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2020

CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint

Yu, M., Guo, G., Huang, L., Deng, L., Chang, C. S., Achyut, B. R., Canning, M., Xu, N., Arbab, A. S., Bollag, R. J., Rodriguez, P. C., Mellor, A. L., Shi, H., Munn, D. H. & Cui, Y., Dec 1 2020, In : Nature communications. 11, 1, 515.

Research output: Contribution to journalArticle

Open Access
fibroblasts
Fibroblasts
Tumors
cancer
Networks (circuits)

Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease

Thangavelu, G., Du, J., Paz, K. G., Loschi, M., Zaiken, M. C., Flynn, R., Taylor, P. A., Kirchmeier, A. K., Panoskaltsis-Mortari, A., Luznik, L., MacDonald, K. P., Hill, G. R., Maillard, I., Munn, D. H., Serody, J. S., Murphy, W. J., Miklos, D., Cutler, C. S., Koreth, J., Antin, J. H. & 5 others, Soiffer, R. J., Ritz, J., Dahlberg, C., Miller, A. T. & Blazar, B. R., Jan 1 2020, In : Blood. 135, 1, p. 28-40 13 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-trisphosphate 3-kinase
Graft vs Host Disease
Inositol
Grafts
Phosphotransferases
2019
1 Citation (Scopus)

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD

Koehn, B. H., Saha, A., McDonald-Hyman, C., Loschi, M., Thangavelu, G., Ma, L., Zaiken, M., Dysthe, J., Krepps, W., Panthera, J., Hippen, K., Jameson, S. C., Miller, J. S., Cooper, M. A., Farady, C. J., Iwawaki, T., Ting, J. P. Y., Serody, J. S., Murphy, W. J., Hill, G. R. & 5 others, Murray, P. J., Bronte, V., Munn, D. H., Zeiser, R. & Blazar, B. R., Nov 7 2019, In : Blood. 134, 19, p. 1670-1682 13 p.

Research output: Contribution to journalArticle

Inflammasomes
Graft vs Host Disease
Interleukin-1
Grafts
Adenosine Triphosphate
2 Citations (Scopus)

Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality

Thangavelu, G., Lee, Y. C., Loschi, M., Melanie Schaechter, K., Feser, C. J., Koehn, B. H., Nowak, E. C., Zeiser, R., Serody, J. S., Murphy, W. J., Munn, D. H., Chambon, P., Noelle, R. J. & Blazar, B. R., May 1 2019, In : Journal of Immunology. 202, 9, p. 2795-2805 11 p.

Research output: Contribution to journalArticle

Retinal Dehydrogenase
Aldehyde Dehydrogenase
Graft vs Host Disease
Tretinoin
Dendritic Cells

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality

Saha, A., Taylor, P. A., Lees, C. J., Panoskaltsis-Mortari, A., Osborn, M. J., Feser, C. J., Thangavelu, G., Melchinger, W., Refaeli, Y., Hill, G. R., Munn, D. H., Murphy, W. J., Serody, J. S., Maillard, I., Kreymborg, K., van den Brink, M., Dong, C., Huang, S., Zang, X., Allison, J. P. & 2 others, Zeiser, R. & Blazar, B. R., Jan 1 2019, In : JCI Insight. 4, 19, e127716.

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
T-Lymphocytes
Mortality
Metabolic Networks and Pathways
Oxygen Consumption
3 Citations (Scopus)

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression

Cao, Y., Trillo-Tinoco, J., Sierra, R. A., Anadon, C., Dai, W., Mohamed, E., Cen, L., Costich, T. L., Magliocco, A., Marchion, D., Klar, R., Michel, S., Jaschinski, F., Reich, R. R., Mehrotra, S., Cubillos-Ruiz, J. R., Munn, D. H., Conejo-Garcia, J. R. & Rodriguez, P. C., Dec 1 2019, In : Nature communications. 10, 1, 1280.

Research output: Contribution to journalArticle

Open Access
Transcription Factor CHOP
effectors
endoplasmic reticulum
Endoplasmic Reticulum Stress
Tumors

GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment

Halaby, M. J., Hezaveh, K., Lamorte, S., Ciudad, M. T., Kloetgen, A., MacLeod, B. L., Guo, M., Chakravarthy, A., Medina, T. D. S., Ugel, S., Tsirigos, A., Bronte, V., Munn, D. H., Pugh, T. J., De Carvalho, D. D., Butler, M. O., Ohashi, P. S., Brooks, D. G. & McGaha, T. L., Dec 13 2019, In : Science immunology. 4, 42

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunosuppression
Macrophages
Melanoma
Neoplasms

Publisher Correction: ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression (Nature Communications, (2019), 10, 1, (1280), 10.1038/s41467-019-09263-1)

Cao, Y., Trillo-Tinoco, J., Sierra, R. A., Anadon, C., Dai, W., Mohamed, E., Cen, L., Costich, T. L., Magliocco, A., Marchion, D., Klar, R., Michel, S., Jaschinski, F., Reich, R. R., Mehrotra, S., Cubillos-Ruiz, J. R., Munn, D. H., Conejo-Garcia, J. R. & Rodriguez, P. C., Dec 1 2019, In : Nature communications. 10, 1, 3680.

Research output: Contribution to journalComment/debate

Open Access
Transcription Factor CHOP
effectors
T-cells
Tumors
tumors

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

Paz, K., Flynn, R., Du, J., Tannheimer, S., Johnson, A. J., Dong, S., Stark, A. K., Okkenhaug, K., Panoskaltsis-Mortari, A., Sage, P. T., Sharpe, A. H., Luznik, L., Ritz, J., Soiffer, R. J., Cutler, C. S., Koreth, J., Antin, J. H., Miklos, D. B., MacDonald, K. P., Hill, G. R. & 10 others, Maillard, I., Serody, J. S., Murphy, W. J., Munn, D. H., Feser, C., Zaiken, M., Vanhaesebroeck, B., Turka, L. A., Byrd, J. C. & Blazar, B. R., Jun 2019, In : American Journal of Transplantation. 19, 6, p. 1820-1830 11 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Graft vs Host Disease
Germinal Center
Bronchiolitis Obliterans
B-Lymphocytes
2018
25 Citations (Scopus)

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B. H., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Myeloid Cells
Immunotherapy
Cell Differentiation
Cross-Priming
5 Citations (Scopus)

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z-C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N. F., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Aug 7 2018, In : Cell Metabolism. 28, 2, p. 228-242.e6

Research output: Contribution to journalArticle

Oxidative Stress
Cell Death
T-Lymphocytes
Adoptive Immunotherapy
Neoplasms
24 Citations (Scopus)

Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans article

Shinde, R., Hezaveh, K., Halaby, M. J., Kloetgen, A., Chakravarthy, A., Da Silva Medina, T., Deol, R., Manion, K. P., Baglaenko, Y., Eldh, M., Lamorte, S., Wallace, D., Chodisetti, S. B., Ravishankar, B., Liu, H., Chaudhary, K., Munn, D. H., Tsirigos, A., Madaio, M. P., Gabrielsson, S. & 4 others, Touma, Z., Wither, J., De Carvalho, D. D. & McGaha, T. L., Jun 1 2018, In : Nature Immunology. 19, 6, p. 571-582 12 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Phagocytes
Peripheral Tolerance
Pattern Recognition Receptors
DNA
22 Citations (Scopus)

Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors

Nayak-Kapoor, A., Hao, Z., Sadek, R., Dobbins, R., Marshall, L., Vahanian, N. N., Jay Ramsey, W., Kennedy, E., Mautino, M. R., Link, C. J., Lin, R. S., Royer-Joo, S., Liang, X., Salphati, L., Morrissey, K. M., Mahrus, S., McCall, B., Pirzkall, A., Munn, D. H., Janik, J. E. & 1 others, Khleif, S. N., Jun 20 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 61.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Kynurenine
Half-Life
Neoplasms
Tryptophan
7 Citations (Scopus)

The host protecting the tumor from the host — targeting PD‑L1 expressed by host cells

Munn, D. H., Feb 1 2018, In : Journal of Clinical Investigation. 128, 2, p. 570-572 3 p.

Research output: Contribution to journalReview article

Neoplasms
Tumor Escape
T-Cell Antigen Receptor
Immunity
Therapeutics
4 Citations (Scopus)

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease

McDonald-Hyman, C., Muller, J. T., Loschi, M., Thangavelu, G., Saha, A., Kumari, S., Reichenbach, D. K., Smith, M. J., Zhang, G., Koehn, B. H., Lin, J., Mitchell, J. S., Fife, B. T., Panoskaltsis-Mortari, A., Feser, C. J., Kirchmeier, A. K., Osborn, M. J., Hippen, K. L., Kelekar, A., Serody, J. S. & 6 others, Turka, L. A., Munn, D. H., Chi, H., Neubert, T. A., Dustin, M. L. & Blazar, B. R., Oct 1 2018, In : Journal of Clinical Investigation. 128, 10, p. 4604-4621 18 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Graft vs Host Disease
Vimentin
Regulatory T-Lymphocytes
Protein Kinase C
15 Citations (Scopus)

Treg Destabilization and reprogramming: Implications for cancer immunotherapy

Munn, D. H., Sharma, M. D. & Johnson, T. S., Sep 15 2018, In : Cancer Research. 78, 18, p. 5191-5199 9 p.

Research output: Contribution to journalReview article

Immunotherapy
Neoplasms
PTEN Phosphohydrolase
Cross-Priming
Indoleamine-Pyrrole 2,3,-Dioxygenase
2017
3 Citations (Scopus)

Adjuvant IL-7 potentiates adoptive T cell therapy by amplifying and sustaining polyfunctional antitumor CD4+ T cells

Ding, Z-C., Habtetsion, T., Cao, Y., Li, T., Liu, C., Kuczma, M., Chen, T., Hao, Z., Bryan, L. J., Munn, D. H. & Zhou, G., Dec 1 2017, In : Scientific reports. 7, 1, 12168.

Research output: Contribution to journalArticle

Interleukin-7
Cell- and Tissue-Based Therapy
T-Lymphocytes
Cytokines
Adoptive Immunotherapy
7 Citations (Scopus)

A novel immunohistochemical score to predict early mortality in acute myeloid leukemia patients based on indoleamine 2,3 dioxygenase expression

Mangaonkar, A., Mondal, A. K., Fulzule, S., Pundkar, C., Park, E. J., Jillella, A., Kota, V., Xu, H., Savage, N. M., Shi, H., Munn, D. & Kolhe, R., Dec 1 2017, In : Scientific Reports. 7, 1, 12892.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Acute Myeloid Leukemia
Mortality
Messenger RNA
Bone Marrow
9 Citations (Scopus)

Chemo-immunotherapy: Role of indoleamine 2,3-dioxygenase in defining immunogenic versus tolerogenic cell death in the tumor microenvironment

Johnson, T. S., Mcgaha, T. & Munn, D. H., Jan 1 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 91-104 14 p. (Advances in Experimental Medicine and Biology; vol. 1036).

Research output: Chapter in Book/Report/Conference proceedingChapter

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumor Microenvironment
Cell death
Chemotherapy
Immunotherapy
15 Citations (Scopus)

IDO, PTEN-expressing Tregs and control of antigen-presentation in the murine tumor microenvironment

Munn, D. H., Sharma, M. D., Johnson, T. S. & Rodriguez, P., Aug 1 2017, In : Cancer Immunology, Immunotherapy. 66, 8, p. 1049-1058 10 p.

Research output: Contribution to journalReview article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumor Microenvironment
Antigen Presentation
Immunosuppressive Agents
Cytotoxins
10 Citations (Scopus)

In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines

Hippen, K. L., O'Connor, R. S., Lemire, A. M., Saha, A., Hanse, E. A., Tennis, N. C., Merkel, S. C., Kelekar, A., Riley, J. L., Levine, B. L., June, C. H., Turka, L. A., Kean, L. S., MacMillan, M. L., Miller, J. S., Wagner, J. E., Munn, D. H. & Blazar, B. R., Dec 2017, In : American Journal of Transplantation. 17, 12, p. 3098-3113 16 p.

Research output: Contribution to journalArticle

Kynurenine
Regulatory T-Lymphocytes
Tryptophan
Graft vs Host Disease
Interleukin-2

Overcoming immune suppression in the tumor microenvironment: Implications for multi-modal therapy

Johnson, T. S. & Munn, D. H., Jan 1 2017, Immunotherapy for Pediatric Malignancies. Springer International Publishing, p. 13-38 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tumor Microenvironment
T-Lymphocytes
Neoplasm Antigens
Immunotherapy
Immunosuppressive Agents
8 Citations (Scopus)

Promoter methylation modulates indoleamine 2,3-dioxygenase 1 induction by activated T cells in human breast cancers

Noonepalle, S. K., Gu, F., Lee, E. J., Choi, J. H., Han, Q., Kim, J., Ouzounova, M., Shull, A. Y., Pei, L., Hsu, P. Y., Kolhe, R., Shi, F., Choi, J., Chiou, K., Huang, T. H. M., Korkaya, H., Deng, L., Xin, H. B., Huang, S., Thangaraju, M. & 5 others, Sreekumar, A., Ambs, S., Tang, S. C., Munn, D. H. & Shi, H., Apr 2017, In : Cancer Immunology Research. 5, 4, p. 330-344 15 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Methylation
Triple Negative Breast Neoplasms
Breast Neoplasms
T-Lymphocytes
2016
19 Citations (Scopus)

Deletion of LRP5 and LRP6 in dendritic cells enhances antitumor immunity

Hong, Y., Manoharan, I., Suryawanshi, A., Shanmugam, A., Swafford, D., Ahmad, S., Chinnadurai, R., Manicassamy, B., He, Y., Mellor, A. L., Thangaraju, M., Munn, D. H. & Manicassamy, S., Apr 2 2016, In : OncoImmunology. 5, 4

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-6
Low Density Lipoprotein Receptor-Related Protein-5
Dendritic Cells
Immunity
Tumor Microenvironment
233 Citations (Scopus)

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

Munn, D. H. & Mellor, A. L., Mar 1 2016, In : Trends in Immunology. 37, 3, p. 193-207 15 p.

Research output: Contribution to journalReview article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumor Microenvironment
Inflammation
Immunotherapy
Regulatory T-Lymphocytes
7 Citations (Scopus)

IL-7 signaling imparts polyfunctionality and stemness potential to CD4+ T cells

Ding, Z-C., Liu, C., Cao, Y., Habtetsion, T., Kuczma, M., Pi, W., Kong, H., Cacan, E., Greer, S. F., Cui, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Jun 2 2016, In : OncoImmunology. 5, 6, e1171445.

Research output: Contribution to journalArticle

Interleukin-7
T-Lymphocytes
Aptitude
Immunotherapy
Neoplasms
149 Citations (Scopus)

Immune suppressive mechanisms in the tumor microenvironment

Munn, D. H. & Bronte, V., Apr 1 2016, In : Current Opinion in Immunology. 39, p. 1-6 6 p.

Research output: Contribution to journalReview article

Tumor Microenvironment
Immunotherapy
Immunosuppressive Agents
Neoplasms
Myeloid Cells
18 Citations (Scopus)

MiR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency

Lu, Y., Hippen, K. L., Lemire, A. L., Gu, J., Wang, W., Ni, X., Ranganathan, P., Levine, B. L., Riley, J. L., June, C. H., Turka, L. A., Munn, D. H., Garzon, R., Lu, L. & Blazar, B. R., Sep 8 2016, In : Blood. 128, 10, p. 1424-1435 12 p.

Research output: Contribution to journalArticle

Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Graft vs Host Disease
MicroRNAs
T-cells
Grafts
38 Citations (Scopus)

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality

Saha, A., O'Connor, R. S., Thangavelu, G., Lovitch, S. B., Dandamudi, D. B., Wilson, C. B., Vincent, B. G., Tkachev, V., Pawlicki, J. M., Furlan, S. N., Kean, L. S., Aoyama, K., Taylor, P. A., Panoskaltsis-Mortari, A., Foncea, R., Ranganathan, P., Devine, S. M., Burrill, J. S., Guo, L., Sacristan, C. & 15 others, Snyder, N. W., Blair, I. A., Milone, M. C., Dustin, M. L., Riley, J. L., Bernlohr, D. A., Murphy, W. J., Fife, B. T., Munn, D. H., Miller, J. S., Serody, J. S., Freeman, G. J., Sharpe, A. H., Turka, L. A. & Blazar, B. R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2642-2660 19 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Tissue Donors
Ligands
T-Lymphocytes
Transplants
65 Citations (Scopus)

STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation

Lemos, H., Mohamed, E., Huang, L., Ou, R., Pacholczyk, G., Arbab, A. S., Munn, D. & Mellor, A. L., Apr 15 2016, In : Cancer Research. 76, 8, p. 2076-2081 6 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Interferons
Growth
Lewis Lung Carcinoma
Genes
38 Citations (Scopus)

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Flynn, R., Paz, K., Du, J., Reichenbach, D. K., Taylor, P. A., Panoskaltsis-Mortari, A., Vulic, A., Luznik, L., MacDonald, K. K. P., Hill, G. R., Nyuydzefe, M. S., Weiss, J. M., Chen, W., Trzeciak, A., Serody, J. S., Aguilar, E. G., Murphy, W. J., Maillard, I., Munn, D. H., Koreth, J. & 6 others, Cutler, C. S., Antin, J. H., Ritz, J., Waksal, S. D., Zanin-Zhorov, A. & Blazar, B. R., Apr 28 2016, In : Blood. 127, 17, p. 2144-2154 11 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Graft vs Host Disease
Grafts
STAT3 Transcription Factor
Interleukin-17
39 Citations (Scopus)

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

McDonald-Hyman, C., Flynn, R., Panoskaltsis-Mortari, A., Peterson, N., MacDonald, K. P. A., Hill, G. R., Luznik, L., Serody, J. S., Murphy, W. J., Maillard, I., Munn, D. H., Turka, L. A., Koreth, J., Cutler, C. S., Soiffer, R. J., Antin, J. H., Ritz, J. & Blazar, B. R., Aug 18 2016, In : Blood. 128, 7, p. 1013-1017 5 p.

Research output: Contribution to journalArticle

T-cells
Adoptive Transfer
Graft vs Host Disease
Regulatory T-Lymphocytes
Grafts
14 Citations (Scopus)

Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase

Huang, L., Ou, R., Rabelo de Souza, G., Cunha, T. M., Lemos, H., Mohamed, E., Li, L., Pacholczyk, G., Randall, J., Munn, D. H. & Mellor, A. L., May 2016, In : PLoS Pathogens. 12, 5, e1005615.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Virus Diseases
Retroviridae Infections
Hypersensitivity
Leukemia
2015
28 Citations (Scopus)

B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality

Veenstra, R. G., Flynn, R., Kreymborg, K., McDonald-Hyman, C., Saha, A., Taylor, P. A., Osborn, M. J., Panoskaltsis-Mortari, A., Schmitt-Graeff, A., Lieberknecht, E., Murphy, W. J., Serody, J. S., Munn, D. H., Freeman, G. J., Allison, J. P., Mak, T. W., Van Brink, M. D., Zeiser, R. & Blazar, B. R., Jan 1 2015, In : Blood. 125, 21, p. 3335-3346 12 p.

Research output: Contribution to journalArticle

T-cells
Graft vs Host Disease
Grafts
T-Lymphocytes
Transplants
51 Citations (Scopus)

Canonical Wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation

Suryawanshi, A., Manoharan, I., Hong, Y., Swafford, D., Majumdar, T., Taketo, M. M., Manicassamy, B., Koni, P. A., Thangaraju, M., Sun, Z., Mellor, A. L., Munn, D. H. & Manicassamy, S., Apr 1 2015, In : Journal of Immunology. 194, 7, p. 3295-3304 10 p.

Research output: Contribution to journalArticle

Autoimmunity
Dendritic Cells
Catenins
Autoimmune Experimental Encephalomyelitis
Low Density Lipoprotein Receptor-Related Protein-6
42 Citations (Scopus)

GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells

Koehn, B. H., Apostolova, P., Haverkamp, J. M., Miller, J. S., McCullar, V., Tolar, J., Munn, D. H., Murphy, W. J., Brickey, W. J., Serody, J. S., Gabrilovich, D. I., Bronte, V., Murray, P. J., Ting, J. P. Y., Zeiser, R. & Blazar, B. R., Sep 24 2015, In : Blood. 126, 13, p. 1621-1628 8 p.

Research output: Contribution to journalArticle

Inflammasomes
Graft vs Host Disease
Grafts
Myeloid-Derived Suppressor Cells
Bone

The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells

Sharma, M. D., Shinde, R., McGaha, T. L., Huang, L., Holmgaard, R., Wolchok, J., Mautino, M., Celis, E., Sharpe, A., Francisco, L., Powell, J., Yagita, H., Mellor, A. L., Blazar, B. & Munn, D. H., Jan 1 2015, In : Journal for ImmunoTherapy of Cancer. 3, O19.

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunosuppressive Agents
144 Citations (Scopus)

Tumor-Expressed IDO Recruits and Activates MDSCs in a Treg-Dependent Manner

Holmgaard, R. B., Zamarin, D., Li, Y., Gasmi, B., Munn, D. H., Allison, J. P., Merghoub, T. & Wolchok, J. D., Oct 13 2015, In : Cell Reports. 13, 2, p. 412-424 13 p.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tumors
Neoplasms
T-cells
Immunosuppressive Agents
35 Citations (Scopus)

β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin a metabolism in dendritic cells

Hong, Y., Manoharan, I., Suryawanshi, A., Majumdar, T., Angus-Hill, M. L., Koni, P. A., Manicassamy, B., Mellor, A. L., Munn, D. H. & Manicassamy, S., Feb 15 2015, In : Cancer Research. 75, 4, p. 656-665 10 p.

Research output: Contribution to journalArticle

Catenins
Regulatory T-Lymphocytes
Vitamins
Dendritic Cells
Vitamin A
2014
607 Citations (Scopus)

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis

Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., Lee, J. R., Offermanns, S. & Ganapathy, V., Jan 16 2014, In : Immunity. 40, 1, p. 128-139 12 p.

Research output: Contribution to journalArticle

Butyrates
Niacin
Colonic Neoplasms
Carcinogenesis
Inflammation
37 Citations (Scopus)

Activation of the STING adaptor attenuates experimental autoimmune encephalitis

Lemos, H., Huang, L., Chandler, P. R., Mohamed, E., Souza, G. R., Li, L., Pacholczyk, G., Barber, G. N., Hayakawa, Y., Munn, D. H. & Mellor, A. L., Jun 15 2014, In : Journal of Immunology. 192, 12, p. 5571-5578 8 p.

Research output: Contribution to journalArticle

Nanoparticles
DNA
Genes
Autoimmunity
Myelin-Oligodendrocyte Glycoprotein
23 Citations (Scopus)

Epitope-optimized alpha-fetoprotein genetic vaccines prevent carcinogen-induced murine autochthonous hepatocellular carcinoma

Hong, Y., Peng, Y., Guo, Z. S., Guevara-Patino, J., Pang, J., Butterfield, L. H., Mivechi, N. F., Munn, D. H., Bartlett, D. L. & He, Y., Apr 2014, In : Hepatology. 59, 4, p. 1448-1458 11 p.

Research output: Contribution to journalArticle

alpha-Fetoproteins
Carcinogens
Epitopes
Hepatocellular Carcinoma
Vaccines
31 Citations (Scopus)

GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology

Liu, H., Huang, L., Bradley, J., Liu, K., Bardhan, K., Ron, D., Mellor, A. L., Munn, D. H. & McGaha, T. L., Feb 1 2014, In : Molecular and Cellular Biology. 34, 3, p. 428-438 11 p.

Research output: Contribution to journalArticle

Physiological Stress
Lipopolysaccharides
Macrophages
Pathology
Cytokines
1 Citation (Scopus)

Highlights and summary of the 28th annual meeting of the Society for Immunotherapy of Cancer

Ascierto, P. A., Munn, D. H., Palucka, A. K. & Sondel, P. M., May 15 2014, In : Journal for ImmunoTherapy of Cancer. 2, 1, 15.

Research output: Contribution to journalReview article

Immunotherapy
Allergy and Immunology
Neoplasms
Posters
Medical Oncology
86 Citations (Scopus)

Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

Dubovsky, J. A., Flynn, R., Du, J., Harrington, B. K., Zhong, Y., Kaffenberger, B., Yang, C., Towns, W. H., Lehman, A., Johnson, A. J., Muthusamy, N., Devine, S. M., Jaglowski, S., Serody, J. S., Murphy, W. J., Munn, D. H., Luznik, L., Hill, G. R., Wong, H. K., MacDonald, K. K. P. & 10 others, Maillard, I., Koreth, J., Elias, L., Cutler, C., Soiffer, R. J., Antin, J. H., Ritz, J., Panoskaltsis-Mortari, A., Byrd, J. C. & Blazar, B. R., Nov 3 2014, In : Journal of Clinical Investigation. 124, 11, p. 4867-4876 10 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
B-Lymphocytes
Therapeutics
T-Lymphocytes
Isoantibodies
59 Citations (Scopus)

Immunosuppressive myeloid cells induced by chemotherapy attenuate antitumor cd4 t-cell responses through the PD-1-PD-L1 axis

Ding, Z. C., Lu, X., Yu, M., Lemos, H., Huang, L., Chandler, P., Liu, K., Walters, M., Krasinski, A., Mack, M., Blazar, B. R., Mellor, A. L., Munn, D. H. & Zhou, G., Jul 1 2014, In : Cancer Research. 74, 13, p. 3441-3453 13 p.

Research output: Contribution to journalArticle

Myeloid Cells
Immunosuppressive Agents
Cyclophosphamide
Drug Therapy
Adoptive Transfer
93 Citations (Scopus)

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Flynn, R., Du, J., Veenstra, R. G., Reichenbach, D. K., Panoskaltsis-Mortari, A., Taylor, P. A., Freeman, G. J., Serody, J. S., Murphy, W. J., Munn, D. H., Sarantopoulos, S., Luznik, L., Maillard, I., Koreth, J., Cutler, C., Soiffer, R. J., Antin, J. H., Ritz, J., Dubovsky, J. A., Byrd, J. C. & 3 others, MacDonald, K. P., Hill, G. R. & Blazar, B. R., Jun 19 2014, In : Blood. 123, 25, p. 3988-3998 11 p.

Research output: Contribution to journalArticle

Bronchiolitis Obliterans
Germinal Center
Graft vs Host Disease
Helper-Inducer T-Lymphocytes
Grafts
58 Citations (Scopus)

Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance

Ravishankar, B., Shinde, R., Liu, H., Chaudhary, K., Bradley, J., Lemos, H. P., Phillip, C., Tanaka, M., Munn, D. H., Mellor, A. L. & McGaha, T. L., Mar 18 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 11, p. 4215-4220 6 p.

Research output: Contribution to journalArticle

Macrophages
Chemotaxis
Innate Immunity
Chemokine CCL22
Transplantation Tolerance
82 Citations (Scopus)

The indoleamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma

Li, M., Bolduc, A. R., Hoda, M. N., Gamble, D. N., Dolisca, S. B., Bolduc, A. K., Hoang, K., Ashley, C., McCall, D., Rojiani, A. M., Maria, B. L., Rixe, O., MacDonald, T. J., Heeger, P. S., Mellor, A. L., Munn, D. H. & Johnson, T. S., Jul 7 2014, In : Journal for ImmunoTherapy of Cancer. 2, 1, 21.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Glioblastoma
Radiotherapy
Neoplasms
Radiation
36 Citations (Scopus)

TLR2-dependent activation of β-catenin pathway in dendritic cells induces regulatory responses and attenuates autoimmune inflammation

Manoharan, I., Hong, Y., Suryawanshi, A., Angus-Hill, M. L., Sun, Z., Mellor, A. L., Munn, D. H. & Manicassamy, S., Oct 15 2014, In : Journal of Immunology. 193, 8, p. 4203-4213 11 p.

Research output: Contribution to journalArticle

Catenins
Autoimmunity
Dendritic Cells
Inflammation
Transcription Factor 7-Like 2 Protein