. M. & Dong, Z., Apr 2017, In : Journal of the American Society of Nephrology. 28, 4, p. 1131-1144 14 p.

Research output: Contribution to journalArticle

Autophagy
Protein Kinases
Cisplatin
Protein Kinase C
Apoptosis
3 Citations (Scopus)

Rapamycin Enhances Repressed Autophagy and Attenuates Aggressive Progression in a Rat Model of IgA Nephropathy

Liu, D., Liu, Y., Chen, G., He, L., Tang, C., Wang, C., Yang, D., Li, H., Dong, Z. & Liu, H., Apr 1 2017, In : American Journal of Nephrology. 45, 4, p. 293-300 8 p.

Research output: Contribution to journalArticle

Autophagy
Sirolimus
Immunoglobulin A
Cyclin D1
Proteinuria
11 Citations (Scopus)

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation

Xu, Y., Wang, Y., Yan, S., Yang, Q., Zhou, Y., Zeng, X., Liu, Z., An, X., Flores Toque, H. A., Dong, Z., Jiang, X., Fulton, D. J., Weintraub, N. L., Li, Q., Bagi, Z., Hong, M., Boison, D., Wu, C. & Huo, Y., Dec 1 2017, In : Nature Communications. 8, 1, 986.

Research output: Contribution to journalArticle

Adenosine Kinase
adenosines
Adenosine
Blood Vessels
Inflammation
12 Citations (Scopus)

The GTPase Rab43 Controls the Anterograde ER-Golgi Trafficking and Sorting of GPCRs

Li, C., Wei, Z., Fan, Y., Huang, W., Su, Y., Li, H., Dong, Z., Fukuda, M., Khater, M. & Wu, G., Oct 24 2017, In : Cell Reports. 21, 4, p. 1089-1101 13 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
G-Protein-Coupled Receptors
Sorting
Endoplasmic Reticulum
Membrane Proteins
72 Citations (Scopus)

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

Xiao, L., Xu, X., Zhang, F., Wang, M., Xu, Y., Tang, D., Wang, J., Qin, Y., Liu, Y., Tang, C., He, L., Greka, A., Zhou, Z., Liu, F., Dong, Z. & Sun, L., Apr 1 2017, In : Redox Biology. 11, p. 297-311 15 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
NF-E2-Related Factor 2
Mitochondria
Diabetic Nephropathies
Antioxidants
2016
28 Citations (Scopus)

Autophagy is activated to protect against endotoxic acute kidney injury

Mei, S., Livingston, M. J., Hao, J., Li, L., Mei, C. & Dong, Z., Feb 26 2016, In : Scientific Reports. 6, 22171.

Research output: Contribution to journalArticle

Autophagy
Acute Kidney Injury
Lipopolysaccharides
Kidney Tubules
Kidney
1 Citation (Scopus)

Blocking rpS6 phosphorylation exacerbates Tsc1 deletion–induced kidney growth

Wu, H., Chen, J., Xu, J., Dong, Z., Meyuhas, O. & Chen, J., Jan 1 2016, In : Journal of the American Society of Nephrology. 27, 4, p. 1145-1158 14 p.

Research output: Contribution to journalArticle

Ribosomal Protein S6
Phosphorylation
Kidney
Growth
Carrier Proteins

Collapsing glomerulopathy with rare associated coxsackie virus infection: A case report

Zhu, X., Liu, H., Yuan, S., Xu, X., Dong, Z. & Liu, F., May 1 2016, In : Experimental and Therapeutic Medicine. 11, 5, p. 1871-1874 4 p.

Research output: Contribution to journalArticle

Coxsackievirus Infections
Satellite Viruses
Kidney
Biopsy
Enterovirus
7 Citations (Scopus)

Conditional ablation of HDAC3 in islet beta cells results in glucose intolerance and enhanced susceptibility to STZ-induced diabetes

Chen, W. B., Gao, L., Wang, J., Wang, Y. G., Dong, Z., Zhao, J., Mi, Q. S. & Zhou, L., Jan 1 2016, In : Oncotarget. 7, 36, p. 57485-57497 13 p.

Research output: Contribution to journalArticle

Glucose Intolerance
Experimental Diabetes Mellitus
Islets of Langerhans
Histone Deacetylases
Insulin
2 Citations (Scopus)

Exploration of pathological prediction of chronic kidney diseases by a novel theory of bi-directional probability

Yang, Y., Luo, M., Xiao, L., Zhu, X. J., Wang, C., Fu, X., Yuan, S. G., Xiao, F., Liu, H., Dong, Z., Liu, F. Y. & Sun, L., Aug 25 2016, In : Scientific Reports. 6, 32151.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Differential Diagnosis
Membranous Glomerulonephritis
Nephrology
Sclerosis
1 Citation (Scopus)

Gene expression analysis indicates divergent mechanisms in DEN-induced carcinogenesis in wild type and bid-deficient livers

Yu, C., Yan, S., Khambu, B., Chen, X., Dong, Z., Luo, J., Michalopoulos, G. K., Wu, S. & Yin, X. M., May 2016, In : PloS one. 11, 5, e0155211.

Research output: Contribution to journalArticle

Gene expression
Liver
carcinogenesis
Carcinogenesis
Genes
3 Citations (Scopus)

Heat shock factor 1 induces crystallin-αB to protect against cisplatin nephrotoxicity

Lou, Q., Hu, Y., Ma, Y. & Dong, Z., Jul 1 2016, In : American Journal of Physiology - Renal Physiology. 311, 1, p. F94-F102

Research output: Contribution to journalArticle

Crystallins
Cisplatin
Shock
Hot Temperature
Heat-Shock Response
27 Citations (Scopus)

KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism

Zhao, E., Ding, J., Xia, Y., Liu, M., Ye, B., Choi, J. H., Yan, C., Dong, Z., Huang, S., Zha, Y., Yang, L., Cui, H. & Ding, H. F., Jan 26 2016, In : Cell Reports. 14, 3, p. 506-519 14 p.

Research output: Contribution to journalArticle

Metabolism
Amino Acids
Serine
Transcriptional Activation
Cell proliferation