BRONCHIOLOALVEOLAR CARCINOMA DIAGNOSIS AND PATHOBIOLOGY

Project: Research project

Description

Adenocarcinomas of the lung, without squamous differentiation or obvious
mucus production, from 51 patients were studied. Twenty-eight tumors
(55%), when stained with rabbit anti-human surfactant apoprotein antiserum
by the peroxidase-antiperoxidase method, demonstrated characteristic
nuclear inclusions. Most of these tumors could be identified
histochemically by the presence of eosinophilic, PAS-positive nuclear
inclusions. In patients with apoprotein immunoreactive tumors there were
nine deaths due to tumor (32%) within five years of diagnosis. Eight of
the nine deaths occurred in patients whoe tumors exceeded three centimeters
in diameter; and an equal number of patients were smokers. The average age
of patients with apoprotein positive tumors was 67.3 years, a figure
greater than that for patients bearing apoprotein negative tumors (61.4
years). Five of the 23 patients with apoprotein negative tumors died of
their neoplasms, in two of the subjects the tumors exceeded three
centimeters in diameter. In that no significant difference in survival was
observed among patients with apoprotein positive and apoprotein negative
tumors, we conclude that subclassification of adenocarcinomas of the lung
as apoprotein positive, i.e., type II pneumocytic, or as apoprotein
negative types, is of no clinical or prognostic significance. Nonetheless
peripheral tumors measuring less than 3 centimeters in size, showing
neither squamous differentiation nor obvious mucus production, should be
recognized as a prognostically favorable group in comparison with other
types of lung carcinomas. (4)
StatusFinished
Effective start/end date8/1/837/31/87

Funding

  • National Institutes of Health

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Bronchiolo-Alveolar Adenocarcinoma
Apoproteins
Neoplasms
Mucus
Surface-Active Agents
Peroxidase
Adenocarcinoma

ASJC

  • Medicine(all)