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• 2020

  Comparison of neuroprotective effects of monomethylfumarate to the sigma 1 receptor ligand (+)-pentazocine in a murine model of retinitis pigmentosa

  Xiao, H., Wang, J., Saul, A. & Smith, S. B., Mar 2020, In: Investigative Ophthalmology and Visual Science. 61, 3, 5.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • citraconic acid
  • sigma-1 receptor
  • Pentazocine
  • Retinitis Pigmentosa
  • Neuroprotective Agents
  5 Scopus citations

• Comparison of Sigma 1 receptor ligands SA4503 and PRE084 to (+)-Pentazocine in the rd10 mouse model of RP

  Wang, J., Xiao, H., Barwick, S. R. & Smith, S. B., Nov 5 2020, In: Investigative Ophthalmology and Visual Science. 61, 13, 13.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SA 4503
  • sigma-1 receptor
  • Pentazocine
  • Ligands
  • Cell Survival

• Enhanced Affinity for 3-Amino-Chromane-Derived σ₁Receptor Ligands

  Porter, M. R., Xiao, H., Maity, S., Vail, N., Smith, S. B. & Topczewski, J. J., Dec 22 2020, In: ACS Omega. 5, 50, p. 32724-32737 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ligands
  • Stereochemistry
  • Enantiomers
  • compound 18
  • phenethylamine

• The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress

  Lee, H., Smith, S. B., Sheu, S. S. & Yoon, Y., May 8 2020, In: Journal of Biological Chemistry. 295, 19, p. 6543-6560 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Oxidative stress
  • Autosomal Dominant Optic Atrophy
  • Optics
  • Cells
  • Cell Survival
  4 Scopus citations
• 2019

  3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT_2B, 5-HT₇, or σ₁ Receptor Ligands

  Porter, M. R., Xiao, H., Wang, J., Smith, S. B. & Topczewski, J. J., Oct 10 2019, In: ACS Medicinal Chemistry Letters. 10, 10, p. 1436-1442 7 p.

  Research output: Contribution to journal › Article › peer-review

  • 1,2,3,4-tetrahydroquinoline
  • phenethylamine
  • G-Protein-Coupled Receptors
  • Oxidative stress
  • serotonin 7 receptor
  5 Scopus citations

• Activation of sigma 1 receptor extends survival of cones and improves visual acuity in a murine model of retinitis pigmentosa

  Wang, J., Saul, A. & Smith, S. B., Oct 1 2019, In: Investigative Ophthalmology and Visual Science. 60, 13, p. 4397-4407 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • sigma-1 receptor
  • Retinitis Pigmentosa
  • Visual Acuity
  • Pentazocine
  • Retinal Cone Photoreceptor Cells
  5 Scopus citations

• A Novel Mechanism of Sigma 1 Receptor Neuroprotection: Modulation of miR-214-3p

  Wang, J. & Smith, S. B., 2019, Advances in Experimental Medicine and Biology. Springer, p. 463-467 5 p. (Advances in Experimental Medicine and Biology; vol. 1185).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • sigma-1 receptor
  • Neuroprotection
  • Modulation
  • MicroRNAs
  • Oxidative stress
  3 Scopus citations

• Excess homocysteine upregulates the NRF2-antioxidant pathway in retinal Müller glial cells

  Navneet, S., Cui, X., Zhao, J., Wang, J., Kaidery, N. A., Thomas, B., Bollinger, K. E., Yoon, Y. & Smith, S. B., Jan 2019, In: Experimental eye research. 178, p. 228-237 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Homocysteine
  • Neuroglia
  • Antioxidants
  • Up-Regulation
  • Oxidative Stress
  7 Scopus citations

• Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2

  Navneet, S., Zhao, J., Wang, J., Mysona, B. A., Barwick, S., Ammal Kaidery, N., Saul, A. B., Kaddour-Djebbar, I., Bollag, W. B., Thomas, B., Bollinger, K. E. & Smith, S. B., Jun 2019, In: Redox Biology. 24, 101199.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroglia
  • Hyperhomocysteinemia
  • Retinal Ganglion Cells
  • Oxidative stress
  • Antioxidants
  11 Scopus citations

• PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus

  Khaled, M. L., Bykhovskaya, Y., Gu, C., Liu, A., Drewry, M. D., Chen, Z., Mysona, B. A., Parker, E., McNabb, R. P., Yu, H., Lu, X., Wang, J., Li, X., Al-Muammar, A., Rotter, J. I., Porter, L. F., Estes, A., Watsky, M. A., Smith, S. B., Xu, H. & 5 others, Abu-Amero, K. K., Kuo, A., Shears, S. B., Rabinowitz, Y. S. & Liu, Y., Dec 1 2019, In: Scientific reports. 9, 1, 19406.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Keratoconus
  • Genes
  • Corneal Pachymetry
  • Whole Exome Sequencing
  • Whole Genome Sequencing
  11 Scopus citations

• The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2

  Wang, J., Zhao, J., Cui, X., Mysona, B. A., Navneet, S., Saul, A., Ahuja, M., Lambert, N., Gazaryan, I. G., Thomas, B., Bollinger, K. E. & Smith, S. B., Apr 2019, In: Free Radical Biology and Medicine. 134, p. 604-616 13 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • Retinal Cone Photoreceptor Cells
  • Molecular Chaperones
  • Cones
  • Modulation
  15 Scopus citations
• 2018

  Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

  Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In: Cell Death and Disease. 9, 10, 1001.

  Research output: Contribution to journal › Article › peer-review

  • Arginase
  • Ischemia
  • Macrophages
  • Reperfusion Injury
  • Knockout Mice
  8 Scopus citations

• Depletion of the receptor-interacting protein kinase 3 (RIP3) decreases photoreceptor cell death during the early stages of ocular murine cytomegalovirus infection

  Xu, J., Mo, J., Liu, X., Marshall, B., Atherton, S. S., Dong, Z., Smith, S. & Zhang, M., May 2018, In: Investigative Ophthalmology and Visual Science. 59, 6, p. 2445-2458 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Receptor-Interacting Protein Serine-Threonine Kinases
  • Muromegalovirus
  • Photoreceptor Cells
  • Cytomegalovirus Infections
  • Protein Kinases
  3 Scopus citations

• Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression

  Chaudhary, K., Promsote, W., Ananth, S., Veeranan-Karmegam, R., Tawfik, A. M., Arjunan, P., Martin, P. M., Smith, S. B., Thangaraju, M., Kisselev, O., Ganapathy, V. & Gnana-Prakasam, J. P., Dec 1 2018, In: Scientific reports. 8, 1, 3025.

  Research output: Contribution to journal › Article › peer-review

  • Iron Overload
  • Diabetic Retinopathy
  • Renin
  • Iron
  • Knockout Mice
  17 Scopus citations

• Relationship between Sigma-1 receptor and BDNF in the visual system

  Mysona, B. A., Zhao, J., Smith, S. & Bollinger, K. E., Feb 2018, In: Experimental eye research. 167, p. 25-30 6 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • Brain-Derived Neurotrophic Factor
  • Optic Disk
  • Astrocytes
  • Retina
  5 Scopus citations

• Sigma 1 receptor: A novel therapeutic target in retinal disease

  Smith, S. B., Wang, J., Cui, X., Mysona, B. A., Zhao, J. & Bollinger, K. E., Nov 2018, In: Progress in Retinal and Eye Research. 67, p. 130-149 20 p.

  Research output: Contribution to journal › Review article › peer-review

  • sigma-1 receptor
  • Retinal Diseases
  • Retina
  • Therapeutics
  • Photoreceptor Cells
  21 Scopus citations
• 2017

  Absence of sigma 1 receptor accelerates photoreceptor cell death in a murine model of retinitis pigmentosa

  Wang, J., Saul, A., Cui, X., Roon, P. & Smith, S. B., Sep 2017, In: Investigative Ophthalmology and Visual Science. 58, 11, p. 4545-4558 14 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • Photoreceptor Cells
  • Retinitis Pigmentosa
  • Cell Death
  • Gliosis
  14 Scopus citations

• Analysis of MTHFR, CBS, glutathione, taurine, and hydrogen sulfide levels in retinas of hyperhomocysteinemic mice

  Cui, X., Navneet, S., Wang, J., Roon, P., Chen, W., Xian, M. & Smith, S. B., Apr 2017, In: Investigative Ophthalmology and Visual Science. 58, 4, p. 1954-1963 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Glutathione Synthase
  • Cystathionine
  • Hydrogen Sulfide
  • Taurine
  • Retina
  8 Scopus citations

• Detailed electroretinographic findings in rd8 mice

  Saul, A. B., Cui, X., Markand, S. & Smith, S. B., Jun 1 2017, In: Documenta Ophthalmologica. 134, 3, p. 195-203 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Retina
  • Light
  • Amacrine Cells
  • Retinal Degeneration
  • Phenotype
  3 Scopus citations

• Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress

  Mohamed, R., Sharma, I., Ibrahim, A. S., Saleh, H., Elsherbiny, N. M., Fulzele, S., Elmasry, K., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., Dec 1 2017, In: Scientific reports. 7, 1, 11952.

  Research output: Contribution to journal › Article › peer-review

  • Hyperhomocysteinemia
  • Oxidative Stress
  • Endothelial Cells
  • Homocysteine
  • Blood-Retinal Barrier
  17 Scopus citations

• Introduction to sigma receptors: Their role in disease and as therapeutic targets

  Smith, S. B., 2017, In: Advances in experimental medicine and biology. 964, p. 1-4 4 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • sigma Receptors
  • sigma-2 receptor
  • Molecular imaging
  • Neurodegenerative diseases
  10 Scopus citations

• p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection

  Zhu, S., Luo, H., Liu, H., Ha, Y., Mays, E. R., Lawrence, R. E., Winkelmann, E., Barrett, A. D., Smith, S. B., Wang, M., Wang, T. & Zhang, W., Sep 2017, In: Antiviral Research. 145, p. 70-81 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Zika Virus Infection
  • Zika Virus
  • Phenotype
  • Intercellular Signaling Peptides and Proteins
  • Posterior Uveitis
  13 Scopus citations

• Protective effects of agonists of growth hormone-releasing hormone (GHRH) in early experimental diabetic retinopathy

  Thounaojam, M. C., Powell, F. L., Patel, S., Gutsaeva, D. R., Tawfik, A., Smith, S. B., Nussbaum, J., Block, N. L., Martin, P. M., Schally, A. V. & Bartoli, M., Dec 12 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 50, p. 13248-13253 6 p.

  Research output: Contribution to journal › Article › peer-review

  • N-Me-Tyr1,D-Ala2,Asn8,Arg29-NHCH3-JI-38
  • Growth Hormone-Releasing Hormone
  • Diabetic Retinopathy
  • GHRH(1-29)NH2, (PhAc-Ada)(0)-Tyr(1), Arg(2), Fpa(5,6), Ala(8), Har(9), Tyr(Me)(10), His(11), Orn(12,) Abu(15), His(20), Orn(21), Nle(27), Arg(28), Har(29)-
  • Retina
  19 Scopus citations

• Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes

  Zhao, J., Mysona, B. A., Wang, J., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., Sep 2017, In: PloS one. 12, 9, e0184421.

  Research output: Contribution to journal › Article › peer-review

  • Astrocytes
  • sigma-1 receptor
  • astrocytes
  • Optic Disk
  • optics
  8 Scopus citations

• The role of sigma1R in mammalian retina

  Wang, J., Cui, X., Roon, P., Saul, A. & Smith, S. B., 2017, In: Advances in experimental medicine and biology. 964, p. 267-284 18 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • Retina
  • Ganglia
  • Neuroprotection
  • Cells
  4 Scopus citations

• The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure

  Lee, H., Smith, S. B. & Yoon, Y., Apr 28 2017, In: Journal of Biological Chemistry. 292, 17, p. 7115-7130 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Autosomal Dominant Optic Atrophy
  • Dynamins
  • Optics
  • Fusion reactions
  • Mitochondrial Dynamics
  60 Scopus citations
• 2016

  (+)-pentazocine reduces NMDA-induced murine retinal ganglion cell death through a σr1-dependent mechanism

  Zhao, J., Mysona, B. A., Qureshi, A., Kim, L., Fields, T., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., Feb 2016, In: Investigative Ophthalmology and Visual Science. 57, 2, p. 453-461 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Pentazocine
  • Retinal Ganglion Cells
  • N-Methylaspartate
  • Cell Death
  • sigma-1 receptor
  15 Scopus citations

• Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration

  Wang, J., Saul, A., Roon, P. & Smith, S. B., Jun 28 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. E3764-E3772

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • Retinal Degeneration
  • Molecular Chaperones
  • Photoreceptor Cells
  • Retinal Diseases
  42 Scopus citations

• Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration

  Ibrahim, A. S., Mander, S., Hussein, K. A., Elsherbiny, N. M., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., 2016, In: Oncotarget. 7, 8, p. 8532-8545 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Hyperhomocysteinemia
  • Retinal Pigments
  • Macular Degeneration
  • Homocysteine
  • Choroidal Neovascularization
  18 Scopus citations

• Mthfr as a modifier of the retinal phenotype of Crb1^rd8/rd8 mice

  Markand, S., Saul, A., Tawfik, A., Cui, X., Rozen, R. & Smith, S. B., Apr 1 2016, In: Experimental eye research. 145, p. 164-172 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Retinal Degeneration
  • Phenotype
  • Mutation
  • Leber Congenital Amaurosis
  • Retinitis Pigmentosa
  6 Scopus citations

• Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease

  Promsote, W., Powell, F. L., Veean, S., Thounaojam, M., Markand, S., Saul, A., Gutsaeva, D., Bartoli, M., Smith, S. B., Ganapathy, V. & Martin, P. M., Dec 10 2016, In: Antioxidants and Redox Signaling. 25, 17, p. 921-935 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Fumarates
  • Sickle Cell Anemia
  • Oxidative stress
  • hemoglobin AA
  • Pathology
  7 Scopus citations

• Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina

  Shanmugam, A. K., Mysona, B. A., Wang, J., Zhao, J., Tawfik, A., Sanders, A., Markand, S., Zorrilla, E., Ganapathy, V., Bollinger, K. E. & Smith, S. B., Aug 2 2016, In: Current Eye Research. 41, 8, p. 1105-1112 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Progesterone Receptors
  • Retina
  • Membranes
  • Intestines
  • sigma-2 receptor
  3 Scopus citations

• Role of sigma 1 receptor in retinal degeneration of the Ins2^Akita/+ murine model of diabetic retinopathy

  Wang, J., Cui, X., Roon, P. & Smith, S. B., May 1 2016, In: Investigative Ophthalmology and Visual Science. 57, 6, p. 2770-2781 12 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • Retinal Degeneration
  • Diabetic Retinopathy
  • Pentazocine
  • Gliosis
  7 Scopus citations
• 2015

  A lipidomic screen of hyperglycemia-treated hrecs links 12/15-lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase

  Ibrahim, A. S., Elshafey, S., Sellak, H., Hussein, K. A., El-Sherbiny, M., Abdelsaid, M., Rizk, N., Beasley, S., Tawfik, A. M., Smith, S. B. & Al-Shabrawey, M., Mar 1 2015, In: Journal of Lipid Research. 56, 3, p. 599-611 13 p.

  Research output: Contribution to journal › Article › peer-review

  • 12-15-lipoxygenase
  • 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
  • 15-hydroxy-5,8,11,13-eicosatetraenoic acid
  • Arachidonate 15-Lipoxygenase
  • NADPH Oxidases
  33 Scopus citations

• Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

  Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B. & Zhang, W., Oct 1 2015, In: Cell Death and Disease. 6, 10, e1900.

  Research output: Contribution to journal › Article › peer-review

  • Endoplasmic Reticulum Stress
  • Glaucoma
  • Intraocular Pressure
  • Inflammation
  • Wounds and Injuries
  30 Scopus citations

• Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in The susceptibility of diabetic models to ischemic acute kidney injury

  Peng, J., Li, X., Zhang, D., Chen, J. K., Su, Y., Smith, S. B. & Dong, Z., Jan 3 2015, In: Kidney International. 87, 1, p. 137-150 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Acute Kidney Injury
  • Hyperglycemia
  • Apoptosis
  • Kidney
  • Glucose
  75 Scopus citations

• Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids

  Ibrahim, A. S., Tawfik, A. M., Hussein, K. A., Elshafey, S., Markand, S., Rizk, N., Duh, E. J., Smith, S. B. & Al-Shabrawey, M., Mar 2015, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1851, 3, p. 290-298 9 p.

  Research output: Contribution to journal › Article › peer-review

  • 12-15-lipoxygenase
  • pigment epithelium-derived factor
  • Eicosanoids
  • 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
  • Hydroxyeicosatetraenoic Acids
  25 Scopus citations

• Retinal ganglion cell loss and mild vasculopathy in methylene tetrahydrofolate reductase (Mthfr)-deficient mice: A model of mild hyperhomocysteinemia

  Markand, S., Saul, A., Roon, P., Prasad, P., Martin, P., Rozen, R., Ganapathy, V. & Smith, S. B., 2015, In: Investigative Ophthalmology and Visual Science. 56, 4, p. 2684-2695 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Hyperhomocysteinemia
  • Retinal Ganglion Cells
  • Immunohistochemistry
  • Electroretinography
  • Fluorescein Angiography
  18 Scopus citations

• Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system x_c^-, the Na⁺-independent glutamate-cystine exchanger

  Wang, J., Shanmugam, A., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Jun 14 2015, In: Free Radical Biology and Medicine. 86, p. 25-36 12 p., 12387.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative stress
  • Neuroglia
  • sigma-1 receptor
  • Cystine
  • Glutamic Acid
  63 Scopus citations

• Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells

  Shanmugam, A., Wang, J., Markand, S., Perry, R. L., Tawfik, A., Zorrilla, E., Ganapathy, V. & Smith, S. B., Mar 1 2015, In: Journal of Neurochemistry. 132, 5, p. 546-558 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuroglia
  • sigma-1 receptor
  • Interleukin-12
  • Chemical activation
  • Lipopolysaccharides
  11 Scopus citations
• 2014

  Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: A model of mild to moderate hyperhomocysteinemia

  Tawfik, A., Markand, S., Al-Shabrawey, M., Mayo, J. N., Reynolds, J., Bearden, S. E., Ganapathy, V. & Smith, S. B., Sep 2014, In: American Journal of Pathology. 184, 9, p. 2573-2585 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Cystathionine
  • Hyperhomocysteinemia
  • Zonula Occludens-1 Protein
  • Occludin
  • Glial Fibrillary Acidic Protein
  24 Scopus citations

• Deletion of hemojuvelin, an iron-regulatory protein, in mice results in abnormal angiogenesis and vasculogenesis in retina along with reactive gliosis

  Tawfik, A., Gnana-Prakasam, J. P., Smith, S. B. & Ganapathy, V., May 8 2014, In: Investigative Ophthalmology and Visual Science. 55, 6, p. 3616-3625 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Iron-Regulatory Proteins
  • Gliosis
  • Retina
  • Microglia
  • Blood Vessels
  8 Scopus citations

• Dysregulation of system x_c^- expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice

  Frederick, N. M., Bertho, J., Patel, K. K., Petr, G. T., Bakradze, E., Smith, S. B. & Rosenberg, P. A., Oct 2014, In: Neurochemistry International. 76, p. 59-69 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Corpus Striatum
  • Huntington Disease
  • Oxidative Stress
  • Cell Line
  • Proteins
  17 Scopus citations

• Folate Transport in Retina and Consequences on Retinal Structure and Function of Hyperhomocysteinemia

  Smith, S. B., Ganapathy, P. S., Bozard, R. B. & Ganapathy, V., Apr 10 2014, Handbook of Nutrition, Diet and the Eye. Elsevier Inc., p. 349-359 11 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Hyperhomocysteinemia
  • Folic Acid
  • Retina
  • Proton-Coupled Folate Transporter
  • Reduced Folate Carrier Protein
  1 Scopus citations

• Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells

  Mo, J., Zhang, M., Marshall, B., Smith, S., Covar, J. & Atherton, S., Aug 14 2014, In: Molecular Vision. 20, p. 1161-1173 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Muromegalovirus
  • Retinal Pigments
  • Cytomegalovirus Infections
  • Autophagy
  • Epithelial Cells
  10 Scopus citations

• Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina.

  Promsote, W., Makala, L., Li, B., Smith, S. B., Singh, N., Ganapathy, V., Pace, B. S. & Martin, P. M., Aug 2014, In: Investigative ophthalmology & visual science. 55, 8, p. 5382-5393 12 p.

  Research output: Contribution to journal › Article › peer-review

  • citraconic acid
  • Fetal Hemoglobin
  • Erythroid Cells
  • Globins
  • Retinal Pigments
  21 Scopus citations

• Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid

  Ananth, S., Gnana-Prakasam, J. P., Bhutia, Y. D., Veeranan-Karmegam, R., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 2014, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 4, p. 603-612 10 p.

  Research output: Contribution to journal › Article › peer-review

  • ATP Binding Cassette Transporter, Subfamily G, Member 1
  • 2,5-dihydroxybenzoic acid
  • Siderophores
  • Hemochromatosis
  • Retina
  22 Scopus citations

• Retinal expression of the serine protease matriptase-2 (tmprss6) and its role in retinal iron homeostasis

  Gnana-Prakasam, J. P., Baldowski, R. B., Ananth, S., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 26 2014, In: Molecular Vision. 20, p. 561-574 14 p.

  Research output: Contribution to journal › Article › peer-review

  • matriptase 2
  • Serine Proteases
  • Retina
  • Iron
  • Homeostasis
  5 Scopus citations

• Role of bax in death of uninfected retinal cells during murine cytomegalovirus retinitis

  Mo, J., Marshall, B., Covar, J., Zhang, N. Y., Smith, S. B., Atherton, S. S. & Zhang, M., Sep 23 2014, In: Investigative Ophthalmology and Visual Science. 55, 11, p. 7137-7146 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytomegalovirus Retinitis
  • Muromegalovirus
  • Receptor-Interacting Protein Serine-Threonine Kinases
  • Caspases
  • Eye
  5 Scopus citations

• Sigma receptor 1 modulates ER stress and Bcl2 in murine retina

  Ha, Y., Shanmugam, A. K., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Apr 2014, In: Cell and Tissue Research. 356, 1, p. 15-27 13 p.

  Research output: Contribution to journal › Article › peer-review

  • sigma-1 receptor
  • Endoplasmic Reticulum Stress
  • Neuroprotection
  • Retina
  • Transcriptome
  33 Scopus citations