Find Research Outputs — Augusta University Research Profiles

Wang, J. & Smith, S. B., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer, p. 463-467 5 p. (Advances in Experimental Medicine and Biology; vol. 1185).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Excess homocysteine upregulates the NRF2-antioxidant pathway in retinal Müller glial cells

Navneet, S., Cui, X., Zhao, J., Wang, J., Kaidery, N. A., Thomas, B., Bollinger, K. E., Yoon, Y. & Smith, S. B., Jan 2019, In : Experimental eye research. 178, p. 228-237 10 p.

Research output: Contribution to journal › Article

6 Scopus citations

Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2

Navneet, S., Zhao, J., Wang, J., Mysona, B. A., Barwick, S., Ammal Kaidery, N., Saul, A. B., Kaddour-Djebbar, I., Bollag, W. B., Thomas, B., Bollinger, K. E. & Smith, S. B., Jun 2019, In : Redox Biology. 24, 101199.

Research output: Contribution to journal › Article

Open Access

5 Scopus citations

PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus

Khaled, M. L., Bykhovskaya, Y., Gu, C., Liu, A., Drewry, M. D., Chen, Z., Mysona, B. A., Parker, E., McNabb, R. P., Yu, H., Lu, X., Wang, J., Li, X., Al-Muammar, A., Rotter, J. I., Porter, L. F., Estes, A., Watsky, M. A., Smith, S. B., Xu, H. & 5 others, Abu-Amero, K. K., Kuo, A., Shears, S. B., Rabinowitz, Y. S. & Liu, Y., Dec 1 2019, In : Scientific reports. 9, 1, 19406.

Research output: Contribution to journal › Article

Open Access

6 Scopus citations

The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2

Wang, J., Zhao, J., Cui, X., Mysona, B. A., Navneet, S., Saul, A., Ahuja, M., Lambert, N., Gazaryan, I. G., Thomas, B., Bollinger, K. E. & Smith, S. B., Apr 2019, In : Free Radical Biology and Medicine. 134, p. 604-616 13 p.

Research output: Contribution to journal › Article

9 Scopus citations

2018

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In : Cell Death and Disease. 9, 10, 1001.

Research output: Contribution to journal › Article

7 Scopus citations

Depletion of the receptor-interacting protein kinase 3 (RIP3) decreases photoreceptor cell death during the early stages of ocular murine cytomegalovirus infection

Xu, J., Mo, J., Liu, X., Marshall, B., Atherton, S. S., Dong, Z., Smith, S. & Zhang, M., May 2018, In : Investigative Ophthalmology and Visual Science. 59, 6, p. 2445-2458 14 p.

Research output: Contribution to journal › Article

3 Scopus citations

Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression

Chaudhary, K., Promsote, W., Ananth, S., Veeranan-Karmegam, R., Tawfik, A. M., Arjunan, P., Martin, P. M., Smith, S. B., Thangaraju, M., Kisselev, O., Ganapathy, V. & Gnana-Prakasam, J. P., Dec 1 2018, In : Scientific reports. 8, 1, 3025.

Research output: Contribution to journal › Article

13 Scopus citations

Relationship between Sigma-1 receptor and BDNF in the visual system

Mysona, B. A., Zhao, J., Smith, S. & Bollinger, K. E., Feb 2018, In : Experimental eye research. 167, p. 25-30 6 p.

Research output: Contribution to journal › Article

3 Scopus citations

Sigma 1 receptor: A novel therapeutic target in retinal disease

Smith, S. B., Wang, J., Cui, X., Mysona, B. A., Zhao, J. & Bollinger, K. E., Nov 2018, In : Progress in Retinal and Eye Research. 67, p. 130-149 20 p.

Research output: Contribution to journal › Review article

15 Scopus citations

2017

Absence of sigma 1 receptor accelerates photoreceptor cell death in a murine model of retinitis pigmentosa

Wang, J., Saul, A., Cui, X., Roon, P. & Smith, S. B., Sep 2017, In : Investigative Ophthalmology and Visual Science. 58, 11, p. 4545-4558 14 p.

Research output: Contribution to journal › Article

12 Scopus citations

Analysis of MTHFR, CBS, glutathione, taurine, and hydrogen sulfide levels in retinas of hyperhomocysteinemic mice

Cui, X., Navneet, S., Wang, J., Roon, P., Chen, W., Xian, M. & Smith, S. B., Apr 2017, In : Investigative Ophthalmology and Visual Science. 58, 4, p. 1954-1963 10 p.

Research output: Contribution to journal › Article

6 Scopus citations

Detailed electroretinographic findings in rd8 mice

Saul, A. B., Cui, X., Markand, S. & Smith, S. B., Jun 1 2017, In : Documenta Ophthalmologica. 134, 3, p. 195-203 9 p.

Research output: Contribution to journal › Article

3 Scopus citations

Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress

Mohamed, R., Sharma, I., Ibrahim, A. S., Saleh, H., Elsherbiny, N. M., Fulzele, S., Elmasry, K., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., Dec 1 2017, In : Scientific reports. 7, 1, 09731.

Research output: Contribution to journal › Article

12 Scopus citations

Introduction to sigma receptors: Their role in disease and as therapeutic targets

Smith, S. B., 2017, In : Advances in experimental medicine and biology. 964, p. 1-4 4 p.

Research output: Contribution to journal › Article

8 Scopus citations

p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection

Zhu, S., Luo, H., Liu, H., Ha, Y., Mays, E. R., Lawrence, R. E., Winkelmann, E., Barrett, A. D., Smith, S. B., Wang, M., Wang, T. & Zhang, W., Sep 2017, In : Antiviral Research. 145, p. 70-81 12 p.

Research output: Contribution to journal › Article

9 Scopus citations

Protective effects of agonists of growth hormone-releasing hormone (GHRH) in early experimental diabetic retinopathy

Thounaojam, M. C., Powell, F. L., Patel, S., Gutsaeva, D. R., Tawfik, A., Smith, S. B., Nussbaum, J., Block, N. L., Martin, P. M., Schally, A. V. & Bartoli, M., Dec 12 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 50, p. 13248-13253 6 p.

Research output: Contribution to journal › Article

16 Scopus citations

Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes

Zhao, J., Mysona, B. A., Wang, J., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., Sep 2017, In : PloS one. 12, 9, e0184421.

Research output: Contribution to journal › Article

8 Scopus citations

The role of sigma1R in mammalian retina

Wang, J., Cui, X., Roon, P., Saul, A. & Smith, S. B., Jan 1 2017, In : Advances in experimental medicine and biology. 964, p. 267-284 18 p.

Research output: Contribution to journal › Article

3 Scopus citations

The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure

Lee, H., Smith, S. B. & Yoon, Y., Apr 28 2017, In : Journal of Biological Chemistry. 292, 17, p. 7115-7130 16 p.

Research output: Contribution to journal › Article

47 Scopus citations

2016

(+)-pentazocine reduces NMDA-induced murine retinal ganglion cell death through a σr1-dependent mechanism

Zhao, J., Mysona, B. A., Qureshi, A., Kim, L., Fields, T., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., Feb 2016, In : Investigative Ophthalmology and Visual Science. 57, 2, p. 453-461 9 p.

Research output: Contribution to journal › Article

15 Scopus citations

Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration

Wang, J., Saul, A., Roon, P. & Smith, S. B., Jun 28 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. E3764-E3772

Research output: Contribution to journal › Article

35 Scopus citations

Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration

Ibrahim, A. S., Mander, S., Hussein, K. A., Elsherbiny, N. M., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., 2016, In : Oncotarget. 7, 8, p. 8532-8545 14 p.

Research output: Contribution to journal › Article

15 Scopus citations

Mthfr as a modifier of the retinal phenotype of Crb1^rd8/rd8 mice

Markand, S., Saul, A., Tawfik, A., Cui, X., Rozen, R. & Smith, S. B., Apr 1 2016, In : Experimental eye research. 145, p. 164-172 9 p.

Research output: Contribution to journal › Article

5 Scopus citations

Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease

Promsote, W., Powell, F. L., Veean, S., Thounaojam, M., Markand, S., Saul, A., Gutsaeva, D., Bartoli, M., Smith, S. B., Ganapathy, V. & Martin, P. M., Dec 10 2016, In : Antioxidants and Redox Signaling. 25, 17, p. 921-935 15 p.

Research output: Contribution to journal › Article

5 Scopus citations

Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina

Shanmugam, A. K., Mysona, B. A., Wang, J., Zhao, J., Tawfik, A., Sanders, A., Markand, S., Zorrilla, E., Ganapathy, V., Bollinger, K. E. & Smith, S. B., Aug 2 2016, In : Current Eye Research. 41, 8, p. 1105-1112 8 p.

Research output: Contribution to journal › Article

3 Scopus citations

Role of sigma 1 receptor in retinal degeneration of the Ins2^Akita/+ murine model of diabetic retinopathy

Wang, J., Cui, X., Roon, P. & Smith, S. B., May 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 6, p. 2770-2781 12 p.

Research output: Contribution to journal › Article

5 Scopus citations

2015

A lipidomic screen of hyperglycemia-treated hrecs links 12/15-lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase

Ibrahim, A. S., Elshafey, S., Sellak, H., Hussein, K. A., El-Sherbiny, M., Abdelsaid, M., Rizk, N., Beasley, S., Tawfik, A. M., Smith, S. B. & Al-Shabrawey, M., Mar 1 2015, In : Journal of Lipid Research. 56, 3, p. 599-611 13 p.

Research output: Contribution to journal › Article

29 Scopus citations

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B. & Zhang, W., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1900.

Research output: Contribution to journal › Article

28 Scopus citations

Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in The susceptibility of diabetic models to ischemic acute kidney injury

Peng, J., Li, X., Zhang, D., Chen, J. K., Su, Y., Smith, S. B. & Dong, Z., Jan 3 2015, In : Kidney International. 87, 1, p. 137-150 14 p.

Research output: Contribution to journal › Article

71 Scopus citations

Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids

Ibrahim, A. S., Tawfik, A. M., Hussein, K. A., Elshafey, S., Markand, S., Rizk, N., Duh, E. J., Smith, S. B. & Al-Shabrawey, M., Mar 2015, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1851, 3, p. 290-298 9 p.

Research output: Contribution to journal › Article

23 Scopus citations

Retinal ganglion cell loss and mild vasculopathy in methylene tetrahydrofolate reductase (Mthfr)-deficient mice: A model of mild hyperhomocysteinemia

Markand, S., Saul, A., Roon, P., Prasad, P., Martin, P., Rozen, R., Ganapathy, V. & Smith, S. B., 2015, In : Investigative Ophthalmology and Visual Science. 56, 4, p. 2684-2695 12 p.

Research output: Contribution to journal › Article

17 Scopus citations

Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system x_c^-, the Na⁺-independent glutamate-cystine exchanger

Wang, J., Shanmugam, A., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Jun 14 2015, In : Free Radical Biology and Medicine. 86, p. 25-36 12 p., 12387.

Research output: Contribution to journal › Article

59 Scopus citations

Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells

Shanmugam, A., Wang, J., Markand, S., Perry, R. L., Tawfik, A., Zorrilla, E., Ganapathy, V. & Smith, S. B., Mar 1 2015, In : Journal of Neurochemistry. 132, 5, p. 546-558 13 p.

Research output: Contribution to journal › Article

10 Scopus citations

2014

Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: A model of mild to moderate hyperhomocysteinemia

Tawfik, A., Markand, S., Al-Shabrawey, M., Mayo, J. N., Reynolds, J., Bearden, S. E., Ganapathy, V. & Smith, S. B., Sep 2014, In : American Journal of Pathology. 184, 9, p. 2573-2585 13 p.

Research output: Contribution to journal › Article

20 Scopus citations

Deletion of hemojuvelin, an iron-regulatory protein, in mice results in abnormal angiogenesis and vasculogenesis in retina along with reactive gliosis

Tawfik, A., Gnana-Prakasam, J. P., Smith, S. B. & Ganapathy, V., May 8 2014, In : Investigative Ophthalmology and Visual Science. 55, 6, p. 3616-3625 10 p.

Research output: Contribution to journal › Article

8 Scopus citations

Dysregulation of system x_c^- expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice

Frederick, N. M., Bertho, J., Patel, K. K., Petr, G. T., Bakradze, E., Smith, S. B. & Rosenberg, P. A., Oct 2014, In : Neurochemistry International. 76, p. 59-69 11 p.

Research output: Contribution to journal › Article

15 Scopus citations

Folate Transport in Retina and Consequences on Retinal Structure and Function of Hyperhomocysteinemia

Smith, S. B., Ganapathy, P. S., Bozard, R. B. & Ganapathy, V., Apr 10 2014, Handbook of Nutrition, Diet and the Eye. Elsevier Inc., p. 349-359 11 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells

Mo, J., Zhang, M., Marshall, B., Smith, S., Covar, J. & Atherton, S., Aug 14 2014, In : Molecular Vision. 20, p. 1161-1173 13 p.

Research output: Contribution to journal › Article

9 Scopus citations

Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina.

Promsote, W., Makala, L., Li, B., Smith, S. B., Singh, N., Ganapathy, V., Pace, B. S. & Martin, P. M., Aug 2014, In : Investigative ophthalmology & visual science. 55, 8, p. 5382-5393 12 p.

Research output: Contribution to journal › Article

21 Scopus citations

Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid

Ananth, S., Gnana-Prakasam, J. P., Bhutia, Y. D., Veeranan-Karmegam, R., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 4, p. 603-612 10 p.

Research output: Contribution to journal › Article

21 Scopus citations

Retinal expression of the serine protease matriptase-2 (tmprss6) and its role in retinal iron homeostasis

Gnana-Prakasam, J. P., Baldowski, R. B., Ananth, S., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 26 2014, In : Molecular Vision. 20, p. 561-574 14 p.

Research output: Contribution to journal › Article

4 Scopus citations

Role of bax in death of uninfected retinal cells during murine cytomegalovirus retinitis

Mo, J., Marshall, B., Covar, J., Zhang, N. Y., Smith, S. B., Atherton, S. S. & Zhang, M., Sep 23 2014, In : Investigative Ophthalmology and Visual Science. 55, 11, p. 7137-7146 10 p.

Research output: Contribution to journal › Article

5 Scopus citations

Sigma receptor 1 modulates ER stress and Bcl2 in murine retina

Ha, Y., Shanmugam, A. K., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Apr 2014, In : Cell and Tissue Research. 356, 1, p. 15-27 13 p.

Research output: Contribution to journal › Article

32 Scopus citations

Sigma receptor ligand, (+)-pentazocine, suppresses inflammatory responses of retinal microglia

Zhao, J., Ha, Y., Liou, G. I., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., May 8 2014, In : Investigative Ophthalmology and Visual Science. 55, 6, p. 3375-3384 10 p.

Research output: Contribution to journal › Article

33 Scopus citations

2013

Alterations of retinal vasculature in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia

Tawfik, A., Al-Shabrawey, M., Roon, P., Sonne, S., Covar, J. A., Matragoon, S., Ganapathy, P. S., Atherton, S. S., El-Remessy, A., Ganapathy, V. & Smith, S. B., Feb 2013, In : Investigative Ophthalmology and Visual Science. 54, 2, p. 939-949 11 p.

Research output: Contribution to journal › Article

17 Scopus citations

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