Radiation Therapy Oncology Group-Statistical Center

  • Sadek, Ramses F (PI)
  • PAJAK, THOMAS (PI)
  • SCOTT, CHARLES (PI)
  • SWANN, SUZANNE (PI)

Project: Research project

Project Details

Description

The RTOG Statistics Department was established to collaborate with RTOG
investigators in defining the optimum management of cancer patients,
particularly when this care includes radiation therapy, either alone or in
combination with other modalities. These efforts should lead to extended
survival, improved tumor control, enhanced quality of life, and an ultimate
cure. To achieve this objective, the Statistical Unit collaborates with RTOG
investigators in conducting multicenter randomized and nonrandomized clinical
trials to evaluate the safety and efficacy of novel therapies, in the
treatment of patients with cancer. The RTOG statisticians work with the RTOG
investigators to develop and implement research strategies in a series of
well-designed trials. They assure that the role of each new treatment regimen
receives adequate phase I/II evaluation. The results can then be incorporated
into designing subsequent phase III trials with minimal delay, a minimum but
sufficient number of patients, and a maximum chance of detecting clinically
significant differences. The RTOG statisticians further collaborate with RTOG
investigators in carefully monitoring ongoing trials, performing timely and
appropriate analyses, and promptly reporting the results. The RTOG Statistics
Department determines randomization schemes and develops systems for
processing and analyzing the clinical databases.
RTOG also conducts studies in correlating laboratory findings and outcomes
research [Quality of Life (QOL), Special Populations (SP), Economic Impact
(EI), and Epidemiology Subcommittees (EP)] endpoints with treatment outcome.
The laboratory studies may lead to a better understanding of the fundamental
nature of the malignant process and predict the responsiveness of tumors to
various therapies. The RTOG evaluates every study for potential inclusion of
outcome research endpoints. In studies where these endpoints are appropriate,
the Statistics Department collaborates with the RTOG investigator on the
design of case report forms to obtain the necessary data. Given these findings
from the laboratory and the outcomes studies, treatments can be more logically
planned for individual patients. The RTOG Statistics Department collaborates
with RTOG investigators in the design, monitoring, and analysis of all these
studies.
StatusNot started

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