Project: Research project

Project Details


The three dimensional structure of DNA as influenced by base sequence,
metal ions, chemical carcinogens and other agents will be studied by
vacuum-ultraviolet circular dichroism (VUV-CD) and time resolved

The electronic states and transitions of the DNA bases, understanding of
which is crucial to the interpretation of CD spectra, will be studied using
vacuum-ultraviolet magnetic circular dichroism (VUV-MCD) and fluorescence
polarization spectroscopy.

A major goal is understanding why VUV-CD is a better indicator of the
helical structure of, and more sensitive to the hydrogen bonding between
DNA strands than is conventional, longer wavelength CD.

The VUV-CD, VUV-MCD, fluorescence polarization and time-resolved
fluorescence experiments will be performed at the National Synchrotron
Light Source.
StatusNot started


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.