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  • Sylvia B Smith

(+)-pentazocine reduces NMDA-induced murine retinal ganglion cell death through a σr1-dependent mechanism

Zhao, J., Mysona, B. A., Qureshi, A., Kim, L., Fields, T., Gonsalvez, G. B., Smith, S. B. & Bollinger, K. E., Feb 2016, In : Investigative Ophthalmology and Visual Science. 57, 2, p. 453-461 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HT2B, 5-HT7, or σ1 Receptor Ligands

Porter, M. R., Xiao, H., Wang, J., Smith, S. B. & Topczewski, J. J., Oct 10 2019, In : ACS Medicinal Chemistry Letters. 10, 10, p. 1436-1442 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
Open Access
2 Scopus citations
37 Scopus citations

Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia

Yu, M., Sturgill-Short, G., Ganapathy, P., Tawfik, A., Peachey, N. S. & Smith, S. B., Mar 2012, In : Experimental eye research. 96, 1, p. 124-131 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

A lipidomic screen of hyperglycemia-treated hrecs links 12/15-lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase

Ibrahim, A. S., Elshafey, S., Sellak, H., Hussein, K. A., El-Sherbiny, M., Abdelsaid, M., Rizk, N., Beasley, S., Tawfik, A. M., Smith, S. B. & Al-Shabrawey, M., Mar 1 2015, In : Journal of Lipid Research. 56, 3, p. 599-611 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Alterations of retinal vasculature in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia

Tawfik, A., Al-Shabrawey, M., Roon, P., Sonne, S., Covar, J. A., Matragoon, S., Ganapathy, P. S., Atherton, S. S., El-Remessy, A., Ganapathy, V. & Smith, S. B., Feb 2013, In : Investigative Ophthalmology and Visual Science. 54, 2, p. 939-949 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: A model of mild to moderate hyperhomocysteinemia

Tawfik, A., Markand, S., Al-Shabrawey, M., Mayo, J. N., Reynolds, J., Bearden, S. E., Ganapathy, V. & Smith, S. B., Sep 2014, In : American Journal of Pathology. 184, 9, p. 2573-2585 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Analysis of MTHFR, CBS, glutathione, taurine, and hydrogen sulfide levels in retinas of hyperhomocysteinemic mice

Cui, X., Navneet, S., Wang, J., Roon, P., Chen, W., Xian, M. & Smith, S. B., Apr 2017, In : Investigative Ophthalmology and Visual Science. 58, 4, p. 1954-1963 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

A Novel Mechanism of Sigma 1 Receptor Neuroprotection: Modulation of miR-214-3p

Wang, J. & Smith, S. B., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer, p. 463-467 5 p. (Advances in Experimental Medicine and Biology; vol. 1185).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In : Cell Death and Disease. 9, 10, 1001.

Research output: Contribution to journalArticle

7 Scopus citations
Open Access
2 Scopus citations

Cutting edge: IRF8 regulates bax transcription in vivo in primary myeloid cells

Yang, J., Hu, X., Zimmerman, M., Torres, C. M., Yang, D., Smith, S. B. & Liu, K., Nov 1 2011, In : Journal of Immunology. 187, 9, p. 4426-4430 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Cystathionine beta synthase expression in mouse retina

Markand, S., Tawfik, A., Ha, Y., Gnana-Prakasam, J., Sonne, S., Ganapathy, V., Sen, N., Xian, M. & Smith, S. B., May 2013, In : Current Eye Research. 38, 5, p. 597-604 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
8 Scopus citations
3 Scopus citations

Detailed electroretinographic findings in rd8 mice

Saul, A. B., Cui, X., Markand, S. & Smith, S. B., Jun 1 2017, In : Documenta Ophthalmologica. 134, 3, p. 195-203 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor

Ha, Y., Saul, A. B., Tawfik, A. M., Zorrilla, E. P., Ganapathy, V. & Smith, S. B., Nov 30 2012, In : Molecular Vision. 18, p. 2860-2870 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway

Al-Gayyar, M. M. H., Mysona, B. A., Matragoon, S., Abdelsaid, M. A., El-Azab, M. F., Shanab, A. Y., Ha, Y., Smith, S. B., Bollinger, K. E. & El-Remessy, A. B., Jan 30 2013, In : PloS one. 8, 1, e54692.

Research output: Contribution to journalArticle

28 Scopus citations

D-serine and serine racemase in the retina

Smith, S. B., Ha, Y. & Ganapathy, V., Nov 24 2011, Amino Acids in Human Nutrition and Health. CABI Publishing, p. 137-149 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dysregulation of system xc- expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice

Frederick, N. M., Bertho, J., Patel, K. K., Petr, G. T., Bakradze, E., Smith, S. B. & Rosenberg, P. A., Oct 2014, In : Neurochemistry International. 76, p. 59-69 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B. & Zhang, W., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1900.

Research output: Contribution to journalArticle

28 Scopus citations

Excess homocysteine upregulates the NRF2-antioxidant pathway in retinal Müller glial cells

Navneet, S., Cui, X., Zhao, J., Wang, J., Kaidery, N. A., Thomas, B., Bollinger, K. E., Yoon, Y. & Smith, S. B., Jan 2019, In : Experimental eye research. 178, p. 228-237 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium

Gnana-Prakasam, J. P., Ananth, S., Prasad, P. D., Zhang, M., Atherton, S. S., Martin, P. M., Smith, S. B. & Ganapathy, V., May 2011, In : Investigative Ophthalmology and Visual Science. 52, 6, p. 3751-3758 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Folate Transport in Retina and Consequences on Retinal Structure and Function of Hyperhomocysteinemia

Smith, S. B., Ganapathy, P. S., Bozard, R. B. & Ganapathy, V., Apr 10 2014, Handbook of Nutrition, Diet and the Eye. Elsevier Inc., p. 349-359 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Functional characterization of folate transport proteins in staten's seruminstitut rabbit corneal epithelial cell line

Jwala, J., Boddu, S. H. S., Paturi, D. K., Shah, S., Smith, S. B., Pal, D. & Mitra, A. K., May 2011, In : Current Eye Research. 36, 5, p. 404-416 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

GADD34 induces cell death through inactivation of Akt following traumatic brain injury

Farook, J. M., Shields, J., Tawfik, A., Markand, S., Sen, T., Smith, S. B., Brann, D., Dhandapani, K. M. & Sen, N., Aug 2013, In : Cell Death and Disease. 4, 8, e754.

Research output: Contribution to journalArticle

44 Scopus citations

GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.

Gambhir, D., Ananth, S., Veeranan-Karmegam, R., Elangovan, S., Hester, S., Jennings, E., Offermanns, S., Nussbaum, J. J., Smith, S. B., Thangaraju, M., Ganapathy, V. & Martin, P. M., Apr 2012, In : Investigative ophthalmology & visual science. 53, 4, p. 2208-2217 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells

Ganapathy, P. S., Perry, R. L., Tawfik, A. M., Smith, R. M., Perry, E., Roon, P., Renee Bozard, B., Ha, Y. & Smith, S. B., Jul 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5551-5558 8 p.

Research output: Contribution to journalArticle

32 Scopus citations
72 Scopus citations

Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress

Mohamed, R., Sharma, I., Ibrahim, A. S., Saleh, H., Elsherbiny, N. M., Fulzele, S., Elmasry, K., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., Dec 1 2017, In : Scientific reports. 7, 1, 09731.

Research output: Contribution to journalArticle

12 Scopus citations

Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration

Ibrahim, A. S., Mander, S., Hussein, K. A., Elsherbiny, N. M., Smith, S. B., Al-Shabrawey, M. & Tawfik, A., 2016, In : Oncotarget. 7, 8, p. 8532-8545 14 p.

Research output: Contribution to journalArticle

15 Scopus citations

Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Müller glial cells and NRF2

Navneet, S., Zhao, J., Wang, J., Mysona, B. A., Barwick, S., Ammal Kaidery, N., Saul, A. B., Kaddour-Djebbar, I., Bollag, W. B., Thomas, B., Bollinger, K. E. & Smith, S. B., Jun 2019, In : Redox Biology. 24, 101199.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth

Sonne, S. R., Bhalla, V. K., Barman, S. A., White, R. E., Zhu, S., Newman, T. M., Prasad, P. D., Smith, S. B., Offermanns, S. & Ganapathy, V., May 14 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 8, p. 1149-1158 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells

Mo, J., Zhang, M., Marshall, B., Smith, S., Covar, J. & Atherton, S., Aug 14 2014, In : Molecular Vision. 20, p. 1161-1173 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
8 Scopus citations

Iron-mediated retinal degeneration in haemojuvelin-knockout mice

Gnana-Prakasam, J. P., Tawfik, A., Romej, M., Ananth, S., Martin, P. M., Smith, S. B. & Ganapathy, V., Jan 15 2012, In : Biochemical Journal. 441, 2, p. 599-608 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression

Chaudhary, K., Promsote, W., Ananth, S., Veeranan-Karmegam, R., Tawfik, A. M., Arjunan, P., Martin, P. M., Smith, S. B., Thangaraju, M., Kisselev, O., Ganapathy, V. & Gnana-Prakasam, J. P., Dec 1 2018, In : Scientific reports. 8, 1, 3025.

Research output: Contribution to journalArticle

13 Scopus citations

Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1)

Ha, Y., Saul, A. B., Tawfik, A. M., Williams, C., Bollinger, K. E., Smith, R., Tachikawa, M., Zorrilla, E., Ganapathy, V. & Smith, S. B., Sep 2011, In : Investigative Ophthalmology and Visual Science. 52, 10, p. 7749-7760 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells

Gnana-Prakasam, J. P., Veeranan-Karmegam, R., Coothankandaswamy, V., Reddy, S. K., Martin, P. M., Thangaraju, M., Smith, S. B. & Ganapathy, V., Jan 2013, In : Investigative Ophthalmology and Visual Science. 54, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Mechanisms of ER Stress in Retinal Disease

Smith, S. B., Dec 1 2012, Retina Fifth Edition. Elsevier Inc., Vol. 1. p. 529-536 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Molecular mechanism of SLC5A8 inactivation in breast cancer

Elangovan, S., Pathania, R., Ramachandran, S., Ananth, S., Padia, R. N., Srinivas, S. R., Babu, E., Hawthorn, L., Schoenlein, P. V., Boettger, T., Smith, S. B., Prasad, P. D., Ganapathy, V. & Thangaraju, M., 2013, In : Molecular and Cellular Biology. 33, 19, p. 3920-3935 16 p.

Research output: Contribution to journalArticle

20 Scopus citations
21 Scopus citations

Mthfr as a modifier of the retinal phenotype of Crb1rd8/rd8 mice

Markand, S., Saul, A., Tawfik, A., Cui, X., Rozen, R. & Smith, S. B., Apr 1 2016, In : Experimental eye research. 145, p. 164-172 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Oral Monomethyl Fumarate Therapy Ameliorates Retinopathy in a Humanized Mouse Model of Sickle Cell Disease

Promsote, W., Powell, F. L., Veean, S., Thounaojam, M., Markand, S., Saul, A., Gutsaeva, D., Bartoli, M., Smith, S. B., Ganapathy, V. & Martin, P. M., Dec 10 2016, In : Antioxidants and Redox Signaling. 25, 17, p. 921-935 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection

Zhu, S., Luo, H., Liu, H., Ha, Y., Mays, E. R., Lawrence, R. E., Winkelmann, E., Barrett, A. D., Smith, S. B., Wang, M., Wang, T. & Zhang, W., Sep 2017, In : Antiviral Research. 145, p. 70-81 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Pigment epithelium-derived factor inhibits retinal microvascular dysfunction induced by 12/15-lipoxygenase-derived eicosanoids

Ibrahim, A. S., Tawfik, A. M., Hussein, K. A., Elshafey, S., Markand, S., Rizk, N., Duh, E. J., Smith, S. B. & Al-Shabrawey, M., Mar 2015, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1851, 3, p. 290-298 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis

Gnana-Prakasam, J. P., Reddy, S. K., Veeranan-Karmegam, R., Smith, S. B., Martin, P. M. & Ganapathy, V., Nov 2011, In : Investigative Ophthalmology and Visual Science. 52, 12, p. 9279-9286 8 p.

Research output: Contribution to journalArticle

18 Scopus citations