• Harshfield, Gregory A (PI)

Project: Research project

Project Details


DESCRIPTION (adapted from investigator's abstract): Cardiovascular disease
remains the leading cause of death. Race and obesity are two of the leading
risk factors for cardiovascular disease and essential hypertension. These two
groups are characterized by impaired sodium regulation, such that they are very
sensitive to the effects of changes in sodium intake. It has been hypothesized
that psychological stress might contribute to the hypertensive process by
inducing a period of sodium retention and thereby increasing the duration blood
pressure remains elevated following the cessation of the stressor. This
hypothesis will be tested by measuring changes in sodium excretion 2 hours
before and 2 hours following a 1 hour stress period in two groups of subjects,
obese and non obese blacks, with the hypothesis that obese subjects will
continue to retain sodium following stress. Furthermore, changes in the
activity of hormonal variables known to influence sodium handling will be
measured, with the hypothesis that the mechanism underlying the patterns will
differ between the two groups specifically, the insulin regulatory system will
be the primary hormone driving the response pattern in the obese individuals,
and the sympathetic nervous system in non-obese subjects. Finally, the groups
will differ in hemodynamic profiles, with the obese subjects continuing to show
an increase in cardiac output and blood pressure following the cessation of the
stressor. This study will provide new information on how psychological factors
contribute to the development of CVD in blacks, particularly obese blacks. In
so doing, it will help clarify the role that stress-induced changes in other
hormones, both alone and in conjunction contribute to the pathological increase
in sodium reabsorption. It will also define the hemodynamic response pattern
associated with these changes. Finally, this study will examine these questions
in a younger cohort than has been studied previously, providing new information
on this population.
Effective start/end date8/3/996/30/02


  • Medicine(all)


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