Ca2+ and ROS Crosstalk Signaling in Cardiac Mitochondria

Opening of mitochondrial permeability transition pore plays a central role in pathological outcomes in heart attack and other cardiovascular disorders. This proposal intends to determine the new mechanisms of how the permeability transition pore is regulated through calcium and mitochondrial dynamics. The findings from the proposed studies will provide novel insight for developing new therapeutic strategy to ameliorate cardiac ischemia-reperfusion injury and other cardiac pathology.