SODIUM EFFECTS ON BONE METABOLISM

Project: Research project

Project Details

Description

The candidate, Laura Carbone M.D., is a new investigator in the field of
metabolic bone diseases. Immediate goals include acquiring expertise in
study design. This will be provided on a ongoing basis by the co-mentors
Dr. Genaro Palmieri, a well known expert in metabolic bone disease, and
Dr. William B. Applegate, an expert in large multi-center clinical trials.
Long term goals include obtaining the skills necessary to do clinical
trials in metabolic bone diseases. This will be provided at this center by
weekly classes in statistics and epidemiology, seminars in nutrition and
osteoporosis and a program leading to a master of science degree in
epidemiology. The specific research plan is detailed below:

Racial differences in bone metabolism, bone mineral density and fracture
rates have been reported between Caucasians and African Americans with
Caucasians generally having increased biochemical markers of bone
metabolism, decreased bone mineral density and higher fracture rats than
African Americans. More recent data, however, suggests that the incidence
of osteoporosis and osteoporotic fractures may be increasing in African
Americans.

Environmental factors, specifically salt intake, have been shown to
influence bone metabolism in Caucasians, but have not been studied in
African Americans, despite the fact that the African American diet may be
high in sodium.

This study proposes to examine the effects of sodium load and then a
sodium restriction diet of calciotropic hormones and biochemical markers
of bone metabolism in African American and Caucasian women.
StatusFinished
Effective start/end date9/1/988/31/04

ASJC

  • Medicine(all)