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2019

Correction: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20 (Oncogene, (2019), 38, 4, (469-482), 10.1038/s41388-018-0472-0)

Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jul 11 2019, In : Oncogene. 38, 28, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Financial Management
Oncogenes
Breast Neoplasms
Laboratory Animals
Genomics

Critical individual roles of the BCR and FGFR1 kinase domains in BCR-FGFR1-driven stem cell leukemia/lymphoma syndrome

Chong, Y., Liu, Y., Lu, S., Cai, B., Qin, H., Chang, C. S., Ren, M., Cowell, J. K. & Hu, T., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Lymphoma
Leukemia
Phosphotransferases
Stem Cells
Receptor, Fibroblast Growth Factor, Type 1
2 Citations (Scopus)

Distinct signaling programs associated with progression of FGFR1 driven leukemia in a mouse model of stem cell leukemia lymphoma syndrome

Silva, M. J., Chang, C. S., Hu, T., Qin, H., Kitamura, E., Hawthorn, L., Ren, M. & Cowell, J. K., Dec 2019, In : Genomics. 111, 6, p. 1566-1573 8 p.

Research output: Contribution to journalArticle

Lymphoma
Leukemia
Stem Cells
Genes
Stem Cell Niche

DNA methyltransferase 1–mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1– driven leukemogenesis

Hu, T., Chong, Y., Cai, B., Liu, Y., Lu, S. & Cowell, J. K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 48, p. 18122-18130 9 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Methylation
Methyltransferases
MicroRNAs
Leukemia
Cell Movement
Malformations of Cortical Development
Null Lymphocytes
Premature Mortality
Actin Cytoskeleton
2 Citations (Scopus)

Loss of the BCR-FGFR1 GEF domain suppresses RhoA activation and enhances B-lymphomagenesis in mice

Hu, T., Chong, Y., Lu, S., Qin, H., Ren, M., Savage, N. M., Chang, C. S. & Cowell, J. K., Jan 1 2019, In : Cancer Research. 79, 1, p. 114-124 11 p.

Research output: Contribution to journalArticle

Guanidine
Nucleotides
Lymphoma
Leukemia
Stem Cells
4 Citations (Scopus)

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

Piranlioglu, R., Lee, E. M., Ouzounova, M., Bollag, R. J., Vinyard, A., Arbab, A. S., Marasco, D., Guzel, M., Cowell, J. K., Thangaraju, M., Chadli, A., Hassan, K. A., Wicha, M. S., Celis, E. & Korkaya, H., Dec 1 2019, In : Nature Communications. 10, 1, 1430.

Research output: Contribution to journalArticle

immunity
mice
Tumors
Immunity
tumors
1 Citation (Scopus)

Selective inactivation of LGI1 in neuronal precursor cells leads to cortical dysplasia in mice

Silva, M. J., Qin, H. & Cowell, J. K., Feb 1 2019, In : Genesis. 57, 2, e23268.

Research output: Contribution to journalArticle

Malformations of Cortical Development
Leucine
Glioma
Seizures
Epilepsy
3 Citations (Scopus)

The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis

Eisa, N. H., Jilani, Y., Kainth, K., Redd, P., Lu, S., Bougrine, O., Sater, H. A., Patwardhan, C. A., Shull, A., Shi, H., Liu, K., Elsherbiny, N. M., Eissa, L. A., El-Shishtawy, M. M., Horuzsko, A., Bollag, R. J., Maihle, N. J., Roig, J., Korkaya, H., Cowell, J. K. & 1 others, Chadli, A., Jan 1 2019, In : Journal of Biological Chemistry. 294, 14, p. 5246-5260 15 p.

Research output: Contribution to journalArticle

Myosins
Carcinogenesis
Phosphotransferases
Cell proliferation
Cells
4 Citations (Scopus)

The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20

Lee, E., Ouzounova, M., Piranlioglu, R., Ma, M. T., Guzel, M., Marasco, D., Chadli, A., Gestwicki, J. E., Cowell, J. K., Wicha, M. S., Hassan, K. A. & Korkaya, H., Jan 24 2019, In : Oncogene. 38, 4, p. 469-482 14 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Cell Death
Triple Negative Breast Neoplasms
Heterografts
Cell Line

Wasf3 Deficiency Reveals Involvement in Metastasis in a Mouse Model of Breast Cancer

Qin, H., Lu, S., Thangaraju, M. & Cowell, J. K., Dec 2019, In : American Journal of Pathology. 189, 12, p. 2450-2458 9 p.

Research output: Contribution to journalArticle

Wiskott-Aldrich Syndrome Protein Family
Breast Neoplasms
Neoplasm Metastasis
Oncogenes
Exons
2018
3 Citations (Scopus)

Celecoxib ameliorates seizure susceptibility in autosomal dominant lateral temporal epilepsy

Zhou, L., Zhou, L., Su, L. D., Cao, S. L., Xie, Y. J., Wang, N., Shao, C. Y., Wang, Y. N., Zhou, J. H., Cowell, J. K. & Shen, Y., Mar 28 2018, In : Journal of Neuroscience. 38, 13, p. 3346-3357 12 p.

Research output: Contribution to journalArticle

Celecoxib
Temporal Lobe Epilepsy
Leucine
Glioma
Seizures
4 Citations (Scopus)

FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lymphoma syndrome

Hu, T., Wu, Q., Chong, Y., Qin, H., Poole, C. J., Van Riggelen, J., Ren, M. & Cowell, J. K., Nov 1 2018, In : Leukemia. 32, 11, p. 2363-2373 11 p.

Research output: Contribution to journalArticle

Lymphoma
Leukemia
Phosphotransferases
Stem Cells
Granzymes
8 Citations (Scopus)

MiR-339 promotes development of stem cell leukemia/lymphoma syndrome via downregulation of the BCL2L11 and BAX proapoptotic genes

Hu, T., Chong, Y., Lu, S., Wang, R., Qin, H., Silva, J., Kitamura, E., Chang, C. S., Hawthorn, L. A. & Cowell, J. K., Jul 1 2018, In : Cancer Research. 78, 13, p. 3522-3531 10 p.

Research output: Contribution to journalArticle

Lymphoma
Leukemia
Stem Cells
Down-Regulation
Cell Survival
9 Citations (Scopus)

The MIR-17/92 cluster is involved in the molecular etiology of the SCLL syndrome driven by the BCR-FGFR1 chimeric kinase

Hu, T., Chong, Y., Qin, H., Kitamura, E., Chang, C. S., Silva, J., Ren, M. & Cowell, J. K., Apr 1 2018, In : Oncogene. 37, 14, p. 1926-1938 13 p.

Research output: Contribution to journalArticle

MicroRNAs
Phosphotransferases
Cell Proliferation
B-Cell Leukemia
Porifera
2017
64 Citations (Scopus)

Monocytic and granulocytic myeloid derived suppressor cells differentially regulate spatiotemporal tumour plasticity during metastatic cascade

Ouzounova, M., Lee, E., Piranlioglu, R., El Andaloussi, A., Kolhe, R., Demirci, M. F., Marasco, D., Asm, I., Chadli, A., Hassan, K. A., Thangaraju, M., Zhou, G., Arbab, A. S., Cowell, J. K. & Korkaya, H., Apr 6 2017, In : Nature Communications. 8, 14979.

Research output: Contribution to journalArticle

suppressors
plastic properties
Plasticity
Tumors
cascades
10 Citations (Scopus)
Receptor, Fibroblast Growth Factor, Type 1
Lymphoma
Leukemia
Mutation
Phosphatidylinositol 3-Kinases
1 Citation (Scopus)

Promotion of invasion by mutant RAS is dependent on activation of the WASF3 metastasis promoter gene

Teng, Y., Ngoka, L. & Cowell, J. K., Jun 2017, In : Genes Chromosomes and Cancer. 56, 6, p. 493-500 8 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Genes
Wiskott-Aldrich Syndrome Protein Family
Actin Cytoskeleton
Phosphatidylinositol 3-Kinases
2016
9 Citations (Scopus)

A model of BCR-FGFR1 driven human AML in immunocompromised mice

Cowell, J. K., Qin, H., Chang, C. S., Kitamura, E. & Ren, M., Nov 1 2016, In : British Journal of Haematology. 175, 3, p. 542-545 4 p.

Research output: Contribution to journalLetter

Acute Myeloid Leukemia
8 Citations (Scopus)

Development of ZMYM2-FGFR1 driven AML in human CD34+ cells in immunocompromised mice

Ren, M., Qin, H., Wu, Q., Savage, N. M., George, T. I. & Cowell, J. K., Aug 15 2016, In : International Journal of Cancer. 139, 4, p. 836-840 5 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Acute Myeloid Leukemia
Phosphotransferases
Chromosomes
Myeloproliferative Disorders
5 Citations (Scopus)

FGFR1OP2-FGFR1 induced myeloid leukemia and T-cell lymphoma in a mouse model

Qin, H., Wu, Q., Cowell, J. K. & Ren, M., Jan 1 2016, In : Haematologica. 101, 3, p. e91-e94

Research output: Contribution to journalLetter

Neoplastic Gene Expression Regulation
Fusion Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Notch1 Receptor
Receptor, Fibroblast Growth Factor, Type 1
5 Citations (Scopus)

Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5 + CK8 + epithelial cells

Wang, Z., Kim, J., Teng, Y., Ding, H., Zhang, J., Hai, T., Cowell, J. K. & Yan, C., Jul 7 2016, In : Oncogene. 35, 27, p. 3555-3564 10 p.

Research output: Contribution to journalArticle

Activating Transcription Factor 3
Prostate
Carcinogenesis
Epithelial Cells
Hormones
27 Citations (Scopus)

Mitochondrial ATAD3A combines with GRP78 to regulate the WASF3 metastasis-promoting protein

Teng, Y., Ren, X., Li, H., Shull, A., Kim, J. & Cowell, J. K., Jan 21 2016, In : Oncogene. 35, 3, p. 333-343 11 p.

Research output: Contribution to journalArticle

Wiskott-Aldrich Syndrome Protein Family
Mitochondrial Membranes
Mitochondria
Neoplasm Metastasis
Breast Neoplasms
7 Citations (Scopus)

Targeting FGFR1 to suppress leukemogenesis in syndromic and de novo AML in murine models

Wu, Q., Bhole, A., Qin, H., Karp, J., Malek, S., Cowell, J. K. & Ren, M., Jan 1 2016, In : Oncotarget. 7, 31, p. 49733-49742 10 p.

Research output: Contribution to journalArticle

Heterografts
Survival
Oncogenes
Lymphoma
Leukemia
21 Citations (Scopus)

Targeting the WASF3-CYFIP1 complex using stapled peptides suppresses cancer cell invasion

Teng, Y., Bahassan, A., Dong, D., Hanold, L. E., Ren, X., Kennedy, E. J. & Cowell, J. K., Feb 15 2016, In : Cancer Research. 76, 4, p. 965-973 9 p.

Research output: Contribution to journalArticle

Peptides
Neoplasms
Wiskott-Aldrich Syndrome Protein Family
Neoplasm Metastasis
Matrix Metalloproteinases
20 Citations (Scopus)

The WASF3-NCKAP1-CYFIP1 complex is essential for breast cancer metastasis

Teng, Y., Qin, H., Bahassan, A., Bendzunas, N. G., Kennedy, E. J. & Cowell, J. K., Sep 1 2016, In : Cancer Research. 76, 17, p. 5133-5142 10 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Proteins
Gene Silencing
Colonic Neoplasms
11 Citations (Scopus)

Transformation of human CD34+ hematopoietic progenitor cells with DEK-NUP214 induces AML in an immunocompromised mouse model

Qin, H., Malek, S., Cowell, J. K. & Ren, M., Oct 27 2016, In : Oncogene. 35, 43, p. 5686-5691 6 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Acute Myeloid Leukemia
Gene Expression
Human Development
Myeloid Cells
11 Citations (Scopus)

Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility

Zhou, H. M., Fang, Y. Y., Weinberger, P. M., Ding, L. L., Cowell, J. K., Hudson, F. Z., Ren, M., Lee, J. R., Chen, Q. K., Su, H., Dynan, W. S. & Lin, Y., Feb 4 2016, In : BMC Cancer. 16, 1, 55.

Research output: Contribution to journalArticle

Cell Movement
Colorectal Neoplasms
Gene Expression
Neoplasm Metastasis
Tail
10 Citations (Scopus)

WASF3 provides the conduit to facilitate invasion and metastasis in breast cancer cells through HER2/HER3 signaling

Teng, Y., Pi, W., Wang, Y. & Cowell, J. K., Sep 1 2016, In : Oncogene. 35, 35, p. 4633-4640 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Genes
Aptitude
Transcriptional Activation
2015
13 Citations (Scopus)

Essential roles of leucine-rich glioma inactivated 1 in the development of embryonic and postnatal cerebellum

Xie, Y. J., Zhou, L., Jiang, N., Zhang, N., Zou, N., Zhou, L., Wang, Y., Cowell, J. K. & Shen, Y., Jan 16 2015, In : Scientific Reports. 5, 7827.

Research output: Contribution to journalArticle

Leucine
Glioma
Cerebellum
Embryonic Development
Ependymoglial Cells
11 Citations (Scopus)

Homozygous deletion of the LGI1 gene in mice leads to developmental abnormalities resulting in cortical dysplasia

Silva, J., Sharma, S. & Cowell, J. K., Sep 1 2015, In : Brain Pathology. 25, 5, p. 587-597 11 p.

Research output: Contribution to journalArticle

Malformations of Cortical Development
Gene Deletion
Synapses
Neurons
Spine
9 Citations (Scopus)

The promise of zebrafish as a chemical screening tool in cancer therapy

Xie, X., Ross, J. L., Cowell, J. K. & Teng, Y., Aug 1 2015, In : Future Medicinal Chemistry. 7, 11, p. 1395-1405 11 p.

Research output: Contribution to journalReview article

Zebrafish
Neoplasms
Therapeutics
Heterologous Transplantation
Preclinical Drug Evaluations
2014
7 Citations (Scopus)

LGI1: From zebrafish to human epilepsy

Cowell, J. K., Jan 1 2014, In : Progress in Brain Research. 213, C, p. 159-179 21 p.

Research output: Contribution to journalArticle

Zebrafish
Epilepsy
Seizures
Neuronal Plasticity
Synaptic Transmission
48 Citations (Scopus)
Breast Neoplasms
Mesoderm
Neoplasm Metastasis
Chromosomes, Human, Pair 1
Cadherins
2013
31 Citations (Scopus)

COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis

Shao, J., Teng, Y., Padia, R., Hong, S., Noh, H., Xie, X., Mumm, J. S., Dong, Z., Ding, H. F., Cowell, J., Kim, J., Han, J. & Huang, S., Sep 2013, In : Neoplasia (United States). 15, 9, p. 1075-1085 11 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Carcinogenesis
Breast Neoplasms
Proto-Oncogene Proteins c-jun
Proteins

Corrigendum to "WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, And MMP-9 expression" [Exp. Cell Res. 308 (2005) 135-145]

Sossey-Alaoui, K., Ranalli, T. A., Li, X., Bakin, A. V. & Cowell, J. K., Mar 10 2013, In : Experimental Cell Research. 319, 5, 1 p.

Research output: Contribution to journalComment/debate

Matrix Metalloproteinases
Cell Movement
corrigendum
25 Citations (Scopus)

Critical role of the WASF3 gene in JAK2/STAT3 regulation of cancer cell motility

Teng, Y., Ghoshal, P., Ngoka, L., Mei, Y. & Cowell, J. K., Sep 1 2013, In : Carcinogenesis. 34, 9, p. 1994-1999 6 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Cell Movement
Genes
Neoplasms
NSC 74859
14 Citations (Scopus)

Dysregulated signaling pathways in the development of CNTRL-FGFR1–induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models

Ren, M., Qin, H., Kitamura, E. & Cowell, J. K., Aug 8 2013, In : Blood. 122, 6, p. 1007-1016 10 p.

Research output: Contribution to journalArticle

Neoplasms
Hematopoietic Stem Cells
Bone Marrow Neoplasms
Clonal Evolution
Severe Combined Immunodeficiency
78 Citations (Scopus)

Evaluating human cancer cell metastasis in zebrafish

Teng, Y., Xie, X., Walker, S., White, D. T., Mumm, J. S. & Cowell, J. K., Oct 4 2013, In : BMC Cancer. 13, 453.

Research output: Contribution to journalArticle

Zebrafish
Neoplasm Metastasis
Neoplasms
Fishes
Fiji
20 Citations (Scopus)

Evaluation of phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) and epidermal growth factor receptor (EGFR) gene mutations in pancreaticobiliary adenocarcinoma

Weiss, G. A., Rossi, M. R., Khushalani, N. I., Lo, K., Gibbs, J. F., Bharthuar, A., Cowell, J. K. & Iyer, R., Mar 2013, In : Journal of Gastrointestinal Oncology. 4, 1, p. 20-29 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
erbB-1 Genes
Epidermal Growth Factor Receptor
Catalytic Domain
Adenocarcinoma
15 Citations (Scopus)

HOXC9 directly regulates distinct sets of genes to coordinate diverse cellular processes during neuronal differentiation

Wang, X., Choi, J-H., Ding, J., Yang, L., Ngoka, L. C., Lee, E. J., Zha, Y., Mao, L., Jin, B., Ren, M., Cowell, J. K., Huang, S., Shi, H., Cui, H. & Ding, H., Nov 25 2013, In : BMC Genomics. 14, 1, 830.

Research output: Contribution to journalArticle

cdc Genes
Genes
DNA Damage
Cell Cycle
Chromosome Mapping
42 Citations (Scopus)

Novel FGFR inhibitor ponatinib suppresses the growth of non-small cell lung cancer cells overexpressing FGFR1

Ren, M., Hong, M., Liu, G., Wang, H., Patel, V. S., Biddinger, P. W., Silva, M. J., Cowell, J. K. & Hao, Z., Jun 1 2013, In : Oncology Reports. 29, 6, p. 2181-2190 10 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Non-Small Cell Lung Carcinoma
Growth
Lung Neoplasms
ponatinib
51 Citations (Scopus)

Ponatinib suppresses the development of myeloid and lymphoid malignancies associated with FGFR1 abnormalities

Ren, M., Qin, H., Ren, R. & Cowell, J. K., Jan 1 2013, In : Leukemia. 27, 1, p. 32-40 9 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 1
Stem Cells
Lymphoma
Leukemia
Phosphotransferases
2012
17 Citations (Scopus)

Acute progression of BCR-FGFR1 induced murine B-lympho/myeloproliferative disorder suggests involvement of lineages at the pro-B cell stage

Ren, M. Q., Tidwell, J. A., Sharma, S. & Cowell, J. K., Jun 6 2012, In : PloS one. 7, 6, e38265.

Research output: Contribution to journalArticle

Myeloproliferative Disorders
B-Lymphoid Precursor Cells
B-lymphocytes
lymphoma
leukemia
18 Citations (Scopus)
Neoplasm Metastasis
Response Elements
Genetic Promoter Regions
Genes
MCF-7 Cells
47 Citations (Scopus)

HSP90 and HSP70 Proteins are essential for stabilization and activation of WASF3 metastasis-promoting protein

Teng, Y., Ngoka, L., Mei, Y., Lesoon, L. & Cowell, J. K., Mar 23 2012, In : Journal of Biological Chemistry. 287, 13, p. 10051-10059 9 p.

Research output: Contribution to journalArticle

Stabilization
Chemical activation
Cells
Neoplasm Metastasis
Wiskott-Aldrich Syndrome Protein Family
56 Citations (Scopus)

Ubiquitin-conjugating enzyme UBE2C: Molecular biology, role in tumorigenesis, and potential as a biomarker

Hao, Z., Zhang, H. & Cowell, J., Jun 1 2012, In : Tumor Biology. 33, 3, p. 723-730 8 p.

Research output: Contribution to journalReview article

Ubiquitin-Conjugating Enzymes
Molecular Biology
Carcinogenesis
Biomarkers
M Phase Cell Cycle Checkpoints
2011
15 Citations (Scopus)

Analysis of wilms tumors using SNP mapping array-based comparative genomic hybridization

Hawthorn, L. & Cowell, J. K., May 4 2011, In : PloS one. 6, 4, e18941.

Research output: Contribution to journalArticle

comparative genomic hybridization
Comparative Genomic Hybridization
Wilms Tumor
Single Nucleotide Polymorphism
Tumors
1 Citation (Scopus)

CML: a model disease with a defined oncogenic driver.

Hao, Z. & Cowell, J. K., Mar 1 2011, In : Clinical advances in hematology & oncology : H&O. 9, 3, p. 247-248 2 p.

Research output: Contribution to journalComment/debate

Molecular Targeted Therapy
Neoplastic Stem Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
28 Citations (Scopus)

Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease

Ren, M. & Cowell, J. K., Jun 23 2011, In : Blood. 117, 25, p. 6837-6847 11 p.

Research output: Contribution to journalArticle

T-cells
T-Cell Lymphoma
Stem cells
Lymphoma
Leukemia