Role of heat shock transcription factor HSF1 in tumorigenesis

  • Mivechi, Nahid F (CoPI)
  • MIVECHI, NAHID (PI)
  • MOSKOFIDIS, DIMITRIOS (CoPI)
  • MIVECHI, NAHID (CoPI)
  • MIVECHI, NAHID (PI)
  • MOSKOFIDIS, DIMITRIOS (CoPI)
  • MIVECHI, NAHID (PI)
  • MIVECHI, NAHID (PI)
  • MIVECHI, NAHID (PI)

Project: Research project

Project Details

Description

Therapeutic  exploitation  of  oncogene  addiction  has  become  a  central  aim  of  modern  cancer  therapy,  but  effective targeted therapies for aggressive cancer types including hepatocellular carcinoma (HCC) are lacking.  In  this  proposal,  a  collaborating  team  of  experts  will  investigate  whether  a  valid  approach  for  therapeutic  interventions  in  HCC  can  be  based  on  a  strategy  to  inhibit  supportive  non-­oncogene  addiction  pathways,  interfering  with  tumor-­promoting  metabolic  reprogramming  and  improving  the  predicted  power  of  anti-­tumor  immunity  through  depletion  of  Hsf1.  This  research  will  provide  the  rationale  to  develop  novel  strategies  to  prevent, and perhaps treat, cancers, including HCC, that arise on the background of chronic hepatic injury due  to impaired liver metabolism, protein homeostasis and suppression of anti-­tumor immunity.   
StatusNot started

Funding

  • National Cancer Institute: $7,393,780.00

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