Find Research Outputs

Search concepts
Selected Filters
2019

Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress

Lv, H., Zhu, C., Wu, R., Ni, H., Lian, J., Xu, Y., Xia, Y., Shi, G., Li, Z., Caldwell, R. B., Caldwell, R. W., Yao, L. & Chen, Y., Jul 2019, In : Journal of Psychiatric Research. 114, p. 55-66 12 p.

Research output: Contribution to journalArticle

Oxidative Stress
Anxiety
Anxiety Disorders
Pyramidal Cells
NADP

Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis

Palani, C. D., Fouda, A. Y., Liu, F., Xu, Z., Mohamed, E., Giri, S., Smith, S. B., Caldwell, R. B. & Narayanan, S. P., Dec 1 2019, In : Molecular Neurobiology. 56, 12, p. 8589-8602 14 p.

Research output: Contribution to journalArticle

Arginase
Autoimmune Experimental Encephalomyelitis
Multiple Sclerosis
Retina
Neuroglia
Arginase
Vasodilation
Hyperglycemia
p38 Mitogen-Activated Protein Kinases
Phosphotransferases
2 Citations (Scopus)

Mechanisms of obesity-induced metabolic and vascular dysfunctions

Atawia, R. T., Bunch, K. L., Flores Toque, H. A., Caldwell, R. B. & Caldwell, R. W., Mar 1 2019, In : Frontiers in Bioscience - Landmark. 24, 5, p. 890-934 45 p.

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Nitric Oxide
Adipocytes
Obesity
2 Citations (Scopus)
Open Access
adipose tissues
Arginase
Obese Mice
diets
sucrose
1 Citation (Scopus)

Targeting polyamine oxidase to prevent excitotoxicity-induced retinal neurodegeneration

Pichavaram, P., Palani, C. D., Patel, C., Xu, Z., Shosha, E., Fouda, A. Y., Caldwell, R. B. & Narayanan, S. P., Jan 1 2019, In : Frontiers in Neuroscience. 13, JAN, 956.

Research output: Contribution to journalArticle

Open Access
N-Methylaspartate
Retina
Aspartic Acid
Retinal Neurons
Retinal Ganglion Cells
2018
22 Citations (Scopus)

Arginase: A multifaceted enzyme important in health and disease

Caldwell, R. W., Rodriguez, P. C., Flores Toque, H. A., Narayanan, S. P. & Caldwell, R. B., Apr 1 2018, In : Physiological reviews. 98, 2, p. 641-665 25 p.

Research output: Contribution to journalReview article

Arginase
Health
Enzymes
Ornithine
Urea
3 Citations (Scopus)

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In : Cell Death and Disease. 9, 10, 1001.

Research output: Contribution to journalArticle

Arginase
Ischemia
Macrophages
Reperfusion Injury
Knockout Mice

Blockade of TREM-1 prevents vitreoretinal neovascularization in mice with oxygen-induced retinopathy

Rojas, M. A., Shen, Z. T., Caldwell, R. B. & Sigalov, A. B., Sep 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 9, p. 2761-2768 8 p.

Research output: Contribution to journalArticle

Myeloid Cells
Oxygen
Retinal Neovascularization
Pathologic Neovascularization
Macrophage Colony-Stimulating Factor
3 Citations (Scopus)

Mechanisms of diabetes-induced endothelial cell senescence: Role of arginase 1

Shosha, E., Xu, Z., Priya Narayanan, S., Lemtalsi, T., Fouda, A. Y., Rojas, M., Xing, J., Fulton, D., William Caldwell, R. & Caldwell, R. B., Apr 17 2018, In : International journal of molecular sciences. 19, 4, 1215.

Research output: Contribution to journalArticle

Arginase
Cell Aging
Endothelial cells
Medical problems
Endothelial Cells
1 Citation (Scopus)

Neurofibromin deficiency induces endothelial cell proliferation and retinal neovascularization

Zhang, H., Hudson, F. Z., Xu, Z., Tritz, R., Rojas, M., Patel, C., Haigh, S. B., Bordán, Z., Ingram, D. A., Fulton, D. J., Weintraub, N. L., Caldwell, R. B. & Stansfield, B. K., May 2018, In : Investigative Ophthalmology and Visual Science. 59, 6, p. 2520-2528 9 p.

Research output: Contribution to journalArticle

Neurofibromin 1
Retinal Neovascularization
Retina
Neurofibromatosis 1
Endothelial Cells
2017

Correction: Diabetes-induced superoxide anion and breakdown of the blood-retinal barrier: Role of the VEGF/uPAR pathway (PLoS ONE (2013) 8:8 (e71868) DOI: 10.1371/journal.pone.0071868)

El-Remessy, A. B., Franklin, T., Ghaley, N., Yang, J., Brands, M. W., Caldwell, R. B. & Behzadian, M. A., Oct 2017, In : PloS one. 12, 10, e0186749.

Research output: Contribution to journalComment/debate

Blood-Retinal Barrier
Medical problems
Superoxides
superoxide anion
Vascular Endothelial Growth Factor A
13 Citations (Scopus)

Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis

Liu, Z., Yan, S., Wang, J., Xu, Y., Wang, Y., Zhang, S., Xu, X., Yang, Q., Zeng, X., Zhou, Y., Gu, X., Lu, S., Fu, Z., Fulton, D. J., Weintraub, N. L., Caldwell, R. B., Zhang, W., Wu, C., Liu, X. L., Chen, J. F. & 10 others, Ahmad, A., Kaddour-Djebbar, I., Al-Shabrawey, M., Li, Q., Jiang, X., Sun, Y., Sodhi, A., Smith, L., Hong, M. & Huo, Y., Dec 1 2017, In : Nature Communications. 8, 1, 584.

Research output: Contribution to journalArticle

glycolysis
Pathologic Neovascularization
angiogenesis
adenosines
Purinergic P1 Receptors
7 Citations (Scopus)

Netrin-1 is a novel regulator of vascular endothelial function in diabetes

Toque, H. A., Fernandez-Flores, A., Mohamed, R., Caldwell, R. B., Ramesh, G. & Caldwell, R. W., Oct 2017, In : PloS one. 12, 10, e0186734.

Research output: Contribution to journalArticle

Medical problems
blood vessels
Blood Vessels
diabetes
aorta
24 Citations (Scopus)

Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1

Bhatta, A., Yao, L., Xu, Z., Toque, H. A., Chen, J., Atawia, R. T., Fouda, A. Y., Bagi, Z., Lucas, R., Caldwell, R. B. & Caldwell, R. W., Nov 1 2017, In : Cardiovascular Research. 113, 13, p. 1664-1676 13 p.

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Endothelial Cells
Obesity
Sucrose
8 Citations (Scopus)

Obesity-induced vascular inflammation involves elevated arginase activity

Yao, L., Bhatta, A., Xu, Z., Chen, J., Toque, H. A., Chen, Y., Xu, Y., Bagi, Z., Lucas, R., Huo, Y., Caldwell, R. B. & Caldwell, R. W., Nov 2017, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 313, 5, p. R560-R571

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Intra-Abdominal Fat
Obesity
Inflammation
2016
14 Citations (Scopus)

Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury

Shosha, E., Xu, Z., Yokota, H., Saul, A., Rojas, M., William Caldwell, R., Caldwell, R. B. & Priya Narayanan, S., Jan 1 2016, In : Cell Death and Disease. 7, 11, e2483.

Research output: Contribution to journalArticle

Arginase
Reperfusion Injury
Ischemia
Reperfusion
Electroretinography
9 Citations (Scopus)

Deregulation of arginase induces bone complications in high-fat/high-sucrose diet diabetic mouse model

Bhatta, A., Sangani, R., Kolhe, R. B., Flores Toque, H. A., Cain, M., Wong, A., Howie, N., Shinde, R., Elsalanty, M. E., Yao, L., Chutkan, N., Hunter, M., Caldwell, R. B., Isales, C. M., Caldwell, R. W. & Fulzele, S. T., Feb 15 2016, In : Molecular and Cellular Endocrinology. 422, p. 211-220 10 p.

Research output: Contribution to journalArticle

Arginase
Deregulation
High Fat Diet
Nutrition
Sucrose
21 Citations (Scopus)

Neuroprotective effect of water-dispersible hesperetin in retinal ischemia reperfusion injury

Shimouchi, A., Yokota, H., Ono, S., Matsumoto, C., Tamai, T., Takumi, H., Narayanan, S. P., Kimura, S., Kobayashi, H., Caldwell, R. B., Nagaoka, T. & Yoshida, A., Jan 1 2016, In : Japanese Journal of Ophthalmology. 60, 1, p. 51-61 11 p.

Research output: Contribution to journalArticle

Neuroprotective Agents
Reperfusion Injury
Water
Ganglia
Reperfusion
3 Citations (Scopus)
Phosphatidylinositol 3-Kinases
Vascular Endothelial Growth Factor A
Oxidative Stress
Endothelial Cells
Scientific Misconduct
5 Citations (Scopus)

Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy

Patel, C., Xu, Z., Shosha, E., Xing, J., Lucas, R., Caldwell, R. W., Caldwell, R. B. & Narayanan, S. P., Sep 1 2016, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 9, p. 1628-1639 12 p.

Research output: Contribution to journalArticle

Hyperoxia
Vascular System Injuries
Retinal Vessels
Endothelial Cells
Polyamines
2015
15 Citations (Scopus)

Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function

Bhatta, A., Yao, L., Flores Toque, H. A., Shatanawi, A., Xu, Z., Caldwell, R. B. & Caldwell, R. W., Mar 25 2015, In : PloS one. 10, 3, e0121727.

Research output: Contribution to journalArticle

Arginase
arginase
angiotensin II
fibrosis
Angiotensin II
24 Citations (Scopus)

Angiotensin II limits NO production by upregulating arginase through a p38 MAPK-ATF-2 pathway

Shatanawi, A., Lemtalsi, T., Yao, L., Patel, C., Caldwell, R. B. & Caldwell, R. W., Jan 5 2015, In : European Journal of Pharmacology. 746, p. 106-114 9 p.

Research output: Contribution to journalArticle

Arginase
Mitogen-Activated Protein Kinase 1
p38 Mitogen-Activated Protein Kinases
Angiotensin II
Nitric Oxide
98 Citations (Scopus)

Arginase: An old enzyme with new tricks

Caldwell, R. B., Flores Toque, H. A., Narayanan, S. P. & Caldwell, R. W., Jan 1 2015, In : Trends in Pharmacological Sciences. 36, 6, p. 395-405 11 p.

Research output: Contribution to journalReview article

Arginase
Enzymes
Cardiovascular system
Ornithine
Neurology
10 Citations (Scopus)

Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia

Wang, L., Bhatta, A., Flores Toque, H. A., Rojas, M. A., Yao, L., Xu, Z., Patel, C., Caldwell, R. B. & Caldwell, R. W., Mar 1 2015, In : Microvascular Research. 98, p. 1-8 8 p.

Research output: Contribution to journalArticle

Arginase
Endothelial cells
Endothelial Cells
Vascular Endothelial Growth Factor A
Hypoxia
2 Citations (Scopus)

Correction: Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function

Bhatta, A., Yao, L., Toque, H. A., Shatanawi, A., Xu, Z., Caldwell, R. B. & Caldwell, R. W., Apr 21 2015, In : PLoS One. 10, 4, e0127110.

Research output: Contribution to journalComment/debate

Arginase
Angiotensin II
16 Citations (Scopus)
Tumor Necrosis Factor Receptors
Diabetic Retinopathy
Type 1 Diabetes Mellitus
Cytokine Receptor gp130
Serum
26 Citations (Scopus)

Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma

Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B. & Zhang, W., Oct 1 2015, In : Cell Death and Disease. 6, 10, e1900.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Glaucoma
Intraocular Pressure
Inflammation
Wounds and Injuries
2014
10 Citations (Scopus)

Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy

Patel, C., Narayanan, S. P., Zhang, W., Xu, Z., Sukumari Ramesh, S., Dhandapani, K. M., Caldwell, R. W. & Caldwell, R. B., Jan 1 2014, In : American Journal of Pathology. 184, 11, p. 3040-3051 12 p.

Research output: Contribution to journalArticle

Pathologic Neovascularization
Endothelins
Oxygen
Physiologic Neovascularization
Vascular Endothelial Growth Factor A
20 Citations (Scopus)

Anti-angiogenic actions of the mangosteen polyphenolic xanthone derivative α-mangostin

Jittiporn, K., Suwanpradid, J., Patel, C., Rojas, M., Thirawarapan, S., Moongkarndi, P., Suvitayavat, W. & Caldwell, R. B., May 2014, In : Microvascular Research. 93, p. 72-79 8 p.

Research output: Contribution to journalArticle

Garcinia mangostana
Xanthones
Vascular Endothelial Growth Factor A
Endothelial cells
Endothelial Cells
17 Citations (Scopus)

Arginase 2 deficiency prevents oxidative stress and limits hyperoxia-induced retinal vascular degeneration

Suwanpradid, J., Rojas, M., Behzadian, M. A., Caldwell, R. W. & Caldwell, R. B., Nov 6 2014, In : PloS one. 9, 11, 110604.

Research output: Contribution to journalArticle

Hyperargininemia
hyperoxia
Arginase
arginase
Retinal Vessels
22 Citations (Scopus)

Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism

Narayanan, S. P., Xu, Z., Putluri, N., Sreekumar, A., Lemtalsi, T., Caldwell, R. W. & Caldwell, R. B., Feb 1 2014, In : Cell Death and Disease. 5, 2, e1075.

Research output: Contribution to journalArticle

Hyperargininemia
Hyperoxia
Polyamines
Oxygen
Retina
82 Citations (Scopus)

Endothelial PFKFB3 plays a critical role in angiogenesis

Xu, Y., An, X., Guo, X., Habtetsion, T. G., Wang, Y., Xu, X., Kandala, S., Li, Q., Li, H., Zhang, C., Caldwell, R. B., Fulton, D. J., Su, Y., Hoda, MD. N., Zhou, G., Wu, C. & Huo, Y., Jun 2014, In : Arteriosclerosis, thrombosis, and vascular biology. 34, 6, p. 1231-1239 9 p.

Research output: Contribution to journalArticle

Phosphofructokinase-2
Protein Isoforms
Glycolysis
Endothelial Cells
Lactic Acid
5 Citations (Scopus)

High glucose upregulates arginase 1 and decreases nitric oxide production through ATF-2 and c-Jun transcription factors

Shatanawi, A., Gharaibeh, M. N., Caldwell, R. B. & Caldwell, R. W., Jan 1 2014, In : Life Science Journal. 11, 5, p. 374-379 6 p., 50.

Research output: Contribution to journalArticle

Arginase
Nitric Oxide
Transcription Factors
Up-Regulation
Glucose
2013
29 Citations (Scopus)
Arginase
rho-Associated Kinases
p38 Mitogen-Activated Protein Kinases
Blood Vessels
Nitrergic Neurons
19 Citations (Scopus)

Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function

Toque, H. A., Nunes, K. P., Yao, L., Xu, Z., Kondrikov, D., Su, Y., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Jan 1 2013, In : PloS one. 8, 8, p. e72277

Research output: Contribution to journalArticle

Arginase
arginase
blood vessels
Blood Vessels
Medical problems
25 Citations (Scopus)
Arginase
Desoxycorticosterone
Blood Vessels
Acetates
Salts
25 Citations (Scopus)

Arginase as a mediator of diabetic retinopathy

Patel, C., Rojas, M., Narayanan, S. P., Zhang, W., Xu, Z., Lemtalsi, T., Jittiporn, K., Caldwell, R. W. & Caldwell, R. B., Sep 16 2013, In : Frontiers in immunology. 4, JUL, Article 173.

Research output: Contribution to journalArticle

Arginase
Diabetic Retinopathy
Retinal Vessels
Retina
Glucose
38 Citations (Scopus)

Arginase in retinopathy

Narayanan, S. P., Rojas, M., Suwanpradid, J., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Sep 1 2013, In : Progress in Retinal and Eye Research. 36, p. 260-280 21 p.

Research output: Contribution to journalArticle

Arginase
Polyamines
Superoxides
Glutamic Acid
Peroxynitrous Acid
24 Citations (Scopus)

Cytokine profiling of young overweight and obese female African American adults with prediabetes

Lucas, R., Parikh, S. J., Sridhar, S., Guo, D. H., Bhagatwala, J., Dong, Y., Caldwell, R., Mellor, A., Caldwell, W., Zhu, H. & Dong, Y., Oct 1 2013, In : Cytokine. 64, 1, p. 310-315 6 p.

Research output: Contribution to journalArticle

Prediabetic State
African Americans
Cytokines
Medical problems
Type 2 Diabetes Mellitus
17 Citations (Scopus)

Diabetes-Induced Superoxide Anion and Breakdown of the Blood-Retinal Barrier: Role of the VEGF/uPAR Pathway

El-Remessy, A. B., Franklin, T., Ghaley, N., Yang, J., Brands, M. W., Caldwell, R. B. & Behzadian, M. A., Aug 7 2013, In : PloS one. 8, 8, e71868.

Research output: Contribution to journalArticle

Blood-Retinal Barrier
Retinaldehyde
Urokinase Plasminogen Activator Receptors
u-plasminogen activator
vascular endothelial growth factors
19 Citations (Scopus)

Hyperoxia causes regression of vitreous neovascularization by downregulating VEGF/VEGFR2 pathway

Liu, H., Zhang, W., Xu, Z., Caldwell, R. W., Caldwell, R. B. & Brooks, S. E., Feb 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 2, p. 918-931 14 p.

Research output: Contribution to journalArticle

Hyperoxia
Vascular Endothelial Growth Factor A
Down-Regulation
Apoptosis
Intraocular Injections
34 Citations (Scopus)

Insights into the arginine paradox: Evidence against the importance of subcellular location of arginase and eNOS

Elms, S., Chen, F., Wang, Y., Qian, J., Askari, B., Yu, Y., Pandey, D., Iddings, J., Caldwell, R. B. & Fulton, D. J. R., Sep 1 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 5, p. H651-H666

Research output: Contribution to journalArticle

Arginase
Nitric Oxide Synthase Type III
Arginine
Nitric Oxide
Citrulline
13 Citations (Scopus)

L-citrulline protects from kidney damage in type 1 diabetic mice

Romero Lucas, M. J., Yao, L., Sridhar, S., Bhatta, A., Dou, H., Ramesh, G., Brands, M. W., Pollock, D. M., Caldwell, R. B., Cederbaum, S. D., Alvin Head, C., Bagi, Z., Lucas, R. & Caldwell, R. W., Dec 1 2013, In : Frontiers in immunology. 4, DEC, Article 480.

Research output: Contribution to journalArticle

Citrulline
Arginase
Kidney
Streptozocin
Knockout Mice
56 Citations (Scopus)

Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout

Yao, L., Chandra, S., Toque, H. A., Bhatta, A., Rojas, M., Caldwell, R. B. & Caldwell, R. W., Mar 1 2013, In : Cardiovascular Research. 97, 3, p. 509-519 11 p.

Research output: Contribution to journalArticle

Arginase
rho-Associated Kinases
Blood Vessels
Aorta
Protein Isoforms
24 Citations (Scopus)

Requirement of NOX2 expression in both retina and bone marrow for diabetes-induced retinal vascular injury

Rojas, M., Zhang, W., Xu, Z., Lemtalsi, T., Chandler, P., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Dec 17 2013, In : PloS one. 8, 12, e84357.

Research output: Contribution to journalArticle

Retinal Vessels
Vascular System Injuries
Medical problems
retina
blood vessels
32 Citations (Scopus)

The role of arginase i in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes

Elms, S. C., Toque, H. A., Rojas, M., Xu, Z., Caldwell, R. W. & Caldwell, R. B., Mar 1 2013, In : Diabetologia. 56, 3, p. 654-662 9 p.

Research output: Contribution to journalArticle

Arginase
Retinal Vessels
Myography
Vasodilation
Blood Vessels
2012
6 Citations (Scopus)

Blockade of VEGF-induced GSK/β-catenin signaling, uPAR expression and increased permeability by dominant negative p38α

Yang, J., Caldwell, R. B. & Behzadian, M. A., Jul 1 2012, In : Experimental eye research. 100, p. 101-108 8 p.

Research output: Contribution to journalArticle

Catenins
Vascular Endothelial Growth Factor A
Permeability
Endothelial Cells
beta Catenin
59 Citations (Scopus)

Diabetes-induced vascular dysfunction involves arginase

Romero, M. J., Iddings, J. A., Platt, D. H., Irfan Ali, M., Cederbaum, S. D., Stepp, D. W., Caldwell, R. B. & Caldwell, R. W., Jan 1 2012, In : American Journal of Physiology - Heart and Circulatory Physiology. 302, 1, p. H159-H166

Research output: Contribution to journalArticle

Arginase
Blood Vessels
Fibrosis
Endothelial Cells
Vasodilation