α-Tocopherol ameliorates cyclophosphamide-induced hyperlipidemia in fibrosarcoma-bearing rats

S. Ilanchezhian, Muthusamy Thangaraju, S. Sasirekha, P. Sachdanandam

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Cyclophosphamide, an alkylating agent, is currently being used for the treatment of various types of cancer, either alone or in combination with other cytostatic drugs. However, cyclophosphamide has a detrimental effect on lipid metabolism and causes hyperlipidemia in patients. Since α-tocopherol is known to reduce hyperlipidemia, we have investigated the effects of adding α-tocopherol to the cyclophosphamide treatment. Our study, carried out on fibrosarcoma-bearing rats, shows that α-tocopherol markedly reduces cyclophosphamide-induced hyperlipidemia and brings lipid metabolism down to values observed in untreated controls.

Original languageEnglish (US)
Pages (from-to)771-774
Number of pages4
JournalAnti-Cancer Drugs
Volume6
Issue number6
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • Cyclophosphamide
  • Fibrosarcoma
  • Lipids
  • α-Tocopherol

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Cancer Research

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