PROJECT NARRATIVE Alzheimer’s disease (AD) is the most common neurodegenerative disorder, currently accounting for 60–80 % of dementia cases. This application aims at identifying the molecular bases underlying the effects of aging on AD-related neuropathology and cognitive deficits. We expect that the results will provide insights into therapeutic interventions targeting specific HDACs and tissue-selective therapy.
- National Institute on Aging: $567,615.00
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