SIGMA LIGAND--PROTECTION OF DIABETES INDUCED RETINOPATHY

Project: Research project

Project Details

Description

DESCRIPTION: (Adapted from the applicant's abstract) Dr. Smith proposes an
interesting hypothesis. In AIM 1 she plans to determine whether excess levels
of homocysteine and glutamate damage retinal ganglion cells in vitro and in
vivo and whether this damage can be blocked by NMDA receptor antagonists and by
sigma receptor ligand. IN AIM 2 she will determine whether sigma receptor
ligands have a protective effect against the retinal ganglion cells death
observed in early stages of diabetes. Finally in AIM 3, the investigator will
use various methods to confirm the presence of type 1 sigma ligand in the
retina. The investigator will analyze the pattern of type 1 sigma receptor
expression in the retina.
StatusFinished
Effective start/end date2/1/001/31/03

ASJC

  • Medicine(all)