Find Research Outputs

Search in all content

Filters for Scholarly Output

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011

Author

  • Rudolf Lucas
2020

Impact of bacterial toxins in the lungs

Lucas, R., Hadizamani, Y., Gonzales, J., Gorshkov, B., Bodmer, T., Berthiaume, Y., Moehrlen, U., Lode, H., Huwer, H., Hudel, M., Mraheil, M. A., Toque, H. A. F., Chakraborty, T. & Hamacher, J., Apr 2020, In : Toxins. 12, 4, 223.

Research output: Contribution to journalArticle

Open Access

Loaded Leukosomes: A Smart Bomb to Halt Vascular Inflammation

Csányi, G., Lucas, R. & Annex, B. H., Jan 3 2020, In : Circulation research. 126, 1, p. 38-40 3 p.

Research output: Contribution to journalEditorial

Short report: Does the 6-minute walk test in hospitalized COPD patients exclusively correlate with lung function parameters or should psychological factors also be taken into account?

Borgmann, M., Ivanda, M., Hadizamani, Y., Mohaupt, M., Bals, R., Lucas, R., Hamacher, J. & Köllner, V., May 2020, In : PloS one. 15, 5, e0232587.

Research output: Contribution to journalArticle

Open Access
2019
2 Scopus citations

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis

Madaio, M. P., Czikora, I., Kvirkvelia, N., McMenamin, M., Yue, Q., Liu, T., Flores Toque, H. A., Sridhar, S., Covington, K., Alaisami, R., O'Connor, P. M., Caldwell, R. W., Chen, J., Clauss, M., Brands, M. W., Eaton, D. C., Romero Lucas, M. J. & Lucas, R., Jun 2019, In : Kidney International. 95, 6, p. 1359-1372 14 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome

Benson, T. W., Weintraub, N. L., Kim, H. W., Seigler, N., Kumar, S., Pye, J., Horimatsu, T., Pellenberg, R., Stepp, D. W., Lucas, R., Bogdanov, V. Y., Litwin, S. E., Brittain, J. E. & Harris, R. A., Oct 1 2018, In : Laboratory Investigation. 98, 10, p. 1300-1310 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cytokine-ion channel interactions in pulmonary inflammation

Hamacher, J., Hadizamani, Y., Borgmann, M., Mohaupt, M., Männel, D. N., Moehrlen, U., Lucas, R. & Stammberger, U., Jan 4 2018, In : Frontiers in immunology. 8, JAN, 1644.

Research output: Contribution to journalReview article

9 Scopus citations

Editorial: Cytokine-ion channel interactions in pulmonary inflammation

Vadász, I. & Lucas, R., Nov 6 2018, In : Frontiers in immunology. 9, NOV, 2598.

Research output: Contribution to journalReview article

Hsp70 suppresses mitochondrial reactive oxygen species and preserves pulmonary microvascular barrier integrity following exposure to bacterial toxins

Li, X., Yu, Y., Gorshkov, B., Haigh, S., Bordan, Z., Weintraub, D., Rudic, R. D., Chakraborty, T., Barman, S. A., Verin, A. D., Su, Y., Lucas, R., Stepp, D. W., Chen, F. & Fulton, D. J., Jun 12 2018, In : Frontiers in immunology. 9, JUN, 1309.

Research output: Contribution to journalArticle

12 Scopus citations

Kidney-targeted inhibition of protein kinase C-α ameliorates nephrotoxic nephritis with restoration of mitochondrial dysfunction

Kvirkvelia, N., McMenamin, M., Warren, M., Jadeja, R. N., Kodeboyina, S. K., Sharma, A., Zhi, W., O'Connor, P. M., Raju, R., Lucas, R. & Madaio, M. P., Aug 2018, In : Kidney International. 94, 2, p. 280-291 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Listeriolysin O causes ENaC dysfunction in human airway epithelial cells

Yang, G., Pillich, H., White, R., Czikora, I., Pochic, I., Yue, Q., Hudel, M., Gorshkov, B. A., Verin, A. D., Sridhar, S., Isales, C. M., Eaton, D. C., Hamacher, J., Chakraborty, T. & Lucas, R., Feb 11 2018, In : Toxins. 10, 2, 79.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Epithelial sodium channel-α mediates the protective effect of the TNF-derived TIP peptide in pneumolysin-induced endothelial barrier dysfunction

Czikora, I., Alli, A. A., Sridhar, S., Matthay, M. A., Pillich, H., Hudel, M., Berisha, B., Gorshkov, B. A., Romero Lucas, M. J., Gonzales, J. N., Wu, G., Huo, Y., Su, Y., Verin, A. D., Fulton, D. J., Chakraborty, T., Eaton, D. C. & Lucas, R., Jul 21 2017, In : Frontiers in immunology. 8, JUL, 842.

Research output: Contribution to journalArticle

13 Scopus citations

Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: A phase IIa randomized placebo-controlled trial

Krenn, K., Lucas, R., Croizé, A., Boehme, S., Klein, K. U., Hermann, R., Markstaller, K. & Ullrich, R., Jul 27 2017, In : Critical Care. 21, 1, 194.

Research output: Contribution to journalArticle

17 Scopus citations

Listeriolysin O regulates the expression of optineurin, an autophagy adaptor that inhibits the growth of Listeria monocytogenes

Puri, M., La Pietra, L., Mraheil, M. A., Lucas, R., Chakraborty, T. & Pillich, H., Sep 5 2017, In : Toxins. 9, 9, 273.

Research output: Contribution to journalArticle

8 Scopus citations

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

Bhatta, A., Yao, L., Xu, Z., Toque, H. A., Chen, J., Atawia, R. T., Fouda, A. Y., Bagi, Z., Lucas, R., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In : Cardiovascular Research. 113, 13, p. 1664-1676 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

Obesity-induced vascular inflammation involves elevated arginase activity

Yao, L., Bhatta, A., Xu, Z., Chen, J., Toque, H. A., Chen, Y., Xu, Y., Bagi, Z., Lucas, R., Huo, Y., Caldwell, R. B. & Caldwell, R. W., Nov 2017, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 313, 5, p. R560-R571

Research output: Contribution to journalArticle

12 Scopus citations

Restoration of epithelial sodium channel function by synthetic peptides in pseudohypoaldosteronism type 1B mutants

Willam, A., Aufy, M., Tzotzos, S., Evanzin, H., Chytracek, S., Geppert, S., Fischer, B., Fischer, H., Pietschmann, H., Czikora, I., Lucas, R., Lemmens-Gruber, R. & Shabbir, W., Feb 24 2017, In : Frontiers in Pharmacology. 8, FEB, 85.

Research output: Contribution to journalArticle

3 Scopus citations

RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins

Chen, F., Wang, Y., Rafikov, R., Haigh, S., Kumar, S., Rafikova, O., Lucas, R., Verin, A. D., Black, S. M. & Fulton, D. J. R., Mar 1 2017, In : Biochemical Pharmacology. 127, p. 34-45 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Role of Adipose Tissue Endothelial ADAM17 in Age-Related Coronary Microvascular Dysfunction

Dou, H., Feher, A., Davila, A. C., Romero, M. J., Patel, V. S., Kamath, V. M., Gooz, M. B., Rudic, R. D., Lucas, R., Fulton, D. J., Weintraub, N. L. & Bagi, Z., Jun 1 2017, In : Arteriosclerosis, thrombosis, and vascular biology. 37, 6, p. 1180-1193 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Solnatide Demonstrates Profound Therapeutic Activity in a Rat Model of Pulmonary Edema Induced by Acute Hypobaric Hypoxia and Exercise

Zhou, Q., Wang, D., Liu, Y., Yang, X., Lucas, R. & Fischer, B., Mar 1 2017, In : CHEST. 151, 3, p. 658-667 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

TNF lectin-like domain restores epithelial sodium channel function in frameshift mutants associated with pseudohypoaldosteronism type 1B

Willam, A., Aufy, M., Tzotzos, S., El-Malazi, D., Poser, F., Wagner, A., Unterköfler, B., Gurmani, D., Martan, D., Iqbal, S. M., Fischer, B., Fischer, H., Pietschmann, H., Czikora, I., Lucas, R., Lemmens-Gruber, R. & Shabbir, W., May 29 2017, In : Frontiers in immunology. 8, MAY, 601.

Research output: Contribution to journalArticle

2016

Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetes

Romero Lucas, M. J., Lucas, R., Dou, H., Sridhar, S., Czikora, I., Mosieri, E. M., Rick, F. G., Block, N. L., Sridhar, S., Fulton, D. J., Weintraub, N. L. & Bagi, Z., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. 1895-1900 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

The lectin-like domain of TNF increases ENaC open probability through a novel site at the interface between the second transmembrane and C-terminal domains of the α-subunit

Lucas, R., Yue, Q., Alli, A., Duke, B. J., Al-Khalili, O., Thai, T. L., Hamacher, J., Sridhar, S., Lebedyeva, I., Su, H., Tzotzos, S., Fischer, B., Gameiro, A. F., Loose, M., Chakraborty, T., Shabbir, W., Aufy, M., Lemmens-Gruber, R., Eaton, D. C. & Czikora, I., Nov 4 2016, In : Journal of Biological Chemistry. 291, 45, p. 23440-23451 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

Patel, C., Xu, Z., Shosha, E., Xing, J., Lucas, R., Caldwell, R. W., Caldwell, R. B. & Narayanan, S. P., Sep 1 2016, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 9, p. 1628-1639 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015
9 Scopus citations

Endothelial nitric oxide synthase deficient mice are protected from lipopolysaccharide induced acute lung injury

Gross, C. M., Rafikov, R., Kumar, S., Aggarwal, S., Ham, P. B., Meadows, M. L., Cherian-Shaw, M., Kangath, A., Sridhar, S., Lucas, R. & Black, S. M., Mar 18 2015, In : PloS one. 10, 3, e0119918.

Research output: Contribution to journalArticle

22 Scopus citations

Glycosylation-dependent activation of epithelial sodium channel by solnatide

Shabbir, W., Tzotzos, S., Bedak, M., Aufy, M., Willam, A., Kraihammer, M., Holzner, A., Czikora, I., Scherbaum-Hazemi, P., Fischer, H., Pietschmann, H., Fischer, B., Lucas, R. & Lemmens-Gruber, R., Dec 15 2015, In : Biochemical Pharmacology. 98, 4, p. 740-753 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Pneumococcal hydrogen peroxide-induced stress signaling regulates inflammatory genes

Loose, M., Hudel, M., Zimmer, K. P., Garcia, E., Hammerschmidt, S., Lucas, R., Chakraborty, T. & Pillich, H., Jan 15 2015, In : Journal of Infectious Diseases. 211, 2, p. 306-316 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
2014

A FIM study to assess safety and exposure of inhaled single doses of AP301 - A specific ENaC channel activator for the treatment of acute lung injury

Schwameis, R., Eder, S., Pietschmann, H., Fischer, B., Mascher, H., Tzotzos, S., Fischer, H., Lucas, R., Zeitlinger, M. & Hermann, R., Mar 2014, In : Journal of Clinical Pharmacology. 54, 3, p. 341-350 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation

Czikora, I., Alli, A., Bao, H. F., Kaftan, D., Sridhar, S., Apell, H. J., Gorshkov, B., White, R., Zimmermann, A., Wendel, A., Pauly-Evers, M., Hamacher, J., Garcia-Gabay, I., Fischer, B., Verin, A., Bagi, Z., Pittet, J. F., Shabbir, W., Lemmens-Gruber, R., Chakraborty, T. & 4 others, Lazrak, A., Matthay, M. A., Eaton, D. C. & Lucas, R., Sep 1 2014, In : American journal of respiratory and critical care medicine. 190, 5, p. 522-532 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Arginase in the vascular endothelium: Friend or foe?

Lucas, R., Fulton, D., Caldwell, R. W. & Romero, M. J., 2014, In : Frontiers in immunology. 5, NOV, 589.

Research output: Contribution to journalEditorial

10 Scopus citations

Dimethylarginine dimethylaminohydrolase II overexpression attenuates LPS-mediated lung leak in acute lung injury

Aggarwal, S., Gross, C. M., Kumar, S., Dimitropoulou, C., Sharma, S., Gorshkov, B. A., Sridhar, S., Lu, Q., Bogatcheva, N. V., Jezierska-Drutel, A. J., Lucas, R., Verin, A. D., Catravas, J. D. & Black, S. M., Mar 2014, In : American journal of respiratory cell and molecular biology. 50, 3, p. 614-625 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Lipopolysaccharide-induced lung injury involves the nitration-mediated activation of RhoA

Rafikov, R., Dimitropoulou, C., Aggarwal, S., Kangath, A., Gross, C., Pardo, D., Sharma, S., Jezierska-Drutel, A., Patel, V., Snead, C., Lucas, R., Verin, A., Fulton, D., Catravas, J. D. & Black, S. M., Feb 21 2014, In : Journal of Biological Chemistry. 289, 8, p. 4710-4722 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

PKC-dependent phosphorylation of eNOS at T495 regulates eNOS coupling and endothelial barrier function in response to G+ -toxins

Chen, F., Kumar, S., Yu, Y., Aggarwal, S., Gross, C., Wang, Y., Chakraborty, T., Verin, A. D., Catravas, J. D., Lucas, R., Black, S. M. & Fulton, D. J. R., Jul 14 2014, In : PloS one. 9, 7, e99823.

Research output: Contribution to journalArticle

34 Scopus citations

Protective effect of adenosine receptors against lipopolysaccharide-induced acute lung injury

Gonzales, J. N., Gorshkov, B. A., Varn, M. N., Zemskova, M. A., Zemskov, E. A., Sridhar, S., Lucas, R. & Verin, A. D., Mar 15 2014, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 306, 6, p. L497-L507

Research output: Contribution to journalArticle

35 Scopus citations

Protective effect of Growth Hormone-Releasing Hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction

Czikora, I., Sridhar, S., Gorshkov, B. A., Alieva, I. B., Kasa, A., Gonzales, J. N., Potapenko, O., Siddaramappa, U. N., Pillich, H., Rick, F. G., Block, N. L., Verin, A. D., Chakraborty, T., Matthay, M. A., Schally, A. V. & Lucas, R., 2014, In : Frontiers in Physiology. 5 JUL, 00259.

Research output: Contribution to journalArticle

11 Scopus citations

Regulation of NADPH oxidase 5 by protein kinase C isoforms

Chen, F., Yu, Y., Haigh, S., Johnson, J., Lucas, R., Stepp, D. W. & Fulton, D. J. R., Feb 5 2014, In : PloS one. 9, 2, e88405.

Research output: Contribution to journalArticle

60 Scopus citations
2013

A Combined impedance and alphaLISA-based approach to identify anti-inflammatory and barrier-protective compounds in human endothelium

Pflüger, M., Kapuscik, A., Lucas, R., Koppensteiner, A., Katzlinger, M., Jokela, J., Eger, A., Jacobi, N., Wiesner, C., Hofmann, E., Önder, K., Kopecky, J., Schütt, W. & Hundsberger, H., Jan 1 2013, In : Journal of Biomolecular Screening. 18, 1, p. 67-74 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Adenosine A1 Receptors Promote Vasa Vasorum Endothelial Cell Barrier Integrity via Gi and Akt-Dependent Actin Cytoskeleton Remodeling

Siddaramappa Umapathy, N., Kaczmarek, E., Fatteh, N., Burns, N., Lucas, R., Stenmark, K. R., Verin, A. D. & Gerasimovskaya, E. V., Apr 16 2013, In : PloS one. 8, 4, e59733.

Research output: Contribution to journalArticle

24 Scopus citations

AP301, a synthetic peptide mimicking the lectin-like domain of TNF, enhances amiloride-sensitive Na+ current in primary dog, pig and rat alveolar type II cells

Tzotzos, S., Fischer, B., Fischer, H., Pietschmann, H., Lucas, R., Dupré, G., Lemmens-Gruber, R., Hazemi, P., Prymaka, V. & Shabbir, W., Jun 2013, In : Pulmonary Pharmacology and Therapeutics. 26, 3, p. 356-363 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Arginase 1: An unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury

Lucas, R., Czikora, I., Sridhar, S., Zemskov, E. A., Oseghale, A., Circo, S., Cederbaum, S. D., Chakraborty, T., Fulton, D. J., Caldwell, R. W. & Romero Lucas, M. J., 2013, In : Frontiers in immunology. 4, AUG, Article 228.

Research output: Contribution to journalArticle

10 Scopus citations

Cytokine profiling of young overweight and obese female African American adults with prediabetes

Lucas, R., Parikh, S. J., Sridhar, S., Guo, D. H., Bhagatwala, J., Dong, Y., Caldwell, R., Mellor, A., Caldwell, W., Zhu, H. & Dong, Y., Oct 2013, In : Cytokine. 64, 1, p. 310-315 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

L-citrulline protects from kidney damage in type 1 diabetic mice

Romero Lucas, M. J., Yao, L., Sridhar, S., Bhatta, A., Dou, H., Ramesh, G., Brands, M. W., Pollock, D. M., Caldwell, R. B., Cederbaum, S. D., Alvin Head, C., Bagi, Z., Lucas, R. & Caldwell, R. W., 2013, In : Frontiers in immunology. 4, DEC, Article 480.

Research output: Contribution to journalArticle

18 Scopus citations

Mechanism of action of novel lung edema therapeutic AP301 by activation of the epithelial sodium channel

Shabbir, W., Scherbaum-Hazemi, P., Tzotzos, S., Fischer, B., Fischer, H., Pietschmann, H., Lucas, R. & Lemmens-Gruber, R., Dec 2013, In : Molecular pharmacology. 84, 6, p. 899-910 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs

Lucas, R., Czikora, I., Sridhar, S., Zemskov, E. A., Gorshkov, B. A., Siddaramappa, U. N., Oseghale, A., Lawson, J., Verin, A. D., Rick, F. G., Block, N. L., Pillich, H., Romero Lucas, M. J., Leustik, M., Schally, A. V. & Chakraborty, T., Jul 2013, In : Toxins. 5, 7, p. 1244-1260 17 p.

Research output: Contribution to journalReview article

19 Scopus citations

The subcellular compartmentalization of arginine metabolizing enzymes and their role in endothelial dysfunction

Chen, F., Lucas, R. & Fulton, D., 2013, In : Frontiers in immunology. 4, JUL, Article 184.

Research output: Contribution to journalShort survey

21 Scopus citations
2012

A computational study of the oligosaccharide binding sites in the lectin-like domain of tumor necrosis factor and the TNF-derived TIP peptide

Dulebo, A., Ettrich, R., Lucas, R. & Kaftan, D., 2012, In : Current Pharmaceutical Design. 18, 27, p. 4236-4243 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema

Lucas, R., Sridhar, S., Rick, F. G., Gorshkov, B. A., Siddaramappa, U. N., Yang, G., Oseghale, A., Verin, A. D., Chakraborty, T., Matthay, M. A., Zemskov, E. A., White, R., Block, N. L. & Schally, A. V., Feb 7 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 6, p. 2084-2089 6 p.

Research output: Contribution to journalArticle

37 Scopus citations

Genetic polymorphism analysis of killer cell immunoglobulin-like receptor genes in the Chinese Uygur population

Wang, H. D., Zhu, B. F., Shen, C. M., Yuan, G. L., Yang, G., Guo, J. N., Yan, J. W., Qin, H. X., Guo, J. X., Zhang, L. P., Jia, X. Q. & Lucas, R., Mar 1 2012, In : Molecular Biology Reports. 39, 3, p. 3017-3028 12 p.

Research output: Contribution to journalArticle

8 Scopus citations