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• 2019

  Hyperglycemia-impaired aortic vasorelaxation mediated through arginase elevation: Role of stress kinase pathways

  Chandra, S., Fulton, D. J. R., Caldwell, R. B., Caldwell, R. W. & Toque, H. A., Feb 5 2019, In: European Journal of Pharmacology. 844, p. 26-37 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Vasodilation
  • Hyperglycemia
  • p38 Mitogen-Activated Protein Kinases
  • Phosphotransferases
  7 Scopus citations
• 2018

  Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

  Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In: Cell Death and Disease. 9, 10, 1001.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Ischemia
  • Macrophages
  • Reperfusion Injury
  • Knockout Mice
  8 Scopus citations
• 2019

  Role of arginase 2 in systemic metabolic activity and adipose tissue fatty acid metabolism in diet-induced obese mice

  Atawia, R. T., Toque, H. A., Meghil, M. M., Benson, T. W., Yiew, N. K. H., Cutler, C. W., Weintraub, N. L., Caldwell, R. B. & Caldwell, R. W., Mar 2 2019, In: International journal of molecular sciences. 20, 6, 1462.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • diets
  • adipose tissues
  • Sugar (sucrose)
  • fatty acids
  • Arginase
  3 Scopus citations
• 2018

  Mechanisms of diabetes-induced endothelial cell senescence: Role of arginase 1

  Shosha, E., Xu, Z., Priya Narayanan, S., Lemtalsi, T., Fouda, A. Y., Rojas, M., Xing, J., Fulton, D., William Caldwell, R. & Caldwell, R. B., Apr 17 2018, In: International journal of molecular sciences. 19, 4, 1215.

  Research output: Contribution to journal › Article › peer-review

  • Endothelial cells
  • Arginase
  • Medical problems
  • Cellular Senescence
  • Galactosidases
  8 Scopus citations
• 2017

  Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

  Bhatta, A., Yao, L., Xu, Z., Toque, H. A., Chen, J., Atawia, R. T., Fouda, A. Y., Bagi, Z., Lucas, R., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In: Cardiovascular Research. 113, 13, p. 1664-1676 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Endothelial Cells
  • Obesity
  • Blood Vessels
  • Sucrose
  38 Scopus citations

• Netrin-1 is a novel regulator of vascular endothelial function in diabetes

  Toque, H. A., Fernandez-Flores, A., Mohamed, R., Caldwell, R. B., Ramesh, G. & Caldwell, R. W., Oct 2017, In: PloS one. 12, 10, e0186734.

  Research output: Contribution to journal › Article › peer-review

  • Netrin-1
  • Medical problems
  • diabetes
  • blood vessels
  • Blood Vessels
  12 Scopus citations
• 2019

  The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

  Madaio, M. P., Czikora, I., Kvirkvelia, N., McMenamin, M., Yue, Q., Liu, T., Flores Toque, H. A., Sridhar, S., Covington, K., Alaisami, R., O'Connor, P. M., Caldwell, R. W., Chen, J., Clauss, M., Brands, M. W., Eaton, D. C., Romero Lucas, M. J. & Lucas, R., Jun 2019, In: Kidney International. 95, 6, p. 1359-1372 14 p.

  Research output: Contribution to journal › Article › peer-review

  • AP301 peptide
  • Epithelial Sodium Channels
  • Nephritis
  • Tumor Necrosis Factor-alpha
  • Serum
  1 Scopus citations
• 2017

  Obesity-induced vascular inflammation involves elevated arginase activity

  Yao, L., Bhatta, A., Xu, Z., Chen, J., Toque, H. A., Chen, Y., Xu, Y., Bagi, Z., Lucas, R., Huo, Y., Caldwell, R. B. & Caldwell, R. W., Nov 2017, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 313, 5, p. R560-R571

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Intra-Abdominal Fat
  • Obesity
  • Endothelial Cells
  • Inflammation
  12 Scopus citations

• Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock

  Subramani, K., Lu, S., Warren, M., Chu, X., Flores Toque, H. A., Caldwell, R. W., Diamond, M. P. & Raju, R. P., Dec 1 2017, In: Scientific reports. 7, 1, 2671.

  Research output: Contribution to journal › Article › peer-review

  • Hemorrhagic Shock
  • Resuscitation
  • Wounds and Injuries
  • Orphan Drug Production
  • Mitochondrial Membrane Potential
  8 Scopus citations
• 2019

  Regulation of MAP kinase-mediated endothelial dysfunction in hyperglycemia via arginase I and eNOS dysregulation

  Mazrouei, S., Sharifpanah, F., Caldwell, R. W., Franz, M., Shatanawi, A., Muessig, J., Fritzenwanger, M., Schulze, P. C. & Jung, C., Sep 2019, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 9, p. 1398-1411 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Hyperglycemia
  • Phosphotransferases
  • p38 Mitogen-Activated Protein Kinases
  • Phosphorylation
  2 Scopus citations
• 2020

  Arginase Pathway in Acute Retina and Brain Injury: Therapeutic Opportunities and Unexplored Avenues

  Fouda, A. Y., Eldahshan, W., Narayanan, S. P., Caldwell, R. W. & Caldwell, R. B., Mar 17 2020, In: Frontiers in Pharmacology. 11, 277.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Arginase
  • Brain Injuries
  • Retina
  • Nervous System Trauma
  • Traumatic Brain Injury
  2 Scopus citations
• 2019

  Age-dependent oxidative stress elevates arginase 1 and uncoupled nitric oxide synthesis in skeletal muscle of aged mice

  Pandya, C. D., Lee, B., Toque, H. A., Mendhe, B., Bragg, R. T., Pandya, B., Atawia, R. T., Isales, C., Hamrick, M., Caldwell, R. W. & Fulzele, S., 2019, In: Oxidative medicine and cellular longevity. 2019, 1704650.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oxidative stress
  • Arginase
  • Muscle
  • Nitric Oxide
  • Skeletal Muscle
  3 Scopus citations

• Mechanisms of obesity-induced metabolic and vascular dysfunctions

  Atawia, R. T., Bunch, K. L., Toque, H. A., Caldwell, R. B. & Caldwell, R. W., Mar 1 2019, In: Frontiers in Bioscience - Landmark. 24, 5, p. 890-934 45 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Nitric Oxide
  • Adipocytes
  • Obesity
  • Blood Vessels
  14 Scopus citations
• 2018

  Arginase: A multifaceted enzyme important in health and disease

  Caldwell, R. W., Rodriguez, P. C., Toque, H. A., Priya Narayanan, S. & Caldwell, R. B., Apr 2018, In: Physiological reviews. 98, 2, p. 641-665 25 p.

  Research output: Contribution to journal › Review article › peer-review

  • Arginase
  • Enzymes
  • Health
  • Ornithine
  • Urea
  60 Scopus citations
• 2019

  Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress

  Lv, H., Zhu, C., Wu, R., Ni, H., Lian, J., Xu, Y., Xia, Y., Shi, G., Li, Z., Caldwell, R. B., Caldwell, R. W., Yao, L. & Chen, Y., Jul 2019, In: Journal of Psychiatric Research. 114, p. 55-66 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative Stress
  • Inhibition (Psychology)
  • Anxiety
  • Anxiety Disorders
  • acetovanillone
  7 Scopus citations
• 2020

  Modulating microglia activation prevents maternal immune activation induced schizophrenia-relevant behavior phenotypes via arginase 1 in the dentate gyrus

  Xia, Y., Zhang, Z., Lin, W., Yan, J., Zhu, C., Yin, D., He, S., Su, Y., Xu, N., Caldwell, R. W., Yao, L. & Chen, Y., Oct 1 2020, In: Neuropsychopharmacology. 45, 11, p. 1896-1908 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Dentate Gyrus
  • Microglia
  • Schizophrenia
  • Mothers
  1 Scopus citations