GENETIC ANALYSIS OF NEUROBLASTOMA

Project: Research project

Description

DESCRIPTION: Neuroblastoma (NB) is the most common solid tumor in children and accounts for 15% of all childhood cancer deaths. Inheritance has been implicated in NB although the location of predisposing gene(s) has not been identified. Constitutional translocations have been valuable tools for gene discovery in a large number of human diseases, where it has been shown repeatedly that the interrupted gene is responsible for the disease. The PI has identified 2 NB subjects with constitutional translocations. The goal of the proposed work is to characterize the breakpoints and identify the genes disrupted by the translocations.
StatusFinished
Effective start/end date1/1/973/31/06

Funding

  • National Institutes of Health: $391,706.00
  • National Institutes of Health: $391,706.00
  • National Institutes of Health
  • National Institutes of Health: $391,706.00
  • National Institutes of Health: $333,000.00
  • National Institutes of Health
  • National Institutes of Health: $391,706.00
  • National Institutes of Health: $170,567.00

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Neuroblastoma
Genes
Neoplasms
Genetic Association Studies
Chromosomes, Human, Pair 10
Chromosome Breakpoints
Neoplasm Metastasis
Amino Acid Motifs
Inborn Genetic Diseases
Chromosomes, Human, Pair 1
Medical Genetics

ASJC

  • Medicine(all)
  • Neuroscience(all)