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2020
Comparison of neuroprotective effects of monomethylfumarate to the sigma 1 receptor ligand (+)-pentazocine in a murine model of retinitis pigmentosa
Xiao, H., Wang, J., Saul, A. & Smith, S. B., Mar 2020, In: Investigative Ophthalmology and Visual Science. 61, 3, 5.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Comparison of Sigma 1 receptor ligands SA4503 and PRE084 to (+)-Pentazocine in the rd10 mouse model of RP
Wang, J., Xiao, H., Barwick, S. R. & Smith, S. B., Nov 5 2020, In: Investigative Ophthalmology and Visual Science. 61, 13, 13.Research output: Contribution to journal › Article › peer-review
Open Access -
Enhanced Affinity for 3-Amino-Chromane-Derived σ1Receptor Ligands
Porter, M. R., Xiao, H., Maity, S., Vail, N., Smith, S. B. & Topczewski, J. J., Dec 22 2020, In: ACS Omega. 5, 50, p. 32724-32737 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress
Lee, H., Smith, S. B., Sheu, S. S. & Yoon, Y., May 8 2020, In: Journal of Biological Chemistry. 295, 19, p. 6543-6560 18 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2019
3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT2B, 5-HT7, or σ1 Receptor Ligands
Porter, M. R., Xiao, H., Wang, J., Smith, S. B. & Topczewski, J. J., Oct 10 2019, In: ACS Medicinal Chemistry Letters. 10, 10, p. 1436-1442 7 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Activation of sigma 1 receptor extends survival of cones and improves visual acuity in a murine model of retinitis pigmentosa
Wang, J., Saul, A. & Smith, S. B., Oct 1 2019, In: Investigative Ophthalmology and Visual Science. 60, 13, p. 4397-4407 11 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
A Novel Mechanism of Sigma 1 Receptor Neuroprotection: Modulation of miR-214-3p
Wang, J. & Smith, S. B., 2019, Advances in Experimental Medicine and Biology. Springer, p. 463-467 5 p. (Advances in Experimental Medicine and Biology; vol. 1185).Research output: Chapter in Book/Report/Conference proceeding › Chapter
3 Scopus citations -
Excess homocysteine upregulates the NRF2-antioxidant pathway in retinal Müller glial cells
Navneet, S., Cui, X., Zhao, J., Wang, J., Kaidery, N. A., Thomas, B., Bollinger, K. E., Yoon, Y. & Smith, S. B., Jan 2019, In: Experimental eye research. 178, p. 228-237 10 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2
Navneet, S., Zhao, J., Wang, J., Mysona, B. A., Barwick, S., Ammal Kaidery, N., Saul, A. B., Kaddour-Djebbar, I., Bollag, W. B., Thomas, B., Bollinger, K. E. & Smith, S. B., Jun 2019, In: Redox Biology. 24, 101199.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
PPIP5K2 and PCSK1 are Candidate Genetic Contributors to Familial Keratoconus
Khaled, M. L., Bykhovskaya, Y., Gu, C., Liu, A., Drewry, M. D., Chen, Z., Mysona, B. A., Parker, E., McNabb, R. P., Yu, H., Lu, X., Wang, J., Li, X., Al-Muammar, A., Rotter, J. I., Porter, L. F., Estes, A., Watsky, M. A., Smith, S. B., Xu, H. & 5 others, , Dec 1 2019, In: Scientific reports. 9, 1, 19406.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
The molecular chaperone sigma 1 receptor mediates rescue of retinal cone photoreceptor cells via modulation of NRF2
Wang, J., Zhao, J., Cui, X., Mysona, B. A., Navneet, S., Saul, A., Ahuja, M., Lambert, N., Gazaryan, I. G., Thomas, B., Bollinger, K. E. & Smith, S. B., Apr 2019, In: Free Radical Biology and Medicine. 134, p. 604-616 13 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
2018
Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses
Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In: Cell Death and Disease. 9, 10, 1001.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Depletion of the receptor-interacting protein kinase 3 (RIP3) decreases photoreceptor cell death during the early stages of ocular murine cytomegalovirus infection
Xu, J., Mo, J., Liu, X., Marshall, B., Atherton, S. S., Dong, Z., Smith, S. & Zhang, M., May 2018, In: Investigative Ophthalmology and Visual Science. 59, 6, p. 2445-2458 14 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression
Chaudhary, K., Promsote, W., Ananth, S., Veeranan-Karmegam, R., Tawfik, A. M., Arjunan, P., Martin, P. M., Smith, S. B., Thangaraju, M., Kisselev, O., Ganapathy, V. & Gnana-Prakasam, J. P., Dec 1 2018, In: Scientific reports. 8, 1, 3025.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Relationship between Sigma-1 receptor and BDNF in the visual system
Mysona, B. A., Zhao, J., Smith, S. & Bollinger, K. E., Feb 2018, In: Experimental eye research. 167, p. 25-30 6 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Sigma 1 receptor: A novel therapeutic target in retinal disease
Smith, S. B., Wang, J., Cui, X., Mysona, B. A., Zhao, J. & Bollinger, K. E., Nov 2018, In: Progress in Retinal and Eye Research. 67, p. 130-149 20 p.Research output: Contribution to journal › Review article › peer-review
21 Scopus citations -
2017
Absence of sigma 1 receptor accelerates photoreceptor cell death in a murine model of retinitis pigmentosa
Wang, J., Saul, A., Cui, X., Roon, P. & Smith, S. B., Sep 2017, In: Investigative Ophthalmology and Visual Science. 58, 11, p. 4545-4558 14 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Analysis of MTHFR, CBS, glutathione, taurine, and hydrogen sulfide levels in retinas of hyperhomocysteinemic mice
Cui, X., Navneet, S., Wang, J., Roon, P., Chen, W., Xian, M. & Smith, S. B., Apr 2017, In: Investigative Ophthalmology and Visual Science. 58, 4, p. 1954-1963 10 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Detailed electroretinographic findings in rd8 mice
Saul, A. B., Cui, X., Markand, S. & Smith, S. B., Jun 1 2017, In: Documenta Ophthalmologica. 134, 3, p. 195-203 9 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress
Mohamed, R., Sharma, I., Ibrahim, A. S., Saleh, H., Elsherbiny, N. M., Fulzele, S., Elmasry, K., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., Dec 1 2017, In: Scientific reports. 7, 1, 11952.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Introduction to sigma receptors: Their role in disease and as therapeutic targets
Smith, S. B., 2017, In: Advances in experimental medicine and biology. 964, p. 1-4 4 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection
Zhu, S., Luo, H., Liu, H., Ha, Y., Mays, E. R., Lawrence, R. E., Winkelmann, E., Barrett, A. D., Smith, S. B., Wang, M., Wang, T. & Zhang, W., Sep 2017, In: Antiviral Research. 145, p. 70-81 12 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Protective effects of agonists of growth hormone-releasing hormone (GHRH) in early experimental diabetic retinopathy
Thounaojam, M. C., Powell, F. L., Patel, S., Gutsaeva, D. R., Tawfik, A., Smith, S. B., Nussbaum, J., Block, N. L., Martin, P. M., Schally, A. V. & Bartoli, M., Dec 12 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 50, p. 13248-13253 6 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes
Zhao, J., Mysona, B. A., Wang, J., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., Sep 2017, In: PloS one. 12, 9, e0184421.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
The role of sigma1R in mammalian retina
Wang, J., Cui, X., Roon, P., Saul, A. & Smith, S. B., 2017, In: Advances in experimental medicine and biology. 964, p. 267-284 18 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure
Lee, H., Smith, S. B. & Yoon, Y., Apr 28 2017, In: Journal of Biological Chemistry. 292, 17, p. 7115-7130 16 p.Research output: Contribution to journal › Article › peer-review
60 Scopus citations -
2016
(+)-pentazocine reduces NMDA-induced murine retinal ganglion cell death through a σr1-dependent mechanism
Zhao, J., Mysona, B. A., Qureshi, A., Kim, L., Fields, T., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., Feb 2016, In: Investigative Ophthalmology and Visual Science. 57, 2, p. 453-461 9 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Activation of the molecular chaperone, sigma 1 receptor, preserves cone function in a murine model of inherited retinal degeneration
Wang, J., Saul, A., Roon, P. & Smith, S. B., Jun 28 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. E3764-E3772Research output: Contribution to journal › Article › peer-review
42 Scopus citations -
Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration
Ibrahim, A. S., Mander, S., Hussein, K. A., Elsherbiny, N. M., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., 2016, In: Oncotarget. 7, 8, p. 8532-8545 14 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Mthfr as a modifier of the retinal phenotype of Crb1rd8/rd8 mice
Markand, S., Saul, A., Tawfik, A., Cui, X., Rozen, R. & Smith, S. B., Apr 1 2016, In: Experimental eye research. 145, p. 164-172 9 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease
Promsote, W., Powell, F. L., Veean, S., Thounaojam, M., Markand, S., Saul, A., Gutsaeva, D., Bartoli, M., Smith, S. B., Ganapathy, V. & Martin, P. M., Dec 10 2016, In: Antioxidants and Redox Signaling. 25, 17, p. 921-935 15 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina
Shanmugam, A. K., Mysona, B. A., Wang, J., Zhao, J., Tawfik, A., Sanders, A., Markand, S., Zorrilla, E., Ganapathy, V., Bollinger, K. E. & Smith, S. B., Aug 2 2016, In: Current Eye Research. 41, 8, p. 1105-1112 8 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Role of sigma 1 receptor in retinal degeneration of the Ins2Akita/+ murine model of diabetic retinopathy
Wang, J., Cui, X., Roon, P. & Smith, S. B., May 1 2016, In: Investigative Ophthalmology and Visual Science. 57, 6, p. 2770-2781 12 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
2015
A lipidomic screen of hyperglycemia-treated hrecs links 12/15-lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase
Ibrahim, A. S., Elshafey, S., Sellak, H., Hussein, K. A., El-Sherbiny, M., Abdelsaid, M., Rizk, N., Beasley, S., Tawfik, A. M., Smith, S. B. & Al-Shabrawey, M., Mar 1 2015, In: Journal of Lipid Research. 56, 3, p. 599-611 13 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations -
Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma
Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B. & Zhang, W., Oct 1 2015, In: Cell Death and Disease. 6, 10, e1900.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in The susceptibility of diabetic models to ischemic acute kidney injury
Peng, J., Li, X., Zhang, D., Chen, J. K., Su, Y., Smith, S. B. & Dong, Z., Jan 3 2015, In: Kidney International. 87, 1, p. 137-150 14 p.Research output: Contribution to journal › Article › peer-review
75 Scopus citations -
Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids
Ibrahim, A. S., Tawfik, A. M., Hussein, K. A., Elshafey, S., Markand, S., Rizk, N., Duh, E. J., Smith, S. B. & Al-Shabrawey, M., Mar 2015, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1851, 3, p. 290-298 9 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
Retinal ganglion cell loss and mild vasculopathy in methylene tetrahydrofolate reductase (Mthfr)-deficient mice: A model of mild hyperhomocysteinemia
Markand, S., Saul, A., Roon, P., Prasad, P., Martin, P., Rozen, R., Ganapathy, V. & Smith, S. B., 2015, In: Investigative Ophthalmology and Visual Science. 56, 4, p. 2684-2695 12 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc-, the Na+-independent glutamate-cystine exchanger
Wang, J., Shanmugam, A., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Jun 14 2015, In: Free Radical Biology and Medicine. 86, p. 25-36 12 p., 12387.Research output: Contribution to journal › Article › peer-review
63 Scopus citations -
Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells
Shanmugam, A., Wang, J., Markand, S., Perry, R. L., Tawfik, A., Zorrilla, E., Ganapathy, V. & Smith, S. B., Mar 1 2015, In: Journal of Neurochemistry. 132, 5, p. 546-558 13 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
2014
Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: A model of mild to moderate hyperhomocysteinemia
Tawfik, A., Markand, S., Al-Shabrawey, M., Mayo, J. N., Reynolds, J., Bearden, S. E., Ganapathy, V. & Smith, S. B., Sep 2014, In: American Journal of Pathology. 184, 9, p. 2573-2585 13 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Deletion of hemojuvelin, an iron-regulatory protein, in mice results in abnormal angiogenesis and vasculogenesis in retina along with reactive gliosis
Tawfik, A., Gnana-Prakasam, J. P., Smith, S. B. & Ganapathy, V., May 8 2014, In: Investigative Ophthalmology and Visual Science. 55, 6, p. 3616-3625 10 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Dysregulation of system xc- expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice
Frederick, N. M., Bertho, J., Patel, K. K., Petr, G. T., Bakradze, E., Smith, S. B. & Rosenberg, P. A., Oct 2014, In: Neurochemistry International. 76, p. 59-69 11 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Folate Transport in Retina and Consequences on Retinal Structure and Function of Hyperhomocysteinemia
Smith, S. B., Ganapathy, P. S., Bozard, R. B. & Ganapathy, V., Apr 10 2014, Handbook of Nutrition, Diet and the Eye. Elsevier Inc., p. 349-359 11 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Scopus citations -
Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells
Mo, J., Zhang, M., Marshall, B., Smith, S., Covar, J. & Atherton, S., Aug 14 2014, In: Molecular Vision. 20, p. 1161-1173 13 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina.
Promsote, W., Makala, L., Li, B., Smith, S. B., Singh, N., Ganapathy, V., Pace, B. S. & Martin, P. M., Aug 2014, In: Investigative ophthalmology & visual science. 55, 8, p. 5382-5393 12 p.Research output: Contribution to journal › Article › peer-review
21 Scopus citations -
Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid
Ananth, S., Gnana-Prakasam, J. P., Bhutia, Y. D., Veeranan-Karmegam, R., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 2014, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 4, p. 603-612 10 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
Retinal expression of the serine protease matriptase-2 (tmprss6) and its role in retinal iron homeostasis
Gnana-Prakasam, J. P., Baldowski, R. B., Ananth, S., Martin, P. M., Smith, S. B. & Ganapathy, V., Apr 26 2014, In: Molecular Vision. 20, p. 561-574 14 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Role of bax in death of uninfected retinal cells during murine cytomegalovirus retinitis
Mo, J., Marshall, B., Covar, J., Zhang, N. Y., Smith, S. B., Atherton, S. S. & Zhang, M., Sep 23 2014, In: Investigative Ophthalmology and Visual Science. 55, 11, p. 7137-7146 10 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Sigma receptor 1 modulates ER stress and Bcl2 in murine retina
Ha, Y., Shanmugam, A. K., Markand, S., Zorrilla, E., Ganapathy, V. & Smith, S. B., Apr 2014, In: Cell and Tissue Research. 356, 1, p. 15-27 13 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations