β-catenin interacts with MyoD and regulates its transcription activity

Chang Hoon Kim, Hannah Neiswender, Joo Baik Eun, Wen C. Xiong, Lin Mei

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58 Scopus citations

Abstract

Wnt regulation of muscle development is thought to be mediated by the β-catenin-TCF/LEF-dependent canonical pathway. Here we demonstrate that β-catenin, not TCF/LEF, is required for muscle differentiation. We showed that β-catenin interacts directly with MyoD, a basic helix-loop-helix transcription factor essential for muscle differentiation and enhances its binding to E box elements and transcriptional activity. MyoD-mediated transactivation is inhibited in muscle cells when β-catenin is deficient or the interaction between MyoD and β-catenin is disrupted. These results demonstrate that β-catenin is necessary for MyoD function, identifying MyoD as an effector in the Wnt canonical pathway.

Original languageEnglish (US)
Pages (from-to)2941-2951
Number of pages11
JournalMolecular and Cellular Biology
Volume28
Issue number9
DOIs
StatePublished - May 1 2008

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Kim, C. H., Neiswender, H., Eun, J. B., Xiong, W. C., & Mei, L. (2008). β-catenin interacts with MyoD and regulates its transcription activity. Molecular and Cellular Biology, 28(9), 2941-2951. https://doi.org/10.1128/MCB.01682-07