α-Tocopherol ameliorates cyclophosphamide-induced hyperlipidemia in fibrosarcoma-bearing rats

S. Ilanchezhian, Muthusamy Thangaraju, S. Sasirekha, P. Sachdanandam

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Cyclophosphamide, an alkylating agent, is currently being used for the treatment of various types of cancer, either alone or in combination with other cytostatic drugs. However, cyclophosphamide has a detrimental effect on lipid metabolism and causes hyperlipidemia in patients. Since α-tocopherol is known to reduce hyperlipidemia, we have investigated the effects of adding α-tocopherol to the cyclophosphamide treatment. Our study, carried out on fibrosarcoma-bearing rats, shows that α-tocopherol markedly reduces cyclophosphamide-induced hyperlipidemia and brings lipid metabolism down to values observed in untreated controls.

Original languageEnglish (US)
Pages (from-to)771-774
Number of pages4
JournalAnti-Cancer Drugs
Volume6
Issue number6
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Tocopherols
Fibrosarcoma
Hyperlipidemias
Cyclophosphamide
Lipid Metabolism
Alkylating Agents
Cytostatic Agents
Therapeutics
Neoplasms

Keywords

  • Cyclophosphamide
  • Fibrosarcoma
  • Lipids
  • α-Tocopherol

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)
  • Cancer Research

Cite this

α-Tocopherol ameliorates cyclophosphamide-induced hyperlipidemia in fibrosarcoma-bearing rats. / Ilanchezhian, S.; Thangaraju, Muthusamy; Sasirekha, S.; Sachdanandam, P.

In: Anti-Cancer Drugs, Vol. 6, No. 6, 01.01.1995, p. 771-774.

Research output: Contribution to journalArticle

Ilanchezhian, S. ; Thangaraju, Muthusamy ; Sasirekha, S. ; Sachdanandam, P. / α-Tocopherol ameliorates cyclophosphamide-induced hyperlipidemia in fibrosarcoma-bearing rats. In: Anti-Cancer Drugs. 1995 ; Vol. 6, No. 6. pp. 771-774.
@article{e3d6b1b121784ae599e67ae97f6cdb22,
title = "α-Tocopherol ameliorates cyclophosphamide-induced hyperlipidemia in fibrosarcoma-bearing rats",
abstract = "Cyclophosphamide, an alkylating agent, is currently being used for the treatment of various types of cancer, either alone or in combination with other cytostatic drugs. However, cyclophosphamide has a detrimental effect on lipid metabolism and causes hyperlipidemia in patients. Since α-tocopherol is known to reduce hyperlipidemia, we have investigated the effects of adding α-tocopherol to the cyclophosphamide treatment. Our study, carried out on fibrosarcoma-bearing rats, shows that α-tocopherol markedly reduces cyclophosphamide-induced hyperlipidemia and brings lipid metabolism down to values observed in untreated controls.",
keywords = "Cyclophosphamide, Fibrosarcoma, Lipids, α-Tocopherol",
author = "S. Ilanchezhian and Muthusamy Thangaraju and S. Sasirekha and P. Sachdanandam",
year = "1995",
month = "1",
day = "1",
doi = "10.1097/00001813-199512000-00009",
language = "English (US)",
volume = "6",
pages = "771--774",
journal = "Anti-Cancer Drugs",
issn = "0959-4973",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - α-Tocopherol ameliorates cyclophosphamide-induced hyperlipidemia in fibrosarcoma-bearing rats

AU - Ilanchezhian, S.

AU - Thangaraju, Muthusamy

AU - Sasirekha, S.

AU - Sachdanandam, P.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Cyclophosphamide, an alkylating agent, is currently being used for the treatment of various types of cancer, either alone or in combination with other cytostatic drugs. However, cyclophosphamide has a detrimental effect on lipid metabolism and causes hyperlipidemia in patients. Since α-tocopherol is known to reduce hyperlipidemia, we have investigated the effects of adding α-tocopherol to the cyclophosphamide treatment. Our study, carried out on fibrosarcoma-bearing rats, shows that α-tocopherol markedly reduces cyclophosphamide-induced hyperlipidemia and brings lipid metabolism down to values observed in untreated controls.

AB - Cyclophosphamide, an alkylating agent, is currently being used for the treatment of various types of cancer, either alone or in combination with other cytostatic drugs. However, cyclophosphamide has a detrimental effect on lipid metabolism and causes hyperlipidemia in patients. Since α-tocopherol is known to reduce hyperlipidemia, we have investigated the effects of adding α-tocopherol to the cyclophosphamide treatment. Our study, carried out on fibrosarcoma-bearing rats, shows that α-tocopherol markedly reduces cyclophosphamide-induced hyperlipidemia and brings lipid metabolism down to values observed in untreated controls.

KW - Cyclophosphamide

KW - Fibrosarcoma

KW - Lipids

KW - α-Tocopherol

UR - http://www.scopus.com/inward/record.url?scp=0029417138&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029417138&partnerID=8YFLogxK

U2 - 10.1097/00001813-199512000-00009

DO - 10.1097/00001813-199512000-00009

M3 - Article

C2 - 8845490

AN - SCOPUS:0029417138

VL - 6

SP - 771

EP - 774

JO - Anti-Cancer Drugs

JF - Anti-Cancer Drugs

SN - 0959-4973

IS - 6

ER -