β-catenin interacts with MyoD and regulates its transcription activity

Chang Hoon Kim, Hannah Neiswender, Joo Baik Eun, Wencheng Xiong, Lin Mei

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Wnt regulation of muscle development is thought to be mediated by the β-catenin-TCF/LEF-dependent canonical pathway. Here we demonstrate that β-catenin, not TCF/LEF, is required for muscle differentiation. We showed that β-catenin interacts directly with MyoD, a basic helix-loop-helix transcription factor essential for muscle differentiation and enhances its binding to E box elements and transcriptional activity. MyoD-mediated transactivation is inhibited in muscle cells when β-catenin is deficient or the interaction between MyoD and β-catenin is disrupted. These results demonstrate that β-catenin is necessary for MyoD function, identifying MyoD as an effector in the Wnt canonical pathway.

Original languageEnglish (US)
Pages (from-to)2941-2951
Number of pages11
JournalMolecular and Cellular Biology
Volume28
Issue number9
DOIs
StatePublished - May 1 2008

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Catenins
E-Box Elements
Basic Helix-Loop-Helix Transcription Factors
Muscles
Wnt Signaling Pathway
Muscle Development
Muscle Cells
Transcriptional Activation

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

β-catenin interacts with MyoD and regulates its transcription activity. / Kim, Chang Hoon; Neiswender, Hannah; Eun, Joo Baik; Xiong, Wencheng; Mei, Lin.

In: Molecular and Cellular Biology, Vol. 28, No. 9, 01.05.2008, p. 2941-2951.

Research output: Contribution to journalArticle

Kim, CH, Neiswender, H, Eun, JB, Xiong, W & Mei, L 2008, 'β-catenin interacts with MyoD and regulates its transcription activity', Molecular and Cellular Biology, vol. 28, no. 9, pp. 2941-2951. https://doi.org/10.1128/MCB.01682-07
Kim, Chang Hoon ; Neiswender, Hannah ; Eun, Joo Baik ; Xiong, Wencheng ; Mei, Lin. / β-catenin interacts with MyoD and regulates its transcription activity. In: Molecular and Cellular Biology. 2008 ; Vol. 28, No. 9. pp. 2941-2951.
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