REGULATION OF HERPES PROTEINS IN PERSISTENT INFECTION

Project: Research project

Project Details

Description

Herpesvirvses are significant human pathogens and cause a variety
of disease syndromes which range in severity from inapparent
infection to life-threatening disease. A hallmark of herpesvirvses
is their ability to establish persistent infection. This ability
is especially evident in diseases such as oral or genital herpes
simplex virus infections, in which periods of latency are
punctuated with episodes of active, localized lesions. Very little
is known about the alterations in virus/cell interactions which
result in herpesviral persistent infection rather than productive,
lytic infection. As a model system for persistent infection by a
cytocidal herpesvirus, persistently infected/oncogenically
transformed cell lines were developed by infection of primary
hamster embryo cells with equine herpesvirus type I (EHV-1)
preparations rich in defective interfering particles (DIPs). Small
populations (
StatusNot started