β-Endorphin and essential hypertension: Importance of the clonidine-naloxone interaction

C. Farsang, J. Kapocsi, K. Varga, L. Vajda, A. Balás-Eltes, G. Kunos

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Analysis of the effect of naloxone (0.4 mg iv.) on clonidine hypotension in 80 patients with essential hypertension revealed that two groups could be separated. In the responding group (43 pts) naloxone increased blood pressure and heart rate in clonidine-treated patients while in the non-responding group (37 pts) it has no such effect. Patients in the responding group had higher cardiac output, stroke volume, plasma renin activity, plasma adrenaline and β-endorphin levels and lower total peripheral resistance, shorter history of hypertension and lower body weight than those in the non-responding group. The pressor effect of naloxone in four responding patients treated with clonidine for 29 months tended to be smaller compared to the response obtained after a 3-day clonidine therapy. Results favour the hypothesis of the existence of two (responding, non-responding) groups of patients with essential hypertension. Further work will clarify whether these groups represent different pathogenesis or indicate only a different stage of hypertension.

Original languageEnglish (US)
Pages (from-to)217-226
Number of pages10
JournalActa Physiologica Hungarica
Volume65
Issue number2
StatePublished - Oct 10 1985

Fingerprint

Endorphins
Clonidine
Naloxone
High Cardiac Output
Hypertension
Renin
Vascular Resistance
Stroke Volume
Hypotension
Epinephrine
Heart Rate
Body Weight
Essential Hypertension
Blood Pressure

ASJC Scopus subject areas

  • Physiology (medical)

Cite this

β-Endorphin and essential hypertension : Importance of the clonidine-naloxone interaction. / Farsang, C.; Kapocsi, J.; Varga, K.; Vajda, L.; Balás-Eltes, A.; Kunos, G.

In: Acta Physiologica Hungarica, Vol. 65, No. 2, 10.10.1985, p. 217-226.

Research output: Contribution to journalArticle

Farsang, C, Kapocsi, J, Varga, K, Vajda, L, Balás-Eltes, A & Kunos, G 1985, 'β-Endorphin and essential hypertension: Importance of the clonidine-naloxone interaction', Acta Physiologica Hungarica, vol. 65, no. 2, pp. 217-226.
Farsang, C. ; Kapocsi, J. ; Varga, K. ; Vajda, L. ; Balás-Eltes, A. ; Kunos, G. / β-Endorphin and essential hypertension : Importance of the clonidine-naloxone interaction. In: Acta Physiologica Hungarica. 1985 ; Vol. 65, No. 2. pp. 217-226.
@article{0cb93d517a724f8da63c3ee1f1be1c64,
title = "β-Endorphin and essential hypertension: Importance of the clonidine-naloxone interaction",
abstract = "Analysis of the effect of naloxone (0.4 mg iv.) on clonidine hypotension in 80 patients with essential hypertension revealed that two groups could be separated. In the responding group (43 pts) naloxone increased blood pressure and heart rate in clonidine-treated patients while in the non-responding group (37 pts) it has no such effect. Patients in the responding group had higher cardiac output, stroke volume, plasma renin activity, plasma adrenaline and β-endorphin levels and lower total peripheral resistance, shorter history of hypertension and lower body weight than those in the non-responding group. The pressor effect of naloxone in four responding patients treated with clonidine for 29 months tended to be smaller compared to the response obtained after a 3-day clonidine therapy. Results favour the hypothesis of the existence of two (responding, non-responding) groups of patients with essential hypertension. Further work will clarify whether these groups represent different pathogenesis or indicate only a different stage of hypertension.",
author = "C. Farsang and J. Kapocsi and K. Varga and L. Vajda and A. Bal{\'a}s-Eltes and G. Kunos",
year = "1985",
month = "10",
day = "10",
language = "English (US)",
volume = "65",
pages = "217--226",
journal = "Physiology International",
issn = "2498-602X",
publisher = "Akademiai Kiado",
number = "2",

}

TY - JOUR

T1 - β-Endorphin and essential hypertension

T2 - Importance of the clonidine-naloxone interaction

AU - Farsang, C.

AU - Kapocsi, J.

AU - Varga, K.

AU - Vajda, L.

AU - Balás-Eltes, A.

AU - Kunos, G.

PY - 1985/10/10

Y1 - 1985/10/10

N2 - Analysis of the effect of naloxone (0.4 mg iv.) on clonidine hypotension in 80 patients with essential hypertension revealed that two groups could be separated. In the responding group (43 pts) naloxone increased blood pressure and heart rate in clonidine-treated patients while in the non-responding group (37 pts) it has no such effect. Patients in the responding group had higher cardiac output, stroke volume, plasma renin activity, plasma adrenaline and β-endorphin levels and lower total peripheral resistance, shorter history of hypertension and lower body weight than those in the non-responding group. The pressor effect of naloxone in four responding patients treated with clonidine for 29 months tended to be smaller compared to the response obtained after a 3-day clonidine therapy. Results favour the hypothesis of the existence of two (responding, non-responding) groups of patients with essential hypertension. Further work will clarify whether these groups represent different pathogenesis or indicate only a different stage of hypertension.

AB - Analysis of the effect of naloxone (0.4 mg iv.) on clonidine hypotension in 80 patients with essential hypertension revealed that two groups could be separated. In the responding group (43 pts) naloxone increased blood pressure and heart rate in clonidine-treated patients while in the non-responding group (37 pts) it has no such effect. Patients in the responding group had higher cardiac output, stroke volume, plasma renin activity, plasma adrenaline and β-endorphin levels and lower total peripheral resistance, shorter history of hypertension and lower body weight than those in the non-responding group. The pressor effect of naloxone in four responding patients treated with clonidine for 29 months tended to be smaller compared to the response obtained after a 3-day clonidine therapy. Results favour the hypothesis of the existence of two (responding, non-responding) groups of patients with essential hypertension. Further work will clarify whether these groups represent different pathogenesis or indicate only a different stage of hypertension.

UR - http://www.scopus.com/inward/record.url?scp=0021996498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021996498&partnerID=8YFLogxK

M3 - Article

C2 - 3157294

AN - SCOPUS:0021996498

VL - 65

SP - 217

EP - 226

JO - Physiology International

JF - Physiology International

SN - 2498-602X

IS - 2

ER -