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  • Sylvia B Smith
2013

Cystathionine beta synthase expression in mouse retina

Markand, S., Tawfik, A., Ha, Y., Gnana-Prakasam, J., Sonne, S., Ganapathy, V., Sen, N., Xian, M. & Smith, S. B., May 2013, In : Current Eye Research. 38, 5, p. 597-604 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Diabetes and Overexpression of proNGF Cause Retinal Neurodegeneration via Activation of RhoA Pathway

Al-Gayyar, M. M. H., Mysona, B. A., Matragoon, S., Abdelsaid, M. A., El-Azab, M. F., Shanab, A. Y., Ha, Y., Smith, S. B., Bollinger, K. E. & El-Remessy, A. B., Jan 30 2013, In : PloS one. 8, 1, e54692.

Research output: Contribution to journalArticle

28 Scopus citations

GADD34 induces cell death through inactivation of Akt following traumatic brain injury

Farook, J. M., Shields, J., Tawfik, A., Markand, S., Sen, T., Smith, S. B., Brann, D., Dhandapani, K. M. & Sen, N., Aug 2013, In : Cell Death and Disease. 4, 8, e754.

Research output: Contribution to journalArticle

44 Scopus citations

Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth

Sonne, S. R., Bhalla, V. K., Barman, S. A., White, R. E., Zhu, S., Newman, T. M., Prasad, P. D., Smith, S. B., Offermanns, S. & Ganapathy, V., May 14 2013, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 8, p. 1149-1158 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells

Gnana-Prakasam, J. P., Veeranan-Karmegam, R., Coothankandaswamy, V., Reddy, S. K., Martin, P. M., Thangaraju, M., Smith, S. B. & Ganapathy, V., Jan 2013, In : Investigative Ophthalmology and Visual Science. 54, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Molecular mechanism of SLC5A8 inactivation in breast cancer

Elangovan, S., Pathania, R., Ramachandran, S., Ananth, S., Padia, R. N., Srinivas, S. R., Babu, E., Hawthorn, L., Schoenlein, P. V., Boettger, T., Smith, S. B., Prasad, P. D., Ganapathy, V. & Thangaraju, M., 2013, In : Molecular and Cellular Biology. 33, 19, p. 3920-3935 16 p.

Research output: Contribution to journalArticle

20 Scopus citations

Regulation of vitamin C transporter in the type 1 diabetic mouse bone and bone marrow

Sangani, R., Naime, M., Zakhary, I., Ahmad, S., Chutkan, N., Zhu, A., Ha, Y., Hamrick, M., Isales, C., Elsalanty, M., Smith, S., Liou, G. I. & Fulzele, S., Dec 2013, In : Experimental and Molecular Pathology. 95, 3, p. 298-306 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

The cystine/glutamate antiporter system xc- in health and disease: From molecular mechanisms to novel therapeutic opportunities

Lewerenz, J., Hewett, S. J., Huang, Y., Lambros, M., Gout, P. W., Kalivas, P. W., Massie, A., Smolders, I., Methner, A., Pergande, M., Smith, S. B., Ganapathy, V. & Maher, P., Feb 10 2013, In : Antioxidants and Redox Signaling. 18, 5, p. 522-555 34 p.

Research output: Contribution to journalReview article

306 Scopus citations
2012

Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia

Yu, M., Sturgill-Short, G., Ganapathy, P., Tawfik, A., Peachey, N. S. & Smith, S. B., Mar 2012, In : Experimental eye research. 96, 1, p. 124-131 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor

Ha, Y., Saul, A. B., Tawfik, A. M., Zorrilla, E. P., Ganapathy, V. & Smith, S. B., Nov 30 2012, In : Molecular Vision. 18, p. 2860-2870 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.

Gambhir, D., Ananth, S., Veeranan-Karmegam, R., Elangovan, S., Hester, S., Jennings, E., Offermanns, S., Nussbaum, J. J., Smith, S. B., Thangaraju, M., Ganapathy, V. & Martin, P. M., Apr 2012, In : Investigative ophthalmology & visual science. 53, 4, p. 2208-2217 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Iron-mediated retinal degeneration in haemojuvelin-knockout mice

Gnana-Prakasam, J. P., Tawfik, A., Romej, M., Ananth, S., Martin, P. M., Smith, S. B. & Ganapathy, V., Jan 15 2012, In : Biochemical Journal. 441, 2, p. 599-608 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Mechanisms of ER Stress in Retinal Disease

Smith, S. B., Dec 1 2012, Retina Fifth Edition. Elsevier Inc., Vol. 1. p. 529-536 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Regulation of proton-coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate

Bozard, B. R., Chothe, P. P., Tawfik, A., Williams, C., Fulzele, S., Prasad, P. D., Martin, P. M., Ganapathy, V. & Smith, S. B., Mar 2012, In : Glia. 60, 3, p. 333-342 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Transport of the synthetic opioid peptide DADLE ([d-Ala2,d-Leu5]-Enkephalin) in neuronal cells

Ananth, S., Thakkar, S. V., Gnana-prakasam, J. P., Martin, P. M., Ganapathy, P. S., Smith, S. B. & Ganapathy, V., Jan 2012, In : Journal of Pharmaceutical Sciences. 101, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2011

Cutting edge: IRF8 regulates bax transcription in vivo in primary myeloid cells

Yang, J., Hu, X., Zimmerman, M., Torres, C. M., Yang, D., Smith, S. B. & Liu, K., Nov 1 2011, In : Journal of Immunology. 187, 9, p. 4426-4430 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

D-serine and serine racemase in the retina

Smith, S. B., Ha, Y. & Ganapathy, V., Nov 24 2011, Amino Acids in Human Nutrition and Health. CABI Publishing, p. 137-149 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium

Gnana-Prakasam, J. P., Ananth, S., Prasad, P. D., Zhang, M., Atherton, S. S., Martin, P. M., Smith, S. B. & Ganapathy, V., May 2011, In : Investigative Ophthalmology and Visual Science. 52, 6, p. 3751-3758 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Functional characterization of folate transport proteins in staten's seruminstitut rabbit corneal epithelial cell line

Jwala, J., Boddu, S. H. S., Paturi, D. K., Shah, S., Smith, S. B., Pal, D. & Mitra, A. K., May 2011, In : Current Eye Research. 36, 5, p. 404-416 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells

Ganapathy, P. S., Perry, R. L., Tawfik, A. M., Smith, R. M., Perry, E., Roon, P., Renee Bozard, B., Ha, Y. & Smith, S. B., Jul 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5551-5558 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1)

Ha, Y., Saul, A. B., Tawfik, A. M., Williams, C., Bollinger, K. E., Smith, R., Tachikawa, M., Zorrilla, E., Ganapathy, V. & Smith, S. B., Sep 2011, In : Investigative Ophthalmology and Visual Science. 52, 10, p. 7749-7760 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis

Gnana-Prakasam, J. P., Reddy, S. K., Veeranan-Karmegam, R., Smith, S. B., Martin, P. M. & Ganapathy, V., Nov 2011, In : Investigative Ophthalmology and Visual Science. 52, 12, p. 9279-9286 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons

Ha, Y., Dun, Y., Thangaraju, M., Duplantier, J., Dong, Z., Liu, K., Ganapathy, V. & Smith, S. B., Jan 2011, In : Investigative Ophthalmology and Visual Science. 52, 1, p. 527-540 14 p.

Research output: Contribution to journalArticle

57 Scopus citations

The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of retinal ganglion cells

Ganapathy, P. S., White, R. E., Ha, Y., Renee Bozard, B., McNeil, P. L., Caldwell, R. W., Kumar, S., Black, S. M. & Smith, S. B., Jul 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5515-5524 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis

Chothe, P. P., Gnana-Prakasam, J. P., Ananth, S., Martin, P. M., Kannan, R., Hinton, D. R., Smith, S. B. & Ganapathy, V., Feb 11 2011, In : Biochemical and Biophysical Research Communications. 405, 2, p. 244-249 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells

Babu, E., Ananth, S., Veeranan-Karmegam, R., Coothankandaswamy, V., Smith, S. B., Boettger, T., Ganapathy, V. & Martin, P. M., Jul 2011, In : Investigative Ophthalmology and Visual Science. 52, 8, p. 5749-5757 9 p.

Research output: Contribution to journalArticle

13 Scopus citations