Project: Research project

Project Details


The major long-term objective of this work is to provide data and
knowledge that can be used to maximize the beneficial effects of
fluoride with the minimum degree of unwanted side effects.
Previous studies supported by this grant have shown that the
levels of fluoride in the oral fluids, and the developing enamel are
direct functions of plasma fluoride levels. Thus, the development
and severity of dental fluorosis and perhaps the cariostatic effect
of the ion are dependent on systemic fluoride levels. Several
studies of factors that may influence plasma and other tissue
fluoride levels are proposed for the next grant period. The
influence of postnatal fluoride intake on the balance and tissue
levels of fluoride in rat neonates will be determined. It is
hypothesized that, due to skeletal-extracellular fluid fluoride
dynamics, neonates may be in a strongly positive on negative
balance depending on the level of intake. The only environmental
variable taken into account when deciding the appropriate water
fluoride level for a community is the average regional
temperature. One of the proposed studies will examine the
effects of water intake on the metabolism and balance of
fluoride. Thus it will provide data relevant to the fluoridation of
water supplies for the prevention of dental caries. Further
studies on the transmucosal migration of fluoride in the GI tract
will be conducted for the purpose of determining whether there
are conditions which lead to the net loss of systemic fluoride via
this route. Other studies will examine more closely the
relationship between the functional mass of the kidneys and the
chronic metabolism and retention of fluoride. The concept of a
skeletal fluoride steady state which holds that when intake is
constant on a chronic basis the skeleton largely or completely
loses its ability to accumulate the ions, will be critically
examined. Further studies of the cariostatic effect of fluoride
will be conducted. These studies will determine the influence of
fluoride on the oral microbial ecology and relate the effects to
the level of cariostasis. Other studies will determine the
cariostatic effect of fluoride given systemically or pre-eruptively
compared to the effects produced by post-eruptive fluoride
exposure alone or to the effects produced by both pre- and post-
eruptive exposure. The proposed studies will thus add
significantly to our knowledge of several aspects of the
metabolism, toxicity and cariostatic mechanism of fluoride.
Effective start/end date7/1/813/31/96


  • Medicine(all)
  • Dentistry(all)