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2020

Double-stranded RNA and Toll-like receptor activation: A novel mechanism for blood pressure regulation

Dela Justina, V., Giachini, F. R., Priviero, F. & Webb, R. C., Jan 1 2020, In : Clinical Science. 134, 2, p. 303-313 11 p.

Research output: Contribution to journalArticle

Double-Stranded RNA
Toll-Like Receptors
Blood Pressure
Blood Vessels
Viral RNA

Mechanotransduction and Uterine Blood Flow in Preeclampsia: The Role of Mechanosensing Piezo 1 Ion Channels

Arishe, O. O., Ebeigbe, A. B. & Webb, R. C., Jan 1 2020, In : American journal of hypertension. 33, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
Pre-Eclampsia
Ion Channels
Blood Vessels
Mechanoreceptors
Pregnancy

Toll-like receptor 9 regulates metabolic profile and contributes to obesity-induced benign prostatic hyperplasia in mice

Calmasini, F. B., McCarthy, C. G., Wenceslau, C. F., Priviero, F. B. M., Antunes, E. & Webb, R. C., Feb 1 2020, In : Pharmacological reports : PR. 72, 1, p. 179-187 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Metabolome
Prostatic Hyperplasia
Obesity
Reactive Oxygen Species
2019

Equilin displays similar endothelium-independent vasodilator potential to 17β-estradiol regardless of lower potential to inhibit calcium entry

Filgueira, F. P., Lobato, N. S., Nascimento, D. L., Ceravolo, G. S., Giachini, F. R. C., Lima, V. V., Dantas, A. P., Fortes, Z. B., Webb, R. C., Tostes, R. C. & Carvalho, M. H. C., Jan 2019, In : Steroids. 141, p. 46-54 9 p.

Research output: Contribution to journalArticle

Equilin
Vasodilator Agents
Endothelium
Estradiol
Calcium
3 Citations (Scopus)

Formyl peptide receptor-1 activation exerts a critical role for the dynamic plasticity of arteries via actin polymerization

Wenceslau, C. F., McCarthy, C. G., Szasz, T., Calmasini, F. B., Mamenko, M. & Webb, R. C., Mar 1 2019, In : Pharmacological Research. 141, p. 276-290 15 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Polymerization
Actins
Arteries
Blood Vessels

Impact of Immune System Activation and Vascular Impairment on Male and Female Sexual Dysfunction

Calmasini, F. B., Klee, N., Webb, R. C. & Priviero, F., Oct 2019, In : Sexual Medicine Reviews. 7, 4, p. 604-613 10 p.

Research output: Contribution to journalReview article

Blood Vessels
Immune System
Inflammation
Cardiovascular Diseases
Penile Erection
2 Citations (Scopus)

Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4

Abdul, Y., Abdelsaid, M., Li, W., Webb, R. C., Sullivan, J. C., Dong, G. & Ergul, A., Mar 1 2019, In : Molecular Neurobiology. 56, 3, p. 1607-1617 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Blood Vessels
Stroke
Endothelial Cells
Iron
1 Citation (Scopus)

Interleukin-10 negatively modulates extracellular signal-regulated kinases 1 and 2 in aorta from hypertensive mouse induced by angiotensin II infusion

Bressan, A. F., Fonseca, G. A., Tostes, R. C., Webb, R. C., Lima, V. V. & Giachini, F. R., Feb 1 2019, In : Fundamental and Clinical Pharmacology. 33, 1, p. 31-40 10 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinase 1
Angiotensin II
Interleukin-10
Aorta

Novel contributors and mechanisms of cellular senescence in hypertension-associated premature vascular aging

McCarthy, C. G., Wenceslau, C. F., Webb, R. C. & Joe, B., Jan 1 2019, In : American journal of hypertension. 32, 8, p. 709-719 11 p.

Research output: Contribution to journalReview article

Premature Aging
Cell Aging
Blood Vessels
Hypertension
Phenotype
1 Citation (Scopus)

Paying the toll for inflammation: Immunoreceptor-mediated vascular dysfunction in hypertension

McCarthy, C. G., Goulopoulou, S. & Webb, R. C., Mar 1 2019, In : Hypertension. 73, 3, p. 514-521 8 p.

Research output: Contribution to journalArticle

Blood Vessels
Hypertension
Inflammation

Reconstitution of autophagy ameliorates vascular function and arterial stiffening in spontaneously hypertensive rats

McCarthy, C. G., Wenceslau, C. F., Calmasini, F. B., Klee, N. S., Brands, M. W., Joe, B. & Webb, R. C., Nov 1 2019, In : American journal of physiology. Heart and circulatory physiology. 317, 5, p. H1013-H1027

Research output: Contribution to journalArticle

Open Access
Autophagy
Inbred SHR Rats
Blood Vessels
Trehalose
Premature Aging

Targeting endothelial barrier dysfunction caused by circulating bacterial and mitochondrial n-formyl peptides with deformylase

Martinez-Quinones, P., Komic, A., McCarthy, C. G., Webb, R. C. & Wenceslau, C. F., Jan 1 2019, In : Frontiers in immunology. 10, JUN, 1270.

Research output: Contribution to journalArticle

Open Access
peptide deformylase
Systemic Inflammatory Response Syndrome
Peptides
Formyl Peptide Receptor
Sepsis
1 Citation (Scopus)

Toll-like receptor 4 and blood pressure: Lessons from animal studies

Nunes, K. P., De Oliveira, A. A., Lima, V. V. & Clinton Webb, R., Jan 1 2019, In : Frontiers in Physiology. 10, MAY, 655.

Research output: Contribution to journalReview article

Open Access
Toll-Like Receptor 4
Immune System
Animal Models
Blood Pressure
Hypertension
1 Citation (Scopus)

Toll-Like Receptor 4 and Heat-Shock Protein 70: Is it a New Target Pathway for Diabetic Vasculopathies?

de Oliveira, A. A., Webb, R. C. & Nunes, K. P., Jan 1 2019, In : Current drug targets. 20, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
HSP70 Heat-Shock Proteins
Toll-Like Receptors
Medical problems
Pattern Recognition Receptors

Transcriptional profiling of uterine leiomyoma rats treated by a traditional herb pair, curcumae rhizoma and sparganii rhizoma

Yu, C. H., Zhao, J. S., Zhao, H., Peng, T., Shen, D. C., Xu, Q. X., Li, Y., Webb, R. C., Wang, M. H., Shi, X. M., Peng, C. & Ding, W. J., Jan 1 2019, In : Brazilian Journal of Medical and Biological Research. 52, 6, e8132.

Research output: Contribution to journalArticle

Open Access
Leiomyoma
Rats
Microarrays
Metabolism
Gene expression

TRPM8 channel activation triggers relaxation of pudendal artery with increased sensitivity in the hypertensive rats

Silva, D. F., Wenceslau, C. F., Mccarthy, C. G., Szasz, T., Ogbi, S. & Webb, R. C., Sep 2019, In : Pharmacological Research. 147, 104329.

Research output: Contribution to journalArticle

Arteries
Erectile Dysfunction
Hypertension
Thermoreceptors
Charybdotoxin
2018
5 Citations (Scopus)

Blockade of Toll-Like Receptor 4 Attenuates Erectile Dysfunction in Diabetic Rats

Nunes, K. P., de Oliveira, A. A., Szasz, T., Biancardi, V. C. & Webb, R. C., Sep 2018, In : Journal of Sexual Medicine. 15, 9, p. 1235-1245 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Erectile Dysfunction
Cyclic GMP
Oxidative Stress
Phenylephrine

Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet

Tomazini Gonçalves, T., Lazaro, C. M., De Mateo, F. G., Campos, M. C. B., Mezencio, J. G. B., Claudino, M. A., Carvalho, P. D. O., Webb, R. C. & Priviero, F. B. M., Jan 1 2018, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 11, p. 321-332 12 p.

Research output: Contribution to journalArticle

High Fat Diet
Blood Vessels
Body Weight
Lipids
Exercise
1 Citation (Scopus)

Establishment of a rat model for uterine leiomyomas based on Western and traditional Chinese medicine theories

Zhao, H., Li, Y., Xu, Q. X., Peng, F., Zhao, J. S., Webb, R. C., Peng, C. & Yu, C. H., Jan 1 2018, In : Brazilian Journal of Medical and Biological Research. 51, 9, e7627.

Research output: Contribution to journalArticle

Chinese Traditional Medicine
Leiomyoma
Medicine
Rats
Progesterone

Increase in soluble protein oligomers triggers the innate immune system promoting inflammation and vascular dysfunction in the pathogenesis of sepsis

Komic, A., Martinez-Quinones, P., McCarthy, C. G., Clinton Webb, R. & Wenceslau, C. F., Jul 1 2018, In : Clinical Science. 132, 13, p. 1433-1438 6 p.

Research output: Contribution to journalArticle

Blood Vessels
Immune System
Sepsis
Inflammation
Formyl Peptide Receptor
1 Citation (Scopus)

Mesenteric arteries from stroke-prone spontaneously hypertensive rats exhibit an increase in nitric-oxide-dependent vasorelaxation

Wynne, B. M., Labazi, H., Lima, V. V., Carneiro, F. S., Webb, R. C., Tostes, R. C. & Giachini, F. R., Jan 1 2018, In : Canadian Journal of Physiology and Pharmacology. 96, 8, p. 719-727 9 p.

Research output: Contribution to journalArticle

Mesenteric Arteries
Inbred SHR Rats
Vasodilation
Nitric Oxide
Stroke

Nitroxyl anion mediates relaxation in mesenteric arteries from angiotensin II hypertensive mice

Wynne, B. M., Labazi, H., Tostes, R. C. & Webb, R. C., Jan 1 2018, In : Current Vascular Pharmacology. 16, 1, p. 93-101 9 p.

Research output: Contribution to journalArticle

Mesenteric Arteries
Angiotensin II
Anions
Nitric Oxide
Acetylcholine
2 Citations (Scopus)

O-Glycosylation with O-linked β-N-acetylglucosamine increases vascular contraction: Possible modulatory role on Interleukin-10 signaling pathway

Miguez, J. S. G., Dela Justina, V., Bressan, A. F. M., Marchi, P. G. F., Honorio-França, A. C., Carneiro, F. S., Webb, R. C., Tostes, R. C., Giachini, F. R. & Lima, V. V., Sep 15 2018, In : Life sciences. 209, p. 78-84 7 p.

Research output: Contribution to journalReview article

Glycosylation
Acetylglucosamine
Interleukin-10
Blood Vessels
Phosphorylation
1 Citation (Scopus)

Protein kinase Cα deletion causes hypotension and decreased vascular contractility

Wynne, B. M., McCarthy, C. G., Szasz, T., Molina, P. A., Chapman, A. B., Webb, R. C., Klein, J. D. & Hoover, R. S., Mar 1 2018, In : Journal of hypertension. 36, 3, p. 510-519 10 p.

Research output: Contribution to journalArticle

Hypotension
Protein Kinase C
Arterial Pressure
Blood Vessels
Salts

To be, or nox to be, endoplasmic reticulum stress in hypertension

Wenceslau, C. F., McCarthy, C. G. & Webb, R. C., Jul 1 2018, In : Hypertension. 72, 1, p. 59-60 2 p.

Research output: Contribution to journalEditorial

Endoplasmic Reticulum Stress
Hypertension
5 Citations (Scopus)
Toll-Like Receptor 9
Toll-Like Receptors
Vascular Smooth Muscle
Polymerization
Protein Kinases
2017
Anniversaries and Special Events
Vasodilator Agents
Vasodilation
2 Citations (Scopus)

Angeli's Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta

Wynne, B. M., Labazi, H., Carneiro, Z. N., Tostes, R. C. & Webb, R. C., Nov 5 2017, In : European Journal of Pharmacology. 814, p. 294-301 8 p.

Research output: Contribution to journalArticle

Endothelin-1
Anions
Blood Vessels
Aorta
Reactive Oxygen Species
5 Citations (Scopus)

Chloroquine Suppresses the Development of Hypertension in Spontaneously Hypertensive Rats

McCarthy, C. G., Wenceslau, C. F., Goulopoulou, S., Baban, B., Matsumoto, T. & Webb, R. C., Feb 1 2017, In : American journal of hypertension. 30, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

Chloroquine
Inbred SHR Rats
Hypertension
Mesenteric Arteries
Myeloid Differentiation Factor 88
8 Citations (Scopus)

High-salt intake augments the activity of the RhoA/ROCK pathway and reduces intracellular calcium in arteries from rats

Crestani, S., Webb, R. C. & Da Silva-Santos, J. E., Jan 1 2017, In : American journal of hypertension. 30, 4, p. 389-399 11 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Arteries
Salts
Calcium
Phenylephrine
7 Citations (Scopus)

Out of the frying pan and into the fire: Damage-Associated molecular patterns and cardiovascular toxicity following cancer therapy

Klee, N. S., McCarthy, C. G., Martinez-Quinones, P. & Webb, R. C., Nov 1 2017, In : Therapeutic Advances in Cardiovascular Disease. 11, 11, p. 297-317 21 p.

Research output: Contribution to journalReview article

Neoplasms
Therapeutics
Cardiovascular Diseases
Survivors
Cardiovascular Agents
3 Citations (Scopus)

Peritoneal cavity lavage reduces the presence of mitochondrial damage associated molecular patterns in open abdomen patients

Martinez-Quinones, P. A., McCarthy, C. G., Mentzer, C. J., Wenceslau, C. F., Holsten, S. B., Webb, R. C. & O'Malley, K., Dec 1 2017, In : Journal of Trauma and Acute Care Surgery. 83, 6, p. 1062-1065 4 p.

Research output: Contribution to journalArticle

Peritoneal Lavage
Peritoneal Cavity
Abdomen
Mitochondrial DNA
Systemic Inflammatory Response Syndrome
9 Citations (Scopus)

Rho-Mancing to Sensitize Calcium Signaling for Contraction in the Vasculature: Role of Rho Kinase

Szasz, T. & Webb, R. C., Jan 1 2017, Advances in Pharmacology. Academic Press Inc., p. 303-322 20 p. (Advances in Pharmacology; vol. 78).

Research output: Chapter in Book/Report/Conference proceedingChapter

Myosin-Light-Chain Phosphatase
rho-Associated Kinases
Calcium Signaling
Muscle Contraction
Vascular Smooth Muscle
10 Citations (Scopus)

Toll-like receptor 4 (TLR4) impairs nitric oxide contributing to Angiotensin II-induced cavernosal dysfunction

Nunes, K. P., Bomfim, G. F., Toque, H. A., Szasz, T. & Clinton Webb, R., Dec 15 2017, In : Life sciences. 191, p. 219-226 8 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Angiotensin II
Nitric Oxide
Nitric Oxide Synthase
Smooth Muscle Myocytes

Update from the editors to our readers

Schiffrin, E. L., Calhoun, D. A., Flack, J. M., Ito, S. & Webb, R. C., Jan 1 2017, In : American journal of hypertension. 30, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

2016

A message from the new editorial team at the American Journal of Hypertension

Schiffrin, E. L., Calhoun, D. A., Flack, J. M., Ito, S. & Webb, R. C., Jan 1 2016, In : American journal of hypertension. 29, 1, 1 p.

Research output: Contribution to journalEditorial

Editorial Policies
Hypertension
3 Citations (Scopus)

Autoimmune therapeutic chloroquine lowers blood pressure and improves endothelial function in spontaneously hypertensive rats

McCarthy, C. G., Wenceslau, C. F., Goulopoulou, S., Ogbi, S., Matsumoto, T. & Webb, R. C., Nov 1 2016, In : Pharmacological Research. 113, p. 384-394 11 p.

Research output: Contribution to journalArticle

Chloroquine
Inbred SHR Rats
Blood Pressure
Hypertension
Autoimmunity
10 Citations (Scopus)

Exposure to stimulatory CpG oligonucleotides during gestation induces maternal hypertension and excess vasoconstriction in pregnant rats

Goulopoulou, S., Wenceslau, C. F., McCarthy, C. G., Matsumoto, T. & Webb, R. C., Apr 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 310, 8, p. H1015-H1025

Research output: Contribution to journalArticle

Vasoconstriction
Oligonucleotides
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Mothers
Hypertension
3 Citations (Scopus)

Formyl peptide receptor activation elicits endothelial cell contraction and vascular leakage

Wenceslau, C. F., McCarthy, C. G. & Webb, R. C., Aug 2 2016, In : Frontiers in immunology. 7, AUG, 297.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Blood Vessels
Endothelial Cells
Systemic Inflammatory Response Syndrome
Sepsis
13 Citations (Scopus)

High-fat diet increases O-GlcNAc levels in cerebral arteries: Link to vascular dysfunction associated with hyperlipidaemia/obesity?

Lima, V. V., Giachini, F. R., Matsumoto, T., Li, W., Bressan, A. F. M., Chawla, D., Webb, R. C., Ergul, A. & Tostes, R. C., Jan 1 2016, In : Clinical Science. 130, 11, p. 871-880 10 p.

Research output: Contribution to journalArticle

Cerebral Arteries
High Fat Diet
Hyperlipidemias
Blood Vessels
Obesity
2 Citations (Scopus)

Impaired Ca2+ Homeostasis and Decreased Orai1 Expression Modulates Arterial Hyporeactivity to Vasoconstrictors During Endotoxemia

Nonato, A. O., Olivon, V. C., Dela Justina, V., Zanotto, C. Z., Webb, R. C., Tostes, R. C., Lima, V. V. & Giachini, F. R., Jun 1 2016, In : Inflammation. 39, 3, p. 1188-1197 10 p.

Research output: Contribution to journalArticle

Endotoxemia
Vasoconstrictor Agents
Homeostasis
Mesenteric Arteries
Vascular Smooth Muscle
6 Citations (Scopus)

Impaired corpus cavernosum relaxation is accompanied by increased oxidative stress and up-regulation of the rho-kinase pathway in diabetic (db/db) mice

Priviero, F. B. M., Toque, H. A. F., Nunes, K. P., Priolli, D. G., Teixeira, C. E. & Webb, R. C., May 1 2016, In : PloS one. 11, 5, e0156030.

Research output: Contribution to journalArticle

rho-Associated Kinases
Oxidative stress
phosphotransferases (kinases)
Oxidative Stress
oxidative stress
15 Citations (Scopus)

Interleukin-10 limits increased blood pressure and vascular RhoA/Rho-kinase signaling in angiotensin II-infused mice

Lima, V. V., Zemse, S. M., Chiao, C. W., Bomfim, G. F., Tostes, R. C., Webb, R. C. & Giachini, F. R., Jan 15 2016, In : Life sciences. 145, p. 137-143 7 p.

Research output: Contribution to journalArticle

rho-Associated Kinases
Blood pressure
Angiotensin II
Interleukin-10
Blood Vessels
19 Citations (Scopus)

Mitochondrial N-formyl peptides cause airway contraction and lung neutrophil infiltration via formyl peptide receptor activation

Wenceslau, C. F., Szasz, T., McCarthy, C. G., Baban, B., NeSmith, E. & Webb, R. C., Apr 1 2016, In : Pulmonary Pharmacology and Therapeutics. 37, p. 49-56 8 p.

Research output: Contribution to journalArticle

Formyl Peptide Receptor
Neutrophil Infiltration
Infiltration
Chemical activation
Systemic Inflammatory Response Syndrome
13 Citations (Scopus)

The toll of the gridiron: Damage-associated molecular patterns and hypertension in American football

McCarthy, C. G. & Webb, R. C., Jan 1 2016, In : FASEB Journal. 30, 1, p. 34-40 7 p.

Research output: Contribution to journalArticle

HMGB1 Protein
Football
Mitochondrial DNA
Hypertension
Pattern Recognition Receptors
17 Citations (Scopus)

Toll-like receptor 4 activation contributes to diabetic bladder dysfunction in a murine model of type 1 diabetes

Szasz, T., Wenceslau, C. F., Burgess, B., Nunes, K. P. & Webb, R. C., Dec 1 2016, In : Diabetes. 65, 12, p. 3754-3764 11 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Type 1 Diabetes Mellitus
Urinary Bladder
Streptozocin
Knockout Mice
69 Citations (Scopus)

Toll-like receptors in the vascular system: Sensing the dangers within

Goulopoulou, S., McCarthy, C. G. & Clinton Webb, R., Jan 1 2016, In : Pharmacological Reviews. 68, 1, p. 142-167 26 p.

Research output: Contribution to journalArticle

Toll-Like Receptors
Blood Vessels
Ligands
Immune System
Cytokines
2015
3 Citations (Scopus)

A Toll-Like Receptor 1/2 Agonist Augments Contractility in Rat Corpus Cavernosum

Stallmann-Jorgensen, I., Ogbi, S., Szasz, T. & Webb, R. C., Aug 1 2015, In : Journal of Sexual Medicine. 12, 8, p. 1722-1731 10 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 1
Toll-Like Receptor 2
Blood Vessels
Phenylephrine
rho-Associated Kinases
12 Citations (Scopus)
Penile Erection
Obese Mice
Oxidative Stress
Antioxidants
NADPH Oxidase
66 Citations (Scopus)

Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats

McCarthy, C. G., Wenceslau, C. F., Goulopoulou, S., Ogbi, S., Baban, B., Sullivan, J. C., Matsumoto, T. & Webb, R. C., Jul 1 2015, In : Cardiovascular Research. 107, 1, p. 119-130 12 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 9
Inbred SHR Rats
Mitochondrial DNA
Blood Vessels
Blood Pressure