Stress Related Mechanisms of Hypertension Risk

Project: Research projectResearch Program Projects

Description

DESCRIPTION (provided by applicant):
This program project application consists of an integrated multidisciplinary
program including 4 closely related projects examining the roles of stress,
lifestyle behaviors and genetic polymorphisms in the development of
preclinical measures of essential hypertension (EH). The Program Project is
supported by 4 cores. Three vasoactive pathways will be examined which may
link exaggerated cardiovascular (CV) reactivity and delayed CV recovery from
stress to development of preclinical measures of EH. These pathways are
Sympathetic Nervous System (SNS), Renin-Angiotensin-Aldosterone System (RAAS)
and Endothelial System (ES). Project 1 involves the continued evaluation of
youth with family histories of EH over a cumulative period of 17 years.
Project 1 will focus upon the role of environmental stress (e.g., lower
socioeconomic status, high personal life stress) in combination with 4
polymorphisms associated with the 3 vasoactive pathways (RAAS, SNS, ES) upon
CV reactivity to acute laboratory challenges and development of preclinical
measures of disease (e.g., increased left ventricular mass, increased resting
blood pressure (BP), increased micro albumin, decreased endothelial function
and increased arterial stiffness). Project 2 will examine possible ethnic
differences in delayed BP recovery to an extended laboratory challenge
primarily due to dysregulation of the RAAS system and ineffective sodium
handling. Relationships between these parameters, 3 polymorphisms associated
with SNS and RAAS and preclinical measures of disease will also be evaluated.
Project 3 will examine impact of exercise training in African American
children on BP reactivity to an acute laboratory challenge and preclinical
measures of disease via improvements in the ES. Project 4 will be conducted
on Dahl salt-sensitive rats and will assess the impact of intermittent stress
and high salt diet upon vascular and renal mechanisms in the development of
EH. It is designed to identify new candidate genes related to vascular and
renal dysfunction associated with stress exposure. These four projects will
each be supported by Bioassay (Core B), Biomedical (Core C) and Data Management
and Statistics (Core D) cores.
StatusActive
Effective start/end date7/1/026/30/19

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $2,111,105.00
  • National Institutes of Health
  • National Institutes of Health: $2,181,209.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $2,111,105.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $2,111,105.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $2,099,274.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $2,052,821.00
  • National Institutes of Health: $2,111,105.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $2,111,105.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

Fingerprint

Hypertension
Renin-Angiotensin System
Natriuresis
Sodium
Biological Assay
Blood Pressure
Pressure
Adiposity
Salts
Genes
African Americans
Angiotensin II
Inbred Dahl Rats
Angiotensin Receptor Antagonists
Angiotensin Type 1 Receptor
Albumins
Blood Vessels
Life Style
Sympathetic Nervous System
Pituitary-Adrenal System

Keywords

  • Medicine(all)