ESTIMATION &TEST OF MARKER ASSOCIATION IN FAMILY DATA

Project: Research project

Description

There is currently an ever-growing number of polymorphic genetic
markers available for the study of marker association with human
disease traits. Knowledge of such associations provides a basic
for genetic counseling. Because the study of familial disease by
segregation and linkage analyses requires the collection of data
on family and pedigree members, it is becoming more and more
necessary to infer marker associations from data that have been
collected with these multiple purposes in mind. Therefore,
comprehensive, rigorous and practical statistical methodologies
will be developed for analyzing from extended human pedigree data
the associations between genetic markers and traits characteristic
of familial diseases. Separate methodologies for qualitative
traits, qualitative traits, and traits with variable age of onset
will be developed. In the case of quantitative traits, the usual
assumption of normality will be relaxed. The models will allow for
a flexible correlation structure among the pedigree individuals.
The statistical properties such as the bias, consistency, power and
robustness of the estimators and the likelihood ratio tests
developed will be studied by mathematical analysis and computer
simulations. Extensions to different types of ascertainments will
be developed. The methods will be applied to analyse pedigree data
obtained from various ongoing studies in order to be sure that the
methods are relevant to real data.
StatusFinished
Effective start/end date9/28/8812/31/93

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $81,063.00
  • National Institutes of Health
  • National Institutes of Health

Fingerprint

pedigree
testing
genetic traits
counseling
quantitative traits
linkage (genetics)
genetic markers
methodology

ASJC

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)