Project: Research project

Project Details


Recent advances in NMR have lead to a new generation of
spectrometers with greatly increased experimental capabilities.
This, along with the already well documented advantages of high
field NMR in studying biological systems, will further enhance the
contribution of NMR in solving structural problems in biology.
With the large amount of sequence information that has been
generated recently using new techniques in molecular biology this
experimental approach to understanding the role of molecular
conformation will move us to the next goal, developing structure-
function relationships so that the full implications of primary
sequence data can be determined. In this proposal, funds are
requested to cover part of the cost of purchasing a high field
NMR spectrometer. this spectrometer would greatly improve
NMR facilities at Emory University and will provide better access
to NMR instrumentation for workers in the Biochemistry and
Physics Departments which do not have such instrumentation of
their own. A major focus of the research on this instrument will
be to further develop new methods focus of the research on this
instrument will be to further develop new methods for sensitivity
enhancement of heteronuclei using proton detected heteronuclear
multiquantum coherence experiments. These experiments will
make available new information from nuclei other than protons to
aid in the analysis of complex biomacromolecules. The
instrument will support research of a total of twelve
investigators, nine investigators from Emory University, seven in
Chemistry and one each in Physics and Biochemistry, and three
investigators from Georgia State University. Research discussed
here covers a wide range of biomedically related systems
including hormones, synthetic vaccines, drug-DNA interactions,
enzymes, and membrane interactions.
StatusNot started