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2019
12 Citations (Scopus)

Effect of crizanlizumab on pain crises in subgroups of patients with sickle cell disease: A SUSTAIN study analysis

Kutlar, A., Kanter, J., Liles, D. K., Alvarez, O. A., Cançado, R. D., Friedrisch, J. R., Knight-Madden, J. M., Bruederle, A., Shi, M., Zhu, Z. & Ataga, K. I., Jan 2019, In : American Journal of Hematology. 94, 1, p. 55-61 7 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Pain
Placebos
Hydroxyurea
P-Selectin
8 Citations (Scopus)

MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease

Li, B., Zhu, X., Ward, C. M., Starlard-Davenport, A., Takezaki, M., Berry, A., Ward, A., Wilder, C., Neunert, C., Kutlar, A. & Pace, B. S., Feb 2019, In : Experimental Hematology. 70, p. 85-96.e5

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
Sickle Cell Anemia
Gene Silencing
MicroRNAs
2018
2 Citations (Scopus)

A thalidomide–hydroxyurea hybrid increases HbF production in sickle cell mice and reduces the release of proinflammatory cytokines in cultured monocytes

Lanaro, C., Franco-Penteado, C. F., Silva, F. H., Fertrin, K. Y., dos Santos, J. L., Wade, M., Yerigenahally, S., de Melo, T. R., Chin, C. M., Kutlar, A., Meiler, S. E. & Costa, F. F., Feb 2018, In : Experimental Hematology. 58, p. 35-38 4 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Monocytes
Hydroxyurea
Cytokines
Thalidomide
8 Citations (Scopus)

CB1R-mediated activation of caspase-3 causes epigenetic and neurobehavioral abnormalities in postnatal ethanol-exposed mice

Subbanna, S., Nagre, N. N., Shivakumar, M., Joshi, V., Psychoyos, D., Kutlar, A., Umapathy, N. S. & Basavarajappa, B. S., Feb 20 2018, In : Frontiers in Molecular Neuroscience. 11, 45.

Research output: Contribution to journalArticle

Epigenomics
Caspase 3
Ethanol
Methyl-CpG-Binding Protein 2
Fetal Alcohol Spectrum Disorders

The missing middle of sickle therapeutics: Multi-agent therapy, targeting risk, using biomarkers

Hebbel, R. P., Elion, J. & Kutlar, A., Dec 2018, In : American Journal of Hematology. 93, 12, p. 1439-1443 5 p.

Research output: Contribution to journalComment/debate

Biomarkers
Therapeutics
2017
140 Citations (Scopus)

Crizanlizumab for the prevention of pain crises in sickle cell disease

Ataga, K. I., Kutlar, A., Kanter, J., Liles, D., Cancado, R., Friedrisch, J., Guthrie, T. H., Knight-Madden, J., Alvarez, O. A., Gordeuk, V. R., Gualandro, S., Colella, M. P., Smith, W. R., Rollins, S. A., Stocker, J. W. & Rother, R. P., Feb 2 2017, In : New England Journal of Medicine. 376, 5, p. 429-439 11 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Placebos
Pain
Acute Chest Syndrome
P-Selectin
10 Citations (Scopus)

Crizanlizumab in sickle cell disease

Ataga, K. I., Kutlar, A. & Kanter, J., May 4 2017, In : New England Journal of Medicine. 376, 18, p. 1795-1796 2 p.

Research output: Contribution to journalLetter

Sickle Cell Anemia
1 Citation (Scopus)

Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with index of hydroxyurea responsiveness

Zhu, X., Hu, T., Ho, M. H., Wang, Y., Yu, M., Patel, N., Pi, W., Choi, J-H., Xu, H., Ganapathy, V., Kutlar, F., Kutlar, A. & Tuan Lo, D., Nov 30 2017, In : Haematologica. 102, 12, p. 1995-2004 10 p.

Research output: Contribution to journalArticle

Erythroblasts
Hydroxyurea
Globins
Sickle Cell Anemia
Genes
23 Citations (Scopus)

Long-term endothelin-a receptor antagonism provides robust renal protection in humanized sickle cell disease mice

Kasztan, M., Fox, B. M., Speed, J. S., De Miguel, C., Gohar, E. Y., Townes, T. M., Kutlar, A., Pollock, J. S. & Pollock, D. M., Aug 2017, In : Journal of the American Society of Nephrology. 28, 8, p. 2443-2458 16 p.

Research output: Contribution to journalArticle

Endothelin Receptors
Sickle Cell Anemia
Kidney
Endothelin A Receptors
Albuminuria
44 Citations (Scopus)

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci

Canver, M. C., Lessard, S., Pinello, L., Wu, Y., Ilboudo, Y., Stern, E. N., Needleman, A. J., Galactéros, F., Brugnara, C., Kutlar, A., McKenzie, C., Reid, M., Chen, D. D., Das, P. P., A Cole, M., Zeng, J., Kurita, R., Nakamura, Y., Yuan, G. C., Lettre, G. & 2 others, Bauer, D. E. & Orkin, S. H., Mar 30 2017, In : Nature Genetics. 49, 4, p. 625-634 10 p.

Research output: Contribution to journalArticle

Mutagenesis
Libraries
Fetal Hemoglobin
Intergenic DNA
Genome-Wide Association Study
2016
17 Citations (Scopus)

Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species

Brett Heimlich, J., Speed, J. S., O'Connor, P. M., Pollock, J. S., Townes, T. M., Meiler, S. E., Kutlar, A. & Pollock, D. M., Jan 1 2016, In : British Journal of Pharmacology. 173, 2, p. 386-395 10 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Endothelin-1
Reactive Oxygen Species
Kidney
Wounds and Injuries
170 Citations (Scopus)

Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia - TCD with Transfusions Changing to Hydroxyurea (TWiTCH): A multicentre, open-label, phase 3, non-inferiority trial

Ware, R. E., Davis, B. R., Schultz, W. H., Brown, R. C., Aygun, B., Sarnaik, S., Odame, I., Fuh, B., George, A., Owen, W., Luchtman-Jones, L., Rogers, Z. R., Hilliard, L., Gauger, C., Piccone, C., Lee, M. T., Kwiatkowski, J. L., Jackson, S., Miller, S. T., Roberts, C. & 25 others, Heeney, M. M., Kalfa, T. A., Nelson, S., Imran, H., Nottage, K., Alvarez, O., Rhodes, M., Thompson, A. A., Rothman, J. A., Helton, K. J., Roberts, D., Coleman, J., Bonner, M. J., Kutlar, A., Patel, N., Wood, J., Piller, L., Wei, P., Luden, J., Mortier, N. A., Stuber, S. E., Luban, N. L. C., Cohen, A. R., Pressel, S. & Adams, R. J., Feb 13 2016, In : The Lancet. 387, 10019, p. 661-670 10 p.

Research output: Contribution to journalArticle

Hydroxyurea
Sickle Cell Anemia
Maintenance
Random Allocation
Stroke

Intrapatient variability in fetal hemoglobin measurements over time in sickle cell patients not on fetal hemoglobin inducing agents

Knapp, E., Cohen, H., Kutlar, A., Ghalie, R. & Manwani, D., Mar 1 2016, In : American Journal of Hematology. 91, 3, p. E11-E12

Research output: Contribution to journalLetter

Antisickling Agents
Fetal Hemoglobin
Statistical Data Interpretation
Butyrates
Sickle Cell Anemia
1 Citation (Scopus)

Progressing Preemptive Genotyping of CYP2C19 Allelic Variants for Sickle Cell Disease Patients

Jaja, C., Barrett, N., Patel, N., Lyon, M., Xu, H. & Kutlar, A., Oct 1 2016, In : Genetic Testing and Molecular Biomarkers. 20, 10, p. 609-615 7 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Alleles
Pharmaceutical Preparations
Phenotype
Proton Pump Inhibitors
12 Citations (Scopus)

Pulmonary platelet thrombi and vascular pathology in acute chest syndrome in patients with sickle cell disease

Anea, C. B., Lyon, M., Lee, I. A., Gonzales, J. N., Adeyemi, A., Falls, G., Kutlar, A. & Brittain, J. E., Feb 1 2016, In : American Journal of Hematology. 91, 2, p. 173-178 6 p.

Research output: Contribution to journalArticle

Acute Chest Syndrome
Sickle Cell Anemia
Blood Vessels
Thrombosis
Blood Platelets
2015
1 Citation (Scopus)

A new ªγ-globin chain variant: Hb F-Sykesville MD [ªγ113(G15)Val → Ile; HBG1: C.340G>A] detected in a caucasian baby

Patel, N., Fixler, J., Unguru, Y., Kutlar, A. & Kutlar, F., Jan 1 2015, In : Hemoglobin. 39, 1, p. 52-54 3 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
A 113
Molecular Pathology
Screening
12 Citations (Scopus)

Coagulation activation in sickle cell trait: An exploratory study

Amin, C., Adam, S., Mooberry, M. J., Kutlar, A., Kutlar, F., Esserman, D., Brittain, J. E., Ataga, K. I., Chang, J. Y., Wolberg, A. S. & Key, N. S., Nov 2015, In : British Journal of Haematology. 171, 4, p. 638-646 9 p.

Research output: Contribution to journalArticle

Sickle Cell Trait
Thromboplastin
Thrombin
Venous Thromboembolism
Sickle Cell Anemia
2 Citations (Scopus)

Preemptive Genotyping of CYP2C8 and CYP2C9 Allelic Variants Involved in NSAIDs Metabolism for Sickle Cell Disease Pain Management

Jaja, C., Bowman, L., Wells, L., Patel, N., Xu, H., Lyon, M. L. & Kutlar, A., Aug 1 2015, In : Clinical and Translational Science. 8, 4, p. 272-280 9 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Non-Steroidal Anti-Inflammatory Agents
Pain Management
Disease Management
Metabolism
2014
35 Citations (Scopus)

A double-blind, placebo-controlled phase II study of the efficacy and safety of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease

Reid, M. E., El Beshlawy, A., Inati, A., Kutlar, A., Abboud, M. R., Haynes, J., Ward, R., Sharon, B., Taher, A. T., Smith, W., Manwani, D. & Ghalie, R. G., Jul 2014, In : American Journal of Hematology. 89, 7, p. 709-713 5 p.

Research output: Contribution to journalArticle

2,2-dimethylbutyric acid
Globins
Sickle Cell Anemia
Placebos
Safety
30 Citations (Scopus)

Cellular adhesion and the endothelium: P-selectin

Kutlar, A. & Embury, S. H., Apr 1 2014, In : Hematology/Oncology Clinics of North America. 28, 2, p. 323-339 17 p.

Research output: Contribution to journalReview article

P-Selectin
Sickle Cell Anemia
Endothelium
Oral Administration
Therapeutics
4 Citations (Scopus)

CYP2C9 allelic variants and frequencies in a pediatric sickle cell disease cohort: Implications for NSAIDs pharmacotherapy

Jaja, C., Patel, N., Scott, S. A., Gibson, R. W. & Kutlar, A., Oct 1 2014, In : Clinical and Translational Science. 7, 5, p. 396-401 6 p.

Research output: Contribution to journalArticle

Drug therapy
Pediatrics
Sickle Cell Anemia
Anti-Inflammatory Agents
Drug Therapy
2 Citations (Scopus)

Two new hemoglobin variants: Hb tallahassee [α3(a1)ser→tyr; Hba2: C.11c>a] and hb madison-nc [β119(gh2)gly→ser; Hbb: C.358g>a]

Kutlar, F., Unguru, Y., Dixon, N., Patel, N., Bailey, L., Zhuang, L., Carmichael, H. & Kutlar, A., 2014, In : Hemoglobin. 38, 3, p. 207-210 4 p.

Research output: Contribution to journalArticle

Globins
Hemoglobins
Codon
Phenotype
Screening
1 Citation (Scopus)

Two new γ chain variants: Hb F-Augusta GA [Gγ59(E3)Lys→Arg; HBG2: C.179A>G] and Hb F-Port Royal-II [Aγ125(H3)Glu→Ala; HBG1: C.377A>C]

Kutlar, F., Ameri, A., Patel, N. H., Zhuang, L., Johnson, L. E., Cheng, M. L. & Kutlar, A., Oct 1 2014, In : Hemoglobin. 38, 5, p. 376-380 5 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
Molecular Pathology
African Americans
Screening
2013
18 Citations (Scopus)

A dose-escalation phase IIa study of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease

Kutlar, A., Reid, M. E., Inati, A., Taher, A. T., Abboud, M. R., El-Beshlawy, A., Buchanan, G. R., Smith, H., Ataga, K. I., Perrine, S. P. & Ghalie, R. G., Nov 1 2013, In : American Journal of Hematology. 88, 11, p. E255-E260

Research output: Contribution to journalArticle

2,2-dimethylbutyric acid
Globins
Sickle Cell Anemia
Sickle Hemoglobin
Fetal Hemoglobin
44 Citations (Scopus)

A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease

Wun, T., Soulieres, D., Frelinger, A. L., Krishnamurti, L., Novelli, E. M., Kutlar, A., Ataga, K. I., Knupp, C. L., McMahon, L. E., Strouse, J. J., Zhou, C., Heath, L. E., Nwachuku, C. E., Jakubowski, J. A., Riesmeyer, J. S. & Winters, K. J., Feb 19 2013, In : Journal of Hematology and Oncology. 6, 1, 17.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Placebos
Platelet Activation
P-Selectin
Platelet Aggregation Inhibitors
142 Citations (Scopus)

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

Monda, K. L., Chen, G. K., Taylor, K. C., Palmer, C., Edwards, T. L., Lange, L. A., Ng, M. C. Y., Adeyemo, A. A., Allison, M. A., Bielak, L. F., Chen, G., Graff, M., Irvin, M. R., Rhie, S. K., Li, G., Liu, Y., Liu, Y., Lu, Y., Nalls, M. A., Sun, Y. V. & 188 others, Wojczynski, M. K., Yanek, L. R., Aldrich, M. C., Ademola, A., Amos, C. I., Bandera, E. V., Bock, C. H., Britton, A., Broeckel, U., Cai, Q., Caporaso, N. E., Carlson, C. S., Carpten, J., Casey, G., Chen, W. M., Chen, F., Chen, Y. D. I., Chiang, C. W. K., Coetzee, G. A., Demerath, E., Deming-Halverson, S. L., Driver, R. W., Dubbert, P., Feitosa, M. F., Feng, Y., Freedman, B. I., Gillanders, E. M., Gottesman, O., Guo, X., Haritunians, T., Harris, T., Harris, C. C., Hennis, A. J. M., Hernandez, D. G., McNeill, L. H., Howard, T. D., Howard, B. V., Howard, V. J., Johnson, K. C., Kang, S. J., Keating, B. J., Kolb, S., Kuller, L. H., Kutlar, A., Langefeld, C. D., Lettre, G., Lohman, K., Lotay, V., Lyon, H., Manson, J. E., Maixner, W., Meng, Y. A., Monroe, K. R., Morhason-Bello, I., Murphy, A. B., Mychaleckyj, J. C., Nadukuru, R., Nathanson, K. L., Nayak, U., N'Diaye, A., Nemesure, B., Wu, S. Y., Leske, M. C., Neslund-Dudas, C., Neuhouser, M., Nyante, S., Ochs-Balcom, H., Ogunniyi, A., Ogundiran, T. O., Ojengbede, O., Olopade, O. I., Palmer, J. R., Ruiz-Narvaez, E. A., Palmer, N. D., Press, M. F., Rampersaud, E., Rasmussen-Torvik, L. J., Rodriguez-Gil, J. L., Salako, B., Schadt, E. E., Schwartz, A. G., Shriner, D. A., Siscovick, D., Smith, S. B., Wassertheil-Smoller, S., Speliotes, E. K., Spitz, M. R., Sucheston, L., Taylor, H., Tayo, B. O., Tucker, M. A., Van Den Berg, D. J., Edwards, D. R. V., Wang, Z., Wiencke, J. K., Winkler, T. W., Witte, J. S., Wrensch, M., Wu, X., Yang, J. J., Levin, A. M., Young, T. R., Zakai, N. A., Cushman, M., Zanetti, K. A., Zhao, J. H., Zhao, W., Zheng, Y., Zhou, J., Ziegler, R. G., Zmuda, J. M., Fernandes, J. K., Gilkeson, G. S., Kamen, D. L., Hunt, K. J., Spruill, I. J., Ambrosone, C. B., Ambs, S., Arnett, D. K., Atwood, L., Becker, D. M., Berndt, S. I., Bernstein, L., Blot, W. J., Borecki, I. B., Bottinger, E. P., Bowden, D. W., Burke, G., Chanock, S. J., Cooper, R. S., Ding, J., Duggan, D., Evans, M. K., Fox, C., Garvey, W. T., Bradfield, J. P., Hakonarson, H., Grant, S. F. A., Hsing, A., Chu, L., Hu, J. J., Huo, D., Ingles, S. A., John, E. M., Jordan, J. M., Kabagambe, E. K., Kardia, S. L. R., Kittles, R. A., Goodman, P. J., Klein, E. A., Kolonel, L. N., Le Marchand, L., Liu, S., McKnight, B., Millikan, R. C., Mosley, T. H., Padhukasahasram, B., Williams, L. K., Patel, S. R., Peters, U., Pettaway, C. A., Peyser, P. A., Psaty, B. M., Redline, S., Rotimi, C. N., Rybicki, B. A., Sale, M. M., Schreiner, P. J., Signorello, L. B., Singleton, A. B., Stanford, J. L., Strom, S. S., Thun, M. J., Vitolins, M., Zheng, W., Moore, J. H., Williams, S. M., Ketkar, S., Zhu, X., Zonderman, A. B., Kooperberg, C., Papanicolaou, G. J., Henderson, B. E., Reiner, A. P., Hirschhorn, J. N., Loos, R. J. F., North, K. E. & Haiman, C. A., Jun 1 2013, In : Nature Genetics. 45, 6, p. 690-696 7 p.

Research output: Contribution to journalArticle

Meta-Analysis
Body Mass Index
Genome-Wide Association Study
Population
Single Nucleotide Polymorphism
6 Citations (Scopus)

Comparison of hematologic measurements between local and central laboratories: Data from the BABY HUG trial

Kalpatthi, R., Thompson, B., Lu, M., Wang, W. C., Patel, N., Kutlar, A., Howard, T., Luchtman-Jones, L. & Miller, S. T., Feb 1 2013, In : Clinical Biochemistry. 46, 3, p. 278-281 4 p.

Research output: Contribution to journalArticle

Monocytes
Neutrophils
Blood
Clinical Trials
Erythrocyte Indices

Corrigendum to "Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemia" [Cytokine 60 (2012) 302-308]

Hyacinth, H. I., Gee, B. E., Adamkiewicz, T. V., Adams, R. J., Kutlar, A., Stiles, J. K. & Hibbert, J. M., Apr 1 2013, In : Cytokine. 62, 1, 1 p.

Research output: Contribution to journalComment/debate

Brain-Derived Neurotrophic Factor
Sickle Cell Anemia
Stroke
Cytokines
corrigendum
19 Citations (Scopus)

Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients

Galarneau, G., Coady, S., Garrett, M. E., Jeffries, N., Puggal, M., Paltoo, D., Soldano, K., Guasch, A., Ashley-Koch, A. E., Telen, M. J., Kutlar, A., Lettre, G. & Papanicolaou, G. J., Jul 18 2013, In : Blood. 122, 3, p. 434-442 9 p.

Research output: Contribution to journalArticle

Acute Chest Syndrome
Sickle Cell Anemia
Genes
Patient Rights
Polymorphism
48 Citations (Scopus)

Genetic modifiers of sickle cell anemia in the baby hug cohort: Influence on laboratory and clinical phenotypes

Sheehan, V. A., Luo, Z., Flanagan, J. M., Howard, T. A., Thompson, B. W., Wang, W. C., Kutlar, A. & Ware, R. E., Jul 1 2013, In : American Journal of Hematology. 88, 7, p. 571-576 6 p.

Research output: Contribution to journalArticle

Hydroxyurea
Sickle Cell Anemia
alpha-Thalassemia
Phenotype
beta-Globins
25 Citations (Scopus)

Genome-wide association study of cardiac structure and systolic function in African Americans the Candidate gene Association Resource (CARe) study

Fox, E. R., Musani, S. K., Barbalic, M., Lin, H., Yu, B., Ogunyankin, K. O., Smith, N. L., Kutlar, A., Glazer, N. L., Post, W. S., Paltoo, D. N., Dries, D. L., Farlow, D. N., Duarte, C. W., Kardia, S. L., Meyers, K. J., Sun, Y. V., Arnett, D. K., Patki, A. A., Sha, J. & 17 others, Cui, X., Samdarshi, T. E., Penman, A. D., Bibbins-Domingo, K., Bůžková, P., Benjamin, E. J., Bluemke, D. A., Morrison, A. C., Heiss, G., Carr, J. J., Tracy, R. P., Mosley, T. H., Taylor, H. A., Psaty, B. M., Heckbert, S. R., Cappola, T. P. & Vasan, R. S., Feb 1 2013, In : Circulation: Cardiovascular Genetics. 6, 1, p. 37-46 10 p.

Research output: Contribution to journalReview article

Genome-Wide Association Study
Genetic Association Studies
African Americans
Genome
Single Nucleotide Polymorphism
5 Citations (Scopus)

GLEE-ful for sickle cell pain?

Kutlar, A., Sep 12 2013, In : Blood. 122, 11, p. 1846-1847 2 p.

Research output: Contribution to journalComment/debate

Neurogenic Inflammation
Sickle Cell Anemia
Mast Cells
Blood
Chemical activation

Hb fulton-georgia [α20(B1)His→Pro; HBA1: C.62A>C]: A new α-Globin variant coinherited with α-Thalassemia-2 (3.7 kb deletion) and Hb SC disease

Zhuang, L., Patel, N., Bryant, S., Kutlar, A., Kutlar, F. & Young, A. N., Sep 12 2013, In : Hemoglobin. 37, 5, p. 481-485 5 p.

Research output: Contribution to journalArticle

Hemoglobin SC Disease
Thalassemia
Globins
Hemoglobins
Genes
84 Citations (Scopus)

Loci influencing blood pressure identified using a cardiovascular gene-centric array

Ganesh, S. K., Tragante, V., Guo, W., Guo, Y., Lanktree, M. B., Smith, E. N., Johnson, T., Castillo, B. A., Barnard, J., Baumert, J., Chang, Y. P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Franceschini, N., Gaunt, T. R., Gho, J. M. I. H., Gieger, C., Gong, Y., Isaacs, A. & 117 others, Kleber, M. E., Leach, I. M., McDonough, C. W., Meijs, M. F. L., Mellander, O., Molony, C. M., Nolte, I. M., Padmanabhan, S., Price, T. S., Rajagopalan, R., Shaffer, J., Shah, S., Shen, H., Soranzo, N., van der Most, P. J., Van Iperen, E. P. A., Van Setten, J. A., Vonk, J. M., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Boer, J. M. A., Boerwinkle, E., Burkley, B., Burt, A., Chakravarti, A., Chen, W., Cooper-DeHoff, R. M., Curtis, S. P., Dreisbach, A., Duggan, D., Ehret, G. B., Fabsitz, R. R., Fornage, M., Fox, E., Furlong, C. E., Gansevoort, R. T., Hofker, M. H., Hovingh, G. K., Kirkland, S. A., Kottke-Marchant, K., Kutlar, A., LaCroix, A. Z., Langaee, T. Y., Li, Y. R., Lin, H., Liu, K., Maiwald, S., Malik, R., Murugesan, G., Newton-Cheh, C., O'Connell, J. R., Onland-Moret, N. C., Ouwehand, W. H., Palmas, W., Penninx, B. W., Pepine, C. J., Pettinger, M., Polak, J. F., Ramachandran, V. S., Ranchalis, J., Redline, S., Ridker, P. M., Rose, L. M., Scharnag, H., Schork, N. J., Shimbo, D., Shuldiner, A. R., Srinivasan, S. R., Stolk, R. P., Taylor, H. A., Thorand, B., Trip, M. D., van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Winkelmann, B. R., Wyatt, S., Young, J. H., Boehm, B. O., Caulfield, M. J., Chasman, D. I., Davidson, K. W., Doevendans, P. A., FitzGerald, G. A., Gums, J. G., Hakonarson, H., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J. P., Koenig, W., Study, L. L. C., März, W., Mitchell, B. D., Murray, S. S., Oldehinkel, A. J., Rader, D. J., Reilly, M. P., Reiner, A. P., Schadt, E. E., Silverstein, R. L., Snieder, H., Stanton, A. V., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Samani, N. J., Johnson, A. D., Munroe, P. B., de Bakker, P. I. W., Zhu, X., Levy, D., Keating, B. J. & Asselbergs, F. W., Apr 1 2013, In : Human Molecular Genetics. 22, 8, p. 1663-1678 16 p.

Research output: Contribution to journalArticle

Blood Pressure
Genes
Introns
Single Nucleotide Polymorphism
Arterial Pressure
10 Citations (Scopus)

Loci influencing blood pressure identified using a cardiovascular gene-centric array

Ganesh, S. K., Tragante, V., Guo, W., Guo, Y., Lanktree, M. B., Smith, E. N., Johnson, T., Castillo, B. A., Barnard, J., Baumert, J., Chang, Y. P. C., Elbers, C. C., Farrall, M., Fischer, M. E., Gaunt, N. F., Johannes, J. M. I., Gieger, C., Gong, Y., Isaacs, A., Kleber, M. E. & 116 others, Leach, I. M., McDonough, C. W., Meijs, M. F. L., Mellander, O., Molony, C. M., Nolte, I. M., Price, S. P., Rajagopalan, R., Shaffer, J., Shah, S., Shen, H., Soranzo, N., van der Most, P. J., Van Iperen, E. P. A., Van Setten, J., Vonk, J. M., Zhang, L., Beitelshees, A. L., Berenson, G. S., Bhatt, D. L., Boer, J. M. A., Boerwinkle, E., Burkley, B., Burt, A., Chakravarti, A., Chen, W., Cooper-DeHoff, R. M., Curtis, S. P., Dreisbach, A., Duggan, D., Ehret, G. B., Fabsitz, R. R., Fornage, M., Fox, E., Furlong, C. E., Gansevoort, R. T., Hofker, M. H., Hovingh, G. K., Kirkland, S. A., Kottke-Marchant, K., Kutlar, A., LaCroix, A. Z., Langaee, T. Y., Li, Y. R., Lin, H., Liu, K., Maiwald, S., Malik, R., Metastroke, C., Murugesan, G., Newton-Cheh, C., O'Connell, J. R., Onland-Moret, N. C., Ouwehand, W. H., Palmas, W., Penninx, B. W., Pepine, C. J., Pettinger, M., Polak, J. F., Ramachandran, V. S., Ranchalis, J., Redline, S., Ridker, P. M., Rose, L. M., Scharnag, H., Schork, N. J., Shimbo, D., Shuldiner, A. R., Srinivasan, S. R., Stolk, R. P., Taylor, H. A., Thorand, B., Trip, M. D., van Duijn, C. M., Verschuren, W. M., Wijmenga, C., Winkelmann, B. R., Wyatt, S., Young, J. H., Boehm, B. O., Caulfield, M. J., Chasman, D. I., Davidson, K. W., Doevendans, P. A., FitzGerald, G. A., Gums, J. G., Hakonarson, H., Hillege, H. L., Illig, T., Jarvik, G. P., Johnson, J. A., Kastelein, J. J. P., Koenig, W., Study, L. L. C., rz, W. M., Mitchell, B. D., Murray, S. S., Oldehinkel, A. J., Rader, D. J., Reilly, M. P., Reiner, A. P., Schadt, E. E., Silverstein, R. L., Snieder, H., Stanton, A. V., Uitterlinden, A. G., van der Harst, P., van der Schouw, Y. T., Samani, N. J., Johnson, A. D., Munroe, P. B., de Bakker, P. I. W., Zhu, X., Levy, D., Keating, B. J. & Asselbergs, F. W., Aug 1 2013, In : Human Molecular Genetics. 22, 16, p. 3394-3395 2 p., ddt177.

Research output: Contribution to journalComment/debate

2012
21 Citations (Scopus)

A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease

Kutlar, A., Ataga, K., Reid, M., Vichinsky, E. P., Neumayr, L., Blair-Britt, L., Labotka, R., Glass, J., Keefer, J. R., Wargin, W. A., Berenson, R. & Perrine, S. P., Nov 1 2012, In : American Journal of Hematology. 87, 11, p. 1017-1021 5 p.

Research output: Contribution to journalArticle

2,2-dimethylbutyric acid
Globins
Sickle Cell Anemia
Hemoglobins
Placebos
49 Citations (Scopus)

A potent oral P-selectin blocking agent improves microcirculatory blood flow and a marker of endothelial cell injury in patients with sickle cell disease

Kutlar, A., Ataga, K. I., Mcmahon, L., Howard, J., Galacteros, F., Hagar, W., Vichinsky, E., Cheung, A. T. W., Matsui, N. & Embury, S. H., May 1 2012, In : American Journal of Hematology. 87, 5, p. 536-539 4 p.

Research output: Contribution to journalLetter

Early Termination of Clinical Trials
Pentosan Sulfuric Polyester
Arterial Occlusive Diseases
P-Selectin
Vascular Cell Adhesion Molecule-1
20 Citations (Scopus)

Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemia

Hyacinth, H. I., Gee, B. E., Adamkiewicz, T. V., Adams, R. J., Kutlar, A., Stiles, J. K. & Hibbert, J. M., Oct 1 2012, In : Cytokine. 60, 1, p. 302-308 7 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Brain
Stroke
Plasmas
Cerebrovascular Circulation
1 Citation (Scopus)

Thalidomide and its analogs for hemoglobinopathies: Two birds with one stone?

Kutlar, A., Meiler, S., Swerdlow, P. & Knight, R., Feb 1 2012, In : Expert Review of Hematology. 5, 1, p. 9-11 3 p.

Research output: Contribution to journalEditorial

Hemoglobinopathies
Thalidomide
beta-Thalassemia
Sickle Cell Anemia
pomalidomide
2011
123 Citations (Scopus)

Association of genetic variation with systolic and diastolic blood pressure among african americans: The candidate gene association resource study

Fox, E. R., Young, J. H., Li, Y., Dreisbach, A. W., Keating, B. J., Musani, S. K., Liu, K., Morrison, A. C., Ganesh, S., Kutlar, A., Ramachandran, V. S., Polak, J. F., Fabsitz, R. R., Dries, D. L., Farlow, D. N., Redline, S., Adeyemo, A., Hirschorn, J. N., Sun, Y. V., Wyatt, S. B. & 23 others, Penman, A. D., Palmas, W., Rotter, J. I., Townsend, R. R., Doumatey, A. P., Tayo, B. O., Mosley, T. H., Lyon, H. N., Kang, S. J., Rotimi, C. N., Cooper, R. S., Franceschini, N., Curb, J. D., Martin, L. W., Eaton, C. B., Kardia, S. L. R., Taylor, H. A., Caulfield, M. J., Ehret, G. B., Johnson, T., Chakravarti, A., Zhu, X. & Levy, D., Jun 1 2011, In : Human Molecular Genetics. 20, 11, p. 2273-2284 12 p., ddr092.

Research output: Contribution to journalArticle

Genetic Association Studies
African Americans
Blood Pressure
Genes
Genome-Wide Association Study
59 Citations (Scopus)

Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: Contributions from the CARe consortium

Zhu, X., Young, J. H., Fox, E., Keating, B. J., Franceschini, N., Kang, S., Tayo, B., Adeyemo, A., Sun, Y. V., Li, Y., Morrison, A., Newton-Cheh, C., Liu, K., Ganesh, S. K., Kutlar, A., Vasan, R. S., Dreisbach, A., Wyatt, S., Polak, J., Palmas, W. & 19 others, Musani, S., Taylor, H., Fabsitz, R., Townsend, R. R., Dries, D., Glessner, J., Chiang, C. W. K., Mosley, T., Kardia, S., Curb, D., Hirschhorn, J. N., Rotimi, C., Reiner, A., Eaton, C., Rotter, J. I., Cooper, R. S., Redline, S., Chakravarti, A. & Levy, D., Jun 1 2011, In : Human Molecular Genetics. 20, 11, p. 2285-2295 11 p., ddr113.

Research output: Contribution to journalArticle

Genetic Loci
Blood Pressure
Genes
African Americans
Single Nucleotide Polymorphism
28 Citations (Scopus)

Design, synthesis, and pharmacological evaluation of novel hybrid compounds to treat sickle cell disease symptoms

Dos Santos, J. L., Lanaro, C., Lima, L. M., Gambero, S., Franco-Penteado, C. F., Alexandre-Moreira, M. S., Wade, M., Yerigenahally, S., Kutlar, A., Meiler, S. E., Costa, F. F. & Chung, M., Aug 25 2011, In : Journal of Medicinal Chemistry. 54, 16, p. 5811-5819 9 p.

Research output: Contribution to journalArticle

Hydroxyurea
Sickle Cell Anemia
Tumor Necrosis Factor-alpha
Pharmacology
Thalidomide
80 Citations (Scopus)

Genetic association for renal traits among participants of African Ancestry reveals new loci for renal function

Liu, C. T., Garnaas, M. K., Tin, A., Kottgen, A., Franceschini, N., Peralta, C. A., de Boer, I. H., Lu, X., Atkinson, E., Ding, J., Nalls, M., Shriner, D., Coresh, J., Kutlar, A., Bibbins-Domingo, K., Siscovick, D., Akylbekova, E., Wyatt, S., Astor, B., Mychaleckjy, J. & 21 others, Li, M., Reilly, M. P., Townsend, R. R., Adeyemo, A., Zonderman, A. B., de Andrade, M., Turner, S. T., Mosley, T. H., Harris, T. B., Rotimi, C. N., Liu, Y., Kardia, S. L. R., Evans, M. K., Shlipak, M. G., Kramer, H., Flessner, M. F., Dreisbach, A. W., Goessling, W., Cupples, L. A., Kao, W. L. & Fox, C. S., Sep 1 2011, In : PLoS Genetics. 7, 9, e1002264.

Research output: Contribution to journalArticle

glomerular filtration rate
renal function
Glomerular Filtration Rate
ancestry
Single Nucleotide Polymorphism
394 Citations (Scopus)

Hydroxycarbamide in very young children with sickle-cell anaemia: A multicentre, randomised, controlled trial (BABY HUG)

Wang, W. C., Ware, R. E., Miller, S. T., Iyer, R. V., Casella, J. F., Minniti, C. P., Rana, S., Thornburg, C. D., Rogers, Z. R., Kalpatthi, R. V., Barredo, J. C., Brown, R. C., Sarnaik, S. A., Howard, T. H., Wynn, L. W., Kutlar, A., Armstrong, F. D., Files, B. A., Goldsmith, J. C., Waclawiw, M. A. & 2 others, Huang, X. & Thompson, B. W., May 14 2011, In : The Lancet. 377, 9778, p. 1663-1672 10 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Randomized Controlled Trials
Placebos
Acute Chest Syndrome
Fetal Hemoglobin
113 Citations (Scopus)

Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: A phase III randomized, placebo-controlled, double-blind study of the gardos channel blocker senicapoc (ICA-17043)

Ataga, K. I., Reid, M., Ballas, S. K., Yasin, Z., Bigelow, C., James, L. S., Smith, W. R., Galacteros, F., Kutlar, A., Hull, J. H. & Stocker, J. W., Apr 1 2011, In : British Journal of Haematology. 153, 1, p. 92-104 13 p.

Research output: Contribution to journalArticle

Erythrocyte Aging
Sickle Cell Anemia
Hemolysis
Double-Blind Method
Placebos
54 Citations (Scopus)

Long-term safety and efficacy of deferasirox (Exjade®) for up to 5years in transfusional iron-overloaded patients with sickle cell disease

Vichinsky, E., Bernaudin, F., Forni, G. L., Gardner, R., Hassell, K., Heeney, M. M., Inusa, B., Kutlar, A., Lane, P., Mathias, L., Porter, J., Tebbi, C., Wilson, F., Griffel, L., Deng, W., Giannone, V. & Coates, T., Aug 1 2011, In : British Journal of Haematology. 154, 3, p. 387-397 11 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Iron
Safety
Deferoxamine
Chelation Therapy
44 Citations (Scopus)

Pomalidomide augments fetal hemoglobin production without the myelosuppressive effects of hydroxyurea in transgenic sickle cell mice

Meiler, S. E., Wade, M., Kutlar, F., Yerigenahally, S. D., Xue, Y., Moutouh-de Parseval, L. A., Corral, L. G., Swerdlow, P. S. & Kutlar, A., Jul 28 2011, In : Blood. 118, 4, p. 1109-1112 4 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Hydroxyurea
Sickle Cell Anemia
Erythropoiesis
Thalidomide
2 Citations (Scopus)

Thalassemia-like phenotype in a novel complex hemoglobinopathy with α, β, δ globin chain abnormalities

Sabio, H., Dixon, N., Patel, N., Obiaga, C., Zhuang, L., Meiler, S. E., Kutlar, A. & Kutlar, F., Dec 1 2011, In : Journal of Pediatric Hematology/Oncology. 33, 8, p. 589-591 3 p.

Research output: Contribution to journalArticle

Hemoglobinopathies
Thalassemia
Globins
Phenotype
Hemoglobin A2
8 Citations (Scopus)

The proinflammatory cytokine GM-CSF downregulates fetal hemoglobin expression by attenuating the cAMP-dependent pathway in sickle cell disease

Ikuta, T., Adekile, A. D., Gutsaeva, D. R., Parkerson, J. B., Yerigenahally, S. D., Clair, B., Kutlar, A., Odo, N. & Head, C. A., Dec 15 2011, In : Blood Cells, Molecules, and Diseases. 47, 4, p. 235-242 8 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Sickle Cell Anemia
Granulocyte-Macrophage Colony-Stimulating Factor
Down-Regulation
Cytokines