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  • Abdullah Kutlar
2020

American Society of Hematology 2020 guidelines for sickle cell disease: management of acute and chronic pain

Brandow, A. M., Carroll, C. P., Creary, S., Edwards-Elliott, R., Glassberg, J., Hurley, R. W., Kutlar, A., Seisa, M., Stinson, J., Strouse, J. J., Yusuf, F., Zempsky, W. & Lang, E., Jun 23 2020, In : Blood Advances. 4, 12, p. 2656-2701 46 p.

Research output: Contribution to journalArticle

Open Access

Characteristics and potential biomarkers of adult sickle cell patients with chronic pain

Albo, C., Kumar, S., Pope, M., Kidwell, K. M., Xu, H., Bowman, L., Wells, L., Barrett, N., Fields, S., Bora, P., Patel, N. & Kutlar, A., 2020, (Accepted/In press) In : European Journal of Haematology.

Research output: Contribution to journalArticle

DIAPH1 Mutation as a Novel Cause of Autosomal Dominant Macrothrombocytopenia and Hearing Loss

Karki, N. R., Ajebo, G. H., Savage, N. & Kutlar, A., 2020, (Accepted/In press) In : Acta Haematologica.

Research output: Contribution to journalArticle

Integration of mobile health into sickle cell disease care to increase hydroxyurea utilization: Protocol for an efficacy and implementation study

Sickle Cell Disease Implementation Consortium, Jul 2020, In : JMIR Research Protocols. 9, 7, e16319.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Regulation of iron homeostasis through the erythroferrone-hepcidin axis in sickle cell disease

Mangaonkar, A. A., Thawer, F., Son, J., Ajebo, G. H., Xu, H., Barrett, N. J., Wells, L. G., Bowman, L., Clair, B., Patel, N., Bora, P., Jung, G., Nemeth, E. & Kutlar, A., Jun 1 2020, In : British Journal of Haematology. 189, 6, p. 1204-1209 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Effect of crizanlizumab on pain crises in subgroups of patients with sickle cell disease: A SUSTAIN study analysis

Kutlar, A., Kanter, J., Liles, D. K., Alvarez, O. A., Cançado, R. D., Friedrisch, J. R., Knight-Madden, J. M., Bruederle, A., Shi, M., Zhu, Z. & Ataga, K. I., Jan 2019, In : American Journal of Hematology. 94, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease

Li, B., Zhu, X., Ward, C. M., Starlard-Davenport, A., Takezaki, M., Berry, A., Ward, A., Wilder, C., Neunert, C., Kutlar, A. & Pace, B. S., Feb 2019, In : Experimental Hematology. 70, p. 85-96.e5

Research output: Contribution to journalArticle

11 Scopus citations
2018

A thalidomide–hydroxyurea hybrid increases HbF production in sickle cell mice and reduces the release of proinflammatory cytokines in cultured monocytes

Lanaro, C., Franco-Penteado, C. F., Silva, F. H., Fertrin, K. Y., dos Santos, J. L., Wade, M., Yerigenahally, S., de Melo, T. R., Chin, C. M., Kutlar, A., Meiler, S. E. & Costa, F. F., Feb 2018, In : Experimental Hematology. 58, p. 35-38 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

CB1R-mediated activation of caspase-3 causes epigenetic and neurobehavioral abnormalities in postnatal ethanol-exposed mice

Subbanna, S., Nagre, N. N., Shivakumar, M., Joshi, V., Psychoyos, D., Kutlar, A., Umapathy, N. S. & Basavarajappa, B. S., Feb 20 2018, In : Frontiers in Molecular Neuroscience. 11, 45.

Research output: Contribution to journalArticle

10 Scopus citations

The missing middle of sickle therapeutics: Multi-agent therapy, targeting risk, using biomarkers

Hebbel, R. P., Elion, J. & Kutlar, A., Dec 2018, In : American Journal of Hematology. 93, 12, p. 1439-1443 5 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
2017

Crizanlizumab for the prevention of pain crises in sickle cell disease

Ataga, K. I., Kutlar, A., Kanter, J., Liles, D., Cancado, R., Friedrisch, J., Guthrie, T. H., Knight-Madden, J., Alvarez, O. A., Gordeuk, V. R., Gualandro, S., Colella, M. P., Smith, W. R., Rollins, S. A., Stocker, J. W. & Rother, R. P., Feb 2 2017, In : New England Journal of Medicine. 376, 5, p. 429-439 11 p.

Research output: Contribution to journalArticle

177 Scopus citations

Crizanlizumab in sickle cell disease

Ataga, K. I., Kutlar, A. & Kanter, J., May 4 2017, In : New England Journal of Medicine. 376, 18, p. 1795-1796 2 p.

Research output: Contribution to journalLetter

21 Scopus citations

Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with index of hydroxyurea responsiveness

Zhu, X., Hu, T., Ho, M. H., Wang, Y., Yu, M., Patel, N., Pi, W., Choi, J-H., Xu, H., Ganapathy, V., Kutlar, F., Kutlar, A. & Tuan Lo, D., Nov 30 2017, In : Haematologica. 102, 12, p. 1995-2004 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Long-term endothelin-a receptor antagonism provides robust renal protection in humanized sickle cell disease mice

Kasztan, M., Fox, B. M., Speed, J. S., De Miguel, C., Gohar, E. Y., Townes, T. M., Kutlar, A., Pollock, J. S. & Pollock, D. M., Aug 2017, In : Journal of the American Society of Nephrology. 28, 8, p. 2443-2458 16 p.

Research output: Contribution to journalArticle

26 Scopus citations

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci

Canver, M. C., Lessard, S., Pinello, L., Wu, Y., Ilboudo, Y., Stern, E. N., Needleman, A. J., Galactéros, F., Brugnara, C., Kutlar, A., McKenzie, C., Reid, M., Chen, D. D., Das, P. P., A Cole, M., Zeng, J., Kurita, R., Nakamura, Y., Yuan, G. C., Lettre, G. & 2 others, Bauer, D. E. & Orkin, S. H., Mar 30 2017, In : Nature Genetics. 49, 4, p. 625-634 10 p.

Research output: Contribution to journalArticle

52 Scopus citations
2016

Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species

Brett Heimlich, J., Speed, J. S., O'Connor, P. M., Pollock, J. S., Townes, T. M., Meiler, S. E., Kutlar, A. & Pollock, D. M., Jan 1 2016, In : British Journal of Pharmacology. 173, 2, p. 386-395 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia - TCD with Transfusions Changing to Hydroxyurea (TWiTCH): A multicentre, open-label, phase 3, non-inferiority trial

Ware, R. E., Davis, B. R., Schultz, W. H., Brown, R. C., Aygun, B., Sarnaik, S., Odame, I., Fuh, B., George, A., Owen, W., Luchtman-Jones, L., Rogers, Z. R., Hilliard, L., Gauger, C., Piccone, C., Lee, M. T., Kwiatkowski, J. L., Jackson, S., Miller, S. T., Roberts, C. & 25 others, Heeney, M. M., Kalfa, T. A., Nelson, S., Imran, H., Nottage, K., Alvarez, O., Rhodes, M., Thompson, A. A., Rothman, J. A., Helton, K. J., Roberts, D., Coleman, J., Bonner, M. J., Kutlar, A., Patel, N., Wood, J., Piller, L., Wei, P., Luden, J., Mortier, N. A., Stuber, S. E., Luban, N. L. C., Cohen, A. R., Pressel, S. & Adams, R. J., Feb 13 2016, In : The Lancet. 387, 10019, p. 661-670 10 p.

Research output: Contribution to journalArticle

205 Scopus citations

Intrapatient variability in fetal hemoglobin measurements over time in sickle cell patients not on fetal hemoglobin inducing agents

Knapp, E., Cohen, H., Kutlar, A., Ghalie, R. & Manwani, D., Mar 1 2016, In : American Journal of Hematology. 91, 3, p. E11-E12

Research output: Contribution to journalLetter

Progressing Preemptive Genotyping of CYP2C19 Allelic Variants for Sickle Cell Disease Patients

Jaja, C., Barrett, N., Patel, N., Lyon, M., Xu, H. & Kutlar, A., Oct 1 2016, In : Genetic Testing and Molecular Biomarkers. 20, 10, p. 609-615 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Pulmonary platelet thrombi and vascular pathology in acute chest syndrome in patients with sickle cell disease

Anea, C. B., Lyon, M., Lee, I. A., Gonzales, J. N., Adeyemi, A., Falls, G., Kutlar, A. & Brittain, J. E., Feb 1 2016, In : American Journal of Hematology. 91, 2, p. 173-178 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2015

A new ªγ-globin chain variant: Hb F-Sykesville MD [ªγ113(G15)Val → Ile; HBG1: C.340G>A] detected in a caucasian baby

Patel, N., Fixler, J., Unguru, Y., Kutlar, A. & Kutlar, F., Jan 1 2015, In : Hemoglobin. 39, 1, p. 52-54 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Coagulation activation in sickle cell trait: An exploratory study

Amin, C., Adam, S., Mooberry, M. J., Kutlar, A., Kutlar, F., Esserman, D., Brittain, J. E., Ataga, K. I., Chang, J. Y., Wolberg, A. S. & Key, N. S., Nov 2015, In : British Journal of Haematology. 171, 4, p. 638-646 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Preemptive Genotyping of CYP2C8 and CYP2C9 Allelic Variants Involved in NSAIDs Metabolism for Sickle Cell Disease Pain Management

Jaja, C., Bowman, L., Wells, L., Patel, N., Xu, H., Lyon, M. & Kutlar, A., Aug 1 2015, In : Clinical and Translational Science. 8, 4, p. 272-280 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2014

A double-blind, placebo-controlled phase II study of the efficacy and safety of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease

Reid, M. E., El Beshlawy, A., Inati, A., Kutlar, A., Abboud, M. R., Haynes, J., Ward, R., Sharon, B., Taher, A. T., Smith, W., Manwani, D. & Ghalie, R. G., Jul 2014, In : American Journal of Hematology. 89, 7, p. 709-713 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Cellular adhesion and the endothelium: P-selectin

Kutlar, A. & Embury, S. H., Apr 1 2014, In : Hematology/Oncology Clinics of North America. 28, 2, p. 323-339 17 p.

Research output: Contribution to journalReview article

32 Scopus citations
4 Scopus citations

Two new hemoglobin variants: Hb tallahassee [α3(a1)ser→tyr; Hba2: C.11c>a] and hb madison-nc [β119(gh2)gly→ser; Hbb: C.358g>a]

Kutlar, F., Unguru, Y., Dixon, N., Patel, N., Bailey, L., Zhuang, L., Carmichael, H. & Kutlar, A., 2014, In : Hemoglobin. 38, 3, p. 207-210 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Two new γ chain variants: Hb F-Augusta GA [Gγ59(E3)Lys→Arg; HBG2: C.179A>G] and Hb F-Port Royal-II [Aγ125(H3)Glu→Ala; HBG1: C.377A>C]

Kutlar, F., Ameri, A., Patel, N. H., Zhuang, L., Johnson, L. E., Cheng, M. L. & Kutlar, A., Oct 1 2014, In : Hemoglobin. 38, 5, p. 376-380 5 p.

Research output: Contribution to journalArticle

1 Scopus citations
2013

A dose-escalation phase IIa study of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease

Kutlar, A., Reid, M. E., Inati, A., Taher, A. T., Abboud, M. R., El-Beshlawy, A., Buchanan, G. R., Smith, H., Ataga, K. I., Perrine, S. P. & Ghalie, R. G., Nov 2013, In : American Journal of Hematology. 88, 11, p. E255-E260

Research output: Contribution to journalArticle

21 Scopus citations

A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease

Wun, T., Soulieres, D., Frelinger, A. L., Krishnamurti, L., Novelli, E. M., Kutlar, A., Ataga, K. I., Knupp, C. L., McMahon, L. E., Strouse, J. J., Zhou, C., Heath, L. E., Nwachuku, C. E., Jakubowski, J. A., Riesmeyer, J. S. & Winters, K. J., 2013, In : Journal of Hematology and Oncology. 6, 1, 17.

Research output: Contribution to journalArticle

48 Scopus citations

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

Monda, K. L., Chen, G. K., Taylor, K. C., Palmer, C., Edwards, T. L., Lange, L. A., Ng, M. C. Y., Adeyemo, A. A., Allison, M. A., Bielak, L. F., Chen, G., Graff, M., Irvin, M. R., Rhie, S. K., Li, G., Liu, Y., Liu, Y., Lu, Y., Nalls, M. A., Sun, Y. V. & 188 others, Wojczynski, M. K., Yanek, L. R., Aldrich, M. C., Ademola, A., Amos, C. I., Bandera, E. V., Bock, C. H., Britton, A., Broeckel, U., Cai, Q., Caporaso, N. E., Carlson, C. S., Carpten, J., Casey, G., Chen, W. M., Chen, F., Chen, Y. D. I., Chiang, C. W. K., Coetzee, G. A., Demerath, E., Deming-Halverson, S. L., Driver, R. W., Dubbert, P., Feitosa, M. F., Feng, Y., Freedman, B. I., Gillanders, E. M., Gottesman, O., Guo, X., Haritunians, T., Harris, T., Harris, C. C., Hennis, A. J. M., Hernandez, D. G., McNeill, L. H., Howard, T. D., Howard, B. V., Howard, V. J., Johnson, K. C., Kang, S. J., Keating, B. J., Kolb, S., Kuller, L. H., Kutlar, A., Langefeld, C. D., Lettre, G., Lohman, K., Lotay, V., Lyon, H., Manson, J. E., Maixner, W., Meng, Y. A., Monroe, K. R., Morhason-Bello, I., Murphy, A. B., Mychaleckyj, J. C., Nadukuru, R., Nathanson, K. L., Nayak, U., N'Diaye, A., Nemesure, B., Wu, S. Y., Leske, M. C., Neslund-Dudas, C., Neuhouser, M., Nyante, S., Ochs-Balcom, H., Ogunniyi, A., Ogundiran, T. O., Ojengbede, O., Olopade, O. I., Palmer, J. R., Ruiz-Narvaez, E. A., Palmer, N. D., Press, M. F., Rampersaud, E., Rasmussen-Torvik, L. J., Rodriguez-Gil, J. L., Salako, B., Schadt, E. E., Schwartz, A. G., Shriner, D. A., Siscovick, D., Smith, S. B., Wassertheil-Smoller, S., Speliotes, E. K., Spitz, M. R., Sucheston, L., Taylor, H., Tayo, B. O., Tucker, M. A., Van Den Berg, D. J., Edwards, D. R. V., Wang, Z., Wiencke, J. K., Winkler, T. W., Witte, J. S., Wrensch, M., Wu, X., Yang, J. J., Levin, A. M., Young, T. R., Zakai, N. A., Cushman, M., Zanetti, K. A., Zhao, J. H., Zhao, W., Zheng, Y., Zhou, J., Ziegler, R. G., Zmuda, J. M., Fernandes, J. K., Gilkeson, G. S., Kamen, D. L., Hunt, K. J., Spruill, I. J., Ambrosone, C. B., Ambs, S., Arnett, D. K., Atwood, L., Becker, D. M., Berndt, S. I., Bernstein, L., Blot, W. J., Borecki, I. B., Bottinger, E. P., Bowden, D. W., Burke, G., Chanock, S. J., Cooper, R. S., Ding, J., Duggan, D., Evans, M. K., Fox, C., Garvey, W. T., Bradfield, J. P., Hakonarson, H., Grant, S. F. A., Hsing, A., Chu, L., Hu, J. J., Huo, D., Ingles, S. A., John, E. M., Jordan, J. M., Kabagambe, E. K., Kardia, S. L. R., Kittles, R. A., Goodman, P. J., Klein, E. A., Kolonel, L. N., Le Marchand, L., Liu, S., McKnight, B., Millikan, R. C., Mosley, T. H., Padhukasahasram, B., Williams, L. K., Patel, S. R., Peters, U., Pettaway, C. A., Peyser, P. A., Psaty, B. M., Redline, S., Rotimi, C. N., Rybicki, B. A., Sale, M. M., Schreiner, P. J., Signorello, L. B., Singleton, A. B., Stanford, J. L., Strom, S. S., Thun, M. J., Vitolins, M., Zheng, W., Moore, J. H., Williams, S. M., Ketkar, S., Zhu, X., Zonderman, A. B., Kooperberg, C., Papanicolaou, G. J., Henderson, B. E., Reiner, A. P., Hirschhorn, J. N., Loos, R. J. F., North, K. E. & Haiman, C. A., Jun 2013, In : Nature Genetics. 45, 6, p. 690-696 7 p.

Research output: Contribution to journalArticle

151 Scopus citations

Comparison of hematologic measurements between local and central laboratories: Data from the BABY HUG trial

Kalpatthi, R., Thompson, B., Lu, M., Wang, W. C., Patel, N., Kutlar, A., Howard, T., Luchtman-Jones, L. & Miller, S. T., Feb 2013, In : Clinical Biochemistry. 46, 3, p. 278-281 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Corrigendum to "Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemia" [Cytokine 60 (2012) 302-308]

Hyacinth, H. I., Gee, B. E., Adamkiewicz, T. V., Adams, R. J., Kutlar, A., Stiles, J. K. & Hibbert, J. M., Apr 1 2013, In : Cytokine. 62, 1, 1 p.

Research output: Contribution to journalComment/debate

Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients

Galarneau, G., Coady, S., Garrett, M. E., Jeffries, N., Puggal, M., Paltoo, D., Soldano, K., Guasch, A., Ashley-Koch, A. E., Telen, M. J., Kutlar, A., Lettre, G. & Papanicolaou, G. J., Jul 18 2013, In : Blood. 122, 3, p. 434-442 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Genetic modifiers of sickle cell anemia in the baby hug cohort: Influence on laboratory and clinical phenotypes

Sheehan, V. A., Luo, Z., Flanagan, J. M., Howard, T. A., Thompson, B. W., Wang, W. C., Kutlar, A. & Ware, R. E., Jul 1 2013, In : American Journal of Hematology. 88, 7, p. 571-576 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Genome-wide association study of cardiac structure and systolic function in African Americans the Candidate gene Association Resource (CARe) study

Fox, E. R., Musani, S. K., Barbalic, M., Lin, H., Yu, B., Ogunyankin, K. O., Smith, N. L., Kutlar, A., Glazer, N. L., Post, W. S., Paltoo, D. N., Dries, D. L., Farlow, D. N., Duarte, C. W., Kardia, S. L., Meyers, K. J., Sun, Y. V., Arnett, D. K., Patki, A. A., Sha, J. & 17 others, Cui, X., Samdarshi, T. E., Penman, A. D., Bibbins-Domingo, K., Bůžková, P., Benjamin, E. J., Bluemke, D. A., Morrison, A. C., Heiss, G., Carr, J. J., Tracy, R. P., Mosley, T. H., Taylor, H. A., Psaty, B. M., Heckbert, S. R., Cappola, T. P. & Vasan, R. S., Feb 2013, In : Circulation: Cardiovascular Genetics. 6, 1, p. 37-46 10 p.

Research output: Contribution to journalReview article

29 Scopus citations

GLEE-ful for sickle cell pain?

Kutlar, A., Sep 12 2013, In : Blood. 122, 11, p. 1846-1847 2 p.

Research output: Contribution to journalComment/debate

5 Scopus citations

Hb fulton-georgia [α20(B1)His→Pro; HBA1: C.62A>C]: A new α-Globin variant coinherited with α-Thalassemia-2 (3.7 kb deletion) and Hb SC disease

Zhuang, L., Patel, N., Bryant, S., Kutlar, A., Kutlar, F. & Young, A. N., Sep 12 2013, In : Hemoglobin. 37, 5, p. 481-485 5 p.

Research output: Contribution to journalArticle

Loci influencing blood pressure identified using a cardiovascular gene-centric array

Ganesh, S. K., Tragante, V., Guo, W., Guo, Y., Lanktree, M. B., Smith, E. N., Johnson, T., Castillo, B. A., Barnard, J., Baumert, J., Chang, Y. P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Gaunt, N. F., Johannes, J. M. I., Gieger, C., Gong, Y., Isaacs, A., Kleber, M. E. & 116 others, Leach, I. M., McDonough, C. W., Meijs, M. F. L., Mellander, O., Molony, C. M., Nolte, I. M., Price, S. P., Rajagopalan, R., Shaffer, J., Shah, S., Shen, H., Soranzo, N., van der Most, P. J., Van Iperen, E. P. A., Van Setten, J., Vonk, J. M., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Boer, J. M. A., Boerwinkle, E., Burkley, B., Burt, A., Chakravarti, A., Chen, W., Cooper-DeHoff, R. M., Curtis, S. P., Dreisbach, A., Duggan, D., Ehret, G. B., Fabsitz, R. R., Fornage, M., Fox, E., Furlong, C. E., Gansevoort, R. T., Hofker, M. H., Hovingh, G. K., Kirkland, S. A., Kottke-Marchant, K., Kutlar, A., LaCroix, A. Z., Langaee, T. Y., Li, Y. R., Lin, H., Liu, K., Maiwald, S., Malik, R., Metastroke, C., Murugesan, G., Newton-Cheh, C., O'Connell, J. R., Onland-Moret, N. C., Ouwehand, W. H., Palmas, W., Penninx, B. W., Pepine, C. J., Pettinger, M., Polak, J. F., Ramachandran, V. S., Ranchalis, J., Redline, S., Ridker, P. M., Rose, L. M., Scharnag, H., Schork, N. J., Shimbo, D., Shuldiner, A. R., Srinivasan, S. R., Stolk, R. P., Taylor, H. A., Thorand, B., Trip, M. D., van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Winkelmann, B. R., Wyatt, S., Young, J. H., Boehm, B. O., Caulfield, M. J., Chasman, D. I., Davidson, K. W., Doevendans, P. A., FitzGerald, G. A., Gums, J. G., Hakonarson, H., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J. P., Koenig, W., Study, L. L. C., rz, W. M., Mitchell, B. D., Murray, S. S., Oldehinkel, A. J., Rader, D. J., Reilly, M. P., Reiner, A. P., Schadt, E. E., Silverstein, R. L., Snieder, H., Stanton, A. V., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Samani, N. J., Johnson, A. D., Munroe, P. B., de Bakker, P. I. W., Zhu, X., Levy, D., Keating, B. J. & Asselbergs, F. W., Aug 2013, In : Human Molecular Genetics. 22, 16, p. 3394-3395 2 p., ddt177.

Research output: Contribution to journalComment/debate

10 Scopus citations

Loci influencing blood pressure identified using a cardiovascular gene-centric array

Ganesh, S. K., Tragante, V., Guo, W., Guo, Y., Lanktree, M. B., Smith, E. N., Johnson, T., Castillo, B. A., Barnard, J., Baumert, J., Chang, Y. P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Franceschini, N., Gaunt, T. R., Gho, J. M. I. H., Gieger, C., Gong, Y., Isaacs, A. & 117 others, Kleber, M. E., Leach, I. M., McDonough, C. W., Meijs, M. F. L., Mellander, O., Molony, C. M., Nolte, I. M., Padmanabhan, S., Price, T. S., Rajagopalan, R., Shaffer, J., Shah, S., Shen, H., Soranzo, N., van der Most, P. J., Van Iperen, E. P. A., Van Setten, J. A., Vonk, J. M., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Boer, J. M. A., Boerwinkle, E., Burkley, B., Burt, A., Chakravarti, A., Chen, W., Cooper-DeHoff, R. M., Curtis, S. P., Dreisbach, A., Duggan, D., Ehret, G. B., Fabsitz, R. R., Fornage, M., Fox, E., Furlong, C. E., Gansevoort, R. T., Hofker, M. H., Hovingh, G. K., Kirkland, S. A., Kottke-Marchant, K., Kutlar, A., LaCroix, A. Z., Langaee, T. Y., Li, Y. R., Lin, H., Liu, K., Maiwald, S., Malik, R., Murugesan, G., Newton-Cheh, C., O'Connell, J. R., Onland-Moret, N. C., Ouwehand, W. H., Palmas, W., Penninx, B. W., Pepine, C. J., Pettinger, M., Polak, J. F., Ramachandran, V. S., Ranchalis, J., Redline, S., Ridker, P. M., Rose, L. M., Scharnag, H., Schork, N. J., Shimbo, D., Shuldiner, A. R., Srinivasan, S. R., Stolk, R. P., Taylor, H. A., Thorand, B., Trip, M. D., van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Winkelmann, B. R., Wyatt, S., Young, J. H., Boehm, B. O., Caulfield, M. J., Chasman, D. I., Davidson, K. W., Doevendans, P. A., FitzGerald, G. A., Gums, J. G., Hakonarson, H., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J. P., Koenig, W., Study, L. L. C., März, W., Mitchell, B. D., Murray, S. S., Oldehinkel, A. J., Rader, D. J., Reilly, M. P., Reiner, A. P., Schadt, E. E., Silverstein, R. L., Snieder, H., Stanton, A. V., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Samani, N. J., Johnson, A. D., Munroe, P. B., de Bakker, P. I. W., Zhu, X., Levy, D., Keating, B. J. & Asselbergs, F. W., Apr 2013, In : Human Molecular Genetics. 22, 8, p. 1663-1678 16 p.

Research output: Contribution to journalArticle

92 Scopus citations
2012

A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease

Kutlar, A., Ataga, K., Reid, M., Vichinsky, E. P., Neumayr, L., Blair-Britt, L., Labotka, R., Glass, J., Keefer, J. R., Wargin, W. A., Berenson, R. & Perrine, S. P., Nov 2012, In : American Journal of Hematology. 87, 11, p. 1017-1021 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

A potent oral P-selectin blocking agent improves microcirculatory blood flow and a marker of endothelial cell injury in patients with sickle cell disease

Kutlar, A., Ataga, K. I., Mcmahon, L., Howard, J., Galacteros, F., Hagar, W., Vichinsky, E., Cheung, A. T. W., Matsui, N. & Embury, S. H., May 2012, In : American Journal of Hematology. 87, 5, p. 536-539 4 p.

Research output: Contribution to journalLetter

53 Scopus citations

Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemia

Hyacinth, H. I., Gee, B. E., Adamkiewicz, T. V., Adams, R. J., Kutlar, A., Stiles, J. K. & Hibbert, J. M., Oct 2012, In : Cytokine. 60, 1, p. 302-308 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Thalidomide and its analogs for hemoglobinopathies: Two birds with one stone?

Kutlar, A., Meiler, S., Swerdlow, P. & Knight, R., Feb 1 2012, In : Expert Review of Hematology. 5, 1, p. 9-11 3 p.

Research output: Contribution to journalEditorial

1 Scopus citations
2011

Association of genetic variation with systolic and diastolic blood pressure among african americans: The candidate gene association resource study

Fox, E. R., Young, J. H., Li, Y., Dreisbach, A. W., Keating, B. J., Musani, S. K., Liu, K., Morrison, A. C., Ganesh, S., Kutlar, A., Ramachandran, V. S., Polak, J. F., Fabsitz, R. R., Dries, D. L., Farlow, D. N., Redline, S., Adeyemo, A., Hirschorn, J. N., Sun, Y. V., Wyatt, S. B. & 23 others, Penman, A. D., Palmas, W., Rotter, J. I., Townsend, R. R., Doumatey, A. P., Tayo, B. O., Mosley, T. H., Lyon, H. N., Kang, S. J., Rotimi, C. N., Cooper, R. S., Franceschini, N., Curb, J. D., Martin, L. W., Eaton, C. B., Kardia, S. L. R., Taylor, H. A., Caulfield, M. J., Ehret, G. B., Johnson, T., Chakravarti, A., Zhu, X. & Levy, D., Jun 2011, In : Human Molecular Genetics. 20, 11, p. 2273-2284 12 p., ddr092.

Research output: Contribution to journalArticle

124 Scopus citations

Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: Contributions from the CARe consortium

Zhu, X., Young, J. H., Fox, E., Keating, B. J., Franceschini, N., Kang, S., Tayo, B., Adeyemo, A., Sun, Y. V., Li, Y., Morrison, A., Newton-Cheh, C., Liu, K., Ganesh, S. K., Kutlar, A., Vasan, R. S., Dreisbach, A., Wyatt, S., Polak, J., Palmas, W. & 19 others, Musani, S., Taylor, H., Fabsitz, R., Townsend, R. R., Dries, D., Glessner, J., Chiang, C. W. K., Mosley, T., Kardia, S., Curb, D., Hirschhorn, J. N., Rotimi, C., Reiner, A., Eaton, C., Rotter, J. I., Cooper, R. S., Redline, S., Chakravarti, A. & Levy, D., Jun 2011, In : Human Molecular Genetics. 20, 11, p. 2285-2295 11 p., ddr113.

Research output: Contribution to journalArticle

62 Scopus citations

Design, synthesis, and pharmacological evaluation of novel hybrid compounds to treat sickle cell disease symptoms

Dos Santos, J. L., Lanaro, C., Lima, L. M., Gambero, S., Franco-Penteado, C. F., Alexandre-Moreira, M. S., Wade, M., Yerigenahally, S., Kutlar, A., Meiler, S. E., Costa, F. F. & Chung, M., Aug 25 2011, In : Journal of Medicinal Chemistry. 54, 16, p. 5811-5819 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Genetic association for renal traits among participants of African Ancestry reveals new loci for renal function

Liu, C. T., Garnaas, M. K., Tin, A., Kottgen, A., Franceschini, N., Peralta, C. A., de Boer, I. H., Lu, X., Atkinson, E., Ding, J., Nalls, M., Shriner, D., Coresh, J., Kutlar, A., Bibbins-Domingo, K., Siscovick, D., Akylbekova, E., Wyatt, S., Astor, B., Mychaleckjy, J. & 21 others, Li, M., Reilly, M. P., Townsend, R. R., Adeyemo, A., Zonderman, A. B., de Andrade, M., Turner, S. T., Mosley, T. H., Harris, T. B., Rotimi, C. N., Liu, Y., Kardia, S. L. R., Evans, M. K., Shlipak, M. G., Kramer, H., Flessner, M. F., Dreisbach, A. W., Goessling, W., Cupples, L. A., Kao, W. L. & Fox, C. S., Sep 2011, In : PLoS Genetics. 7, 9, e1002264.

Research output: Contribution to journalArticle

84 Scopus citations

Hydroxycarbamide in very young children with sickle-cell anaemia: A multicentre, randomised, controlled trial (BABY HUG)

Wang, W. C., Ware, R. E., Miller, S. T., Iyer, R. V., Casella, J. F., Minniti, C. P., Rana, S., Thornburg, C. D., Rogers, Z. R., Kalpatthi, R. V., Barredo, J. C., Brown, R. C., Sarnaik, S. A., Howard, T. H., Wynn, L. W., Kutlar, A., Armstrong, F. D., Files, B. A., Goldsmith, J. C., Waclawiw, M. A. & 2 others, Huang, X. & Thompson, B. W., May 14 2011, In : The Lancet. 377, 9778, p. 1663-1672 10 p.

Research output: Contribution to journalArticle

426 Scopus citations

Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: A phase III randomized, placebo-controlled, double-blind study of the gardos channel blocker senicapoc (ICA-17043)

Ataga, K. I., Reid, M., Ballas, S. K., Yasin, Z., Bigelow, C., James, L. S., Smith, W. R., Galacteros, F., Kutlar, A., Hull, J. H. & Stocker, J. W., Apr 1 2011, In : British Journal of Haematology. 153, 1, p. 92-104 13 p.

Research output: Contribution to journalArticle

121 Scopus citations